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Sun-Kyeong Lee PhD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 1835
Academic Research Building, MC 1835
263 Farmington Avenue
Phone860-679-8177
Fax860-679-8891
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    Other Positions
    TitleAssistant Professor
    InstitutionUConn Health Center
    DepartmentCenter on Aging


    Collapse Biography 
    Collapse awards and honors
    1982 - 1985Member, Korean Entomological Society
    1982 - 1985Member, Korean Zoological Society
    1987 - 1996Member, American Society for Integrative & Comparative Biology
    1990Doctoral Dissertation Fellowship Award
    1991 - 1998Member in training, American Society for Bone & Mineral Research
    1993Annual Judge Award for Outstanding Presentation, New England Endocrinology Conference
    2002Mazess Research Grant Award, National Osteoporosis Foundation
    2010Accepted for NIA Summer Institute on Aging Research

    Collapse Overview 
    Collapse overview
    Dr. Lee is an assistant professor in the UConn Center on Aging at the UConn School of Medicine. Dr. Lee received her undergraduate degree from Korea University and her postdoctoral degree from the University of Connecticut. She has conducted basic osteoclast biology research at the UConn Health Center for the last 20 years, initially as a postdoctoral fellow and an independent investigator. Dr. Lee's research activities include studying the role of cytokines and hormones in the regulation of bone resorption and formation with the hope of providing new and improved therapies for the treatment of osteoporosis. She also studies the role of macrophage migration inhibitory factor (MIF) and their receptors in the development and function of osteoclasts. One of Dr. Lee's major academic activities includes mentoring Ph.D. students, dental master's degree students and postdoctoral fellows. She is also a member of the skeletal, craniofacial and oral biology graduate program at the UConn Health Center.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jacome-Galarza CE, Lee SK, Lorenzo JA, Aguila HL. Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow. J Bone Miner Res. 2011 Jun; 26(6):1207-16. PMID: 21611963; PMCID: PMC3312755.
    2. Jacquin C, Koczon-Jaremko B, Aguila HL, Leng L, Bucala R, Kuchel GA, Lee SK. Macrophage migration inhibitory factor inhibits osteoclastogenesis. Bone. 2009 Oct; 45(4):640-9. PMID: 19591967.
      View in: PubMed
    3. Taxel P, Kaneko H, Lee SK, Aguila HL, Raisz LG, Lorenzo JA. Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study. Osteoporos Int. 2008 Feb; 19(2):193-9. PMID: 17768586.
      View in: PubMed
    4. Lee SJ, Rossi RJ, Lee SK, Croft M, Kwon BS, Mittler RS, Vella AT. CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent. J Immunol. 2007 Aug 15; 179(4):2203-14. PMID: 17675480.
      View in: PubMed
    5. Liu F, Lee SK, Adams DJ, Gronowicz GA, Kream BE. CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment. Bone. 2007 Apr; 40(4):1135-43. PMID: 17275432; PMCID: PMC1995436.
    6. Lee SH, Rho J, Jeong D, Sul JY, Kim T, Kim N, Kang JS, Miyamoto T, Suda T, Lee SK, Pignolo RJ, Koczon-Jaremko B, Lorenzo J, Choi Y. v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med. 2006 Dec; 12(12):1403-9. PMID: 17128270.
      View in: PubMed
    7. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006 Nov; 21(11):1704-12. PMID: 17002560.
      View in: PubMed
    8. Lee SK, Lorenzo J. Cytokines regulating osteoclast formation and function. Curr Opin Rheumatol. 2006 Jul; 18(4):411-8. PMID: 16763463.
      View in: PubMed
    9. Kacena MA, Nelson T, Clough ME, Lee SK, Lorenzo JA, Gundberg CM, Horowitz MC. Megakaryocyte-mediated inhibition of osteoclast development. Bone. 2006 Nov; 39(5):991-9. PMID: 16782418.
      View in: PubMed
    10. Lee SK, Kalinowski JF, Jacquin C, Adams DJ, Gronowicz G, Lorenzo JA. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res. 2006 May; 21(5):695-702. PMID: 16734384.
      View in: PubMed
    11. Lee SK, Surh CD. Role of interleukin-7 in bone and T-cell homeostasis. Immunol Rev. 2005 Dec; 208:169-80. PMID: 16313348.
      View in: PubMed
    12. Lee SK, Gardner AE, Kalinowski JF, Jastrzebski SL, Lorenzo JA. RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production. Bone. 2006 May; 38(5):678-85. PMID: 16309985.
      View in: PubMed
    13. Jacquin C, Gran DE, Lee SK, Lorenzo JA, Aguila HL. Identification of multiple osteoclast precursor populations in murine bone marrow. J Bone Miner Res. 2006 Jan; 21(1):67-77. PMID: 16355275.
      View in: PubMed
    14. Kim N, Kadono Y, Takami M, Lee J, Lee SH, Okada F, Kim JH, Kobayashi T, Odgren PR, Nakano H, Yeh WC, Lee SK, Lorenzo JA, Choi Y. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 2005 Sep 5; 202(5):589-95. PMID: 16147974; PMCID: PMC2212875.
    15. Lee SK, Kalinowski JF, Jastrzebski SL, Puddington L, Lorenzo JA. Interleukin-7 is a direct inhibitor of in vitro osteoclastogenesis. Endocrinology. 2003 Aug; 144(8):3524-31. PMID: 12865334.
      View in: PubMed
    16. Katavic V, Grcevic D, Lee SK, Kalinowski J, Jastrzebski S, Dougall W, Anderson D, Puddington L, Aguila HL, Lorenzo JA. The surface antigen CD45R identifies a population of estrogen-regulated murine marrow cells that contain osteoclast precursors. Bone. 2003 Jun; 32(6):581-90. PMID: 12810165.
      View in: PubMed
    17. Lee SK, Kalinowski J, Jastrzebski S, Lorenzo JA. 1,25(OH)2 vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures is mediated in part by enhanced IL-1 alpha and receptor activator of NF-kappa B ligand production in osteoblasts. J Immunol. 2002 Sep 1; 169(5):2374-80. PMID: 12193704.
      View in: PubMed
    18. Lee SK, Lorenzo JA. Regulation of receptor activator of nuclear factor-kappa B ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow cultures. Bone. 2002 Jul; 31(1):252-9. PMID: 12110442.
      View in: PubMed
    19. Grcevic D, Lee SK, Marusic A, Lorenzo JA. Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis. J Immunol. 2000 Oct 15; 165(8):4231-8. PMID: 11035056.
      View in: PubMed
    20. Lee SK, Lorenzo JA. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology. 1999 Aug; 140(8):3552-61. PMID: 10433211.
      View in: PubMed
    21. Hurley MM, Lee SK, Raisz LG, Bernecker P, Lorenzo J. Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures. Bone. 1998 Apr; 22(4):309-16. PMID: 9556129.
      View in: PubMed
    22. Vargas SJ, Naprta A, Lee SK, Kalinowski J, Kawaguchi H, Pilbeam CC, Raisz LG, Lorenzo JA. Lack of evidence for an increase in interleukin-6 expression in adult murine bone, bone marrow, and marrow stromal cell cultures after ovariectomy. J Bone Miner Res. 1996 Dec; 11(12):1926-34. PMID: 8970895.
      View in: PubMed
    23. Vargas SJ, Naprta A, Glaccum M, Lee SK, Kalinowski J, Lorenzo JA. Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor. J Bone Miner Res. 1996 Nov; 11(11):1736-44. PMID: 8915781.
      View in: PubMed
    24. Lee SK, Goldring SR, Lorenzo JA. Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin. Endocrinology. 1995 Oct; 136(10):4572-81. PMID: 7664679.
      View in: PubMed
    25. Rahimi P, Wang CY, Stashenko P, Lee SK, Lorenzo JA, Graves DT. Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse. Endocrinology. 1995 Jun; 136(6):2752-9. PMID: 7750500.
      View in: PubMed
    26. Lee SK, Clark NB. Effects of cytochalasin B on calcium transport by 1,25(OH)2D3- or PTH-treated chick embryonic yolk sac in vitro and in vivo. J Exp Zool. 1993 May 15; 266(1):11-8. PMID: 8492082.
      View in: PubMed
    27. Clark NB, Murphy MJ, Lee SK. Ontogeny of vitamin D action on the morphology and calcium transport properties of the chick embryonic yolk sac. J Dev Physiol. 1989 Apr; 11(4):243-51. PMID: 2607094.
      View in: PubMed
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