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Achilles J Pappano PhD

TitleProfessor
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 6125
MC 6125
263 Farmington Avenue
Phone860-679-2410
Fax860-679-3693
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    Other Positions
    TitleProfessor
    InstitutionUConn Health Center
    DepartmentCalhoun Cardiology Center


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shen JB, Yang R, Pappano A, Liang BT. Cardiac P2X purinergic receptors as a new pathway for increasing Na? entry in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1469-77. PMID: 25239801; PMCID: PMC4233301.
    2. Pappano A. Letters to the editor: Cardiomyocyte-secreted acetylcholine. FASEB J. 2014 Jan; 28(1):1-2. PMID: 24385568.
      View in: PubMed
    3. Achilles J. Pappano, PhD Withrow Gil Wier, PhD. Cardiovascular Physiology. 2012; 304.
    4. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar TS, Jacobson KA, Hintze T, Recchia FA, Liang BT. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. J Pharmacol Exp Ther. 2010 Jun; 333(3):920-8. PMID: 20200116; PMCID: PMC2879931.
    5. Shen JB, Shutt R, Agosto M, Pappano A, Liang BT. Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1089-95. PMID: 19201994; PMCID: PMC2670706.
    6. Sonin D, Zhou SY, Cronin C, Sonina T, Wu J, Jacobson KA, Pappano A, Liang BT. Role of P2X purinergic receptors in the rescue of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H1191-H1197. PMID: 18641271; PMCID: PMC2544491.
    7. Shen JB, Pappano AJ. An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current. J Pharmacol Exp Ther. 2008 May; 325(2):507-12. PMID: 18276848.
      View in: PubMed
    8. Shen JB, Shutt R, Pappano A, Liang BT. Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3056-62. PMID: 17873021.
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    9. Shen JB, Pappano AJ, Liang BT. Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors. FASEB J. 2006 Feb; 20(2):277-84. PMID: 16449800.
      View in: PubMed
    10. Jiang B, Liu ZH, Pappano AJ. [Preliminary studies of the mechanism of carbachol increase contraction in rat ventricular myocytes]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 Aug; 20(3):243-7. PMID: 21192414.
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    11. Gómez AM, Kerfant BG, Vassort G, Pappano AJ. Autonomic regulation of calcium and potassium channels is oppositely modulated by microtubules in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2065-71. PMID: 14739139.
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    12. Jiang B, Zhou XP, Pappano AJ. [The role of L-type Ca2+ current and reverse mode Na+ -Ca2+ exchange in activation of excitation-contraction coupling in guinea-pig ventricular myocytes]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003 May; 19(2):122-6. PMID: 21207655.
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    13. Shen JB, Pappano AJ. On the role of phosphatase in regulation of cardiac L-type calcium current by cyclic GMP. J Pharmacol Exp Ther. 2002 May; 301(2):501-6. PMID: 11961049.
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    14. Imai Y, Jiang B, Pappano AJ. Mechanism for muscarinic inhibition of I(Ca(L)) is determined by the path for elevating cyclic AMP in cardiac myocytes. Cardiovasc Res. 2001 Aug 1; 51(2):331-43. PMID: 11470473.
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    15. Shen JB, Pappano AJ. Carbachol inhibits the L-type Ca2+ current augmented by 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid in guinea pig ventricular myocytes: calcium-sensitivity hypothesis for muscarinic inhibition. J Pharmacol Exp Ther. 2001 Aug; 298(2):857-64. PMID: 11454952.
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    16. Shen JB, Jiang B, Pappano AJ. Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 2000 Aug; 294(2):562-70. PMID: 10900233.
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    17. Sakai R, Shen JB, Pappano AJ. Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. 1999 Aug; 34(2):304-15. PMID: 10445683.
      View in: PubMed
    18. Shen JB, Jiang B, Pappano AJ. Lack of effect of McN-A-343 on membrane current and contraction in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1999 Aug; 290(2):641-8. PMID: 10411573.
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    19. Pappano AJ. On the effects of overexpression of beta 2-adrenoceptors in a transgenic mouse model. Cardiovasc Res. 1999 Apr; 42(1):3-5. PMID: 10434988.
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    20. Saeki T, Shen JB, Pappano AJ. Inositol-1,4,5-trisphosphate increases contractions but not L-type calcium current in guinea pig ventricular myocytes. Cardiovasc Res. 1999 Mar; 41(3):620-8. PMID: 10435034.
      View in: PubMed
    21. Protas L, Shen JB, Pappano AJ. Carbachol increases contractions and intracellular Ca++ transients in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1998 Jan; 284(1):66-74. PMID: 9435162.
      View in: PubMed
    22. Saeki T, Shen JB, Pappano AJ. Carbachol promotes Na+ entry and augments Na/Ca exchange current in guinea pig ventricular myocytes. Am J Physiol. 1997 Oct; 273(4 Pt 2):H1984-93. PMID: 9362270.
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    23. Shen JB, Pappano AJ. Mechanisms for depolarization by l-palmitoylcarnitine in single guinea pig ventricular myocytes. J Cardiovasc Electrophysiol. 1997 Feb; 8(2):172-83. PMID: 9048248.
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    24. Shirayama T, Pappano AJ. Biphasic effects of intrapipette cyclic guanosine monophosphate on L-type calcium current and contraction of guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1996 Dec; 279(3):1274-81. PMID: 8968351.
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    25. Vites AM, Pappano AJ. Regulation of InsP3-induced contractions by myoplasmic calcium in permeabilized atrial muscle. Cardiovasc Res. 1995 Dec; 30(6):905-14. PMID: 8746205.
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    26. Sipido KR, Carmeliet E, Pappano A. Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes. J Physiol. 1995 Nov 15; 489 ( Pt 1):1-17. PMID: 8583394; PMCID: PMC1156787.
    27. Shen JB, Pappano AJ. Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1027-36. PMID: 7900857.
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    28. Webb WW, Pappano AJ. Muscarinic agonist-induced positive inotropic response in chick atria. Life Sci. 1995; 57(25):2365-76. PMID: 7491095.
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    29. Mubagwa K, Gilbert JC, Pappano AJ. Differential time course for desensitization to muscarinic effects on K+ and Ca2+ channels. Pflugers Arch. 1994 Oct; 428(5-6):542-51. PMID: 7838676.
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    30. Mubagwa K, Pappano AJ. N-ethylmaleimide increases the L-type calcium current in guinea-pig ventricular myocytes. Arch Int Pharmacodyn Ther. 1994 Mar-Apr; 327(2):125-41. PMID: 7979823.
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    31. Vites AM, Pappano AJ. Distinct modes of inhibition by ruthenium red and ryanodine of calcium-induced calcium release in avian atrium. J Pharmacol Exp Ther. 1994 Mar; 268(3):1476-84. PMID: 7511166.
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    32. Mubagwa K, Shirayama T, Moreau M, Pappano AJ. Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1353-63. PMID: 7694486.
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    33. Gruver C, Pappano AJ. Effect of membrane incorporation of 1-palmitoylcarnitine on surface charge of human erythrocytes. J Mol Cell Cardiol. 1993 Oct; 25(10):1275-84. PMID: 8263958.
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    34. Shirayama T, Matsumoto K, Pappano AJ. Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides. J Pharmacol Exp Ther. 1993 May; 265(2):641-8. PMID: 8388456.
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    35. Tanaka M, Gilbert J, Pappano AJ. Inhibition of sodium pump by l-palmitoylcarnitine in single guinea-pig ventricular myocytes. J Mol Cell Cardiol. 1992 Jul; 24(7):711-9. PMID: 1328655.
      View in: PubMed
    36. Mubagwa K, Vites AM, Pappano AJ. Stimulant effects of muscarinic agonists in embryonic chick ventricular muscle. Are the effects mediated by protein kinase C? J Pharmacol Exp Ther. 1992 Mar; 260(3):1323-30. PMID: 1312167.
      View in: PubMed
    37. Vites AM, Pappano AJ. Ruthenium red selectively prevents Ins(1,4,5)P3-but not caffeine-gated calcium release in avian atrium. Am J Physiol. 1992 Jan; 262(1 Pt 2):H268-77. PMID: 1370752.
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    38. Gilbert JC, Shirayama T, Pappano AJ. Inositol trisphosphate promotes Na-Ca exchange current by releasing calcium from sarcoplasmic reticulum in cardiac myocytes. Circ Res. 1991 Dec; 69(6):1632-9. PMID: 1954683.
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    39. Pappano AJ, Mubagwa K. Muscarinic agonist-induced actions on potassium and calcium channels in atrial myocytes: differential desensitization. Eur Heart J. 1991 Dec; 12 Suppl F:70-5. PMID: 1666556.
      View in: PubMed
    40. Matsumoto K, Pappano AJ. Carbachol activates a novel sodium current in isolated guinea pig ventricular myocytes via M2 muscarinic receptors. Mol Pharmacol. 1991 Mar; 39(3):359-63. PMID: 1706471.
      View in: PubMed
    41. Vites AM, Pappano A. Inositol 1,4,5-trisphosphate releases intracellular Ca2+ in permeabilized chick atria. Am J Physiol. 1990 Jun; 258(6 Pt 2):H1745-52. PMID: 2360668.
      View in: PubMed
    42. Mészàros J, Pappano AJ. Electrophysiological effects of L-palmitoylcarnitine in single ventricular myocytes. Am J Physiol. 1990 Apr; 258(4 Pt 2):H931-8. PMID: 2331016.
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    43. Pappano AJ, Matsumoto K, Mészáros J, Tanaka M. Carbachol depolarizes and evokes an inward current in heart muscle: a novel action of muscarinic agonist. Prog Clin Biol Res. 1990; 334:313-22. PMID: 2309008.
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    44. Pappano AJ. Development of cholinergic neuroeffector transmission in the avian heart. Implications for regulatory mechanisms. Ann N Y Acad Sci. 1990; 588:131-6. PMID: 2162649.
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    45. Matsumoto K, Pappano AJ. Sodium-dependent membrane current induced by carbachol in single guinea-pig ventricular myocytes. J Physiol. 1989 Aug; 415:487-502. PMID: 2561791; PMCID: PMC1189188.
    46. Agnarsson U, Tajima T, Pappano AJ. Carbachol depolarizes and accelerates pacemaker activity in the sinoatrial node of chicks treated with pertussis toxin. J Pharmacol Exp Ther. 1988 Oct; 247(1):150-5. PMID: 3262738.
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    47. Mészáros J, Villanova L, Pappano AJ. Calcium ions and 1-palmitoyl carnitine reduce erythrocyte electrophoretic mobility: test of a surface charge hypothesis. J Mol Cell Cardiol. 1988 Jun; 20(6):481-92. PMID: 3216404.
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    48. Pappano AJ, Matsumoto K, Tajima T, Agnarsson U, Webb W. Pertussis toxin-insensitive mechanism for carbachol-induced depolarization and positive inotropic effect in heart muscle. Trends Pharmacol Sci. 1988 Feb; Suppl:35-9. PMID: 3074534.
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    49. Tajima T, Tsuji Y, Sorota S, Pappano AJ. Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein. Circ Res. 1987 Oct; 61(4 Pt 2):I105-11. PMID: 3115621.
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    50. Tajima T, Tsuji Y, Brown JH, Pappano AJ. Pertussis toxin-insensitive phosphoinositide hydrolysis, membrane depolarization, and positive inotropic effect of carbachol in chick atria. Circ Res. 1987 Sep; 61(3):436-45. PMID: 3040295.
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    51. Epstein PM, Andrenyak DM, Smith CJ, Pappano AJ. Ontogenetic changes in adenylate cyclase, cyclic AMP phosphodiesterase and calmodulin in chick ventricular myocardium. Biochem J. 1987 Apr 15; 243(2):525-31. PMID: 2820384; PMCID: PMC1147886.
    52. Tsuji Y, Tajima T, Yuen J, Pappano AJ. Positive inotropic effects of acetylcholine and BAY K 8644 in embryonic chick ventricle. Am J Physiol. 1987 Apr; 252(4 Pt 2):H807-15. PMID: 2436490.
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    53. Rardon DP, Pappano AJ. Carbachol inhibits electrophysiological effects of cyclic AMP in ventricular myocytes. Am J Physiol. 1986 Sep; 251(3 Pt 2):H601-11. PMID: 2428257.
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    54. Sorota S, Adam LP, Pappano AJ. Comparison of muscarinic receptor properties in hatched chick heart atrium and ventricle. J Pharmacol Exp Ther. 1986 Mar; 236(3):602-9. PMID: 3754007.
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    55. Katz AM, Hager WD, Messineo FC, Pappano AJ. Cellular actions and pharmacology of calcium-channel blockers. Am J Emerg Med. 1985 Dec; 3(6 Suppl):1-9. PMID: 4084378.
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    56. Sorota S, Tsuji Y, Tajima T, Pappano AJ. Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium. Circ Res. 1985 Nov; 57(5):748-58. PMID: 2414029.
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    57. Smith CJ, Pappano AJ. A role for adenylate cyclase in the subsensitivity to isoproterenol during ontogenesis of the embryonic chick ventricle. J Pharmacol Exp Ther. 1985 Nov; 235(2):335-43. PMID: 2997430.
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    58. Tsuji Y, Inoue D, Pappano AJ. beta-Adrenoceptor agonist accelerates recovery from inactivation of calcium-dependent action potentials. J Mol Cell Cardiol. 1985 May; 17(5):517-21. PMID: 2863384.
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    59. Löffelholz K, Pappano AJ. The parasympathetic neuroeffector junction of the heart. Pharmacol Rev. 1985 Mar; 37(1):1-24. PMID: 2408285.
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    60. Inoue D, Pappano AJ. Block of avian cardiac fast sodium channels by tetrodotoxin is enhanced by repetitive depolarization but not by steady depolarization. J Mol Cell Cardiol. 1984 Oct; 16(10):943-52. PMID: 6096567.
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    61. Katz AM, Hager WD, Messineo FC, Pappano AJ. Cellular actions and pharmacology of the calcium channel blocking drugs. Am J Med. 1984 Aug 31; 77(2B):2-10. PMID: 6486125.
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    62. Pappano AJ, Inoue D. Development of different electrophysiological mechanisms for muscarinic inhibition of atria and ventricles. Fed Proc. 1984 Aug; 43(11):2607-12. PMID: 6745450.
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    63. Inoue D, Hachisu M, Pappano AJ. Acetylcholine increases resting membrane potassium conductance in atrial but not in ventricular muscle during muscarinic inhibition of Ca++-dependent action potentials in chick heart. Circ Res. 1983 Aug; 53(2):158-67. PMID: 6883643.
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    64. Inoue D, Pappano AJ. L-palmitylcarnitine and calcium ions act similarly on excitatory ionic currents in avian ventricular muscle. Circ Res. 1983 Jun; 52(6):625-34. PMID: 6305529.
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    65. Hachisu M, Pappano AJ. A comparative study of the blockade of calcium-dependent action potentials by verapamil, nifedipine and nimodipine in ventricular muscle. J Pharmacol Exp Ther. 1983 Apr; 225(1):112-20. PMID: 6834265.
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    66. Sperelakis N, Pappano AJ. Physiology and pharmacology of developing heart cells. Pharmacol Ther. 1983; 22(1):1-39. PMID: 6318234.
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    67. Pappano AJ, Hartigan PM, Coutu MD. Acetylcholine inhibits positive inotropic effect of cholera toxin in ventricular muscle. Am J Physiol. 1982 Sep; 243(3):H434-41. PMID: 6287867.
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    68. Andrenyak D, Higgins D, Pappano AJ. Release of 3H-norepinephrine from adrenergic nerves in chick heart. Dev Neurosci. 1982 Mar-Jun; 5(2-3):181-8. PMID: 6181955.
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    69. Higgins D, Pappano AJ. Development of transmitter secretory mechanisms by adrenergic neurons in the embryonic chick heart ventricle. Dev Biol. 1981 Oct 15; 87(1):148-62. PMID: 6116633.
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    70. Higgins D, Pappano AJ. Developmental changes in the sensitivity of the chick embryo ventricle to beta-adrenergic agonist during adrenergic innervation. Circ Res. 1981 Feb; 48(2):245-53. PMID: 6109580.
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    71. Biegon RL, Epstein PM, Pappano AJ. Muscarinic antagonism of the effects of phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle. J Pharmacol Exp Ther. 1980 Nov; 215(2):348-56. PMID: 6160237.
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    72. Katz AM, McCall D, Messineo FC, Pappano A, Dobbs W. Comments on "cardiotonic activity of amrinone-win 40680 [5-amino-3-4'-bypyridin-6(1H)-one]". Circ Res. 1980 Jun; 46(6):887-8. PMID: 7379253.
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    73. Biegon RL, Pappano AJ. Dual mechanism for inhibition of calcium-dependent action potentials by acetylcholine in avian ventricular muscle. Relationship to cyclic AMP. Circ Res. 1980 Mar; 46(3):353-62. PMID: 6244118.
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    74. Pappano AJ, Carmeliet EE. Epinephrine and the pacemaking mechanism at plateau potentials in sheep cardiac Purkinje fibers. Pflugers Arch. 1979 Oct; 382(1):17-26. PMID: 574937.
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    75. Higgins D, Pappano AJ. A histochemical study of the ontogeny of catecholamine-containing axons in the chick embryo heart. J Mol Cell Cardiol. 1979 Jul; 11(7):661-8. PMID: 384004.
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    76. Iijima T, Pappano AJ. Ontogenetic increase of the maximal rate of rise of the chick embryonic heart action potential. Relationship to voltage, time, and tetrodotoxin. Circ Res. 1979 Mar; 44(3):358-67. PMID: 761318.
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    77. Biegon R, Pappano A. Regulation of calcium dependent action potentials by neurotransmitters in embryonic heart muscle. Proc West Pharmacol Soc. 1979; 22:327-31. PMID: 42086.
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    78. Levi R, Pappano AJ. Modification of the effects of histamine and norepinephrine on the sinoatrial node pacemaker by potassium and calcium. J Pharmacol Exp Ther. 1978 Mar; 204(3):625-33. PMID: 633068.
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    79. Pappano AJ. Ontogenetic development of autonomic neuroeffector transmission and transmitter reactivity in embryonic and fetal hearts. Pharmacol Rev. 1977 Mar; 29(1):3-33. PMID: 22089.
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    80. Freer RJ, Pappano AJ, Peach MJ, Bing KT, McLean MJ, Vogel S, Sperelakis N. Mechanism for the postive inotropic effect of angiotensin II on isolated cardiac muscle. Circ Res. 1976 Aug; 39(2):178-83. PMID: 939002.
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    81. Pappano AJ. Action potentials in chick atria. Ontogenetic changes in the dependence of tetrodotoxin-resistant action potentials on calcium, strontium, barium. Circ Res. 1976 Jul; 39(1):99-105. PMID: 1277409.
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    82. Pappano AJ. Onset of chronotropic effects of nicotinic drugs and tyramine on the sinoatrial pacemaker in chick embryo heart: relationship to the development of autonomic neuroeffector transmission. J Pharmacol Exp Ther. 1976 Mar; 196(3):676-84. PMID: 177754.
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    83. Löffelholz K, Pappano AJ. Increased sensitivity of sinoatrial pace-maker to acetylcholine and to catecholamines at the onset of autonomic neuroeffector transmission in chick embryo heart. J Pharmacol Exp Ther. 1974 Dec; 191(3):479-86. PMID: 4372341.
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    84. Pappano AJ, Löffelholz K. Ontogenesis of adrenergic and cholinergic neuroeffector transmission in chick embryo heart. J Pharmacol Exp Ther. 1974 Dec; 191(3):468-78. PMID: 4372340.
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    85. Pappano AJ, Skowronek CA. Reactivity of chick embryo heart to cholinergic agonists during ontogenesis: decline in desensitization at the onset of cholinergic transmission. J Pharmacol Exp Ther. 1974 Oct; 191(1):109-18. PMID: 4371671.
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    86. Löffelholz K, Pappano AJ. Ontogenetic changes in pacemaker activity in chick heart. Life Sci. 1974 May 1; 14(9):1755-63. PMID: 4407740.
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    87. Pappano AJ. Action potentials in chick atria. Increased susceptibility to blockade by tetrodotoxin during embryonic development. Circ Res. 1972 Sep; 31(3):379-88. PMID: 5057018.
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    88. Pappano AJ. Sodium-dependent depolarization of noninnervated embryonic chick heart by acetylcholine. J Pharmacol Exp Ther. 1972 Feb; 180(2):340-50. PMID: 5010676.
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    89. Pappano AJ. Propranolol-insensitive effects of epinephrine on action potential repolarization in electrically driven atria of the guinea pig. J Pharmacol Exp Ther. 1971 Apr; 177(1):85-95. PMID: 5566775.
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    90. Pappano AJ, Rembish RA. Negative chronotropic effects of McN A-343 and nicotine in isolated guinea-pig atria: insensitivity to blockade by tetrodotoxin. J Pharmacol Exp Ther. 1971 Apr; 177(1):40-7. PMID: 5566773.
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    91. Pappano AJ, Rembish RA. Nicotine-induced restoration of action potentials to cardiac tissue depolarized by potassium. Life Sci I. 1970 Dec 15; 9(24):1381-8. PMID: 5493320.
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    92. Pappano AJ. Calcium-dependent action potentials produced by catecholamines in guinea pig atrial muscle fibers depolarized by potassium. Circ Res. 1970 Sep; 27(3):379-90. PMID: 5452736.
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    93. Pappano AJ. Biphasic effect of nicotine on action potential repolarization in electrically driven guinea-pig atria. J Pharmacol Exp Ther. 1970 Apr; 172(2):255-65. PMID: 5441154.
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    94. Pappano AJ, Sperelakis N. Low K+ conductance and low resting potentials of isolated single cultured heart cells. Am J Physiol. 1969 Oct; 217(4):1076-82. PMID: 5824308.
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    95. Sperelakis N, Pappano AJ. Depolarization of cultured heart cells by a lipid-soluble acetylcholine analogue. Am J Physiol. 1969 Aug; 217(2):625-9. PMID: 5799395.
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    96. Pappano AJ, Sperelakis N. Spike electrogenesis in cultured heart cells. Am J Physiol. 1969 Aug; 217(2):615-24. PMID: 5799394.
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    97. Sperelakis N, Pappano AJ. Increase in PNa and PK of cultured heart cells produced by veratridine. J Gen Physiol. 1969 Jan; 53(1):97-114. PMID: 5761875; PMCID: PMC2202897.
    98. Pappano AJ, Sperelakis N. Spontaneous contractions of cultured heart cells in high K+ media. Exp Cell Res. 1969 Jan; 54(1):58-68. PMID: 5771099.
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    99. Volle RL, Pappano AJ. Some relationships between drugs and ions at a ganglionic synapse. Fed Proc. 1968 Jan-Feb; 27(1):110-4. PMID: 4157315.
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    100. Pappano AJ, Volle RL. Actions of lithium ions in mammalian sympathetic ganglia. J Pharmacol Exp Ther. 1967 Aug; 157(2):346-55. PMID: 6039826.
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    101. Pappano AJ, Volle RL. Observations on the role of calcium ions in ganglionic responses to acetylcholine. J Pharmacol Exp Ther. 1966 May; 152(2):171-80. PMID: 5944363.
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    102. Pappano AJ, Volle RL. Lithium's failure to replace sodium in mammalian sympathetic ganglia. Science. 1966 Apr 1; 152(3718):85-7. PMID: 5910015.
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    103. PAPPANO AJ, VOLLE RL. A COMPARISON OF THE RESPONSES OF SYMPATHETIC GANGLIA AND CHEMORECEPTORS TO CHOLINOMIMETIC AGENTS AND SODIUM CYANIDE. J Pharmacol Exp Ther. 1965 Mar; 147:324-9. PMID: 14269607.
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    104. TAKESHIGE C, PAPPANO AJ, DEGROAT WC, VOLLE RL. GANGLIONIC BLOCKADE PRODUCED IN SYMPATHETIC GANGLIA BY CHOLINOMIMETIC DRUGS. J Pharmacol Exp Ther. 1963 Sep; 141:333-42. PMID: 14064196.
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    105. PAPPANO AJ, VOLLE RL. The reversal by atropine of ganglionic blockade produced by acetylcholine or methacholine. Life Sci. 1962 Dec; 1:677-82. PMID: 13941331.
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