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Nitya G Chakraborty PhD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 1628
MC 1628
263 Farmington Avenue
Phone860-679-1446
Fax860-679-1159
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jha SS, Chakraborty NG, Singh P, Mukherji B, Dorsky DI. Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+)  CD25(-) and CD8(+) T cells attenuates effector function. Immunology. 2015 May; 145(1):124-35. PMID: 25495780; PMCID: PMC4405330 [Available on 05/01/16].
    2. Karimi S, Chattopadhyay S, Chakraborty NG. Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy. Immunology. 2015 Feb; 144(2):186-96. PMID: 25243729; PMCID: PMC4298413 [Available on 02/01/16].
    3. Chakraborty NG, Yadav M, Dadras SS, Singh P, Chhabra A, Feinn R, Kerr PE, Grant-Kels JM, Mukherji B, Hegde UP. Analyses of T cell-mediated immune response to a human melanoma-associated antigen by the young and the elderly. Hum Immunol. 2013 May; 74(5):640-7. PMID: 23391568.
      View in: PubMed
    4. Kaur N, Naga OS, Norell H, Al-Khami AA, Scheffel MJ, Chakraborty NG, Voelkel-Johnson C, Mukherji B, Mehrotra S. T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules. Cytokine. 2011 Aug; 55(2):307-17. PMID: 21602054; PMCID: PMC3595556.
    5. Hegde UP, Chakraborty N, Mukherji B, Grant Kels JM. Metastatic melanoma in the older patient: immunologic insights and treatment outcomes. Expert Rev Pharmacoecon Outcomes Res. 2011 Apr; 11(2):185-93. PMID: 21476820.
      View in: PubMed
    6. Ray S, Chhabra A, Chakraborty NG, Hegde U, Dorsky DI, Chodon T, von Euw E, Comin-Anduix B, Koya RC, Ribas A, Economou JS, Rosenberg SA, Mukherji B. MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro. Clin Immunol. 2010 Sep; 136(3):338-47. PMID: 20547105; PMCID: PMC2917536.
    7. Ménoret A, McAleer JP, Ngoi SM, Ray S, Eddy NA, Fenteany G, Lee SJ, Rossi RJ, Mukherji B, Allen DL, Chakraborty NG, Vella AT. The oxazolidinone derivative locostatin induces cytokine appeasement. J Immunol. 2009 Dec 1; 183(11):7489-96. PMID: 19917702; PMCID: PMC2799496.
    8. Hegde UP, Chakraborty N, Kerr P, Grant-Kels JM. Melanoma in the elderly patient: relevance of the aging immune system. Clin Dermatol. 2009 Nov-Dec; 27(6):537-44. PMID: 19880041.
      View in: PubMed
    9. Ray S, Chhabra A, Mehrotra S, Chakraborty NG, Ribas A, Economou J, Mukherji B. Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma. Clin Dermatol. 2009 Nov-Dec; 27(6):603-13. PMID: 19880048.
      View in: PubMed
    10. Chattopadhyay S, Chakraborty NG. GITR expression on T-cell receptor-stimulated human CD8 T cell in a JNK-dependent pathway. Indian J Hum Genet. 2009 Sep; 15(3):121-4. PMID: 21088717; PMCID: PMC2922628.
    11. Norell H, Martins da Palma T, Lesher A, Kaur N, Mehrotra M, Naga OS, Spivey N, Olafimihan S, Chakraborty NG, Voelkel-Johnson C, Nishimura MI, Mukherji B, Mehrotra S. Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Res. 2009 Aug 1; 69(15):6282-9. PMID: 19638595; PMCID: PMC2719828.
    12. Chakraborty NG. Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy. Indian J Hum Genet. 2009 Jan; 15(1):3-8. PMID: 20407642; PMCID: PMC2846567.
    13. Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D, Mukherji B. CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol. 2008 Jul 15; 181(2):1063-70. PMID: 18606658; PMCID: PMC2715965.
    14. Chhabra A, Chakraborty NG, Mukherji B. Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35. Clin Immunol. 2008 Mar; 126(3):251-9. PMID: 18249038; PMCID: PMC2352151.
    15. Hegde U, Chhabra A, Chattopadhyay S, Das R, Ray S, Chakraborty NG. Presence of low dose of fludarabine in cultures blocks regulatory T cell expansion and maintains tumor-specific cytotoxic T lymphocyte activity generated with peripheral blood lymphocytes. Pathobiology. 2008; 75(3):200-8. PMID: 18550918.
      View in: PubMed
    16. Chakraborty NG. Genetically predisposed, life style and occurrence of metastatic cancer. Indian J Hum Genet. 2007 May; 13(2):48-9. PMID: 21957344; PMCID: PMC3168157.
    17. Das R, Dhokalia A, Huang XZ, Hammamieh R, Chakraborty N, Lindler LE, Jett M. Study of proinflammatory responses induced by Yersinia pestis in human monocytes using cDNA arrays. Genes Immun. 2007 Jun; 8(4):308-19. PMID: 17429414.
      View in: PubMed
    18. Chhabra A, Mehrotra S, Chakraborty NG, Dorsky DI, Mukherji B. Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. Eur J Immunol. 2006 Dec; 36(12):3167-74. PMID: 17109472.
      View in: PubMed
    19. Mehrotra S, Chhabra A, Hegde U, Chakraborty NG, Mukherji B. Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death. J Leukoc Biol. 2007 Feb; 81(2):539-47. PMID: 17062604.
      View in: PubMed
    20. Chattopadhyay S, Mehrotra S, Chhabra A, Hegde U, Mukherji B, Chakraborty NG. Effect of CD4+CD25+ and CD4+CD25- T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. J Immunol. 2006 Jan 15; 176(2):984-90. PMID: 16393984.
      View in: PubMed
    21. Mehrotra S, Zaidi N, Chakraborty NG, Mukherji B. Macrophages as stimulators of MART-1 27-35 epitope-specific human cytolytic T lymphocytes in vitro. Pathobiology. 2006; 73(5):238-43. PMID: 17314494.
      View in: PubMed
    22. Chattopadhyay S, Chakraborty NG. Continuous presence of Th1 conditions is necessary for longer lasting tumor-specific CTL activity in stimulation cultures with PBL. Hum Immunol. 2005 Aug; 66(8):884-91. PMID: 16216672.
      View in: PubMed
    23. Chattopadhyay S, Chakraborty NG, Mukherji B. Regulatory T cells and tumor immunity. Cancer Immunol Immunother. 2005 Dec; 54(12):1153-61. PMID: 15868167.
      View in: PubMed
    24. Mehrotra S, Chhabra A, Chakraborty A, Chattopadhyay S, Slowik M, Stevens R, Zengou R, Mathias C, Butterfield LH, Dorsky DI, Economou JS, Mukherji B, Chakraborty NG. Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. Immunology. 2004 Dec; 113(4):472-81. PMID: 15554925; PMCID: PMC1782594.
    25. Mehrotra S, Chhabra A, Chattopadhyay S, Dorsky DI, Chakraborty NG, Mukherji B. Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy. J Immunol. 2004 Nov 15; 173(10):6017-24. PMID: 15528336.
      View in: PubMed
    26. Chhabra A, Mehrotra S, Chakraborty NG, Mukherji B, Dorsky DI. Cross-presentation of a human tumor antigen delivered to dendritic cells by HSV VP22-mediated protein translocation. Eur J Immunol. 2004 Oct; 34(10):2824-33. PMID: 15368298.
      View in: PubMed
    27. Chakraborty NG, Chattopadhyay S, Mehrotra S, Chhabra A, Mukherji B. Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma. Hum Immunol. 2004 Aug; 65(8):794-802. PMID: 15336780.
      View in: PubMed
    28. Mehrotra S, Stevens R, Zengou R, Chakraborty NG, Butterfield LH, Economou JS, Dorsky DI, Mukherji B. Regulation of melanoma epitope-specific cytolytic T lymphocyte response by immature and activated dendritic cells, in vitro. Cancer Res. 2003 Sep 1; 63(17):5607-14. PMID: 14500402.
      View in: PubMed
    29. Chakraborty NG, Stevens RL, Mehrotra S, Laska E, Taxel P, Sporn JR, Schauer P, Albertsen PC. Recognition of PSA-derived peptide antigens by T cells from prostate cancer patients without any prior stimulation. Cancer Immunol Immunother. 2003 Aug; 52(8):497-505. PMID: 12783216.
      View in: PubMed
    30. Chakraborty A, Li L, Chakraborty NG, Mukherji B. Stimulatory and inhibitory differentiation of human myeloid dendritic cells. Clin Immunol. 2000 Feb; 94(2):88-98. PMID: 10637093.
      View in: PubMed
    31. Chakraborty N, Bilgrami S, Maness L, Guo C, Perez-Diez A, Mukherji B, Tutschka P. Myeloablative chemotherapy with autologous peripheral blood stem cell transplantation for metastatic breast cancer: immunologic consequences affecting clinical outcome. Bone Marrow Transplant. 1999 Oct; 24(8):837-43. PMID: 10516693.
      View in: PubMed
    32. Chakraborty NG, Li L, Sporn JR, Kurtzman SH, Ergin MT, Mukherji B. Emergence of regulatory CD4+ T cell response to repetitive stimulation with antigen-presenting cells in vitro: implications in designing antigen-presenting cell-based tumor vaccines. J Immunol. 1999 May 1; 162(9):5576-83. PMID: 10228040.
      View in: PubMed
    33. Bilgrami S, Chakraborty NG, Rodriguez-Pinero F, Khan AM, Feingold JM, Bona RD, Edwards RL, Dorsky D, Clive J, Mukherji B, Tutschka PJ. Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. Bone Marrow Transplant. 1999 Mar; 23(5):469-74. PMID: 10100561.
      View in: PubMed
    34. Chakraborty A, Li L, Chakraborty NG, Mukherji B. Stimulatory and inhibitory maturation of human macrophage-derived dendritic cells. Pathobiology. 1999; 67(5-6):282-6. PMID: 10725803.
      View in: PubMed
    35. Pérez-Díez A, Butterfield LH, Li L, Chakraborty NG, Economou JS, Mukherji B. Generation of CD8+ and CD4+ T-cell response to dendritic cells genetically engineered to express the MART-1/Melan-A gene. Cancer Res. 1998 Dec 1; 58(23):5305-9. PMID: 9850054.
      View in: PubMed
    36. Butterfield LH, Jilani SM, Chakraborty NG, Bui LA, Ribas A, Dissette VB, Lau R, Gamradt SC, Glaspy JA, McBride WH, Mukherji B, Economou JS. Generation of melanoma-specific cytotoxic T lymphocytes by dendritic cells transduced with a MART-1 adenovirus. J Immunol. 1998 Nov 15; 161(10):5607-13. PMID: 9820539.
      View in: PubMed
    37. Chakraborty NG, Sporn JR, Tortora AF, Kurtzman SH, Yamase H, Ergin MT, Mukherji B. Immunization with a tumor-cell-lysate-loaded autologous-antigen-presenting-cell-based vaccine in melanoma. Cancer Immunol Immunother. 1998 Sep; 47(1):58-64. PMID: 9755879.
      View in: PubMed
    38. Chakraborty NG, Mukherji B. Human melanoma-specific, noncytolytic CD8+ T cells that can synthesize type I cytokine. Cancer Res. 1998 Apr 1; 58(7):1363-6. PMID: 9537230.
      View in: PubMed
    39. Hu X, Chakraborty NG, Sporn JR, Kurtzman SH, Ergin MT, Mukherji B. Enhancement of cytolytic T lymphocyte precursor frequency in melanoma patients following immunization with the MAGE-1 peptide loaded antigen presenting cell-based vaccine. Cancer Res. 1996 Jun 1; 56(11):2479-83. PMID: 8653680.
      View in: PubMed
    40. Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergin MT, Ozols J, Meehan J, et al. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):8078-82. PMID: 7644541; PMCID: PMC41290.
    41. Yamasaki S, Okino T, Chakraborty NG, Adkisson WO, Sampieri A, Padula SJ, Mauri F, Mukherji B. Presentation of synthetic peptide antigen encoded by the MAGE-1 gene by granulocyte/macrophage-colony-stimulating-factor-cultured macrophages from HLA-A1 melanoma patients. Cancer Immunol Immunother. 1995 Apr; 40(4):268-71. PMID: 7750125.
      View in: PubMed
    42. Mukherji B, Chakraborty NG. Immunobiology and immunotherapy of melanoma. Curr Opin Oncol. 1995 Mar; 7(2):175-84. PMID: 7756383.
      View in: PubMed
    43. Chakraborty A, Chakraborty NG, Chattopadhyay U. Age related natural killer activity of peripheral blood lymphocytes from healthy subjects and cancer patients. A comparative in vitro study with interleukin-2. Tumori. 1994 Jun 30; 80(3):233-7. PMID: 8053083.
      View in: PubMed
    44. Okino T, Chakraborty NG, Stabach P, Twardzik DR, Padula SJ, Mukherji B. Inhibition of interleukin-2 synthesis and interleukin-2 receptor alpha expression on T cells by a cell-free factor derived from a CD4+ regulatory T cell clone. Clin Immunol Immunopathol. 1993 Sep; 68(3):256-62. PMID: 8103719.
      View in: PubMed
    45. Chakraborty NG, Okino T, Stabach P, Padula SJ, Yamase H, Morse E, Sha'afi RI, Twardzik DR, Shultz LJ, Mukherji B. Adoptive transfer of activated human autologous macrophages results in regression of transplanted human melanoma cells in SCID mice. In Vivo. 1991 Nov-Dec; 5(6):609-14. PMID: 1810447.
      View in: PubMed
    46. Okino T, Chakraborty NG, Ergin MT, Mukherji B. Suppressor function of lymphocytes activated in in vitro co-culture against autologous tumor cells and expanded in interleukin-2. In Vivo. 1991 Nov-Dec; 5(6):631-5. PMID: 1687355.
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    47. Chakraborty NG, Sporn JR, Pasquale DR, Ergin MT, Mukherji B. Suppression of lymphokine-activated killer cell generation by tumor-infiltrating lymphocytes. Clin Immunol Immunopathol. 1991 Jun; 59(3):407-16. PMID: 2029793.
      View in: PubMed
    48. Sivanandham M, Chakraborty NG, Robbins GR, Mukherji B. Clonal expansion of T cells following in vitro stimulation with autologous melanoma cells and interleukin-2 studied by molecular analysis of a T cell receptor. Immunol Lett. 1991 May; 28(2):155-9. PMID: 1679414.
      View in: PubMed
    49. Sunderman FW, Sporn J, Hopfer SM, Sweeney KR, Chakraborty NG, Greenberg B. Platinum in blood mononuclear cells from patients after cisplatin therapy. Ann Clin Lab Sci. 1990 Nov-Dec; 20(6):379-84. PMID: 2073087.
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    50. Chakraborty NG, Twardzik DR, Sivanandham M, Ergin MT, Hellstrom KE, Mukherji B. Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response. J Immunol. 1990 Oct 1; 145(7):2359-64. PMID: 1975829.
      View in: PubMed
    51. Mukherji B, Chakraborty NG, Sivanandham M. T-cell clones that react against autologous human tumors. Immunol Rev. 1990 Aug; 116:33-62. PMID: 2146210.
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    52. Mukherji B, Guha A, Chakraborty NG, Sivanandham M, Nashed AL, Sporn JR, Ergin MT. Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma. J Exp Med. 1989 Jun 1; 169(6):1961-76. PMID: 2471770; PMCID: PMC2189343.
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