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Rajesh V Lalla DDS, PhD

TitleAssistant Clinical Professor
InstitutionUConn Health Center
DepartmentOral Health and Diagnostic Sciences
AddressMC 1605
MC 1605
263 Farmington Avenue
Phone860-679-2952
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    Dr. Lalla is a board-certified clinician and scholar who conducts clinical research on a variety of oral mucosal disorders, including mucositis secondary to cancer treatment, recurrent aphthous stomatitis (canker sores) and oral candidiasis (thrush). His research has been funded by the federal government (through the National Institutes of Health), the American Cancer Society, the Donaghue Foundation, and industry. In addition to clinical care and research, Dr. Lalla is also involved in clinical and classroom teaching of Oral Medicine and directs a course on Evidence-based Decision Making. Dr. Lalla serves as Associate Dean for Research in the School of Dental Medicine. He also serves on several institutional committees and is a past Chair of the Institutional Review Board, which oversees the conduct of clinical research. Dr. Lalla holds several leadership positions at the international level. He is a past Chair of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology (MASCC/ISOO), and is a member of the MASCC Board of Directors and President-elect of MASCC. Dr. Lalla has written more than 75 peer-reviewed scientific articles or book chapters, many of them dealing with oral complications in cancer patients. He is also asked to speak on oral complications of cancer therapy at the national and international levels. He has reviewed articles written by others for over 25 scientific journals. Dr. Lalla also serves as a consultant on various topics including oral mucositis, oropharyngeal candidiasis, recurrent aphthous stomatitis, and clinical trial design and outcomes.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. De Sanctis V, Bossi P, Sanguineti G, Trippa F, Ferrari D, Bacigalupo A, Ripamonti CI, Buglione M, Pergolizzi S, Langendjik JA, Murphy B, Raber-Durlacher J, Russi EG, Lalla RV. Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements. Crit Rev Oncol Hematol. 2016 Apr; 100:147-66. PMID: 26947812.
      View in: PubMed
    2. Soto M, Lalla RV, Gouveia RV, Zecchin VG, Seber A, Lopes NN. Pilot Study on the Efficacy of Combined Intraoral and Extraoral Low-Level Laser Therapy for Prevention of Oral Mucositis in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation. Photomed Laser Surg. 2015 Nov; 33(11):540-6. PMID: 26501372.
      View in: PubMed
    3. Krause CE, Otieno BA, Bishop GW, Phadke G, Choquette L, Lalla RV, Peterson DE, Rusling JF. Ultrasensitive microfluidic array for serum pro-inflammatory cytokines and C-reactive protein to assess oral mucositis risk in cancer patients. Anal Bioanal Chem. 2015 Sep; 407(23):7239-43. PMID: 26143063; PMCID: PMC4553140 [Available on 09/01/16].
    4. Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, van de Wetering MD, Rao NG, Potting C, Cheng KK, Freidank A, Brennan MT, Bowen J, Dennis K, Lalla RV. Erratum to: Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer. 2015 Feb; 23(2):601-2. PMID: 25475737.
      View in: PubMed
    5. Wahl MJ, Pinto A, Kilham J, Lalla RV. Dental surgery in anticoagulated patients--stop the interruption. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Feb; 119(2):136-57. PMID: 25577414.
      View in: PubMed
    6. Lalla RV. Alleviating mucositis: are we on track for a novel therapeutic? Expert Rev Gastroenterol Hepatol. 2015 Feb; 9(2):127-8. PMID: 25270956.
      View in: PubMed
    7. Lalla RV, Choquette LE, Curley KF, Dowsett RJ, Feinn RS, Hegde UP, Pilbeam CC, Salner AL, Sonis ST, Peterson DE. Randomized double-blind placebo-controlled trial of celecoxib for oral mucositis in patients receiving radiation therapy for head and neck cancer. Oral Oncol. 2014 Nov; 50(11):1098-103. PMID: 25151488.
      View in: PubMed
    8. Lalla RV, Dongari-Bagtzoglou A. Antifungal medications or disinfectants for denture stomatitis. Evid Based Dent. 2014 Jun; 15(2):61-2. PMID: 24971864.
      View in: PubMed
    9. Lalla RV, Saunders DP, Peterson DE. Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am. 2014 Apr; 58(2):341-9. PMID: 24655526.
      View in: PubMed
    10. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014 May 15; 120(10):1453-61. PMID: 24615748; PMCID: PMC4164022.
    11. Boers-Doets CB, Raber-Durlacher JE, Treister NS, Epstein JB, Arends AB, Wiersma DR, Lalla RV, Logan RM, van Erp NP, Gelderblom H. Mammalian target of rapamycin inhibitor-associated stomatitis. Future Oncol. 2013 Dec; 9(12):1883-92. PMID: 24295418.
      View in: PubMed
    12. Peterson DE, Srivastava R, Lalla RV. Oral mucosal injury in oncology patients: perspectives on maturation of a field. Oral Dis. 2015 Mar; 21(2):133-41. PMID: 24131518.
      View in: PubMed
    13. Wahl MJ, Pinto A, Lalla RV. Interruption of warfarin anticoagulation for dental surgery. Chest. 2013 Oct; 144(4):1424. PMID: 24081367.
      View in: PubMed
    14. McGuire DB, Fulton JS, Park J, Brown CG, Correa ME, Eilers J, Elad S, Gibson F, Oberle-Edwards LK, Bowen J, Lalla RV. Systematic review of basic oral care for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov; 21(11):3165-77. PMID: 24018908.
      View in: PubMed
    15. Lalla RV, Ashbury FD. The MASCC/ISOO mucositis guidelines: dissemination and clinical impact. Support Care Cancer. 2013 Nov; 21(11):3161-3. PMID: 23942597.
      View in: PubMed
    16. Jensen SB, Jarvis V, Zadik Y, Barasch A, Ariyawardana A, Hovan A, Yarom N, Lalla RV, Bowen J, Elad S. Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov; 21(11):3223-32. PMID: 23900593.
      View in: PubMed
    17. Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ, Logan RM, Nair RG, Stringer AM, Yazbeck R, Elad S, Lalla RV. Emerging evidence on the pathobiology of mucositis. Support Care Cancer. 2013 Nov; 21(11):3233-41. PMID: 23842598.
      View in: PubMed
    18. Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, van de Wetering MD, Rao NG, Potting C, Cheng KK, Freidank A, Brennan MT, Bowen J, Dennis K, Lalla RV. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov; 21(11):3191-207. PMID: 23832272.
      View in: PubMed
    19. Yarom N, Ariyawardana A, Hovan A, Barasch A, Jarvis V, Jensen SB, Zadik Y, Elad S, Bowen J, Lalla RV. Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov; 21(11):3209-21. PMID: 23764678.
      View in: PubMed
    20. Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, Lalla RV. Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov; 21(11):3179-89. PMID: 23702538.
      View in: PubMed
    21. Al-Dasooqi N, Sonis ST, Bowen JM, Bateman E, Blijlevens N, Gibson RJ, Logan RM, Nair RG, Stringer AM, Yazbeck R, Elad S, Lalla RV. Emerging evidence on the pathobiology of mucositis. Support Care Cancer. 2013 Jul; 21(7):2075-83. PMID: 23604521.
      View in: PubMed
    22. Lalla RV, Patton LL, Dongari-Bagtzoglou A. Oral candidiasis: pathogenesis, clinical presentation, diagnosis and treatment strategies. J Calif Dent Assoc. 2013 Apr; 41(4):263-8. PMID: 23705242.
      View in: PubMed
    23. D'Amato-Palumbo S, Kaplan AA, Feinn RS, Lalla RV. Retrospective study of microorganisms associated with vascular access infections in hemodialysis patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan; 115(1):56-61. PMID: 23217535; PMCID: PMC3880246.
    24. Lalla RV. The MASCC/ISOO Mucositis Guidelines Update: introduction to the first set of articles. Support Care Cancer. 2013 Jan; 21(1):301-2. PMID: 23161340.
      View in: PubMed
    25. Gibson RJ, Keefe DM, Lalla RV, Bateman E, Blijlevens N, Fijlstra M, King EE, Stringer AM, van der Velden WJ, Yazbeck R, Elad S, Bowen JM. Systematic review of agents for the management of gastrointestinal mucositis in cancer patients. Support Care Cancer. 2013 Jan; 21(1):313-26. PMID: 23142924.
      View in: PubMed
    26. Baccaglini L, Theriaque DW, Shuster JJ, Serrano G, Lalla RV. Validation of anamnestic diagnostic criteria for recurrent aphthous stomatitis. J Oral Pathol Med. 2013 Apr; 42(4):290-4. PMID: 23106421; PMCID: PMC3950972.
    27. Elad S, Bowen J, Zadik Y, Lalla RV. Development of the MASCC/ISOO Clinical Practice Guidelines for Mucositis: considerations underlying the process. Support Care Cancer. 2013 Jan; 21(1):309-12. PMID: 23064884.
      View in: PubMed
    28. Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, Lalla RV. Systematic review of amifostine for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Jan; 21(1):357-64. PMID: 23052919.
      View in: PubMed
    29. Migliorati C, Hewson I, Lalla RV, Antunes HS, Estilo CL, Hodgson B, Lopes NN, Schubert MM, Bowen J, Elad S. Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Jan; 21(1):333-41. PMID: 23001179.
      View in: PubMed
    30. Peterson DE, Ohrn K, Bowen J, Fliedner M, Lees J, Loprinzi C, Mori T, Osaguona A, Weikel DS, Elad S, Lalla RV. Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer. 2013 Jan; 21(1):327-32. PMID: 22993025.
      View in: PubMed
    31. Raber-Durlacher JE, von Bültzingslöwen I, Logan RM, Bowen J, Al-Azri AR, Everaus H, Gerber E, Gomez JG, Pettersson BG, Soga Y, Spijkervet FK, Tissing WJ, Epstein JB, Elad S, Lalla RV. Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Jan; 21(1):343-55. PMID: 22987094.
      View in: PubMed
    32. Bowen JM, Elad S, Hutchins RD, Lalla RV. Methodology for the MASCC/ISOO Mucositis Clinical Practice Guidelines Update. Support Care Cancer. 2013 Jan; 21(1):303-8. PMID: 22960942.
      View in: PubMed
    33. Lalla RV, Choquette LE, Feinn RS, Zawistowski H, Latortue MC, Kelly ET, Baccaglini L. Multivitamin therapy for recurrent aphthous stomatitis: a randomized, double-masked, placebo-controlled trial. J Am Dent Assoc. 2012 Apr; 143(4):370-6. PMID: 22467697; PMCID: PMC3880249.
    34. Gatehouse CS, Tennen HA, Feinn RS, Abu-Hasaballah KS, Lalla RV. Association between interactive voice response adherence and subject retention in a randomized controlled trial. Contemp Clin Trials. 2012 Jul; 33(4):589-92. PMID: 22484338; PMCID: PMC3714213.
    35. Lalla RV, Bowen J, Elad S. Mouth care protocol for oral mucositis. J Oncol Pharm Pract. 2012 Mar; 18(1):158. PMID: 22392965.
      View in: PubMed
    36. Huling LB, Baccaglini L, Choquette L, Feinn RS, Lalla RV. Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med. 2012 Feb; 41(2):149-52. PMID: 22077475; PMCID: PMC3323121.
    37. Lalla RV, Peterson DE, Aframian DJ. Should warfarin be discontinued before a dental extraction? Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Feb; 113(2):149-50; author reply 150-2. PMID: 22677726.
      View in: PubMed
    38. Lalla RV, Gordon GB, Schubert M, Silverman S, Hutten M, Sonis ST, LeVeque F, Peterson DE. A randomized, double-blind, placebo-controlled trial of misoprostol for oral mucositis secondary to high-dose chemotherapy. Support Care Cancer. 2012 Aug; 20(8):1797-804. PMID: 21964618.
      View in: PubMed
    39. Lalla RV. Translating mucositis research from animal models to humans: challenges and opportunities. J Support Oncol. 2011 Sep-Oct; 9(5):169. PMID: 22024304.
      View in: PubMed
    40. Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M, Rogers RS. Urban legends: recurrent aphthous stomatitis. Oral Dis. 2011 Nov; 17(8):755-70. PMID: 21812866; PMCID: PMC3192917.
    41. Peterson DE, Bensadoun RJ, Lalla RV, McGuire DB. Supportive care treatment guidelines: value, limitations, and opportunities. Semin Oncol. 2011 Jun; 38(3):367-73. PMID: 21600365.
      View in: PubMed
    42. Bensadoun RJ, Patton LL, Lalla RV, Epstein JB. Oropharyngeal candidiasis in head and neck cancer patients treated with radiation: update 2011. Support Care Cancer. 2011 Jun; 19(6):737-44. PMID: 21479787.
      View in: PubMed
    43. Lalla RV, Bensadoun RJ. Miconazole mucoadhesive tablet for oropharyngeal candidiasis. Expert Rev Anti Infect Ther. 2011 Jan; 9(1):13-7. PMID: 21171872; PMCID: PMC3076938.
    44. Blondin JM, Abu-Hasaballah KS, Tennen H, Lalla RV. Electronic versus paper diaries: a pilot study of concordance and adherence in head and neck cancer patients receiving radiation therapy. Head Neck Oncol. 2010; 2:29. PMID: 20955592; PMCID: PMC2972290.
    45. Lopes NN, Plapler H, Lalla RV, Chavantes MC, Yoshimura EM, da Silva MA, Alves MT. Effects of low-level laser therapy on collagen expression and neutrophil infiltrate in 5-fluorouracil-induced oral mucositis in hamsters. Lasers Surg Med. 2010 Aug; 42(6):546-52. PMID: 20662031.
      View in: PubMed
    46. Vazquez JA, Patton LL, Epstein JB, Ramlachan P, Mitha I, Noveljic Z, Fourie J, Conway B, Lalla RV, Barasch A, Attali P. Randomized, comparative, double-blind, double-dummy, multicenter trial of miconazole buccal tablet and clotrimazole troches for the treatment of oropharyngeal candidiasis: study of miconazole Lauriad® efficacy and safety (SMiLES). HIV Clin Trials. 2010 Jul-Aug; 11(4):186-96. PMID: 20974574.
      View in: PubMed
    47. Peterson DE, Lalla RV. Oral mucositis: the new paradigms. Curr Opin Oncol. 2010 Jul; 22(4):318-22. PMID: 20485169; PMCID: PMC3716390.
    48. Lalla RV, Latortue MC, Hong CH, Ariyawardana A, D'Amato-Palumbo S, Fischer DJ, Martof A, Nicolatou-Galitis O, Patton LL, Elting LS, Spijkervet FK, Brennan MT. A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer. 2010 Aug; 18(8):985-92. PMID: 20449755; PMCID: PMC2914797.
    49. Kozlak ST, Walsh SJ, Lalla RV. Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis. J Oral Pathol Med. 2010 May; 39(5):420-3. PMID: 20141576; PMCID: PMC3323114.
    50. Lalla RV, Pilbeam CC, Walsh SJ, Sonis ST, Keefe DM, Peterson DE. Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study. Support Care Cancer. 2010 Jan; 18(1):95-103. PMID: 19404685.
      View in: PubMed
    51. Lopes NN, Plapler H, Chavantes MC, Lalla RV, Yoshimura EM, Alves MT. Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols. Support Care Cancer. 2009 Nov; 17(11):1409-15. PMID: 19234862.
      View in: PubMed
    52. Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dent Clin North Am. 2008 Jan; 52(1):61-77, viii. PMID: 18154865; PMCID: PMC2266835.
    53. Aframian DJ, Lalla RV, Peterson DE. Management of dental patients taking common hemostasis-altering medications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar; 103 Suppl:S45.e1-11. PMID: 17379154.
      View in: PubMed
    54. Lalla RV, Peterson DE. Treatment of mucositis, including new medications. Cancer J. 2006 Sep-Oct; 12(5):348-54. PMID: 17034671.
      View in: PubMed
    55. Bensadoun RJ, Schubert MM, Lalla RV, Keefe D. Amifostine in the management of radiation-induced and chemo-induced mucositis. Support Care Cancer. 2006 Jun; 14(6):566-72. PMID: 16586122.
      View in: PubMed
    56. Lalla RV, Schubert MM, Bensadoun RJ, Keefe D. Anti-inflammatory agents in the management of alimentary mucositis. Support Care Cancer. 2006 Jun; 14(6):558-65. PMID: 16565821.
      View in: PubMed
    57. Lalla RV. Velafermin (CuraGen). Curr Opin Investig Drugs. 2005 Nov; 6(11):1179-85. PMID: 16312140.
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    58. Lalla RV, Peterson DE. Oral mucositis. Dent Clin North Am. 2005 Jan; 49(1):167-84, ix. PMID: 15567367.
      View in: PubMed
    59. Raber-Durlacher JE, Barasch A, Peterson DE, Lalla RV, Schubert MM, Fibbe WE. Oral complications and management considerations in patients treated with high-dose chemotherapy. Support Cancer Ther. 2004 Jul 1; 1(4):219-29. PMID: 18628146.
      View in: PubMed
    60. Lalla RV, Boisoneau DS, Spiro JD, Kreutzer DL. Expression of vascular endothelial growth factor receptors on tumor cells in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2003 Aug; 129(8):882-8. PMID: 12925349.
      View in: PubMed
    61. Lalla RV, Tanzer ML, Kreutzer DL. Identification of a region of the fibrin molecule involved in upregulation of interleukin-8 expression from human oral squamous cell carcinoma cells. Arch Oral Biol. 2003 Apr; 48(4):263-71. PMID: 12663071.
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    62. Lalla RV, Spiro JD, Tanzer ML, Kreutzer DL. Association of fibrin and interleukin 8 in human oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Apr; 95(4):452-7. PMID: 12686929.
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    63. Lalla RV, D'Ambrosio JA. Dental management considerations for the patient with diabetes mellitus. J Am Dent Assoc. 2001 Oct; 132(10):1425-32. PMID: 11680359.
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    64. Lalla RV, Goralnick SJ, Tanzer ML, Kreutzer DL. Fibrin induces IL-8 expression from human oral squamous cell carcinoma cells. Oral Oncol. 2001 Apr; 37(3):234-42. PMID: 11287277.
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