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Last Name
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Sandra K Weller PhD

TitleProfessor and Chair
InstitutionUConn Health Center
DepartmentMolecular, Microbial and Structural Biology
AddressMC 3205
MC 3205
263 Farmington Avenue
Phone860-679-2310
Fax860-679-1239
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    Other Positions
    TitleBoard of Trustees Distinguished Professor
    InstitutionUConn Health Center
    DepartmentMolecular, Microbial and Structural Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Darwish AS, Grady LM, Bai P, Weller SK. ICP8 Filament Formation Is Essential for Replication Compartment Formation during Herpes Simplex Virus Infection. J Virol. 2015; 90(5):2561-70. PMID: 26676794.
      View in: PubMed
    2. Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I. Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1. J Biol Chem. 2015 Sep 18; 290(38):22907-18. PMID: 26224631; PMCID: PMC4645603 [Available on 09/18/16].
    3. Mossman KL, Weller SK. HSV cheats the executioner. Cell Host Microbe. 2015 Feb 11; 17(2):148-51. PMID: 25674981.
      View in: PubMed
    4. Albright BS, Kosinski A, Szczepaniak R, Cook EA, Stow ND, Conway JF, Weller SK. The putative herpes simplex virus 1 chaperone protein UL32 modulates disulfide bond formation during infection. J Virol. 2015 Jan; 89(1):443-53. PMID: 25320327; PMCID: PMC4301124.
    5. Smith S, Reuven N, Mohni KN, Schumacher AJ, Weller SK. Structure of the herpes simplex virus 1 genome: manipulation of nicks and gaps can abrogate infectivity and alter the cellular DNA damage response. J Virol. 2014 Sep 1; 88(17):10146-56. PMID: 24965466; PMCID: PMC4136335.
    6. Weller SK, Sawitzke JA. Recombination promoted by DNA viruses: phage ? to herpes simplex virus. Annu Rev Microbiol. 2014; 68:237-58. PMID: 25002096; PMCID: PMC4303060.
    7. Grady LM, Bai P, Weller SK. HSV-1 protein expression using recombinant baculoviruses. Methods Mol Biol. 2014; 1144:293-304. PMID: 24671692; PMCID: PMC4427568.
    8. Mohni KN, Smith S, Dee AR, Schumacher AJ, Weller SK. Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling. PLoS Pathog. 2013; 9(10):e1003652. PMID: 24098119; PMCID: PMC3789782.
    9. Weller SK, Kuchta RD. The DNA helicase-primase complex as a target for herpes viral infection. Expert Opin Ther Targets. 2013 Oct; 17(10):1119-32. PMID: 23930666; PMCID: PMC4098783.
    10. Mohni KN, Dee AR, Smith S, Schumacher AJ, Weller SK. Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins. J Virol. 2013 Jan; 87(1):531-42. PMID: 23097436; PMCID: PMC3536419.
    11. Weller S, Bonnet M, Delagreverie H, Israel L, Chrabieh M, Maródi L, Rodriguez-Gallego C, Garty BZ, Roifman C, Issekutz AC, Zitnik SE, Hoarau C, Camcioglu Y, Vasconcelos J, Rodrigo C, Arkwright PD, Cerutti A, Meffre E, Zhang SY, Alcais A, Puel A, Casanova JL, Picard C, Weill JC, Reynaud CA. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients. Blood. 2012 Dec 13; 120(25):4992-5001. PMID: 23002119; PMCID: PMC3525023.
    12. Weller SK, Coen DM. Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol. 2012 Sep; 4(9):a013011. PMID: 22952399; PMCID: PMC3428768.
    13. Schumacher AJ, Mohni KN, Kan Y, Hendrickson EA, Stark JM, Weller SK. The HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanism. PLoS Pathog. 2012; 8(8):e1002862. PMID: 22912580; PMCID: PMC3415443.
    14. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. J Virol. 2011 Dec; 85(23):12241-53. PMID: 21957315; PMCID: PMC3209375.
    15. Szczepaniak R, Nellissery J, Jadwin JA, Makhov AM, Kosinski A, Conway JF, Weller SK. Disulfide bond formation contributes to herpes simplex virus capsid stability and retention of pentons. J Virol. 2011 Sep; 85(17):8625-34. PMID: 21697480; PMCID: PMC3165804.
    16. Albright BS, Nellissery J, Szczepaniak R, Weller SK. Disulfide bond formation in the herpes simplex virus 1 UL6 protein is required for portal ring formation and genome encapsidation. J Virol. 2011 Sep; 85(17):8616-24. PMID: 21593161; PMCID: PMC3165836.
    17. Weller SK. Herpes simplex virus reorganizes the cellular DNA repair and protein quality control machinery. PLoS Pathog. 2010; 6(11):e1001105. PMID: 21124825; PMCID: PMC2991270.
    18. Chen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SK. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. J Virol. 2011 Jan; 85(2):968-78. PMID: 21068246; PMCID: PMC3019990.
    19. Balasubramanian N, Bai P, Buchek G, Korza G, Weller SK. Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex. J Virol. 2010 Dec; 84(24):12504-14. PMID: 20943970; PMCID: PMC3004347.
    20. Mohni KN, Livingston CM, Cortez D, Weller SK. ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. J Virol. 2010 Dec; 84(23):12152-64. PMID: 20861269; PMCID: PMC2976399.
    21. Nicolas A, Alazard-Dany N, Biollay C, Arata L, Jolinon N, Kuhn L, Ferro M, Weller SK, Epstein AL, Salvetti A, Greco A. Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments. J Virol. 2010 Sep; 84(17):8871-87. PMID: 20573815; PMCID: PMC2919046.
    22. Bastian TW, Livingston CM, Weller SK, Rice SA. Herpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection. J Virol. 2010 Mar; 84(5):2384-94. PMID: 20032172; PMCID: PMC2820935.
    23. Livingston CM, Ifrim MF, Cowan AE, Weller SK. Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. PLoS Pathog. 2009 Oct; 5(10):e1000619. PMID: 19816571; PMCID: PMC2752995.
    24. Faili A, Stary A, Delbos F, Weller S, Aoufouchi S, Sarasin A, Weill JC, Reynaud CA. A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta. J Immunol. 2009 May 15; 182(10):6353-9. PMID: 19414788.
      View in: PubMed
    25. Pauklin S, Burkert JS, Martin J, Osman F, Weller S, Boulton SJ, Whitby MC, Petersen-Mahrt SK. Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Genetics. 2009 May; 182(1):41-54. PMID: 19237686; PMCID: PMC2674839.
    26. Aoufouchi S, Faili A, Zober C, D'Orlando O, Weller S, Weill JC, Reynaud CA. Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med. 2008 Jun 9; 205(6):1357-68. PMID: 18474627; PMCID: PMC2413033.
    27. Livingston CM, DeLuca NA, Wilkinson DE, Weller SK. Oligomerization of ICP4 and rearrangement of heat shock proteins may be important for herpes simplex virus type 1 prereplicative site formation. J Virol. 2008 Jul; 82(13):6324-36. PMID: 18434395; PMCID: PMC2447070.
    28. Chattopadhyay S, Weller SK. Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer. J Virol. 2007 Dec; 81(24):13659-67. PMID: 17942532; PMCID: PMC2168873.
    29. Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol. 2007 Sep; 81(18):9653-64. PMID: 17609267; PMCID: PMC2045397.
    30. Nellissery JK, Szczepaniak R, Lamberti C, Weller SK. A putative leucine zipper within the herpes simplex virus type 1 UL6 protein is required for portal ring formation. J Virol. 2007 Sep; 81(17):8868-77. PMID: 17581990; PMCID: PMC1951442.
    31. Chen Y, Livingston CM, Carrington-Lawrence SD, Bai P, Weller SK. A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently. J Virol. 2007 Aug; 81(16):8742-51. PMID: 17553899; PMCID: PMC1951384.
    32. Saffran HA, Pare JM, Corcoran JA, Weller SK, Smiley JR. Herpes simplex virus eliminates host mitochondrial DNA. EMBO Rep. 2007 Feb; 8(2):188-93. PMID: 17186027; PMCID: PMC1796774.
    33. Chattopadhyay S, Chen Y, Weller SK. The two helicases of herpes simplex virus type 1 (HSV-1). Front Biosci. 2006; 11:2213-23. PMID: 16720308.
      View in: PubMed
    34. Wilkinson DE, Weller SK. Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection. J Cell Sci. 2006 Jul 1; 119(Pt 13):2695-703. PMID: 16757521; PMCID: PMC4427570.
    35. Chattopadhyay S, Weller SK. DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding. J Virol. 2006 May; 80(9):4491-500. PMID: 16611909; PMCID: PMC1471996.
    36. Pierce AT, DeSalvo J, Foster TP, Kosinski A, Weller SK, Halford WP. Beta interferon and gamma interferon synergize to block viral DNA and virion synthesis in herpes simplex virus-infected cells. J Gen Virol. 2005 Sep; 86(Pt 9):2421-32. PMID: 16099899; PMCID: PMC1366490.
    37. Burch AD, Weller SK. Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus. J Virol. 2005 Aug; 79(16):10740-9. PMID: 16051866; PMCID: PMC1182622.
    38. Reuven NB, Weller SK. Herpes simplex virus type 1 single-strand DNA binding protein ICP8 enhances the nuclease activity of the UL12 alkaline nuclease by increasing its processivity. J Virol. 2005 Jul; 79(14):9356-8. PMID: 15994834; PMCID: PMC1168754.
    39. Chen Y, Carrington-Lawrence SD, Bai P, Weller SK. Mutations in the putative zinc-binding motif of UL52 demonstrate a complex interdependence between the UL5 and UL52 subunits of the human herpes simplex virus type 1 helicase/primase complex. J Virol. 2005 Jul; 79(14):9088-96. PMID: 15994803; PMCID: PMC1168741.
    40. Wilkinson DE, Weller SK. Inhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection. J Virol. 2005 Jun; 79(11):7162-71. PMID: 15890955; PMCID: PMC1112160.
    41. Reuven NB, Willcox S, Griffith JD, Weller SK. Catalysis of strand exchange by the HSV-1 UL12 and ICP8 proteins: potent ICP8 recombinase activity is revealed upon resection of dsDNA substrate by nuclease. J Mol Biol. 2004 Sep 3; 342(1):57-71. PMID: 15313607; PMCID: PMC4412345.
    42. Burch AD, Weller SK. Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. J Virol. 2004 Jul; 78(13):7175-85. PMID: 15194794; PMCID: PMC421678.
    43. Reuven NB, Antoku S, Weller SK. The UL12.5 gene product of herpes simplex virus type 1 exhibits nuclease and strand exchange activities but does not localize to the nucleus. J Virol. 2004 May; 78(9):4599-608. PMID: 15078942; PMCID: PMC387724.
    44. Wilkinson DE, Weller SK. Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response. J Virol. 2004 May; 78(9):4783-96. PMID: 15078960; PMCID: PMC387708.
    45. Faili A, Aoufouchi S, Weller S, Vuillier F, Stary A, Sarasin A, Reynaud CA, Weill JC. DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. J Exp Med. 2004 Jan 19; 199(2):265-70. PMID: 14734526; PMCID: PMC2211761.
    46. Stracker TH, Cassell GD, Ward P, Loo YM, van Breukelen B, Carrington-Lawrence SD, Hamatake RK, van der Vliet PC, Weller SK, Melendy T, Weitzman MD. The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. J Virol. 2004 Jan; 78(1):441-53. PMID: 14671124; PMCID: PMC303412.
    47. Marintcheva B, Weller SK. Existence of transdominant and potentiating mutants of UL9, the herpes simplex virus type 1 origin-binding protein, suggests that levels of UL9 protein may be regulated during infection. J Virol. 2003 Sep; 77(17):9639-51. PMID: 12915576; PMCID: PMC187383.
    48. Przech AJ, Yu D, Weller SK. Point mutations in exon I of the herpes simplex virus putative terminase subunit, UL15, indicate that the most conserved residues are essential for cleavage and packaging. J Virol. 2003 Sep; 77(17):9613-21. PMID: 12915573; PMCID: PMC187393.
    49. Wilkinson DE, Weller SK. The role of DNA recombination in herpes simplex virus DNA replication. IUBMB Life. 2003 Aug; 55(8):451-8. PMID: 14609200.
      View in: PubMed
    50. Reuven NB, Staire AE, Myers RS, Weller SK. The herpes simplex virus type 1 alkaline nuclease and single-stranded DNA binding protein mediate strand exchange in vitro. J Virol. 2003 Jul; 77(13):7425-33. PMID: 12805441; PMCID: PMC164775.
    51. Carrington-Lawrence SD, Weller SK. Recruitment of polymerase to herpes simplex virus type 1 replication foci in cells expressing mutant primase (UL52) proteins. J Virol. 2003 Apr; 77(7):4237-47. PMID: 12634381; PMCID: PMC150627.
    52. Marintcheva B, Weller SK. Helicase motif Ia is involved in single-strand DNA-binding and helicase activities of the herpes simplex virus type 1 origin-binding protein, UL9. J Virol. 2003 Feb; 77(4):2477-88. PMID: 12551986; PMCID: PMC141079.
    53. Martinez R, Goldstein JN, Weller SK. The product of the UL12.5 gene of herpes simplex virus type 1 is not essential for lytic viral growth and is not specifically associated with capsids. Virology. 2002 Jul 5; 298(2):248-57. PMID: 12127788.
      View in: PubMed
    54. Newcomb WW, Juhas RM, Thomsen DR, Homa FL, Burch AD, Weller SK, Brown JC. The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid. J Virol. 2001 Nov; 75(22):10923-32. PMID: 11602732; PMCID: PMC114672.
    55. Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Corey L, Gruber WC, Rathore M, Bradley JS, Diaz PS, Kumar M, Arvin AM, Gutierrez K, Shelton M, Weiner LB, Sleasman JW, de Sierra TM, Weller S, Soong SJ, Kiell J, Lakeman FD, Whitley RJ. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics. 2001 Aug; 108(2):230-8. PMID: 11483782.
      View in: PubMed
    56. Burkham J, Coen DM, Hwang CB, Weller SK. Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments. J Virol. 2001 Mar; 75(5):2353-67. PMID: 11160739; PMCID: PMC114819.
    57. Biswas N, Weller SK. The UL5 and UL52 subunits of the herpes simplex virus type 1 helicase-primase subcomplex exhibit a complex interdependence for DNA binding. J Biol Chem. 2001 May 18; 276(20):17610-9. PMID: 11278618.
      View in: PubMed
    58. Sheaffer AK, Newcomb WW, Gao M, Yu D, Weller SK, Brown JC, Tenney DJ. Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation. J Virol. 2001 Jan; 75(2):687-98. PMID: 11134282; PMCID: PMC113965.
    59. Marintcheva B, Weller SK. A tale of two HSV-1 helicases: roles of phage and animal virus helicases in DNA replication and recombination. Prog Nucleic Acid Res Mol Biol. 2001; 70:77-118. PMID: 11642367.
      View in: PubMed
    60. Marintcheva B, Weller SK. Residues within the conserved helicase motifs of UL9, the origin-binding protein of herpes simplex virus-1, are essential for helicase activity but not for dimerization or origin binding activity. J Biol Chem. 2001 Mar 2; 276(9):6605-15. PMID: 11062243.
      View in: PubMed
    61. Sheaffer AK, Newcomb WW, Brown JC, Gao M, Weller SK, Tenney DJ. Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids. J Virol. 2000 Aug; 74(15):6838-48. PMID: 10888623; PMCID: PMC112201.
    62. Newcomb WW, Trus BL, Cheng N, Steven AC, Sheaffer AK, Tenney DJ, Weller SK, Brown JC. Isolation of herpes simplex virus procapsids from cells infected with a protease-deficient mutant virus. J Virol. 2000 Feb; 74(4):1663-73. PMID: 10644336; PMCID: PMC111641.
    63. Biswas N, Weller SK. A mutation in the C-terminal putative Zn2+ finger motif of UL52 severely affects the biochemical activities of the HSV-1 helicase-primase subcomplex. J Biol Chem. 1999 Mar 19; 274(12):8068-76. PMID: 10075707.
      View in: PubMed
    64. Burkham J, Coen DM, Weller SK. ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase. J Virol. 1998 Dec; 72(12):10100-7. PMID: 9811750; PMCID: PMC110544.
    65. Goldstein JN, Weller SK. In vitro processing of herpes simplex virus type 1 DNA replication intermediates by the viral alkaline nuclease, UL12. J Virol. 1998 Nov; 72(11):8772-81. PMID: 9765421; PMCID: PMC110293.
    66. Gao M, Robertson BJ, McCann PJ, O'Boyle DR, Weller SK, Newcomb WW, Brown JC, Weinheimer SP. Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus. Virology. 1998 Sep 30; 249(2):460-70. PMID: 9791036.
      View in: PubMed
    67. Yu D, Weller SK. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging. J Virol. 1998 Sep; 72(9):7428-39. PMID: 9696839; PMCID: PMC109972.
    68. Goldstein JN, Weller SK. The exonuclease activity of HSV-1 UL12 is required for in vivo function. Virology. 1998 May 10; 244(2):442-57. PMID: 9601512.
      View in: PubMed
    69. Yu D, Weller SK. Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1. Virology. 1998 Mar 30; 243(1):32-44. PMID: 9527913.
      View in: PubMed
    70. Lamberti C, Weller SK. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments. J Virol. 1998 Mar; 72(3):2463-73. PMID: 9499108; PMCID: PMC109547.
    71. Lukonis CJ, Burkham J, Weller SK. Herpes simplex virus type 1 prereplicative sites are a heterogeneous population: only a subset are likely to be precursors to replication compartments. J Virol. 1997 Jun; 71(6):4771-81. PMID: 9151871; PMCID: PMC191699.
    72. Bronstein JC, Weller SK, Weber PC. The product of the UL12.5 gene of herpes simplex virus type 1 is a capsid-associated nuclease. J Virol. 1997 Apr; 71(4):3039-47. PMID: 9060664; PMCID: PMC191433.
    73. Yu D, Sheaffer AK, Tenney DJ, Weller SK. Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins. J Virol. 1997 Apr; 71(4):2656-65. PMID: 9060618; PMCID: PMC191387.
    74. Lukonis CJ, Weller SK. Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10. J Virol. 1997 Mar; 71(3):2390-9. PMID: 9032376; PMCID: PMC191349.
    75. Graves-Woodward KL, Gottlieb J, Challberg MD, Weller SK. Biochemical analyses of mutations in the HSV-1 helicase-primase that alter ATP hydrolysis, DNA unwinding, and coupling between hydrolysis and unwinding. J Biol Chem. 1997 Feb 14; 272(7):4623-30. PMID: 9020191.
      View in: PubMed
    76. Lamberti C, Weller SK. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion. Virology. 1996 Dec 15; 226(2):403-7. PMID: 8955060.
      View in: PubMed
    77. Malik AK, Weller SK. Use of transdominant mutants of the origin-binding protein (UL9) of herpes simplex virus type 1 to define functional domains. J Virol. 1996 Nov; 70(11):7859-66. PMID: 8892908; PMCID: PMC190857.
    78. Malik AK, Shao L, Shanley JD, Weller SK. Intracellular localization of the herpes simplex virus type-1 origin binding protein, UL9. Virology. 1996 Oct 15; 224(2):380-9. PMID: 8874499.
      View in: PubMed
    79. Lukonis CJ, Weller SK. The herpes simplex virus type 1 transactivator ICPO mediates aberrant intracellular localization of the viral helicase/primase complex subunits. Virology. 1996 Jun 15; 220(2):495-501. PMID: 8669135.
      View in: PubMed
    80. Graves-Woodward KL, Weller SK. Replacement of gly815 in helicase motif V alters the single-stranded DNA-dependent ATPase activity of the herpes simplex virus type 1 helicase-primase. J Biol Chem. 1996 Jun 7; 271(23):13629-35. PMID: 8662872.
      View in: PubMed
    81. Martinez R, Sarisky RT, Weber PC, Weller SK. Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates. J Virol. 1996 Apr; 70(4):2075-85. PMID: 8642627; PMCID: PMC190043.
    82. Lukonis CJ, Weller SK. Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication. J Virol. 1996 Mar; 70(3):1751-8. PMID: 8627697; PMCID: PMC190000.
    83. Martinez R, Shao L, Bronstein JC, Weber PC, Weller SK. The product of a 1.9-kb mRNA which overlaps the HSV-1 alkaline nuclease gene (UL12) cannot relieve the growth defects of a null mutant. Virology. 1996 Jan 15; 215(2):152-64. PMID: 8560762.
      View in: PubMed
    84. Shao L, Rapp LM, Weller SK. Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus. Virology. 1993 Sep; 196(1):146-62. PMID: 8395111.
      View in: PubMed
    85. Martinez R, Shao L, Weller SK. The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function. J Virol. 1992 Nov; 66(11):6735-46. PMID: 1328687; PMCID: PMC240170.
    86. Malik AK, Martinez R, Muncy L, Carmichael EP, Weller SK. Genetic analysis of the herpes simplex virus type 1 UL9 gene: isolation of a LacZ insertion mutant and expression in eukaryotic cells. Virology. 1992 Oct; 190(2):702-15. PMID: 1325702.
      View in: PubMed
    87. Zhu LA, Weller SK. The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function. J Virol. 1992 Jan; 66(1):469-79. PMID: 1309257; PMCID: PMC238307.
    88. Zhu LA, Weller SK. The UL5 gene of herpes simplex virus type 1: isolation of a lacZ insertion mutant and association of the UL5 gene product with other members of the helicase-primase complex. J Virol. 1992 Jan; 66(1):458-68. PMID: 1309255; PMCID: PMC238306.
    89. Weller SK, Seghatoleslami MR, Shao L, Rowse D, Carmichael EP. The herpes simplex virus type 1 alkaline nuclease is not essential for viral DNA synthesis: isolation and characterization of a lacZ insertion mutant. J Gen Virol. 1990 Dec; 71 ( Pt 12):2941-52. PMID: 2177086.
      View in: PubMed
    90. Heilbronn R, Weller SK, zur Hausen H. Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication. Virology. 1990 Nov; 179(1):478-81. PMID: 2171219.
      View in: PubMed
    91. Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK, Coen DM. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology. 1989 Nov; 173(1):276-83. PMID: 2554573.
      View in: PubMed
    92. Coen DM, Goldstein DJ, Weller SK. Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir. Antimicrob Agents Chemother. 1989 Aug; 33(8):1395-9. PMID: 2552912; PMCID: PMC172665.
    93. Crute JJ, Tsurumi T, Zhu LA, Weller SK, Olivo PD, Challberg MD, Mocarski ES, Lehman IR. Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products. Proc Natl Acad Sci U S A. 1989 Apr; 86(7):2186-9. PMID: 2538835; PMCID: PMC286876.
    94. Carmichael EP, Weller SK. Herpes simplex virus type 1 DNA synthesis requires the product of the UL8 gene: isolation and characterization of an ICP6::lacZ insertion mutation. J Virol. 1989 Feb; 63(2):591-9. PMID: 2536095; PMCID: PMC247728.
    95. Zhu L, Weller SK. UL5, a protein required for HSV DNA synthesis: genetic analysis, overexpression in Escherichia coli, and generation of polyclonal antibodies. Virology. 1988 Oct; 166(2):366-78. PMID: 2845650.
      View in: PubMed
    96. Goldstein DJ, Weller SK. Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant. Virology. 1988 Sep; 166(1):41-51. PMID: 2842955.
      View in: PubMed
    97. Goldstein DJ, Weller SK. An ICP6::lacZ insertional mutagen is used to demonstrate that the UL52 gene of herpes simplex virus type 1 is required for virus growth and DNA synthesis. J Virol. 1988 Aug; 62(8):2970-7. PMID: 2839713; PMCID: PMC253735.
    98. Goldstein DJ, Weller SK. Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant. J Virol. 1988 Jan; 62(1):196-205. PMID: 2824847; PMCID: PMC250519.
    99. Carmichael EP, Kosovsky MJ, Weller SK. Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis. J Virol. 1988 Jan; 62(1):91-9. PMID: 2824860; PMCID: PMC250505.
    100. Weller SK, Carmichael EP, Aschman DP, Goldstein DJ, Schaffer PA. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA. Virology. 1987 Nov; 161(1):198-210. PMID: 2823462.
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    101. Gibbs JS, Chiou HC, Hall JD, Mount DW, Retondo MJ, Weller SK, Coen DM. Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):7969-73. PMID: 2999787; PMCID: PMC390892.
    102. Chiou HC, Weller SK, Coen DM. Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Virology. 1985 Sep; 145(2):213-26. PMID: 2992151.
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    103. Weller SK, Spadaro A, Schaffer JE, Murray AW, Maxam AM, Schaffer PA. Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis. Mol Cell Biol. 1985 May; 5(5):930-42. PMID: 2987682; PMCID: PMC366807.
    104. Schaffer PA, Weller SK, Pancake BA, Coen DM. Genetics of herpes simplex virus. J Invest Dermatol. 1984 Jul; 83(1 Suppl):42s-47s. PMID: 6330220.
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    105. Coen DM, Aschman DP, Gelep PT, Retondo MJ, Weller SK, Schaffer PA. Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus. J Virol. 1984 Jan; 49(1):236-47. PMID: 6317891; PMCID: PMC255447.
    106. Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA. Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment. Virology. 1983 Oct 30; 130(2):290-305. PMID: 6316633.
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    107. Weller SK, Lee KJ, Sabourin DJ, Schaffer PA. Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein. J Virol. 1983 Jan; 45(1):354-66. PMID: 6296442; PMCID: PMC256417.
    108. Weller SK, Temin HM. Cell killing by avian leukosis viruses. J Virol. 1981 Sep; 39(3):713-21. PMID: 6270346; PMCID: PMC171305.
    109. Temin HM, Keshet E, Weller SK. Correlation of transient accumulation of linear unintegrated viral DNA and transient cell killing by avian leukosis and reticuloendotheliosis viruses. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:773-8. PMID: 6253212.
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    110. Weller SK, Joy AE, Temin HM. Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus. J Virol. 1980 Jan; 33(1):494-506. PMID: 6245246; PMCID: PMC288564.
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