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Last Name
Institution

Christopher D Heinen PhD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 3101
MC 3101
263 Farmington Avenue
Phone860-679-8859
Fax860-679-7639
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    Other Positions
    TitleAssistant Professor
    InstitutionUConn Health Center
    DepartmentMolecular, Microbial and Structural Biology

    TitleAssistant Professor
    InstitutionUConn Health Center
    DepartmentNeag Cancer Center


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fishel R, Heinen CD. Enhanced gene targeting to evaluate Lynch syndrome alterations. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):3918-20. PMID: 27035997.
      View in: PubMed
    2. Heinen CD. Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer. DNA Repair (Amst). 2016 Feb; 38:127-34. PMID: 26710976.
      View in: PubMed
    3. Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutat Res Rev Mutat Res. 2016 Jan-Mar; 767:77-91. PMID: 27036068.
      View in: PubMed
    4. Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895-2015. Nat Rev Cancer. 2015 Mar; 15(3):181-94. PMID: 25673086.
      View in: PubMed
    5. Lin B, Gupta D, Heinen CD. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. J Biol Chem. 2014 Aug 29; 289(35):24314-24. PMID: 25012654; PMCID: PMC4148860.
    6. Heinen CD. Translating mismatch repair mechanism into cancer care. Curr Drug Targets. 2014 Jan; 15(1):53-64. PMID: 24387335.
      View in: PubMed
    7. Thompson BA, Spurdle AB, Plazzer JP, Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capell√° G, den Dunnen JT, du Sart D, Fabre A, Farrell MP, Farrington SM, Frayling IM, Frebourg T, Goldgar DE, Heinen CD, Holinski-Feder E, Kohonen-Corish M, Robinson KL, Leung SY, Martins A, Moller P, Morak M, Nystrom M, Peltomaki P, Pineda M, Qi M, Ramesar R, Rasmussen LJ, Royer-Pokora B, Scott RJ, Sijmons R, Tavtigian SV, Tops CM, Weber T, Wijnen J, Woods MO, Macrae F, Genuardi M. Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. Nat Genet. 2014 Feb; 46(2):107-15. PMID: 24362816; PMCID: PMC4294709.
    8. Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. Hum Mutat. 2013 Jun; 34(6):923-4. PMID: 23554108.
      View in: PubMed
    9. Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future. Hum Mutat. 2012 Dec; 33(12):1617-25. PMID: 22833534.
      View in: PubMed
    10. Heinen CD, Juel Rasmussen L. Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. Hered Cancer Clin Pract. 2012; 10(1):9. PMID: 22824075; PMCID: PMC3434035.
    11. Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control. 2012 Feb; 23(2):355-61. PMID: 22187142.
      View in: PubMed
    12. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. J Virol. 2011 Dec; 85(23):12241-53. PMID: 21957315; PMCID: PMC3209375.
    13. Heinen CD, Cyr JL, Cook C, Punja N, Sakato M, Forties RA, Lopez JM, Hingorani MM, Fishel R. Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. J Biol Chem. 2011 Nov 18; 286(46):40287-95. PMID: 21937421; PMCID: PMC3220577.
    14. Cyr JL, Brown GD, Stroop J, Heinen CD. The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex. Mol Carcinog. 2012 Aug; 51(8):647-58. PMID: 21837758; PMCID: PMC3220760.
    15. Hollenbach JP, Resch AM, Palakodeti D, Graveley BR, Heinen CD. Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells. PLoS One. 2011; 6(7):e21808. PMID: 21747960; PMCID: PMC3128615.
    16. Mastrocola AS, Heinen CD. Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo. Hum Mutat. 2010 Oct; 31(10):E1699-708. PMID: 20672385; PMCID: PMC2947597.
    17. Anderson JC, Pleau DC, Rajan TV, Protiva P, Swede H, Brenner B, Heinen CD, Lambrecht RW, Rosenberg DW. Increased frequency of serrated aberrant crypt foci among smokers. Am J Gastroenterol. 2010 Jul; 105(7):1648-54. PMID: 20234347.
      View in: PubMed
    18. Mastrocola AS, Heinen CD. Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. DNA Repair (Amst). 2010 Feb 4; 9(2):120-33. PMID: 20004149; PMCID: PMC2819642.
    19. Heinen CD. Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutat Res. 2010 Nov 10; 693(1-2):32-45. PMID: 19766128; PMCID: PMC2891646.
    20. Cyr JL, Heinen CD. Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. J Biol Chem. 2008 Nov 14; 283(46):31641-8. PMID: 18790734; PMCID: PMC2581557.
    21. Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res. 2007 Apr 15; 67(8):3551-4. PMID: 17440063.
      View in: PubMed
    22. Greenspan EJ, Cyr JL, Pleau DC, Levine J, Rajan TV, Rosenberg DW, Heinen CD. Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis. 2007 Apr; 28(4):769-76. PMID: 17088260.
      View in: PubMed
    23. Stevens RG, Swede H, Heinen CD, Jablonski M, Grupka M, Ross B, Parente M, Tirnauer JS, Giardina C, Rajan TV, Rosenberg DW, Levine J. Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Lett. 2007 Apr 18; 248(2):262-8. PMID: 16950561.
      View in: PubMed
    24. Shim KS, Tombline G, Heinen CD, Charbonneau N, Schmutte C, Fishel R. Magnesium influences the discrimination and release of ADP by human RAD51. DNA Repair (Amst). 2006 Jun 10; 5(6):704-17. PMID: 16624636.
      View in: PubMed
    25. Shim KS, Schmutte C, Tombline G, Heinen CD, Fishel R. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. J Biol Chem. 2004 Jul 16; 279(29):30385-94. PMID: 15123651.
      View in: PubMed
    26. Heinen CD, Goss KH, Cornelius JR, Babcock GF, Knudsen ES, Kowalik T, Groden J. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology. 2002 Sep; 123(3):751-63. PMID: 12198702.
      View in: PubMed
    27. Heinen CD, Schmutte C, Fishel R. DNA repair and tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biol Ther. 2002 Sep-Oct; 1(5):477-85. PMID: 12496472.
      View in: PubMed
    28. Heinen CD, Wilson T, Mazurek A, Berardini M, Butz C, Fishel R. HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions. Cancer Cell. 2002 Jun; 1(5):469-78. PMID: 12124176.
      View in: PubMed
    29. Tombline G, Heinen CD, Shim KS, Fishel R. Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides. J Biol Chem. 2002 Apr 26; 277(17):14434-42. PMID: 11839741.
      View in: PubMed
    30. Fishel R, Acharya S, Berardini M, Bocker T, Charbonneau N, Cranston A, Gradia S, Guerrette S, Heinen CD, Mazurek A, Snowden T, Schmutte C, Shim KS, Tombline G, Wilson T. Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch. Cold Spring Harb Symp Quant Biol. 2000; 65:217-24. PMID: 12760035.
      View in: PubMed
    31. Heinen CD, Noffsinger AE, Belli J, Straughen J, Fischer J, Groden J, Fenoglio-Preiser CM. Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation. Genes Chromosomes Cancer. 1997 Jul; 19(3):170-5. PMID: 9218998.
      View in: PubMed
    32. Heinen CD, Shivapurkar N, Tang Z, Groden J, Alabaster O. Microsatellite instability in aberrant crypt foci from human colons. Cancer Res. 1996 Dec 1; 56(23):5339-41. PMID: 8968080.
      View in: PubMed
    33. Heinen CD, Richardson D, White R, Groden J. Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein. Cancer Res. 1995 Nov 1; 55(21):4797-9. PMID: 7585508.
      View in: PubMed
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