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Leslie M Loew PhD

TitleBoehringer Ingelheim Chair in Cell Sciences Professor of Cell Biology
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 6406
Cell and Genome Sciences Building, MC 6406
400 Farmington Avenue
Phone860-679-3568
Fax860-679-1039
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    Other Positions
    TitleDirector
    InstitutionUConn Health Center
    DepartmentCenter for Cell Analysis and Modeling

    TitleProfessor
    InstitutionUniversity of Connecticut
    DepartmentComputer Science and Engineering


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Acker CD, Hoyos E, Loew LM. EPSPs Measured in Proximal Dendritic Spines of Cortical Pyramidal Neurons. eNeuro. 2016 Mar-Apr; 3(2). PMID: 27257618.
      View in: PubMed
    2. Michalski PJ, Loew LM. SpringSaLaD: A Spatial, Particle-Based Biochemical Simulation Platform with Excluded Volume. Biophys J. 2016 Feb 2; 110(3):523-9. PMID: 26840718.
      View in: PubMed
    3. Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner JM, Scellini B, Guo A, Song LS, Yan P, Loew LM, Tardiff J, Tesi C, Vanzi F, Cerbai E, Pavone FS, Sacconi L, Poggesi C. Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2016 Feb; 91:42-51. PMID: 26714042.
      View in: PubMed
    4. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Correction: Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2015 Dec 7; 211(5):1095-8. PMID: 26644519.
      View in: PubMed
    5. Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, Mayer BJ. Integration of linear and dendritic actin nucleation in Nck-induced actin comets. Mol Biol Cell. 2016 Jan 15; 27(2):247-59. PMID: 26609071.
      View in: PubMed
    6. Loew LM. Author Appreciation. Biophys J. 2015 Aug 4; 109(3):E1-2. PMID: 26244747; PMCID: PMC4571019 [Available on 08/04/16].
    7. Frank P, Siebenhofer B, Hanzer T, Geiss AF, Schadauer F, Reiner-Rozman C, Durham B, Loew LM, Ludwig B, Richter OM, Nowak C, Naumann RL. Proteo-lipobeads for the oriented encapsulation of membrane proteins. Soft Matter. 2015 Apr 21; 11(15):2906-8. PMID: 25763882; PMCID: PMC4387127.
    8. Loew L, Beckett D, Egelman EH, Scarlata S. Reproducibility of research in biophysics. Biophys J. 2015 Apr 7; 108(7):E1. PMID: 25863074; PMCID: PMC4390833 [Available on 04/07/16].
    9. Brown SA, Loew LM. Integration of modeling with experimental and clinical findings synthesizes and refines the central role of inositol 1,4,5-trisphosphate receptor 1 in spinocerebellar ataxia. Front Neurosci. 2014; 8:453. PMID: 25653583; PMCID: PMC4300941.
    10. Brown SA, McCullough LD, Loew LM. Computational neurobiology is a useful tool in translational neurology: the example of ataxia. Front Neurosci. 2015; 9:1. PMID: 25653585; PMCID: PMC4300942.
    11. Loew LM. Design and Use of Organic Voltage Sensitive Dyes. Adv Exp Med Biol. 2015; 859:27-53. PMID: 26238048.
      View in: PubMed
    12. Loew LM, Lewis A. Second Harmonic Imaging of Membrane Potential. Adv Exp Med Biol. 2015; 859:473-92. PMID: 26238065.
      View in: PubMed
    13. Willadt S, Canepari M, Yan P, Loew LM, Vogt KE. Combined optogenetics and voltage sensitive dye imaging at single cell resolution. Front Cell Neurosci. 2014; 8:311. PMID: 25339864; PMCID: PMC4189389.
    14. Crocini C, Coppini R, Ferrantini C, Yan P, Loew LM, Tesi C, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15196-201. PMID: 25288764; PMCID: PMC4210349.
    15. Wilson SA, Millard A, Lewis A, Loew LM. Monitoring membrane potential with second-harmonic generation. Cold Spring Harb Protoc. 2014 Jun; 2014(6):643-54. PMID: 24890213.
      View in: PubMed
    16. Loew LM. Biophysical journal and the biophysics community. Biophys J. 2014 May 6; 106(9):E01-2. PMID: 24806940; PMCID: PMC4017278.
    17. Loew LM, Wang DN. Science communication: Quality at stake. Science. 2013 Dec 6; 342(6163):1169. PMID: 24311662.
      View in: PubMed
    18. Falkenberg CV, Blinov ML, Loew LM. Pleomorphic ensembles: formation of large clusters composed of weakly interacting multivalent molecules. Biophys J. 2013 Dec 3; 105(11):2451-60. PMID: 24314076; PMCID: PMC3853317.
    19. Blinov ML, Schaff JC, Ruebenacker O, Wei X, Vasilescu D, Gao F, Morgan F, Ye L, Lakshminarayana A, Moraru II, Loew LM. Pathway Commons at virtual cell: use of pathway data for mathematical modeling. Bioinformatics. 2014 Jan 15; 30(2):292-4. PMID: 24273241; PMCID: PMC3892693.
    20. Habib-E-Rasul Mullah S, Komuro R, Yan P, Hayashi S, Inaji M, Momose-Sato Y, Loew LM, Sato K. Evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system. J Membr Biol. 2013 Sep; 246(9):679-88. PMID: 23975337; PMCID: PMC4096138.
    21. Loew LM, Hell SW. Superresolving dendritic spines. Biophys J. 2013 Feb 19; 104(4):741-3. PMID: 23442950; PMCID: PMC3576544.
    22. Ditlev JA, Mayer BJ, Loew LM. There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton. Biophys J. 2013 Feb 5; 104(3):520-32. PMID: 23442903; PMCID: PMC3566448.
    23. Kwiatek JM, Owen DM, Abu-Siniyeh A, Yan P, Loew LM, Gaus K. Characterization of a new series of fluorescent probes for imaging membrane order. PLoS One. 2013; 8(2):e52960. PMID: 23390489; PMCID: PMC3563652.
    24. Falkenberg CV, Loew LM. Computational analysis of Rho GTPase cycling. PLoS Comput Biol. 2013; 9(1):e1002831. PMID: 23326220; PMCID: PMC3542069.
    25. Acker CD, Loew LM. Characterization of voltage-sensitive dyes in living cells using two-photon excitation. Methods Mol Biol. 2013; 995:147-60. PMID: 23494378.
      View in: PubMed
    26. Tsuda S, Kee MZ, Cunha C, Kim J, Yan P, Loew LM, Augustine GJ. Probing the function of neuronal populations: combining micromirror-based optogenetic photostimulation with voltage-sensitive dye imaging. Neurosci Res. 2013 Jan; 75(1):76-81. PMID: 23254260; PMCID: PMC3594342.
    27. Yan P, Acker CD, Zhou WL, Lee P, Bollensdorff C, Negrean A, Lotti J, Sacconi L, Antic SD, Kohl P, Mansvelder HD, Pavone FS, Loew LM. Palette of fluorinated voltage-sensitive hemicyanine dyes. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20443-8. PMID: 23169660; PMCID: PMC3528613.
    28. Leão RN, Mikulovic S, Leão KE, Munguba H, Gezelius H, Enjin A, Patra K, Eriksson A, Loew LM, Tort AB, Kullander K. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci. 2012 Nov; 15(11):1524-30. PMID: 23042082; PMCID: PMC3483451.
    29. Lee P, Wang K, Woods CE, Yan P, Kohl P, Ewart P, Loew LM, Terrar DA, Bollensdorff C. Cardiac electrophysiological imaging systems scalable for high-throughput drug testing. Pflugers Arch. 2012 Dec; 464(6):645-56. PMID: 23053475; PMCID: PMC3513599.
    30. Lee P, Yan P, Ewart P, Kohl P, Loew LM, Bollensdorff C. Simultaneous measurement and modulation of multiple physiological parameters in the isolated heart using optical techniques. Pflugers Arch. 2012 Oct; 464(4):403-14. PMID: 22886365; PMCID: PMC3495582.
    31. Lee P, Taghavi F, Yan P, Ewart P, Ashley EA, Loew LM, Kohl P, Bollensdorff C, Woods CE. In situ optical mapping of voltage and calcium in the heart. PLoS One. 2012; 7(8):e42562. PMID: 22876327; PMCID: PMC3411684.
    32. Brown SA, Loew LM. Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia. BMC Syst Biol. 2012; 6:70. PMID: 22703638; PMCID: PMC3468360.
    33. Michalski PJ, Loew LM. CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximation. Phys Biol. 2012 Jun; 9(3):036010. PMID: 22683827; PMCID: PMC3507550.
    34. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2012 May 28; 197(5):643-58. PMID: 22613834; PMCID: PMC3365498.
    35. Sacconi L, Ferrantini C, Lotti J, Coppini R, Yan P, Loew LM, Tesi C, Cerbai E, Poggesi C, Pavone FS. Action potential propagation in transverse-axial tubular system is impaired in heart failure. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5815-9. PMID: 22451916; PMCID: PMC3326470.
    36. Cowan AE, Moraru II, Schaff JC, Slepchenko BM, Loew LM. Spatial modeling of cell signaling networks. Methods Cell Biol. 2012; 110:195-221. PMID: 22482950; PMCID: PMC3519356.
    37. Acker CD, Yan P, Loew LM. Single-voxel recording of voltage transients in dendritic spines. Biophys J. 2011 Jul 20; 101(2):L11-3. PMID: 21767473; PMCID: PMC3136788.
    38. Fedorov VV, Ambrosi CM, Kostecki G, Hucker WJ, Glukhov AV, Wuskell JP, Loew LM, Moazami N, Efimov IR. Anatomic localization and autonomic modulation of atrioventricular junctional rhythm in failing human hearts. Circ Arrhythm Electrophysiol. 2011 Aug; 4(4):515-25. PMID: 21646375; PMCID: PMC3196522.
    39. Lee P, Bollensdorff C, Quinn TA, Wuskell JP, Loew LM, Kohl P. Single-sensor system for spatially resolved, continuous, and multiparametric optical mapping of cardiac tissue. Heart Rhythm. 2011 Sep; 8(9):1482-91. PMID: 21459161; PMCID: PMC3167353.
    40. Brown SA, Moraru II, Schaff JC, Loew LM. Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling. J Comput Neurosci. 2011 Oct; 31(2):385-400. PMID: 21340454; PMCID: PMC3221887.
    41. Fedorov VV, Glukhov AV, Chang R, Kostecki G, Aferol H, Hucker WJ, Wuskell JP, Loew LM, Schuessler RB, Moazami N, Efimov IR. Optical mapping of the isolated coronary-perfused human sinus node. J Am Coll Cardiol. 2010 Oct 19; 56(17):1386-94. PMID: 20946995; PMCID: PMC3008584.
    42. Ytzhak S, Wuskell JP, Loew LM, Ehrenberg B. Lipid composition affects the rate of photosensitized dissipation of cross-membrane diffusion potential on liposomes. J Phys Chem B. 2010 Aug 12; 114(31):10097-104. PMID: 20536150; PMCID: PMC2916951.
    43. Kapustina M, Vitriol E, Elston TC, Loew LM, Jacobson K. Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics. Cytoskeleton (Hoboken). 2010 Aug; 67(8):519-34. PMID: 20623665; PMCID: PMC2929670.
    44. Warren M, Spitzer KW, Steadman BW, Rees TD, Venable P, Taylor T, Shibayama J, Yan P, Wuskell JP, Loew LM, Zaitsev AV. High-precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS. Am J Physiol Heart Circ Physiol. 2010 Oct; 299(4):H1271-81. PMID: 20601458; PMCID: PMC2957348.
    45. Slepchenko BM, Loew LM. Use of virtual cell in studies of cellular dynamics. Int Rev Cell Mol Biol. 2010; 283:1-56. PMID: 20801417; PMCID: PMC3519358.
    46. Mayer BJ, Blinov ML, Loew LM. Molecular machines or pleiomorphic ensembles: signaling complexes revisited. J Biol. 2009; 8(9):81. PMID: 19835637; PMCID: PMC2776906.
    47. Ditlev JA, Vacanti NM, Novak IL, Loew LM. An open model of actin dendritic nucleation. Biophys J. 2009 May 6; 96(9):3529-42. PMID: 19413959; PMCID: PMC2711424.
    48. Kee MZ, Wuskell JP, Loew LM, Augustine GJ, Sekino Y. Imaging activity of neuronal populations with new long-wavelength voltage-sensitive dyes. Brain Cell Biol. 2008 Dec; 36(5-6):157-72. PMID: 19219551; PMCID: PMC3663446.
    49. Moraru II, Schaff JC, Slepchenko BM, Blinov ML, Morgan F, Lakshminarayana A, Gao F, Li Y, Loew LM. Virtual Cell modelling and simulation software environment. IET Syst Biol. 2008 Sep; 2(5):352-62. PMID: 19045830; PMCID: PMC2711391.
    50. Yan P, Xie A, Wei M, Loew LM. Amino(oligo)thiophene-based environmentally sensitive biomembrane chromophores. J Org Chem. 2008 Sep 5; 73(17):6587-94. PMID: 18665648; PMCID: PMC2713772.
    51. Holmes RM, Loew LM. Geometry shapes cell signaling network output. Chem Biol. 2008 Jun; 15(6):523-4. PMID: 18559261.
      View in: PubMed
    52. Brown SA, Morgan F, Watras J, Loew LM. Analysis of phosphatidylinositol-4,5-bisphosphate signaling in cerebellar Purkinje spines. Biophys J. 2008 Aug; 95(4):1795-812. PMID: 18487300; PMCID: PMC2483750.
    53. Zhou WL, Yan P, Wuskell JP, Loew LM, Antic SD. Dynamics of action potential backpropagation in basal dendrites of prefrontal cortical pyramidal neurons. Eur J Neurosci. 2008 Feb; 27(4):923-36. PMID: 18279369; PMCID: PMC2715167.
    54. Matiukas A, Mitrea BG, Qin M, Pertsov AM, Shvedko AG, Warren MD, Zaitsev AV, Wuskell JP, Wei MD, Watras J, Loew LM. Near-infrared voltage-sensitive fluorescent dyes optimized for optical mapping in blood-perfused myocardium. Heart Rhythm. 2007 Nov; 4(11):1441-51. PMID: 17954405; PMCID: PMC2121222.
    55. Teisseyre TZ, Millard AC, Yan P, Wuskell JP, Wei MD, Lewis A, Loew LM. Nonlinear optical potentiometric dyes optimized for imaging with 1064-nm light. J Biomed Opt. 2007 Jul-Aug; 12(4):044001. PMID: 17867805.
      View in: PubMed
    56. Zhou WL, Yan P, Wuskell JP, Loew LM, Antic SD. Intracellular long-wavelength voltage-sensitive dyes for studying the dynamics of action potentials in axons and thin dendrites. J Neurosci Methods. 2007 Aug 30; 164(2):225-39. PMID: 17560661; PMCID: PMC2001318.
    57. Loew LM. Where does all the PIP2 come from? J Physiol. 2007 Aug 1; 582(Pt 3):945-51. PMID: 17395623; PMCID: PMC2075267.
    58. Yan P, Millard AC, Wei M, Loew LM. Unique contrast patterns from resonance-enhanced chiral SHG of cell membranes. J Am Chem Soc. 2006 Aug 30; 128(34):11030-1. PMID: 16925413; PMCID: PMC2505333.
    59. Jin L, Millard AC, Wuskell JP, Dong X, Wu D, Clark HA, Loew LM. Characterization and application of a new optical probe for membrane lipid domains. Biophys J. 2006 Apr 1; 90(7):2563-75. PMID: 16415047; PMCID: PMC1403187.
    60. Matiukas A, Mitrea BG, Pertsov AM, Wuskell JP, Wei MD, Watras J, Millard AC, Loew LM. New near-infrared optical probes of cardiac electrical activity. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2633-43. PMID: 16399869.
      View in: PubMed
    61. Millard AC, Jin L, Wuskell JP, Boudreau DM, Lewis A, Loew LM. Wavelength- and time-dependence of potentiometric non-linear optical signals from styryl dyes. J Membr Biol. 2005 Nov; 208(2):103-11. PMID: 16645740.
      View in: PubMed
    62. Milojkovic BA, Wuskell JP, Loew LM, Antic SD. Initiation of sodium spikelets in basal dendrites of neocortical pyramidal neurons. J Membr Biol. 2005 Nov; 208(2):155-69. PMID: 16645744.
      View in: PubMed
    63. Wuskell JP, Boudreau D, Wei MD, Jin L, Engl R, Chebolu R, Bullen A, Hoffacker KD, Kerimo J, Cohen LB, Zochowski MR, Loew LM. Synthesis, spectra, delivery and potentiometric responses of new styryl dyes with extended spectral ranges. J Neurosci Methods. 2006 Mar 15; 151(2):200-15. PMID: 16253342.
      View in: PubMed
    64. Hernjak N, Slepchenko BM, Fernald K, Fink CC, Fortin D, Moraru II, Watras J, Loew LM. Modeling and analysis of calcium signaling events leading to long-term depression in cerebellar Purkinje cells. Biophys J. 2005 Dec; 89(6):3790-806. PMID: 16169982; PMCID: PMC1366947.
    65. Watras J, Fink CC, Loew LM. Endogenous inhibitors of InsP3-induced Ca2+ release in neuroblastoma cells. Brain Res. 2005 Sep 7; 1055(1-2):60-72. PMID: 16095574.
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    66. Moraru II, Loew LM. Intracellular signaling: spatial and temporal control. Physiology (Bethesda). 2005 Jun; 20:169-79. PMID: 15888574.
      View in: PubMed
    67. Jin L, Millard AC, Wuskell JP, Clark HA, Loew LM. Cholesterol-enriched lipid domains can be visualized by di-4-ANEPPDHQ with linear and nonlinear optics. Biophys J. 2005 Jul; 89(1):L04-6. PMID: 15879475; PMCID: PMC1366585.
    68. Millard AC, Terasaki M, Loew LM. Second harmonic imaging of exocytosis at fertilization. Biophys J. 2005 Jun; 88(6):L46-8. PMID: 15849238; PMCID: PMC1305673.
    69. Mayya V, Loew LM. STAT module can function as a biphasic amplitude filter. Syst Biol (Stevenage). 2005 Mar; 2(1):43-52. PMID: 17091582.
      View in: PubMed
    70. Novak IL, Slepchenko BM, Mogilner A, Loew LM. Cooperativity between cell contractility and adhesion. Phys Rev Lett. 2004 Dec 31; 93(26 Pt 1):268109. PMID: 15698031.
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    71. Fall CP, Wagner JM, Loew LM, Nuccitelli R. Cortically restricted production of IP3 leads to propagation of the fertilization Ca2+ wave along the cell surface in a model of the Xenopus egg. J Theor Biol. 2004 Dec 21; 231(4):487-96. PMID: 15488526.
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    72. Wagner J, Fall CP, Hong F, Sims CE, Allbritton NL, Fontanilla RA, Moraru II, Loew LM, Nuccitelli R. A wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support. Cell Calcium. 2004 May; 35(5):433-47. PMID: 15003853.
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    73. Obaid AL, Loew LM, Wuskell JP, Salzberg BM. Novel naphthylstyryl-pyridium potentiometric dyes offer advantages for neural network analysis. J Neurosci Methods. 2004 Apr 30; 134(2):179-90. PMID: 15003384.
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    74. Millard AC, Jin L, Wei MD, Wuskell JP, Lewis A, Loew LM. Sensitivity of second harmonic generation from styryl dyes to transmembrane potential. Biophys J. 2004 Feb; 86(2):1169-76. PMID: 14747351; PMCID: PMC1303909.
    75. Campagnola PJ, Loew LM. Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms. Nat Biotechnol. 2003 Nov; 21(11):1356-60. PMID: 14595363.
      View in: PubMed
    76. Slepchenko BM, Schaff JC, Macara I, Loew LM. Quantitative cell biology with the Virtual Cell. Trends Cell Biol. 2003 Nov; 13(11):570-6. PMID: 14573350.
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    77. Millard AC, Jin L, Lewis A, Loew LM. Direct measurement of the voltage sensitivity of second-harmonic generation from a membrane dye in patch-clamped cells. Opt Lett. 2003 Jul 15; 28(14):1221-3. PMID: 12885027.
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    78. Xu C, Loew LM. Activation of phospholipase C increases intramembrane electric fields in N1E-115 neuroblastoma cells. Biophys J. 2003 Jun; 84(6):4144-56. PMID: 12770917; PMCID: PMC1302993.
    79. Xu C, Watras J, Loew LM. Kinetic analysis of receptor-activated phosphoinositide turnover. J Cell Biol. 2003 May 26; 161(4):779-91. PMID: 12771127; PMCID: PMC2199375.
    80. Xu C, Loew LM. The effect of asymmetric surface potentials on the intramembrane electric field measured with voltage-sensitive dyes. Biophys J. 2003 Apr; 84(4):2768-80. PMID: 12668484; PMCID: PMC1302842.
    81. Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP, Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M, Gor V, Goryanin II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS, Kasberger JL, Kremling A, Kummer U, Le Novère N, Loew LM, Lucio D, Mendes P, Minch E, Mjolsness ED, Nakayama Y, Nelson MR, Nielsen PF, Sakurada T, Schaff JC, Shapiro BE, Shimizu TS, Spence HD, Stelling J, Takahashi K, Tomita M, Wagner J, Wang J. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics. 2003 Mar 1; 19(4):524-31. PMID: 12611808.
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    82. Asamoah OK, Wuskell JP, Loew LM, Bezanilla F. A fluorometric approach to local electric field measurements in a voltage-gated ion channel. Neuron. 2003 Jan 9; 37(1):85-97. PMID: 12526775.
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    83. Millard AC, Campagnola PJ, Mohler W, Lewis A, Loew LM. Second harmonic imaging microscopy. Methods Enzymol. 2003; 361:47-69. PMID: 12624906.
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    84. de Lorimier RM, Smith JJ, Dwyer MA, Looger LL, Sali KM, Paavola CD, Rizk SS, Sadigov S, Conrad DW, Loew L, Hellinga HW. Construction of a fluorescent biosensor family. Protein Sci. 2002 Nov; 11(11):2655-75. PMID: 12381848; PMCID: PMC2373719.
    85. Moraru II, Schaff JC, Slepchenko BM, Loew LM. The virtual cell: an integrated modeling environment for experimental and computational cell biology. Ann N Y Acad Sci. 2002 Oct; 971:595-6. PMID: 12438191.
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    86. Smith AE, Slepchenko BM, Schaff JC, Loew LM, Macara IG. Systems analysis of Ran transport. Science. 2002 Jan 18; 295(5554):488-91. PMID: 11799242.
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    87. Loew LM. The Virtual Cell project. Novartis Found Symp. 2002; 247:151-60; discussion 160-1, 198-206, 244-52. PMID: 12539954.
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    88. Loew LM, Campagnola P, Lewis A, Wuskell JP. Confocal and nonlinear optical imaging of potentiometric dyes. Methods Cell Biol. 2002; 70:429-52. PMID: 12512332.
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    89. Slepchenko BM, Schaff JC, Carson JH, Loew LM. Computational cell biology: spatiotemporal simulation of cellular events. Annu Rev Biophys Biomol Struct. 2002; 31:423-41. PMID: 11988477.
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    90. Loew LM, Schaff JC. The Virtual Cell: a software environment for computational cell biology. Trends Biotechnol. 2001 Oct; 19(10):401-6. PMID: 11587765.
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    91. Mannella CA, Pfeiffer DR, Bradshaw PC, Moraru II, Slepchenko B, Loew LM, Hsieh CE, Buttle K, Marko M. Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications. IUBMB Life. 2001 Sep-Nov; 52(3-5):93-100. PMID: 11798041.
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    92. Campagnola PJ, Clark HA, Mohler WA, Lewis A, Loew LM. Second-harmonic imaging microscopy of living cells. J Biomed Opt. 2001 Jul; 6(3):277-86. PMID: 11516317.
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    93. Carson JH, Cowan A, Loew LM. Computational cell biologists snowed in at Cranwell. Trends Cell Biol. 2001 Jun; 11(6):236-8. PMID: 11424906.
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    94. Roy P, Rajfur Z, Jones D, Marriott G, Loew L, Jacobson K. Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. J Cell Biol. 2001 May 28; 153(5):1035-48. PMID: 11381088; PMCID: PMC2174335.
    95. Terasaki M, Loew L, Lippincott-Schwartz J, Zaal K. Fluorescent staining of subcellular organelles: ER, Golgi complex, and mitochondria. Curr Protoc Cell Biol. 2001 May; Chapter 4:Unit 4.4. PMID: 18228364.
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    96. Khatchatouriants A, Lewis A, Rothman Z, Loew L, Treinin M. GFP is a selective non-linear optical sensor of electrophysiological processes in Caenorhabditis elegans. Biophys J. 2000 Nov; 79(5):2345-52. PMID: 11053114; PMCID: PMC1301122.
    97. Antic S, Wuskell JP, Loew L, Zecevic D. Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ. J Physiol. 2000 Aug 15; 527 Pt 1:55-69. PMID: 10944170; PMCID: PMC2270048.
    98. Fink CC, Slepchenko B, Moraru II, Watras J, Schaff JC, Loew LM. An image-based model of calcium waves in differentiated neuroblastoma cells. Biophys J. 2000 Jul; 79(1):163-83. PMID: 10866945; PMCID: PMC1300923.
    99. Schaff JC, Slepchenko BM, Loew LM. Physiological modeling with virtual cell framework. Methods Enzymol. 2000; 321:1-23. PMID: 10909048.
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    100. Campagnola PJ, Wei MD, Lewis A, Loew LM. High-resolution nonlinear optical imaging of live cells by second harmonic generation. Biophys J. 1999 Dec; 77(6):3341-9. PMID: 10585956; PMCID: PMC1300605.
    101. Fink CC, Slepchenko B, Moraru II, Schaff J, Watras J, Loew LM. Morphological control of inositol-1,4,5-trisphosphate-dependent signals. J Cell Biol. 1999 Nov 29; 147(5):929-36. PMID: 10579714; PMCID: PMC2169350.
    102. Fink CC, Slepchenko B, Loew LM. Determination of time-dependent inositol-1,4,5-trisphosphate concentrations during calcium release in a smooth muscle cell. Biophys J. 1999 Jul; 77(1):617-28. PMID: 10388786; PMCID: PMC1300358.
    103. Peleg G, Lewis A, Linial M, Loew LM. Nonlinear optical measurement of membrane potential around single molecules at selected cellular sites. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6700-4. PMID: 10359775; PMCID: PMC21978.
    104. Schaff J, Loew LM. The virtual cell. Pac Symp Biocomput. 1999; 228-39. PMID: 10380200.
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    105. Tuft RA, Loew LM. A tribute to Fredric Stewart Fay: June 5, 1943 - March 18, 1997. Biophys J. 1998 Oct; 75(4):1599-602. PMID: 9746503; PMCID: PMC1299833.
    106. Fink C, Morgan F, Loew LM. Intracellular fluorescent probe concentrations by confocal microscopy. Biophys J. 1998 Oct; 75(4):1648-58. PMID: 9746507; PMCID: PMC1299837.
    107. Wu JY, Lam YW, Falk CX, Cohen LB, Fang J, Loew L, Prechtl JC, Kleinfeld D, Tsau Y. Voltage-sensitive dyes for monitoring multineuronal activity in the intact central nervous system. Histochem J. 1998 Mar; 30(3):169-87. PMID: 10188925.
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    108. Zhang J, Davidson RM, Wei MD, Loew LM. Membrane electric properties by combined patch clamp and fluorescence ratio imaging in single neurons. Biophys J. 1998 Jan; 74(1):48-53. PMID: 9449308; PMCID: PMC1299360.
    109. Antic S, Major G, Chen WR, Wuskel J, Loew L, Zecevic D. Fast voltage-sensitive dye recording of membrane potential changes at multiple sites on an individual nerve cell in the rat cortical slice. Biol Bull. 1997 Oct; 193(2):261. PMID: 9390400.
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    110. Schaff J, Fink CC, Slepchenko B, Carson JH, Loew LM. A general computational framework for modeling cellular structure and function. Biophys J. 1997 Sep; 73(3):1135-46. PMID: 9284281; PMCID: PMC1181013.
    111. Baxter WT, Davidenko JM, Loew LM, Wuskell JP, Jalife J. Technical features of a CCD video camera system to record cardiac fluorescence data. Ann Biomed Eng. 1997 Jul-Aug; 25(4):713-25. PMID: 9236983.
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    112. Tsau Y, Wenner P, O'Donovan MJ, Cohen LB, Loew LM, Wuskell JP. Dye screening and signal-to-noise ratio for retrogradely transported voltage-sensitive dyes. J Neurosci Methods. 1996 Dec 28; 70(2):121-9. PMID: 9007751.
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    113. Zhang J, Loew LM, Davidson RM. Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells. Biophys J. 1996 Nov; 71(5):2501-8. PMID: 8913589; PMCID: PMC1233738.
    114. Ben-Oren I, Peleg G, Lewis A, Minke B, Loew L. Infrared nonlinear optical measurements of membrane potential in photoreceptor cells. Biophys J. 1996 Sep; 71(3):1616-20. PMID: 8874036; PMCID: PMC1233629.
    115. Brown MJ, Loew LM. Graded fibronectin receptor aggregation in migrating cells. Cell Motil Cytoskeleton. 1996; 34(3):185-93. PMID: 8816285.
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    116. Loew LM, Carrington W, Tuft RA, Fay FS. Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12579-83. PMID: 7809081; PMCID: PMC45482.
    117. Bedlack RS, Wei MD, Fox SH, Gross E, Loew LM. Distinct electric potentials in soma and neurite membranes. Neuron. 1994 Nov; 13(5):1187-93. PMID: 7946355.
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    118. Brown MJ, Loew LM. Electric field-directed fibroblast locomotion involves cell surface molecular reorganization and is calcium independent. J Cell Biol. 1994 Oct; 127(1):117-28. PMID: 7929557; PMCID: PMC2120190.
    119. Gross E, Bedlack RS, Loew LM. Dual-wavelength ratiometric fluorescence measurement of the membrane dipole potential. Biophys J. 1994 Jul; 67(1):208-16. PMID: 7918989; PMCID: PMC1225351.
    120. Ehrenberg B, Loew LM. Absolute spectroscopic determination of cross-membrane potential. J Fluoresc. 1993 Dec; 3(4):265-9. PMID: 24234908.
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    121. Loew LM, Tuft RA, Carrington W, Fay FS. Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria. Biophys J. 1993 Dec; 65(6):2396-407. PMID: 8312478; PMCID: PMC1225980.
    122. Bouevitch O, Lewis A, Pinevsky I, Wuskell JP, Loew LM. Probing membrane potential with nonlinear optics. Biophys J. 1993 Aug; 65(2):672-9. PMID: 8218895; PMCID: PMC1225769.
    123. Loew LM. Confocal microscopy of potentiometric fluorescent dyes. Methods Cell Biol. 1993; 38:195-209. PMID: 8246781.
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    124. Loew LM, Cohen LB, Dix J, Fluhler EN, Montana V, Salama G, Wu JY. A naphthyl analog of the aminostyryl pyridinium class of potentiometric membrane dyes shows consistent sensitivity in a variety of tissue, cell, and model membrane preparations. J Membr Biol. 1992 Oct; 130(1):1-10. PMID: 1469705.
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    125. Bedlack RS, Wei M, Loew LM. Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. Neuron. 1992 Sep; 9(3):393-403. PMID: 1524823.
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    126. Loew LM. Voltage-sensitive dyes: measurement of membrane potentials induced by DC and AC electric fields. Bioelectromagnetics. 1992; Suppl 1:179-89. PMID: 1285714.
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    127. Howcroft TK, Loew LM, Cragoe EJ, Lindquist RR. Cytotoxic T lymphocyte (CTL)-mediated cytolysis proceeds in the absence of Na+/H+ antiport activity: regulation of cytosolic pH by the Na+/H+ antiport in a cloned CTL. Cell Immunol. 1991 Jun; 135(1):208-21. PMID: 1850326.
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    128. Farkas DL, Wei MD, Febbroriello P, Carson JH, Loew LM. Simultaneous imaging of cell and mitochondrial membrane potentials. Biophys J. 1989 Dec; 56(6):1053-69. PMID: 2611324; PMCID: PMC1280610.
    129. Lojewska Z, Farkas DL, Ehrenberg B, Loew LM. Analysis of the effect of medium and membrane conductance on the amplitude and kinetics of membrane potentials induced by externally applied electric fields. Biophys J. 1989 Jul; 56(1):121-8. PMID: 2752081; PMCID: PMC1280457.
    130. Montana V, Farkas DL, Loew LM. Dual-wavelength ratiometric fluorescence measurements of membrane potential. Biochemistry. 1989 May 30; 28(11):4536-9. PMID: 2765500.
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    131. Rosenberg I, Bach D, Loew LM, Gitler C. Isolation, characterization and partial purification of a transferable membrane channel (amoebapore) produced by Entamoeba histolytica. Mol Biochem Parasitol. 1989 Mar 15; 33(3):237-47. PMID: 2468084.
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    132. Gross D, Loew LM. Fluorescent indicators of membrane potential: microspectrofluorometry and imaging. Methods Cell Biol. 1989; 30:193-218. PMID: 2648110.
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    133. Ehrenberg B, Montana V, Wei MD, Wuskell JP, Loew LM. Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes. Biophys J. 1988 May; 53(5):785-94. PMID: 3390520; PMCID: PMC1330255.
    134. Huang JY, Lewis A, Loew L. Nonlinear optical properties of potential sensitive styryl dyes. Biophys J. 1988 May; 53(5):665-70. PMID: 3390517; PMCID: PMC1330244.
    135. Lojewska Z, Loew LM. Insertion of amphiphilic molecules into membranes is catalyzed by a high molecular weight non-ionic surfactant. Biochim Biophys Acta. 1987 May 12; 899(1):104-12. PMID: 3567187.
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    136. Ehrenberg B, Farkas DL, Fluhler EN, Lojewska Z, Loew LM. Membrane potential induced by external electric field pulses can be followed with a potentiometric dye. Biophys J. 1987 May; 51(5):833-7. PMID: 3593876; PMCID: PMC1329971.
    137. Naccache PH, Molski MM, Volpi M, Shefcyk J, Molski TF, Loew L, Becker EL, Sha'afi RI. Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. J Leukoc Biol. 1986 Nov; 40(5):533-48. PMID: 3021882.
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    138. Gross D, Loew LM, Webb WW. Optical imaging of cell membrane potential changes induced by applied electric fields. Biophys J. 1986 Aug; 50(2):339-48. PMID: 3741986; PMCID: PMC1329750.
    139. Gross D, Loew LM, Ryan TA, Webb WW. Spatially-resolved optical imaging of membrane potentials induced by applied electric fields. Prog Clin Biol Res. 1986; 210:263-70. PMID: 3960915.
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    140. Fluhler E, Burnham VG, Loew LM. Spectra, membrane binding, and potentiometric responses of new charge shift probes. Biochemistry. 1985 Oct 8; 24(21):5749-55. PMID: 4084490.
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    141. Pryor C, Bridge M, Loew LM. Aggregation, lipid exchange, and metastable phases of dimyristoylphosphatidylethanolamine vesicles. Biochemistry. 1985 Apr 23; 24(9):2203-9. PMID: 3995010.
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    142. Loew LM, Benson L, Lazarovici P, Rosenberg I. Fluorometric analysis of transferable membrane pores. Biochemistry. 1985 Apr 23; 24(9):2101-4. PMID: 2581609.
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    143. Loew LM, Cohen LB, Salzberg BM, Obaid AL, Bezanilla F. Charge-shift probes of membrane potential. Characterization of aminostyrylpyridinium dyes on the squid giant axon. Biophys J. 1985 Jan; 47(1):71-7. PMID: 3978192; PMCID: PMC1435075.
    144. Loew LM, Rosenberg I, Bridge M, Gitler C. Diffusion potential cascade. Convenient detection of transferable membrane pores. Biochemistry. 1983 Feb 15; 22(4):837-44. PMID: 6838828.
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    145. Loew LM. Design and characterization of electrochromic membrane probes. J Biochem Biophys Methods. 1982 Aug; 6(3):243-60. PMID: 7130621.
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    146. Loew LM, Simpson LL. Charge-shift probes of membrane potential: a probable electrochromic mechanism for p-aminostyrylpyridinium probes on a hemispherical lipid bilayer. Biophys J. 1981 Jun; 34(3):353-65. PMID: 7248466; PMCID: PMC1327479.
    147. Loew LM, Scully S, Simpson L, Waggoner AS. Evidence for a charge-shift electrochromic mechanism in a probe of membrane potential. Nature. 1979 Oct 11; 281(5731):497-9. PMID: 492309.
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    148. Loew LM, Bonneville GW, Surow J. Charge shift optical probes of membrane potential. Theory. Biochemistry. 1978 Sep 19; 17(19):4065-71. PMID: 708694.
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