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Lynn Puddington PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentImmunology
AddressMC 1319
MC 1319
263 Farmington Avenue
Phone860-679-4655
Fax860-679-1868
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Colpitts SL, Puddington L, Lefrançois L. IL-15 receptor a signaling constrains the development of IL-17-producing ?d T cells. Proc Natl Acad Sci U S A. 2015 Aug 4; 112(31):9692-7. PMID: 26195801; PMCID: PMC4534247 [Available on 02/04/16].
    2. Bose TO, Colpitts SL, Pham QM, Puddington L, Lefrançois L. CD11a is essential for normal development of hematopoietic intermediates. J Immunol. 2014 Sep 15; 193(6):2863-72. PMID: 25108025; PMCID: PMC4157082.
    3. Sheridan BS, Pham QM, Lee YT, Cauley LS, Puddington L, Lefrançois L. Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function. Immunity. 2014 May 15; 40(5):747-57. PMID: 24792910; PMCID: PMC4045016.
    4. Matson AP, Cloutier MM, Dhongade A, Puddington L, Rafti E. Maternal allergy is associated with surface-bound IgE on cord blood basophils. Pediatr Allergy Immunol. 2013 Sep; 24(6):614-21. PMID: 23980848; PMCID: PMC3798094.
    5. Jellison ER, Turner MJ, Blair DA, Lingenheld EG, Zu L, Puddington L, Lefrançois L. Distinct mechanisms mediate naive and memory CD8 T-cell tolerance. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21438-43. PMID: 23236165; PMCID: PMC3535649.
    6. Paveglio S, Puddington L, Rafti E, Matson AP. FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice. Clin Exp Allergy. 2012 Dec; 42(12):1791-800. PMID: 23181795; PMCID: PMC3508740.
    7. Housley WJ, Adams CO, Nichols FC, Puddington L, Lingenheld EG, Zhu L, Rajan TV, Clark RB. Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function. J Immunol. 2011 Jun 15; 186(12):6779-87. PMID: 21572024.
      View in: PubMed
    8. Wu CA, Paveglio SA, Lingenheld EG, Zhu L, Lefrançois L, Puddington L. Transmission of murine cytomegalovirus in breast milk: a model of natural infection in neonates. J Virol. 2011 May; 85(10):5115-24. PMID: 21367905; PMCID: PMC3126164.
    9. Matson AP, Thrall RS, Rafti E, Lingenheld EG, Puddington L. IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring. Clin Mol Allergy. 2010; 8:9. PMID: 20626874; PMCID: PMC2914046.
    10. Wu CA, Peluso JJ, Zhu L, Lingenheld EG, Walker ST, Puddington L. Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell Immunol. 2010; 264(1):32-41. PMID: 20494340; PMCID: PMC2902557.
    11. Matson AP, Thrall RS, Rafti E, Puddington L. Breastmilk from allergic mothers can protect offspring from allergic airway inflammation. Breastfeed Med. 2009 Sep; 4(3):167-74. PMID: 19301986; PMCID: PMC2757118.
    12. Housley WJ, O'Conor CA, Nichols F, Puddington L, Lingenheld EG, Zhu L, Clark RB. PPARgamma regulates retinoic acid-mediated DC induction of Tregs. J Leukoc Biol. 2009 Aug; 86(2):293-301. PMID: 19401386; PMCID: PMC2814813.
    13. Turner MJ, Jellison ER, Lingenheld EG, Puddington L, Lefrançois L. Avidity maturation of memory CD8 T cells is limited by self-antigen expression. J Exp Med. 2008 Aug 4; 205(8):1859-68. PMID: 18625745; PMCID: PMC2525599.
    14. Wu CA, Peluso JJ, Shanley JD, Puddington L, Thrall RS. Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease. Am J Pathol. 2008 Mar; 172(3):714-24. PMID: 18258850; PMCID: PMC2258267.
    15. Puddington L, Matson A. Breathing easier with breast milk. Nat Med. 2008 Feb; 14(2):116-8. PMID: 18256610.
      View in: PubMed
    16. Matson AP, Zhu L, Lingenheld EG, Schramm CM, Clark RB, Selander DM, Thrall RS, Breen E, Puddington L. Maternal transmission of resistance to development of allergic airway disease. J Immunol. 2007 Jul 15; 179(2):1282-91. PMID: 17617621; PMCID: PMC3155847.
    17. Lefrançois L, Puddington L. Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo. Annu Rev Immunol. 2006; 24:681-704. PMID: 16551263.
      View in: PubMed
    18. Schluns KS, Nowak EC, Cabrera-Hernandez A, Puddington L, Lefrançois L, Aguila HL. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5616-21. PMID: 15060278; PMCID: PMC397446.
    19. Schramm CM, Puddington L, Wu C, Guernsey L, Gharaee-Kermani M, Phan SH, Thrall RS. Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease. Am J Pathol. 2004 Jan; 164(1):295-304. PMID: 14695342; PMCID: PMC1602237.
    20. Lee SK, Kalinowski JF, Jastrzebski SL, Puddington L, Lorenzo JA. Interleukin-7 is a direct inhibitor of in vitro osteoclastogenesis. Endocrinology. 2003 Aug; 144(8):3524-31. PMID: 12865334.
      View in: PubMed
    21. Katavic V, Grcevic D, Lee SK, Kalinowski J, Jastrzebski S, Dougall W, Anderson D, Puddington L, Aguila HL, Lorenzo JA. The surface antigen CD45R identifies a population of estrogen-regulated murine marrow cells that contain osteoclast precursors. Bone. 2003 Jun; 32(6):581-90. PMID: 12810165.
      View in: PubMed
    22. Laky K, Lewis JM, Tigelaar RE, Puddington L. Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. J Immunol. 2003 Apr 15; 170(8):4087-94. PMID: 12682238.
      View in: PubMed
    23. Wu CA, Puddington L, Whiteley HE, Yiamouyiannis CA, Schramm CM, Mohammadu F, Thrall RS. Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease. J Immunol. 2001 Sep 1; 167(5):2798-807. PMID: 11509625.
      View in: PubMed
    24. Laky K, Lefrançois L, Lingenheld EG, Ishikawa H, Lewis JM, Olson S, Suzuki K, Tigelaar RE, Puddington L. Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med. 2000 May 1; 191(9):1569-80. PMID: 10790431; PMCID: PMC2213426.
    25. Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ. The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol. 2000 Feb 1; 164(3):1364-71. PMID: 10640751.
      View in: PubMed
    26. Schramm CM, Puddington L, Yiamouyiannis CA, Lingenheld EG, Whiteley HE, Wolyniec WW, Noonan TC, Thrall RS. Proinflammatory roles of T-cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma. Am J Respir Cell Mol Biol. 2000 Feb; 22(2):218-25. PMID: 10657943.
      View in: PubMed
    27. Yiamouyiannis CA, Schramm CM, Puddington L, Stengel P, Baradaran-Hosseini E, Wolyniec WW, Whiteley HE, Thrall RS. Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model. Am J Pathol. 1999 Jun; 154(6):1911-21. PMID: 10362818; PMCID: PMC1866641.
    28. Lefrançois L, Parker CM, Olson S, Muller W, Wagner N, Schön MP, Puddington L. The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med. 1999 May 17; 189(10):1631-8. PMID: 10330442; PMCID: PMC2193647.
    29. Lefrançois L, Puddington L. Anatomy of T-cell development in the intestine. Gastroenterology. 1998 Dec; 115(6):1588-91. PMID: 9834291.
      View in: PubMed
    30. Laky K, Lefrançois L, von Freeden-Jeffry U, Murray R, Puddington L. The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells. J Immunol. 1998 Jul 15; 161(2):707-13. PMID: 9670946.
      View in: PubMed
    31. Laky K, Lefrançois L, Puddington L. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J Immunol. 1997 Feb 1; 158(3):1417-27. PMID: 9013987.
      View in: PubMed
    32. Lefrançois L, Fuller B, Huleatt JW, Olson S, Puddington L. On the front lines: intraepithelial lymphocytes as primary effectors of intestinal immunity. Springer Semin Immunopathol. 1997; 18(4):463-75. PMID: 9144865.
      View in: PubMed
    33. Lefrançois L, Puddington L. The role of the thymus in intestinal intraepithelial T-cell development. Ann N Y Acad Sci. 1996 Feb 13; 778:36-46. PMID: 8610990.
      View in: PubMed
    34. Lefrançois L, Puddington L. Extrathymic intestinal T-cell development: virtual reality? Immunol Today. 1995 Jan; 16(1):16-21. PMID: 7880383.
      View in: PubMed
    35. Puddington L, Olson S, Lefrançois L. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity. 1994 Dec; 1(9):733-9. PMID: 7534619.
      View in: PubMed
    36. Lefrançois L, Barrett TA, Havran WL, Puddington L. Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells. Eur J Immunol. 1994 Mar; 24(3):635-40. PMID: 7907296.
      View in: PubMed
    37. Kündig TM, Bachmann MF, Lefrancois L, Puddington L, Hengartner H, Zinkernagel RM. Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells. J Immunol. 1993 May 15; 150(10):4450-6. PMID: 8097755.
      View in: PubMed
    38. Meisheri KD, Johnson GA, Puddington L. Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem Pharmacol. 1993 Jan 26; 45(2):271-9. PMID: 8435087.
      View in: PubMed
    39. Meisheri KD, Oleynek JJ, Puddington L. Role of protein sulfation in vasodilation induced by minoxidil sulfate, a K+ channel opener. J Pharmacol Exp Ther. 1991 Sep; 258(3):1091-7. PMID: 1890613.
      View in: PubMed
    40. Lyles DS, Puddington L, McCreedy BJ. Vesicular stomatitis virus M protein in the nuclei of infected cells. J Virol. 1988 Nov; 62(11):4387-92. PMID: 2845149; PMCID: PMC253880.
    41. Scullion BF, Hou Y, Puddington L, Rose JK, Jacobson K. Effects of mutations in three domains of the vesicular stomatitis viral glycoprotein on its lateral diffusion in the plasma membrane. J Cell Biol. 1987 Jul; 105(1):69-75. PMID: 3038931; PMCID: PMC2114925.
    42. Puddington L, Woodgett C, Rose JK. Replacement of the cytoplasmic domain alters sorting of a viral glycoprotein in polarized cells. Proc Natl Acad Sci U S A. 1987 May; 84(9):2756-60. PMID: 3033661; PMCID: PMC304737.
    43. Puddington L, Bevan MJ, Rose JK, Lefrançois L. N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells. J Virol. 1986 Nov; 60(2):708-17. PMID: 3022003; PMCID: PMC288945.
    44. Puddington L, Machamer CE, Rose JK. Cytoplasmic domains of cellular and viral integral membrane proteins substitute for the cytoplasmic domain of the vesicular stomatitis virus glycoprotein in transport to the plasma membrane. J Cell Biol. 1986 Jun; 102(6):2147-57. PMID: 3011809; PMCID: PMC2114239.
    45. Lefrancois L, Puddington L, Machamer CE, Bevan MJ. Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens. J Exp Med. 1985 Oct 1; 162(4):1275-93. PMID: 2413157; PMCID: PMC2187862.
    46. Puddington L, Lively MO, Lyles DS. Role of the nuclear envelope in synthesis, processing, and transport of membrane glycoproteins. J Biol Chem. 1985 May 10; 260(9):5641-7. PMID: 2985606.
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