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Jian-Bing Shen MD, PhD

TitleResearch Scientist
InstitutionUConn Health Center
DepartmentCalhoun Cardiology Center
AddressMC 3946
MC 3946
263 Farmington Avenue
Phone860-679-3785
Fax860-679-1426
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    Other Positions
    TitleInstructor
    InstitutionUConn Health Center
    DepartmentMedicine


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar TS, Jacobson KA, Hintze T, Recchia FA, Liang BT. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. J Pharmacol Exp Ther. 2010 Jun; 333(3):920-8. PMID: 20200116; PMCID: PMC2879931.
    2. Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK. Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol. 2009 Jun; 11(6):769-76. PMID: 19465920; PMCID: PMC2693472.
    3. Shen JB, Shutt R, Agosto M, Pappano A, Liang BT. Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1089-95. PMID: 19201994; PMCID: PMC2670706.
    4. Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Geragthy MT, Innis JW, Obersztyn E, Nowakowska B, Rosengren SS, Bader PI, Grange DK, Naqvi S, Garnica AD, Bernes SM, Fong CT, Summers A, Walters WD, Lupski JR, Stankiewicz P, Cheung SW, Patel A. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet. 2008 Dec; 40(12):1466-71. PMID: 19029900; PMCID: PMC2680128.
    5. Shen JB, Pappano AJ. An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current. J Pharmacol Exp Ther. 2008 May; 325(2):507-12. PMID: 18276848.
      View in: PubMed
    6. Shen JB, Shutt R, Pappano A, Liang BT. Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3056-62. PMID: 17873021.
      View in: PubMed
    7. Shen JB, Cronin C, Sonin D, Joshi BV, Gongora Nieto M, Harrison D, Jacobson KA, Liang BT. P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1077-84. PMID: 17040972.
      View in: PubMed
    8. Shen JB, Pappano AJ, Liang BT. Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors. FASEB J. 2006 Feb; 20(2):277-84. PMID: 16449800.
      View in: PubMed
    9. Shen JB, Pappano AJ. On the role of phosphatase in regulation of cardiac L-type calcium current by cyclic GMP. J Pharmacol Exp Ther. 2002 May; 301(2):501-6. PMID: 11961049.
      View in: PubMed
    10. Shen JB, Pappano AJ. Carbachol inhibits the L-type Ca2+ current augmented by 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid in guinea pig ventricular myocytes: calcium-sensitivity hypothesis for muscarinic inhibition. J Pharmacol Exp Ther. 2001 Aug; 298(2):857-64. PMID: 11454952.
      View in: PubMed
    11. Shen JB, Jiang B, Pappano AJ. Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 2000 Aug; 294(2):562-70. PMID: 10900233.
      View in: PubMed
    12. Sakai R, Shen JB, Pappano AJ. Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. 1999 Aug; 34(2):304-15. PMID: 10445683.
      View in: PubMed
    13. Shen JB, Jiang B, Pappano AJ. Lack of effect of McN-A-343 on membrane current and contraction in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1999 Aug; 290(2):641-8. PMID: 10411573.
      View in: PubMed
    14. Saeki T, Shen JB, Pappano AJ. Inositol-1,4,5-trisphosphate increases contractions but not L-type calcium current in guinea pig ventricular myocytes. Cardiovasc Res. 1999 Mar; 41(3):620-8. PMID: 10435034.
      View in: PubMed
    15. Protas L, Shen JB, Pappano AJ. Carbachol increases contractions and intracellular Ca++ transients in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1998 Jan; 284(1):66-74. PMID: 9435162.
      View in: PubMed
    16. Saeki T, Shen JB, Pappano AJ. Carbachol promotes Na+ entry and augments Na/Ca exchange current in guinea pig ventricular myocytes. Am J Physiol. 1997 Oct; 273(4 Pt 2):H1984-93. PMID: 9362270.
      View in: PubMed
    17. Shen JB, Pappano AJ. Mechanisms for depolarization by l-palmitoylcarnitine in single guinea pig ventricular myocytes. J Cardiovasc Electrophysiol. 1997 Feb; 8(2):172-83. PMID: 9048248.
      View in: PubMed
    18. Shen JB, Pappano AJ. Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1027-36. PMID: 7900857.
      View in: PubMed
    19. Shen JB, Vassalle M. Cesium abolishes the barium-induced pacemaker potential and current in guinea pig ventricular myocytes. J Cardiovasc Electrophysiol. 1994 Dec; 5(12):1031-44. PMID: 7697205.
      View in: PubMed
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