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Last Name
Institution

Ion I Moraru PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentCenter for Cell Analysis and Modeling
AddressMC 6406
Cell and Genome Sciences Building, MC 6406
400 Farmington Avenue
Phone860-679-2908
Fax860-679-1039
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    Other Positions
    TitleAssociate Professor
    InstitutionUConn Health Center
    DepartmentCell Biology


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Singh A, Rigatti M, Le AV, Carlson CR, Moraru II, Dodge-Kafka KL. Analysis of AKAP7? Dimerization. J Signal Transduct. 2015; 2015:371626. PMID: 26417456; PMCID: PMC4568377.
    2. Rigatti M, Le AV, Gerber C, Moraru II, Dodge-Kafka KL. Phosphorylation state-dependent interaction between AKAP7d/? and phospholamban increases phospholamban phosphorylation. Cell Signal. 2015 Sep; 27(9):1807-15. PMID: 26027516.
      View in: PubMed
    3. Blinov ML, Schaff JC, Ruebenacker O, Wei X, Vasilescu D, Gao F, Morgan F, Ye L, Lakshminarayana A, Moraru II, Loew LM. Pathway Commons at virtual cell: use of pathway data for mathematical modeling. Bioinformatics. 2014 Jan 15; 30(2):292-4. PMID: 24273241; PMCID: PMC3892693.
    4. Blinov ML, Moraru II. Logic modeling and the ridiculome under the rug. BMC Biol. 2012; 10:92. PMID: 23171629; PMCID: PMC3503555.
    5. Blinov ML, Moraru II. Leveraging modeling approaches: reaction networks and rules. Adv Exp Med Biol. 2012; 736:517-30. PMID: 22161349; PMCID: PMC3363960.
    6. Cowan AE, Moraru II, Schaff JC, Slepchenko BM, Loew LM. Spatial modeling of cell signaling networks. Methods Cell Biol. 2012; 110:195-221. PMID: 22482950; PMCID: PMC3519356.
    7. Waltemath D, Adams R, Bergmann FT, Hucka M, Kolpakov F, Miller AK, Moraru II, Nickerson D, Sahle S, Snoep JL, Le Novère N. Reproducible computational biology experiments with SED-ML--the Simulation Experiment Description Markup Language. BMC Syst Biol. 2011; 5:198. PMID: 22172142; PMCID: PMC3292844.
    8. Brown SA, Moraru II, Schaff JC, Loew LM. Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling. J Comput Neurosci. 2011 Oct; 31(2):385-400. PMID: 21340454; PMCID: PMC3221887.
    9. Ruebenacker O, Moraru II, Schaff JC, Blinov ML. Integrating BioPAX pathway knowledge with SBML models. IET Syst Biol. 2009 Sep; 3(5):317-28. PMID: 21028923.
      View in: PubMed
    10. Moraru II, Schaff JC, Slepchenko BM, Blinov ML, Morgan F, Lakshminarayana A, Gao F, Li Y, Loew LM. Virtual Cell modelling and simulation software environment. IET Syst Biol. 2008 Sep; 2(5):352-62. PMID: 19045830; PMCID: PMC2711391.
    11. Blinov ML, Ruebenacker O, Moraru II. Complexity and modularity of intracellular networks: a systematic approach for modelling and simulation. IET Syst Biol. 2008 Sep; 2(5):363-8. PMID: 19045831; PMCID: PMC2675916.
    12. Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell. 2008 May 16; 133(4):666-80. PMID: 18485874; PMCID: PMC2728678.
    13. Hernjak N, Slepchenko BM, Fernald K, Fink CC, Fortin D, Moraru II, Watras J, Loew LM. Modeling and analysis of calcium signaling events leading to long-term depression in cerebellar Purkinje cells. Biophys J. 2005 Dec; 89(6):3790-806. PMID: 16169982; PMCID: PMC1366947.
    14. Moraru II, Loew LM. Intracellular signaling: spatial and temporal control. Physiology (Bethesda). 2005 Jun; 20:169-79. PMID: 15888574.
      View in: PubMed
    15. Wagner J, Fall CP, Hong F, Sims CE, Allbritton NL, Fontanilla RA, Moraru II, Loew LM, Nuccitelli R. A wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support. Cell Calcium. 2004 May; 35(5):433-47. PMID: 15003853.
      View in: PubMed
    16. Moraru II, Schaff JC, Slepchenko BM, Loew LM. The virtual cell: an integrated modeling environment for experimental and computational cell biology. Ann N Y Acad Sci. 2002 Oct; 971:595-6. PMID: 12438191.
      View in: PubMed
    17. Fink CC, Slepchenko B, Moraru II, Watras J, Schaff JC, Loew LM. An image-based model of calcium waves in differentiated neuroblastoma cells. Biophys J. 2000 Jul; 79(1):163-83. PMID: 10866945; PMCID: PMC1300923.
    18. Watras J, Orlando R, Moraru II. An endogenous sulfated inhibitor of neuronal inositol trisphosphate receptors. Biochemistry. 2000 Mar 28; 39(12):3452-60. PMID: 10727240.
      View in: PubMed
    19. Fink CC, Slepchenko B, Moraru II, Schaff J, Watras J, Loew LM. Morphological control of inositol-1,4,5-trisphosphate-dependent signals. J Cell Biol. 1999 Nov 29; 147(5):929-36. PMID: 10579714; PMCID: PMC2169350.
    20. Moraru II, Kaftan EJ, Ehrlich BE, Watras J. Regulation of type 1 inositol 1,4,5-trisphosphate-gated calcium channels by InsP3 and calcium: Simulation of single channel kinetics based on ligand binding and electrophysiological analysis. J Gen Physiol. 1999 Jun; 113(6):837-49. PMID: 10352034; PMCID: PMC2225610.
    21. Moraru II, Syrbu S, Michaels K, Kim DH, Malchoff D, Watras J. Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Ann N Y Acad Sci. 1998 Sep 16; 853:329-32. PMID: 10603972.
      View in: PubMed
    22. Moraru II, Syrbu S, Zecevic N, Hager WD, Watras J, Messineo F. An antibody to annexin V blocks Ca(2+)-dependent ATPase activity of sarcoplasmic reticulum in human failing hearts. Ann N Y Acad Sci. 1998 Sep 16; 853:333-7. PMID: 10603973.
      View in: PubMed
    23. Moraru II, Jones RM, Popescu LM, Engelman RM, Das DK. Prazosin reduces myocardial ischemia/reperfusion-induced Ca2+ overloading in rat heart by inhibiting phosphoinositide signaling. Biochim Biophys Acta. 1995 Jul 20; 1268(1):1-8. PMID: 7626655.
      View in: PubMed
    24. Das DK, Maulik N, Moraru II. Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress. J Mol Cell Cardiol. 1995 Jan; 27(1):181-93. PMID: 7760341.
      View in: PubMed
    25. Watras J, Moraru I, Costa DJ, Kindman LA. Two inositol 1,4,5-trisphosphate binding sites in rat basophilic leukemia cells: relationship between receptor occupancy and calcium release. Biochemistry. 1994 Nov 29; 33(47):14359-67. PMID: 7947846.
      View in: PubMed
    26. Das DK, Moraru II, Maulik N, Engelman RM. Gene expression during myocardial adaptation to ischemia and reperfusion. Ann N Y Acad Sci. 1994 Jun 17; 723:292-307. PMID: 8030873.
      View in: PubMed
    27. Moraru II, Popescu LM, Liu X, Engelman RM, Das DK. Role of phospholipase A2, C, and D activities during myocardial ischemia and reperfusion. Ann N Y Acad Sci. 1994 Jun 17; 723:328-32. PMID: 8030876.
      View in: PubMed
    28. Benevolensky D, Moraru II, Watras J. Micromolar calcium decreases affinity of inositol trisphosphate receptor in vascular smooth muscle. Biochem J. 1994 May 1; 299 ( Pt 3):631-6. PMID: 8192651; PMCID: PMC1138067.
    29. Lu D, Maulik N, Moraru II, Kreutzer DL, Das DK. Molecular adaptation of vascular endothelial cells to oxidative stress. Am J Physiol. 1993 Mar; 264(3 Pt 1):C715-22. PMID: 8460674.
      View in: PubMed
    30. Liu X, Engelman RM, Moraru II, Rousou JA, Flack JE, Deaton DW, Maulik N, Das DK. Heat shock. A new approach for myocardial preservation in cardiac surgery. Circulation. 1992 Nov; 86(5 Suppl):II358-63. PMID: 1424025.
      View in: PubMed
    31. Moraru II, Popescu LM, Maulik N, Liu X, Das DK. Phospholipase D signaling in ischemic heart. Biochim Biophys Acta. 1992 Jun 9; 1139(1-2):148-54. PMID: 1610913.
      View in: PubMed
    32. Prasad MR, Popescu LM, Moraru II, Liu XK, Maity S, Engelman RM, Das DK. Role of phospholipases A2 and C in myocardial ischemic reperfusion injury. Am J Physiol. 1991 Mar; 260(3 Pt 2):H877-83. PMID: 2000982.
      View in: PubMed
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