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Linda H Shapiro PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 3501
MC 3501
263 Farmington Avenue
Phone860-679-4373
Fax860-679-1201
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gerber C, Harel M, Lynch ML, Herbst KW, Ferrer FA, Shapiro LH. Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study. J Pediatr Urol. 2016 Apr; 12(2):120.e1-7. PMID: 26705690.
      View in: PubMed
    2. Harel M, Ferrer FA, Shapiro LH, Makari JH. Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma. Urol Oncol. 2016 Feb; 34(2):103-15. PMID: 26519985.
      View in: PubMed
    3. Li MH, Swenson R, Harel M, Jana S, Stolarzewicz E, Hla T, Shapiro LH, Ferrer F. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep; 354(3):261-8. PMID: 26105954; PMCID: PMC4538871 [Available on 09/01/16].
    4. Ghosh M, Subramani J, Rahman MM, Shapiro LH. CD13 restricts TLR4 endocytic signal transduction in inflammation. J Immunol. 2015 May 1; 194(9):4466-76. PMID: 25801433; PMCID: PMC4402264 [Available on 05/01/16].
    5. Kim J, Shapiro L, Flynn A. The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease. Pharmacol Ther. 2015 Jul; 151:8-15. PMID: 25709098.
      View in: PubMed
    6. Ghosh M, Gerber C, Rahman MM, Vernier KM, Pereira FE, Subramani J, Caromile LA, Shapiro LH. Molecular mechanisms regulating CD13-mediated adhesion. Immunology. 2014 Aug; 142(4):636-47. PMID: 24627994; PMCID: PMC4107673.
    7. Rahman MM, Ghosh M, Subramani J, Fong GH, Carlson ME, Shapiro LH. CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury. Stem Cells. 2014 Jun; 32(6):1564-77. PMID: 24307555; PMCID: PMC4037355.
    8. Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. 2014 May; 191(5 Suppl):1508-16. PMID: 24679864.
      View in: PubMed
    9. Rahman MM, Subramani J, Ghosh M, Denninger JK, Takeda K, Fong GH, Carlson ME, Shapiro LH. CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle. Front Physiol. 2014; 4:402. PMID: 24409152; PMCID: PMC3885827.
    10. Subramani J, Ghosh M, Rahman MM, Caromile LA, Gerber C, Rezaul K, Han DK, Shapiro LH. Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. J Immunol. 2013 Oct 1; 191(7):3905-12. PMID: 23997214; PMCID: PMC3810388.
    11. Conway RE, Joiner K, Patterson A, Bourgeois D, Rampp R, Hannah BC, McReynolds S, Elder JM, Gilfilen H, Shapiro LH. Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2. Angiogenesis. 2013 Oct; 16(4):847-60. PMID: 23775497.
      View in: PubMed
    12. Pereira FE, Cronin C, Ghosh M, Zhou SY, Agosto M, Subramani J, Wang R, Shen JB, Schacke W, Liang B, Yang TH, McAulliffe B, Liang BT, Shapiro LH. CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. Cardiovasc Res. 2013 Oct 1; 100(1):74-83. PMID: 23761403; PMCID: PMC3778957.
    13. Grant CL, Caromile LA, Ho V, Durrani K, Rahman MM, Claffey KP, Fong GH, Shapiro LH. Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization. PLoS One. 2012; 7(7):e41285. PMID: 22815987; PMCID: PMC3399825.
    14. Ghosh M, McAuliffe B, Subramani J, Basu S, Shapiro LH. CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake. J Immunol. 2012 Jun 1; 188(11):5489-99. PMID: 22544935; PMCID: PMC3358354.
    15. Winnicka B, O'Conor C, Schacke W, Vernier K, Grant CL, Fenteany FH, Pereira FE, Liang B, Kaur A, Zhao R, Montrose DC, Rosenberg DW, Aguila HL, Shapiro LH. CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse. J Leukoc Biol. 2010 Aug; 88(2):347-59. PMID: 20430777; PMCID: PMC2908940.
    16. Cuvelier GD, Kariminia A, Fujii H, Aslanian S, Wall D, Goldman F, Grupp SA, Dunn SE, Krailo M, Shapiro LH, Gilman A, Schultz KR. Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031. Bone Marrow Transplant. 2010 Nov; 45(11):1653-7. PMID: 20190833; PMCID: PMC3058262.
    17. Mina-Osorio P, Winnicka B, O'Conor C, Grant CL, Vogel LK, Rodriguez-Pinto D, Holmes KV, Ortega E, Shapiro LH. CD13 is a novel mediator of monocytic/endothelial cell adhesion. J Leukoc Biol. 2008 Aug; 84(2):448-59. PMID: 18495788; PMCID: PMC2493070.
    18. Mahoney KM, Petrovic N, Schacke W, Shapiro LH. CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element. Gene. 2007 Nov 15; 403(1-2):178-87. PMID: 17897790; PMCID: PMC2045687.
    19. Petrovic N, Schacke W, Gahagan JR, O'Conor CA, Winnicka B, Conway RE, Mina-Osorio P, Shapiro LH. CD13/APN regulates endothelial invasion and filopodia formation. Blood. 2007 Jul 1; 110(1):142-50. PMID: 17363739; PMCID: PMC1896108.
    20. Conway RE, Petrovic N, Li Z, Heston W, Wu D, Shapiro LH. Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. Mol Cell Biol. 2006 Jul; 26(14):5310-24. PMID: 16809768; PMCID: PMC1592718.
    21. Fontijn D, Duyndam MC, van Berkel MP, Yuana Y, Shapiro LH, Pinedo HM, Broxterman HJ, Boven E. CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells. Br J Cancer. 2006 Jun 5; 94(11):1627-36. PMID: 16685268; PMCID: PMC2361307.
    22. Mina-Osorio P, Shapiro LH, Ortega E. CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells. J Leukoc Biol. 2006 Apr; 79(4):719-30. PMID: 16415167.
      View in: PubMed
    23. Wentworth DE, Tresnan DB, Turner BC, Lerman IR, Bullis B, Hemmila EM, Levis R, Shapiro LH, Holmes KV. Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo. Virology. 2005 May 10; 335(2):185-97. PMID: 15840518.
      View in: PubMed
    24. Petrovic N, Bhagwat SV, Ratzan WJ, Ostrowski MC, Shapiro LH. CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. J Biol Chem. 2003 Dec 5; 278(49):49358-68. PMID: 14507917.
      View in: PubMed
    25. Bhagwat SV, Petrovic N, Okamoto Y, Shapiro LH. The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis. Blood. 2003 Mar 1; 101(5):1818-26. PMID: 12406907.
      View in: PubMed
    26. Sampath J, Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP, Schuetz JD. Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1. J Biol Chem. 2001 Oct 19; 276(42):39359-67. PMID: 11483599.
      View in: PubMed
    27. Bhagwat SV, Lahdenranta J, Giordano R, Arap W, Pasqualini R, Shapiro LH. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood. 2001 Feb 1; 97(3):652-9. PMID: 11157481; PMCID: PMC4470622.
    28. Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 2000 Feb 1; 60(3):722-7. PMID: 10676659; PMCID: PMC4469333.
    29. Hegde SP, Zhao J, Ashmun RA, Shapiro LH. c-Maf induces monocytic differentiation and apoptosis in bipotent myeloid progenitors. Blood. 1999 Sep 1; 94(5):1578-89. PMID: 10477683.
      View in: PubMed
    30. Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Mol Cell Biol. 1999 Aug; 19(8):5601-7. PMID: 10409749; PMCID: PMC84412.
    31. Inoue K, Sherr CJ, Shapiro LH. Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. J Biol Chem. 1998 Oct 30; 273(44):29188-94. PMID: 9786929.
      View in: PubMed
    32. Hedge SP, Kumar A, Kurschner C, Shapiro LH. c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. Mol Cell Biol. 1998 May; 18(5):2729-37. PMID: 9566892; PMCID: PMC110652.
    33. Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Mol Cell Biol. 1998 Apr; 18(4):2218-29. PMID: 9528793; PMCID: PMC121466.
    34. Gangi-Peterson L, Peterson SN, Shapiro LH, Golding A, Caricchio R, Cohen DI, Margulies DH, Cohen PL. bca: an activation-related B-cell gene. Mol Immunol. 1998 Jan; 35(1):55-63. PMID: 9683264.
      View in: PubMed
    35. Golay J, Broccoli V, Borleri GM, Erba E, Faretta M, Basilico L, Ying GG, Piccinini G, Shapiro LH, Lovric J, Nawrath M, Mölling K, Rambaldi A, Introna M. Redundant functions of B-Myb and c-Myb in differentiating myeloid cells. Cell Growth Differ. 1997 Dec; 8(12):1305-16. PMID: 9419419.
      View in: PubMed
    36. Lerche C, Vogel LK, Shapiro LH, Norén O, Sjöström H. Human aminopeptidase N is encoded by 20 exons. Mamm Genome. 1996 Sep; 7(9):712-3. PMID: 8703138.
      View in: PubMed
    37. Saito M, Kumagai M, Okazaki T, Nakazawa S, Shapiro LH, Look AT, Campana D. Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells. Leukemia. 1995 Sep; 9(9):1508-16. PMID: 7658720.
      View in: PubMed
    38. Yoshihara T, Inaba T, Shapiro LH, Kato JY, Look AT. E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF. Mol Cell Biol. 1995 Jun; 15(6):3247-55. PMID: 7760820; PMCID: PMC230557.
    39. Shapiro LH. Myb and Ets proteins cooperate to transactivate an early myeloid gene. J Biol Chem. 1995 Apr 14; 270(15):8763-71. PMID: 7721782.
      View in: PubMed
    40. Parolini O, Rohrer J, Shapiro LH, Conley ME. B-cell-specific demethylation of BTK, the defective gene in X-linked agammaglobulinemia. Immunogenetics. 1995; 42(2):129-35. PMID: 7541776.
      View in: PubMed
    41. Shapiro LH, Look AT. Transcriptional regulation in myeloid cell differentiation. Curr Opin Hematol. 1995 Jan; 2(1):3-11. PMID: 9371966.
      View in: PubMed
    42. Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Mol Cell Biol. 1994 Dec; 14(12):8085-95. PMID: 7969146; PMCID: PMC359347.
    43. Shapiro DN, Jones BG, Shapiro LH, Dias P, Houghton PJ. Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma. J Clin Invest. 1994 Sep; 94(3):1235-42. PMID: 8083365; PMCID: PMC295208.
    44. Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. Mol Cell Biol. 1994 May; 14(5):3403-13. PMID: 8164688; PMCID: PMC358705.
    45. Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 1992 Jul 24; 257(5069):531-4. PMID: 1386162.
      View in: PubMed
    46. Ashmun RA, Shapiro LH, Look AT. Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies. Blood. 1992 Jun 15; 79(12):3344-9. PMID: 1375850.
      View in: PubMed
    47. Yeager CL, Ashmun RA, Williams RK, Cardellichio CB, Shapiro LH, Look AT, Holmes KV. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature. 1992 Jun 4; 357(6377):420-2. PMID: 1350662.
      View in: PubMed
    48. Privitera E, Kamps MP, Hayashi Y, Inaba T, Shapiro LH, Raimondi SC, Behm F, Hendershot L, Carroll AJ, Baltimore D, et al. Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. Blood. 1992 Apr 1; 79(7):1781-8. PMID: 1348433.
      View in: PubMed
    49. Roberts WM, Shapiro LH, Ashmun RA, Look AT. Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters. Blood. 1992 Feb 1; 79(3):586-93. PMID: 1531036.
      View in: PubMed
    50. Shapiro LH, Ashmun RA, Roberts WM, Look AT. Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells. J Biol Chem. 1991 Jun 25; 266(18):11999-2007. PMID: 1675638.
      View in: PubMed
    51. Look AT, Ashmun RA, Shapiro LH, Peiper SC. Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J Clin Invest. 1989 Apr; 83(4):1299-307. PMID: 2564851; PMCID: PMC303821.
    52. Shapiro LH, Venta PJ, Tashian RE. Molecular analysis of G+C-rich upstream sequences regulating transcription of the human carbonic anhydrase II gene. Mol Cell Biol. 1987 Dec; 7(12):4589-93. PMID: 2830500; PMCID: PMC368150.
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