Keywords
Last Name
Institution

Andrew Arnold MD

TitleProfessor
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 3101
MC 3101
263 Farmington Avenue
Phone860-679-7640
Fax860-679-7639
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    Other Positions
    TitleProfessor
    InstitutionUConn Health Center
    DepartmentGenetics and Developmental Biology

    TitleDirector
    InstitutionUConn Health Center
    DepartmentCenter for Molecular Medicine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Corrado KR, Andrade SC, Bellizzi J, D'Souza-Li L, Arnold A. Polyclonality of Parathyroid Tumors in Neonatal Severe Hyperparathyroidism. J Bone Miner Res. 2015 Oct; 30(10):1797-802. PMID: 25828954.
      View in: PubMed
    2. Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG. Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget. 2015 Apr 20; 6(11):8525-38. PMID: 25940700; PMCID: PMC4496164.
    3. Soong CP, Arnold A. Erratum: Recurrent ZFX mutations in human sporadic parathyroid adenomas. Oncoscience. 2015; 2(1):1-2. PMID: 25821839; PMCID: PMC4341459.
    4. Soong CP, Arnold A. Recurrent ZFX mutations in human sporadic parathyroid adenomas. Oncoscience. 2014; 1(5):360-6. PMID: 25594030; PMCID: PMC4278311.
    5. Arnold A, Soong CP. New role for ZFX in oncogenesis. Cell Cycle. 2014; 13(22):3465-6. PMID: 25493409; PMCID: PMC4612122 [Available on 12/10/15].
    6. Costa-Guda J, Arnold A. Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. Mol Cell Endocrinol. 2014 Apr 5; 386(1-2):46-54. PMID: 24035866; PMCID: PMC3943641.
    7. Costa-Guda J, Soong CP, Parekh VI, Agarwal SK, Arnold A. Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas. Horm Cancer. 2013 Oct; 4(5):301-7. PMID: 23715670.
      View in: PubMed
    8. Costa-Guda J, Imanishi Y, Palanisamy N, Kawamata N, Phillip Koeffler H, Chaganti RS, Arnold A. Allelic imbalance in sporadic parathyroid carcinoma and evidence for its de novo origins. Endocrine. 2013 Oct; 44(2):489-95. PMID: 23435613; PMCID: PMC3683451.
    9. Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012 Mar; 122(3):833-43. PMID: 22307325; PMCID: PMC3287228.
    10. Imanishi Y, Kawata T, Kenko T, Wada M, Nagano N, Miki T, Arnold A, Inaba M. Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism. Calcif Tissue Int. 2011 Jul; 89(1):29-35. PMID: 21541686.
      View in: PubMed
    11. Costa-Guda J, Marinoni I, Molatore S, Pellegata NS, Arnold A. Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2011 Apr; 96(4):E701-6. PMID: 21289244; PMCID: PMC3070245.
    12. Juhlin CC, Haglund F, Obara T, Arnold A, Larsson C, Höög A. Absence of nucleolar parafibromin immunoreactivity in subsets of parathyroid malignant tumours. Virchows Arch. 2011 Jul; 459(1):47-53. PMID: 21221636.
      View in: PubMed
    13. Mallya SM, Wu HI, Saria EA, Corrado KR, Arnold A. Tissue-specific regulatory regions of the PTH gene localized by novel chromosome 11 rearrangement breakpoints in a parathyroid adenoma. J Bone Miner Res. 2010 Dec; 25(12):2606-12. PMID: 20641034; PMCID: PMC3119366.
    14. Lauter K, Arnold A. Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism. J Bone Miner Res. 2009 Jan; 24(1):102-4. PMID: 18767934; PMCID: PMC2689078.
    15. Moore AF, Wexler TL, Yung RL, Kish J, Larvie M, Lauter K, Arnold A, Finkelstein JS, Burnett-Bowie SM. An unusual case of primary hyperparathyroidism with profoundly elevated parathyroid hormone levels. Endocr Pract. 2008 Oct; 14(7):892-7. PMID: 18996820.
      View in: PubMed
    16. Lauter KB, Arnold A. Mutational analysis of CDKN1B, a candidate tumor-suppressor gene, in refractory secondary/tertiary hyperparathyroidism. Kidney Int. 2008 May; 73(10):1137-40. PMID: 18288099.
      View in: PubMed
    17. Costa-Guda J, Tokura T, Roth SI, Arnold A. Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas. BMC Endocr Disord. 2007; 7:8. PMID: 17916247; PMCID: PMC2099428.
    18. Kawata T, Imanishi Y, Kobayashi K, Miki T, Arnold A, Inaba M, Nishizawa Y. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol. 2007 Oct; 18(10):2683-8. PMID: 17855636.
      View in: PubMed
    19. Mallya SM, Buchberger GK, Arnold A. Effects of anesthetic agents on serum parathyroid hormone and calcium concentrations in mice. Vet Anaesth Analg. 2007 Nov; 34(6):403-7. PMID: 17565572.
      View in: PubMed
    20. Costa-Guda J, Arnold A. Absence of stabilizing mutations of beta-catenin encoded by CTNNB1 exon 3 in a large series of sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2007 Apr; 92(4):1564-6. PMID: 17284619.
      View in: PubMed
    21. Costa-Guda J, Lauter K, Naveh-Many T, Silver J, Arnold A. Mutational analysis of the PTH 3'-untranslated region in parathyroid disorders. Clin Endocrinol (Oxf). 2006 Dec; 65(6):806-9. PMID: 17121534.
      View in: PubMed
    22. Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO. Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res. 2006 Oct; 21(10):1666-71. PMID: 16995822.
      View in: PubMed
    23. Samander EH, Arnold A. Mutational analysis of the vitamin D receptor does not support its candidacy as a tumor suppressor gene in parathyroid adenomas. J Clin Endocrinol Metab. 2006 Dec; 91(12):5019-21. PMID: 17003089.
      View in: PubMed
    24. Lafferty FW, Hamlin CR, Corrado KR, Arnold A, Shuck JM. Primary hyperparathyroidism with a low-normal, atypical serum parathyroid hormone as shown by discordant immunoassay curves. J Clin Endocrinol Metab. 2006 Oct; 91(10):3826-9. PMID: 16849415.
      View in: PubMed
    25. Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R. Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol. 2006 Jul; 26(14):5449-69. PMID: 16809779; PMCID: PMC1592725.
    26. Jiménez C, Cote G, Arnold A, Gagel RF. Review: Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes? J Clin Endocrinol Metab. 2006 Aug; 91(8):2851-8. PMID: 16735498.
      View in: PubMed
    27. VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. J Clin Endocrinol Metab. 2006 Feb; 91(2):580-3. PMID: 16263810.
      View in: PubMed
    28. Kawata T, Imanishi Y, Kobayashi K, Kenko T, Wada M, Ishimura E, Miki T, Nagano N, Inaba M, Arnold A, Nishizawa Y. Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism. Eur J Endocrinol. 2005 Oct; 153(4):587-94. PMID: 16189180.
      View in: PubMed
    29. Arnold A, Papanikolaou A. Cyclin D1 in breast cancer pathogenesis. J Clin Oncol. 2005 Jun 20; 23(18):4215-24. PMID: 15961768.
      View in: PubMed
    30. Krebs LJ, Shattuck TM, Arnold A. HRPT2 mutational analysis of typical sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2005 Sep; 90(9):5015-7. PMID: 15956079.
      View in: PubMed
    31. Shattuck TM, Westra WH, Ladenson PW, Arnold A. Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma. N Engl J Med. 2005 Jun 9; 352(23):2406-12. PMID: 15944425.
      View in: PubMed
    32. Mallya SM, Gallagher JJ, Wild YK, Kifor O, Costa-Guda J, Saucier K, Brown EM, Arnold A. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol. 2005 Oct; 19(10):2603-9. PMID: 15928311.
      View in: PubMed
    33. Costa-Guda J, Rosen ED, Jensen RT, Chung DC, Arnold A. Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours. Clin Endocrinol (Oxf). 2005 May; 62(5):603-6. PMID: 15853832.
      View in: PubMed
    34. Libutti SK, Crabtree JS, Lorang D, Burns AL, Mazzanti C, Hewitt SM, O'Connor S, Ward JM, Emmert-Buck MR, Remaley A, Miller M, Turner E, Alexander HR, Arnold A, Marx SJ, Collins FS, Spiegel AM. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res. 2003 Nov 15; 63(22):8022-8. PMID: 14633735.
      View in: PubMed
    35. Shattuck TM, Välimäki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med. 2003 Oct 30; 349(18):1722-9. PMID: 14585940.
      View in: PubMed
    36. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug; 59(2):180-9. PMID: 12864795.
      View in: PubMed
    37. Mallya SM, Gallagher JJ, Arnold A. Analysis of microsatellite instability in sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2003 Mar; 88(3):1248-51. PMID: 12629114.
      View in: PubMed
    38. Arnold A, Shattuck TM, Mallya SM, Krebs LJ, Costa J, Gallagher J, Wild Y, Saucier K. Molecular pathogenesis of primary hyperparathyroidism. J Bone Miner Res. 2002 Nov; 17 Suppl 2:N30-6. PMID: 12412775.
      View in: PubMed
    39. Imanishi Y, Hall C, Sablosky M, Brown EM, Arnold A. A new method for in vivo analysis of parathyroid hormone-calcium set point in mice. J Bone Miner Res. 2002 Sep; 17(9):1656-61. PMID: 12211436.
      View in: PubMed
    40. Shattuck TM, Costa J, Bernstein M, Jensen RT, Chung DC, Arnold A. Mutational analysis of Smad3, a candidate tumor suppressor implicated in TGF-beta and menin pathways, in parathyroid adenomas and enteropancreatic endocrine tumors. J Clin Endocrinol Metab. 2002 Aug; 87(8):3911-4. PMID: 12161532.
      View in: PubMed
    41. Krebs LJ, Arnold A. Molecular basis of hyperparathyroidism and potential targets for drug development. Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul; 2(2):167-79. PMID: 12476790.
      View in: PubMed
    42. Imanishi Y, Tahara H, Palanisamy N, Spitalny S, Salusky IB, Goodman W, Brandi ML, Drüeke TB, Sarfati E, Ureña P, Chaganti RS, Arnold A. Clonal chromosomal defects in the molecular pathogenesis of refractory hyperparathyroidism of uremia. J Am Soc Nephrol. 2002 Jun; 13(6):1490-8. PMID: 12039978.
      View in: PubMed
    43. Hosokawa Y, Papanikolaou A, Cardiff RD, Yoshimoto K, Bernstein M, Wang TC, Schmidt EV, Arnold A. In vivo analysis of mammary and non-mammary tumorigenesis in MMTV-cyclin D1 transgenic mice deficient in p53. Transgenic Res. 2001 Oct; 10(5):471-8. PMID: 11708657.
      View in: PubMed
    44. Imanishi Y, Hosokawa Y, Yoshimoto K, Schipani E, Mallya S, Papanikolaou A, Kifor O, Tokura T, Sablosky M, Ledgard F, Gronowicz G, Wang TC, Schmidt EV, Hall C, Brown EM, Bronson R, Arnold A. Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice. J Clin Invest. 2001 May; 107(9):1093-102. PMID: 11342573; PMCID: PMC209274.
    45. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Joshi V, Arnold A, Malchoff DM. Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metab. 2000 May; 85(5):1758-64. PMID: 10843148.
      View in: PubMed
    46. Mallya SM, Arnold A. Cyclin D1 in parathyroid disease. Front Biosci. 2000 Mar 1; 5:D367-71. PMID: 10704427.
      View in: PubMed
    47. Brown SB, Brierley TT, Palanisamy N, Salusky IB, Goodman W, Brandi ML, Drüeke TB, Sarfati E, Ureña P, Chaganti RS, Pike JW, Arnold A. Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia. J Clin Endocrinol Metab. 2000 Feb; 85(2):868-72. PMID: 10690903.
      View in: PubMed
    48. Carling T, Imanishi Y, Gaz RD, Arnold A. RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations. Clin Endocrinol (Oxf). 1999 Oct; 51(4):403-7. PMID: 10583305.
      View in: PubMed
    49. Carling T, Imanishi Y, Gaz RD, Arnold A. Analysis of the RAD54 gene on chromosome 1p as a potential tumor-suppressor gene in parathyroid adenomas. Int J Cancer. 1999 Sep 24; 83(1):80-2. PMID: 10449612.
      View in: PubMed
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