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Lawrence A Klobutcher PhD

TitleProfessor
InstitutionUConn Health Center
DepartmentMolecular, Microbial and Structural Biology
AddressMC 3305
MC 3305
263 Farmington Avenue
Phone860-679-2816
Fax860-679-3408
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    Other Positions
    TitleAssociate Dean
    InstitutionUConn Health Center
    DepartmentGraduate School


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Samaranayake HS, Cowan AE, Klobutcher LA. Vacuolar protein sorting protein 13A, TtVPS13A, localizes to the tetrahymena thermophila phagosome membrane and is required for efficient phagocytosis. Eukaryot Cell. 2011 Sep; 10(9):1207-18. PMID: 21764909; PMCID: PMC3187053.
    2. Klobutcher LA. In memoriam: David Marshall Prescott (1926-2011). J Eukaryot Microbiol. 2011 Jul-Aug; 58(4):394-6. PMID: 21699622.
      View in: PubMed
    3. Turanov AA, Lobanov AV, Fomenko DE, Morrison HG, Sogin ML, Klobutcher LA, Hatfield DL, Gladyshev VN. Genetic code supports targeted insertion of two amino acids by one codon. Science. 2009 Jan 9; 323(5911):259-61. PMID: 19131629; PMCID: PMC3088105.
    4. Jacobs ME, DeSouza LV, Samaranayake H, Pearlman RE, Siu KW, Klobutcher LA. The Tetrahymena thermophila phagosome proteome. Eukaryot Cell. 2006 Dec; 5(12):1990-2000. PMID: 17012537; PMCID: PMC1694822.
    5. Salas-Marco J, Fan-Minogue H, Kallmeyer AK, Klobutcher LA, Farabaugh PJ, Bedwell DM. Distinct paths to stop codon reassignment by the variant-code organisms Tetrahymena and Euplotes. Mol Cell Biol. 2006 Jan; 26(2):438-47. PMID: 16382136; PMCID: PMC1346903.
    6. Klobutcher LA, Ragkousi K, Setlow P. The Bacillus subtilis spore coat provides "eat resistance" during phagocytic predation by the protozoan Tetrahymena thermophila. Proc Natl Acad Sci U S A. 2006 Jan 3; 103(1):165-70. PMID: 16371471; PMCID: PMC1324984.
    7. Klobutcher LA. Sequencing of random Euplotes crassus macronuclear genes supports a high frequency of +1 translational frameshifting. Eukaryot Cell. 2005 Dec; 4(12):2098-105. PMID: 16339727; PMCID: PMC1317503.
    8. Jacobs ME, Cortezzo DE, Klobutcher LA. Assessing the effectiveness of coding and non-coding regions in antisense ribosome inhibition of gene expression in Tetrahymena. J Eukaryot Microbiol. 2004 Sep-Oct; 51(5):536-41. PMID: 15537088.
      View in: PubMed
    9. Möllenbeck M, Gavin MC, Klobutcher LA. Evolution of programmed ribosomal frameshifting in the TERT genes of Euplotes. J Mol Evol. 2004 Jun; 58(6):701-11. PMID: 15461427.
      View in: PubMed
    10. Jacobs ME, Sánchez-Blanco A, Katz LA, Klobutcher LA. Tec3, a new developmentally eliminated DNA element in Euplotes crassus. Eukaryot Cell. 2003 Feb; 2(1):103-14. PMID: 12582127; PMCID: PMC141165.
    11. Klobutcher LA, Farabaugh PJ. Shifty ciliates: frequent programmed translational frameshifting in euplotids. Cell. 2002 Dec 13; 111(6):763-6. PMID: 12526802.
      View in: PubMed
    12. Jahn CL, Klobutcher LA. Genome remodeling in ciliated protozoa. Annu Rev Microbiol. 2002; 56:489-520. PMID: 12142486.
      View in: PubMed
    13. Möllenbeck M, Klobutcher LA. De novo telomere addition to spacer sequences prior to their developmental degradation in Euplotes crassus. Nucleic Acids Res. 2002 Jan 15; 30(2):523-31. PMID: 11788715; PMCID: PMC99826.
    14. Ghosh S, Barrett DM, Klobutcher LA. The Euplotes crassus conjugation-specific conN1 gene encodes a transcription elongation factor TFIIS-like protein. J Eukaryot Microbiol. 2001 Mar-Apr; 48(2):218-20. PMID: 12095110.
      View in: PubMed
    15. Jacobs ME, Ling Z, Klobutcher LA. conZA8 encodes an abundant protein targeted to the developing macronucleus in Euplotes crassus. J Eukaryot Microbiol. 2000 Mar-Apr; 47(2):105-15. PMID: 10750837.
      View in: PubMed
    16. Ghosh S, Klobutcher LA. A development-specific histone H3 localizes to the developing macronucleus of Euplotes. Genesis. 2000 Mar; 26(3):179-88. PMID: 10705378.
      View in: PubMed
    17. Klobutcher LA. Characterization of in vivo developmental chromosome fragmentation intermediates in E. crassus. Mol Cell. 1999 Nov; 4(5):695-704. PMID: 10619017.
      View in: PubMed
    18. Klobutcher LA, Gygax SE, Podoloff JD, Vermeesch JR, Price CM, Tebeau CM, Jahn CL. Conserved DNA sequences adjacent to chromosome fragmentation and telomere addition sites in Euplotes crassus. Nucleic Acids Res. 1998 Sep 15; 26(18):4230-40. PMID: 9722644; PMCID: PMC147820.
    19. Jahn CL, Ling Z, Tebeau CM, Klobutcher LA. An unusual histone H3 specific for early macronuclear development in Euplotes crassus. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1332-7. PMID: 9037053; PMCID: PMC19791.
    20. Ling Z, Ghosh S, Jacobs ME, Klobutcher LA. Conjugation-specific genes in the ciliate Euplotes crassus: gene expression from the old macronucleus. J Eukaryot Microbiol. 1997 Jan-Feb; 44(1):1-11. PMID: 9172827.
      View in: PubMed
    21. Klobutcher LA, Herrick G. Developmental genome reorganization in ciliated protozoa: the transposon link. Prog Nucleic Acid Res Mol Biol. 1997; 56:1-62. PMID: 9187050.
      View in: PubMed
    22. Jacobs ME, Klobutcher LA. The long and the short of developmental DNA deletion in Euplotes crassus. J Eukaryot Microbiol. 1996 Nov-Dec; 43(6):442-52. PMID: 8976602.
      View in: PubMed
    23. Hale CA, Jacobs ME, Estes HG, Ghosh S, Klobutcher LA. Micronuclear and macronuclear sequences of a Euplotes crassus gene encoding a putative nuclear protein kinase. J Eukaryot Microbiol. 1996 Sep-Oct; 43(5):389-92. PMID: 8822809.
      View in: PubMed
    24. Tourancheau AB, Tsao N, Klobutcher LA, Pearlman RE, Adoutte A. Genetic code deviations in the ciliates: evidence for multiple and independent events. EMBO J. 1995 Jul 3; 14(13):3262-7. PMID: 7621837; PMCID: PMC394388.
    25. Klobutcher LA, Herrick G. Consensus inverted terminal repeat sequence of Paramecium IESs: resemblance to termini of Tc1-related and Euplotes Tec transposons. Nucleic Acids Res. 1995 Jun 11; 23(11):2006-13. PMID: 7596830; PMCID: PMC306976.
    26. Klobutcher LA. Developmentally excised DNA sequences in Euplotes crassus capable of forming G quartets. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):1979-83. PMID: 7892211; PMCID: PMC42406.
    27. Ghosh S, Jaraczewski JW, Klobutcher LA, Jahn CL. Characterization of transcription initiation, translation initiation, and poly(A) addition sites in the gene-sized macronuclear DNA molecules of Euplotes. Nucleic Acids Res. 1994 Jan 25; 22(2):214-21. PMID: 7907176; PMCID: PMC307774.
    28. Klobutcher LA, Turner LR, LaPlante J. Circular forms of developmentally excised DNA in Euplotes crassus have a heteroduplex junction. Genes Dev. 1993 Jan; 7(1):84-94. PMID: 8422990.
      View in: PubMed
    29. Klobutcher LA, Jahn CL. Developmentally controlled genomic rearrangements in ciliated protozoa. Curr Opin Genet Dev. 1991 Oct; 1(3):397-403. PMID: 1668650.
      View in: PubMed
    30. Klobutcher LA, Turner LR, Peralta ME. Sequence of a Euplotes crassus macronuclear DNA molecule encoding a protein with homology to a rat form-I phosphoinositide-specific phospholipase C. J Protozool. 1991 Jul-Aug; 38(4):425-7. PMID: 1664853.
      View in: PubMed
    31. Tausta SL, Turner LR, Buckley LK, Klobutcher LA. High fidelity developmental excision of Tec1 transposons and internal eliminated sequences in Euplotes crassus. Nucleic Acids Res. 1991 Jun 25; 19(12):3229-36. PMID: 1648202; PMCID: PMC328315.
    32. Baird SE, Klobutcher LA. Differential DNA amplification and copy number control in the hypotrichous ciliate Euplotes crassus. J Protozool. 1991 Mar-Apr; 38(2):136-40. PMID: 1902260.
      View in: PubMed
    33. Tausta SL, Klobutcher LA. Internal eliminated sequences are removed prior to chromosome fragmentation during development in Euplotes crassus. Nucleic Acids Res. 1990 Feb 25; 18(4):845-53. PMID: 2107532; PMCID: PMC330336.
    34. Tausta SL, Klobutcher LA. Detection of circular forms of eliminated DNA during macronuclear development in E. crassus. Cell. 1989 Dec 22; 59(6):1019-26. PMID: 2598258.
      View in: PubMed
    35. Baird SE, Fino GM, Tausta SL, Klobutcher LA. Micronuclear genome organization in Euplotes crassus: a transposonlike element is removed during macronuclear development. Mol Cell Biol. 1989 Sep; 9(9):3793-807. PMID: 2550802; PMCID: PMC362441.
    36. Baird SE, Klobutcher LA. Characterization of chromosome fragmentation in two protozoans and identification of a candidate fragmentation sequence in Euplotes crassus. Genes Dev. 1989 May; 3(5):585-97. PMID: 2744456.
      View in: PubMed
    37. Baird SE, Klobutcher LA. Genetic characterization and use of a restriction fragment length variant in the hypotrichous ciliate Euplotes crassus. J Protozool. 1988 Nov; 35(4):459-65. PMID: 2904496.
      View in: PubMed
    38. Klobutcher LA, Huff ME, Gonye GE. Alternative use of chromosome fragmentation sites in the ciliated protozoan Oxytricha nova. Nucleic Acids Res. 1988 Jan 11; 16(1):251-64. PMID: 2829118; PMCID: PMC334624.
    39. Klobutcher LA. Micronuclear organization of macronuclear genes in the hypotrichous ciliate Oxytricha nova. J Protozool. 1987 Nov; 34(4):424-8. PMID: 3123648.
      View in: PubMed
    40. Ribas-Aparicio RM, Sparkowski JJ, Proulx AE, Mitchell JD, Klobutcher LA. Nucleic acid splicing events occur frequently during macronuclear development in the protozoan Oxytricha nova and involve the elimination of unique DNA. Genes Dev. 1987 Jun; 1(4):323-36. PMID: 3678825.
      View in: PubMed
    41. Klobutcher LA, Vailonis-Walsh AM, Cahill K, Ribas-Aparicio RM. Gene-sized macronuclear DNA molecules are clustered in micronuclear chromosomes of the ciliate Oxytricha nova. Mol Cell Biol. 1986 Nov; 6(11):3606-13. PMID: 3025603; PMCID: PMC367120.
    42. Klobutcher LA, Jahn CL, Prescott DM. Internal sequences are eliminated from genes during macronuclear development in the ciliated protozoan Oxytricha nova. Cell. 1984 Apr; 36(4):1045-55. PMID: 6323015.
      View in: PubMed
    43. Boswell RE, Klobutcher LA, Prescott DM. Inverted terminal repeats are added to genes during macronuclear development in Oxytricha nova. Proc Natl Acad Sci U S A. 1982 May; 79(10):3255-9. PMID: 6808504; PMCID: PMC346394.
    44. Klobutcher LA, Swanton MT, Donini P, Prescott DM. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus. Proc Natl Acad Sci U S A. 1981 May; 78(5):3015-9. PMID: 6265931; PMCID: PMC319490.
    45. Klobutcher LA, Ruddle FH. Chromosome mediated gene transfer. Annu Rev Biochem. 1981; 50:533-54. PMID: 7023365.
      View in: PubMed
    46. Klobutcher LA, Miller CL, Ruddle FH. Chromosome-mediated gene transfer results in two classes of unstable transformants. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3610-4. PMID: 6932038; PMCID: PMC349667.
    47. Klobutcher LA, Ruddle FH. Phenotype stabilisation and integration of transferred material in chromosome-mediated gene transfer. Nature. 1979 Aug 23; 280(5724):657-60. PMID: 471042.
      View in: PubMed
    48. Sundar Raj CV, Church RL, Klobutcher LA, Ruddle FH. Genetics of the connective tissue proteins: assignment of the gene for human type I procollagen to chromosome 17 by analysis of cell hybrids and microcell hybrids. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4444-8. PMID: 412188; PMCID: PMC431959.
    49. Klobutcher LA. Aging and frequency-dependent mating in Drosophila. Behav Genet. 1977 Jan; 7(1):33-6. PMID: 843316.
      View in: PubMed
    50. Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH. Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel. Birth Defects Orig Artic Ser. 1976; 12(7):171-4. PMID: 192365.
      View in: PubMed
    51. Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH. Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel. Cytogenet Cell Genet. 1976; 16(1-5):171-4. PMID: 185014.
      View in: PubMed
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