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Stefan Brocke M.D.

TitleAssociate Professor
InstitutionUConn Health Center
Address263 Farmington Ave
Phone860-679-8860
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dong H, Claffey KP, Brocke S, Epstein PM. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul; 152(1):17-28. PMID: 26022351.
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    2. Schubert C, Guttek K, Grüngreiff K, Thielitz A, Bühling F, Reinhold A, Brocke S, Reinhold D. Oral zinc aspartate treats experimental autoimmune encephalomyelitis. Biometals. 2014 Dec; 27(6):1249-62. PMID: 25146336.
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    3. Reinhold D, Brocke S. DPP4-directed therapeutic strategies for MERS-CoV. Lancet Infect Dis. 2014 Feb; 14(2):100-1. PMID: 24457167.
      View in: PubMed
    4. Dong H, Claffey KP, Brocke S, Epstein PM. Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells. Springerplus. 2013; 2:680. PMID: 24683528; PMCID: PMC3967736.
    5. Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013 Dec 15; 456(3):463-73. PMID: 24007532.
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    6. Stoye D, Schubert C, Goihl A, Guttek K, Reinhold A, Brocke S, Grüngreiff K, Reinhold D. Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice. Biometals. 2012 Jun; 25(3):529-39. PMID: 22350510.
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    7. Housley WJ, Adams CO, Vang AG, Brocke S, Nichols FC, LaCombe M, Rajan TV, Clark RB. Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity. J Immunol. 2011 Oct 15; 187(8):4161-9. PMID: 21908737; PMCID: PMC3189448.
    8. Biton A, Ansorge S, Bank U, Täger M, Reinhold D, Brocke S. Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions. Immunobiology. 2011 Dec; 216(12):1295-301. PMID: 21802166.
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    9. Reinhold D, Bank U, Entz D, Goihl A, Stoye D, Wrenger S, Brocke S, Thielitz A, Stefin S, Nordhoff K, Heimburg A, Täger M, Ansorge S. PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice. Biol Chem. 2011 Mar; 392(3):233-7. PMID: 21194377.
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    10. Bhowmick S, Clark RB, Brocke S, Cone RE. Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. Int Immunol. 2011 Feb; 23(2):119-28. PMID: 21273399; PMCID: PMC3030727.
    11. Vang AG, Ben-Sasson SZ, Dong H, Kream B, DeNinno MP, Claffey MM, Housley W, Clark RB, Epstein PM, Brocke S. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010; 5(8):e12011. PMID: 20711499; PMCID: PMC2918507.
    12. Reinhold D, Goihl A, Wrenger S, Reinhold A, Kühlmann UC, Faust J, Neubert K, Thielitz A, Brocke S, Täger M, Ansorge S, Bank U. Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice. Clin Chem Lab Med. 2009; 47(3):268-74. PMID: 19676138.
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    13. Kobayashi N, Kiptoo P, Kobayashi H, Ridwan R, Brocke S, Siahaan TJ. Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. Clin Immunol. 2008 Oct; 129(1):69-79. PMID: 18676182; PMCID: PMC2597351.
    14. Reinhold D, Bank U, Täger M, Ansorge S, Wrenger S, Thielitz A, Lendeckel U, Faust J, Neubert K, Brocke S. DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis. Front Biosci. 2008; 13:2356-63. PMID: 17981717.
      View in: PubMed
    15. Badriyyah M, Mazeh H, Brocke S, Osmanova V, Freund HR, Hanani M. Prevention of lipopolysaccharide-induced intussusception in mice by the COX2 inhibitor rofecoxib. Pediatr Surg Int. 2008 Mar; 24(3):333-6. PMID: 17985132.
      View in: PubMed
    16. Waiczies S, Bendix I, Prozorovski T, Ratner M, Nazarenko I, Pfueller CF, Brandt AU, Herz J, Brocke S, Ullrich O, Zipp F. Geranylgeranylation but not GTP loading determines rho migratory function in T cells. J Immunol. 2007 Nov 1; 179(9):6024-32. PMID: 17947676.
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    17. Reinhold D, Biton A, Goihl A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S. Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses. Ann N Y Acad Sci. 2007 Sep; 1110:402-9. PMID: 17911455.
      View in: PubMed
    18. Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, Lendeckel U, Röcken C, Faust J, Neubert K, Schraven B, Martin R, Ansorge S, Brocke S, Reinhold D. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J Immunol. 2007 Apr 1; 178(7):4632-40. PMID: 17372022.
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    19. Reinhold D, Biton A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Int Immunopharmacol. 2006 Dec 20; 6(13-14):1935-42. PMID: 17161346.
      View in: PubMed
    20. Dong H, Osmanova V, Epstein PM, Brocke S. Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Biochem Biophys Res Commun. 2006 Jun 30; 345(2):713-9. PMID: 16696947.
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    21. Preller V, Gerber A, Togni M, Wrenger S, Schraven B, Röcken C, Marguet D, Ansorge S, Brocke S, Reinhold D. CD26/DP IV in T cell activation and autoimmunity. Adv Exp Med Biol. 2006; 575:187-93. PMID: 16700522.
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    22. Biton A, Bank U, Täger M, Ansorge S, Reinhold D, Lendeckel U, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Adv Exp Med Biol. 2006; 575:177-86. PMID: 16700521.
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    23. Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Schulze Topphoff U, Vogt J, Prozorovski T, Meier S, Osmanova V, Pohl E, Bechmann I, Nitsch R, Zipp F. Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron. 2005 May 5; 46(3):421-32. PMID: 15882642.
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    24. Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, Infante-Duarte C, Brocke S, Zipp F. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol. 2004 Nov 1; 173(9):5794-800. PMID: 15494532.
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    25. Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M, Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells. Eur J Immunol. 2004 May; 34(5):1333-41. PMID: 15114666.
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    26. Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M, Galun E, Peled A. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood. 2003 Sep 15; 102(6):1951-8. PMID: 12730102.
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    27. Aktas O, Waiczies S, Smorodchenko A, Dorr J, Seeger B, Prozorovski T, Sallach S, Endres M, Brocke S, Nitsch R, Zipp F. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J Exp Med. 2003 Mar 17; 197(6):725-33. PMID: 12629065; PMCID: PMC2193848.
    28. Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biol Chem. 2002 Jul-Aug; 383(7-8):1133-8. PMID: 12437097.
      View in: PubMed
    29. Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. J Immunol. 2001 Feb 1; 166(3):2041-8. PMID: 11160254.
      View in: PubMed
    30. Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. Dipeptidyl peptidase IV in inflammatory CNS disease. Adv Exp Med Biol. 2000; 477:145-53. PMID: 10849741.
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    31. Brocke S. T cell receptor peptides for the vaccination therapy of multiple sclerosis. Ernst Schering Res Found Workshop. 2000; (30):167-79. PMID: 10943323.
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    32. Reinhold D, Hemmer B, Gran B, Steinbrecher A, Brocke S, Kähne T, Wrenger S, Born I, Faust J, Neubert K, Martin R, Ansorge S. Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease. Adv Exp Med Biol. 2000; 477:155-60. PMID: 10849742.
      View in: PubMed
    33. Brocke S, Piercy C, Steinman L, Weissman IL, Veromaa T. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6896-901. PMID: 10359810; PMCID: PMC22013.
    34. Constantin G, Laudanna C, Brocke S, Butcher EC. Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor. J Immunol. 1999 Jan 15; 162(2):1144-9. PMID: 9916745.
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    35. Jeong MC, Izikson L, Uccelli A, Brocke S, Oksenberg JR. Differential display analysis of murine encephalitogenic mRNA. Int Immunol. 1998 Dec; 10(12):1819-23. PMID: 9885902.
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    36. Ufret-Vincenty RL, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfennig KW, Brocke S. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J Exp Med. 1998 Nov 2; 188(9):1725-38. PMID: 9802984; PMCID: PMC2212527.
    37. Constantin G, Brocke S, Izikson A, Laudanna C, Butcher EC. Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis. Eur J Immunol. 1998 Nov; 28(11):3523-9. PMID: 9842895.
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    38. Xu S, Jordan EK, Brocke S, Bulte JW, Quigley L, Tresser N, Ostuni JL, Yang Y, McFarland HF, Frank JA. Study of relapsing remitting experimental allergic encephalomyelitis SJL mouse model using MION-46L enhanced in vivo MRI: early histopathological correlation. J Neurosci Res. 1998 Jun 1; 52(5):549-58. PMID: 9632311.
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    39. Li W, Quigley L, Yao DL, Hudson LD, Brenner M, Zhang BJ, Brocke S, McFarland HF, Webster HD. Chronic relapsing experimental autoimmune encephalomyelitis: effects of insulin-like growth factor-I treatment on clinical deficits, lesion severity, glial responses, and blood brain barrier defects. J Neuropathol Exp Neurol. 1998 May; 57(5):426-38. PMID: 9596413.
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    40. Xu S, Jordan EK, Li W, Yang Y, Chesnick SA, Webster HD, Brocke S, Quigley L, McFarland HF, Frank JA. In vivo three-dimensional MR microscopy of mice with chronic relapsing experimental autoimmune encephalomyelitis after treatment with insulin-like growth factor-I. AJNR Am J Neuroradiol. 1998 Apr; 19(4):653-8. PMID: 9576650.
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    41. Brocke S, Hausmann S, Steinman L, Wucherpfennig KW. Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Semin Immunol. 1998 Feb; 10(1):57-67. PMID: 9529656.
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    42. Shaw MK, Lorens JB, Dhawan A, DalCanto R, Tse HY, Tran AB, Bonpane C, Eswaran SL, Brocke S, Sarvetnick N, Steinman L, Nolan GP, Fathman CG. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 1997 May 5; 185(9):1711-4. PMID: 9151908; PMCID: PMC2196296.
    43. Liblau R, Steinman L, Brocke S. Experimental autoimmune encephalomyelitis in IL-4-deficient mice. Int Immunol. 1997 May; 9(5):799-803. PMID: 9184926.
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    44. Gaur A, Boehme SA, Chalmers D, Crowe PD, Pahuja A, Ling N, Brocke S, Steinman L, Conlon PJ. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J Neuroimmunol. 1997 Apr; 74(1-2):149-58. PMID: 9119968.
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    45. Brenner T, Brocke S, Szafer F, Sobel RA, Parkinson JF, Perez DH, Steinman L. Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis. J Immunol. 1997 Mar 15; 158(6):2940-6. PMID: 9058833.
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    46. Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med. 1996 Aug; 2(8):899-905. PMID: 8705860.
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    47. Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, Fairchild PJ, Wraith DC, O'Garra A, Fathman CG, Steinman L. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature. 1996 Jan 25; 379(6563):343-6. PMID: 8552189.
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    48. Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol. 1996 Jan 1; 156(1):5-7. PMID: 8598493.
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    49. Gijbels K, Brocke S, Abrams JS, Steinman L. Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol Med. 1995 Nov; 1(7):795-805. PMID: 8612202; PMCID: PMC2230023.
    50. Karin N, Mitchell DJ, Brocke S, Ling N, Steinman L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production. J Exp Med. 1994 Dec 1; 180(6):2227-37. PMID: 7525850; PMCID: PMC2191798.
    51. Brocke S, Gaur A, Piercy C, Gautam A, Gijbels K, Fathman CG, Steinman L. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature. 1993 Oct 14; 365(6447):642-4. PMID: 7692305.
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    52. Gaur A, Fathman CG, Steinman L, Brocke S. SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein. J Immunol. 1993 Apr 1; 150(7):3062-9. PMID: 7681087.
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    53. Mielke ME, Rosen H, Brocke S, Peters C, Hahn H. Protective immunity and granuloma formation are mediated by two distinct tumor necrosis factor alpha- and gamma interferon-dependent T cell-phagocyte interactions in murine listeriosis: dissociation on the basis of phagocyte adhesion mechanisms. Infect Immun. 1992 May; 60(5):1875-82. PMID: 1563777; PMCID: PMC257088.
    54. Brocke S, Chakraborty T, Mohasseb I, Reichert H, Lombardi O, Hahn H, Mielke M. Protective immunity and granulomatous inflammation is mediated in vivo by T cells reactive to epitopes common to avirulent and listeriolysin-negative mutants of Listeria monocytogenes. Cell Immunol. 1992 Mar; 140(1):42-53. PMID: 1739988.
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    55. Brocke S, Hahn H. Heat-killed Listeria monocytogenes and L. monocytogenes soluble antigen induce clonable CD4+ T lymphocytes with protective and chemotactic activities in vivo. Infect Immun. 1991 Dec; 59(12):4531-9. PMID: 1682264; PMCID: PMC259074.
    56. Brosh N, Lotan M, Eisenbach L, Brocke S, Tartakovsky B. Fertility impairment and improved fetal survival induced by a tumor cell line in mice. Am J Reprod Immunol. 1991 Aug; 26(1):47-51. PMID: 1741939.
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    57. Brocke S, Chakraborty T, Lombardi O, Hahn H, Mielke M. Listeriolysin negative mutants of Listeria monocytogenes specifically stimulate T-lymphocytes mediating protection and granulomatous inflammation. Zentralbl Bakteriol. 1991 Apr; 275(1):112-7. PMID: 1930559.
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    58. Brocke S, Dayan M, Rothbard J, Fuchs S, Mozes E. The autoimmune response of different mouse strains to T-cell epitopes of the human acetylcholine receptor alpha subunit. Immunology. 1990 Apr; 69(4):495-500. PMID: 1692300; PMCID: PMC1385618.
    59. Brocke S, Dayan M, Steinman L, Rothbard J, Mozes E. Inhibition of T cell proliferation specific for acetylcholine receptor epitopes related to myasthenia gravis with antibody to T cell receptor or with competitive synthetic polymers. Int Immunol. 1990; 2(8):735-42. PMID: 1707306.
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    60. Mozes E, Dayan M, Zisman E, Brocke S, Licht A, Pecht I. Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells. EMBO J. 1989 Dec 20; 8(13):4049-52. PMID: 2480232; PMCID: PMC401581.
    61. Takács L, Ruscetti FW, Kovacs EJ, Rocha B, Brocke S, Diamantstein T, Mathieson BJ. Immature, double negative (CD4-,CD8-) rat thymocytes do not express IL-2 receptors. J Immunol. 1988 Dec 1; 141(11):3810-8. PMID: 3263434.
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    62. Hahn HJ, Gerdes J, Lucke S, Liepe L, Kauert C, Volk HD, Wacker HH, Brocke S, Stein H, Diamantstein T. Phenotypical characterization of the cells invading pancreatic islets of diabetic BB/OK rats: effect of interleukin 2 receptor-targeted immunotherapy. Eur J Immunol. 1988 Dec; 18(12):2037-42. PMID: 3065088.
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    63. Brocke S, Takacs L, Gerdes J, Osawa H, Diamantstein T. The ontogeny of the interleukin 2 receptor expression and of the interleukin 2 responsiveness in the rat thymus. Immunobiology. 1987 May; 174(3):266-73. PMID: 3114132.
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    64. Volk HD, Brocke S, Osawa H, Diamantstein T. Suppression of the local graft-vs.-host reaction in rats by treatment with a monoclonal antibody specific for the interleukin 2 receptor. Eur J Immunol. 1986 Oct; 16(10):1309-12. PMID: 2945730.
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