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William A Mohler PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentGenetics and Developmental Biology
AddressMC 6403
Cell and Genome Sciences Building, MC 6403
400 Farmington Avenue
Phone860-679-1833
Fax860-760-6140
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    Other Positions
    TitleAssociate Professor
    InstitutionUConn Health Center
    DepartmentCenter for Cell Analysis and Modeling


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shinn-Thomas JH, Del Campo JJ, Wang J, Mohler WA. The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins. PLoS One. 2016; 11(1):e0146874. PMID: 26800457.
      View in: PubMed
    2. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Correction: Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2015 Dec 7; 211(5):1095-8. PMID: 26644519.
      View in: PubMed
    3. Christensen RP, Bokinsky A, Santella A, Wu Y, Marquina-Solis J, Guo M, Kovacevic I, Kumar A, Winter PW, Tashakkori N, McCreedy E, Liu H, McAuliffe M, Mohler W, Colón-Ramos DA, Bao Z, Shroff H. Untwisting the Caenorhabditis elegans embryo. Elife. 2015; 4. PMID: 26633880.
      View in: PubMed
    4. Santella A, Catena R, Kovacevic I, Shah P, Yu Z, Marquina-Solis J, Kumar A, Wu Y, Schaff J, Colón-Ramos D, Shroff H, Mohler WA, Bao Z. WormGUIDES: an interactive single cell developmental atlas and tool for collaborative multidimensional data exploration. BMC Bioinformatics. 2015; 16:189. PMID: 26051157; PMCID: PMC4459063.
    5. Sánchez-Blanco A, Rodríguez-Matellán AG, Reis-Sobreiro M, Sáenz-Narciso B, Cabello J, Mohler WA, Mollinedo F. Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids. Cell Cycle. 2014; 13(21):3375-89. PMID: 25485582; PMCID: PMC4614342.
    6. Bernadskaya YY, Wallace A, Nguyen J, Mohler WA, Soto MC. UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complex. PLoS Genet. 2012; 8(8):e1002863. PMID: 22876199; PMCID: PMC3410845.
    7. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2012 May 28; 197(5):643-58. PMID: 22613834; PMCID: PMC3365498.
    8. Xiong H, Mohler WA, Soto MC. The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote. Dev Biol. 2011 Sep 15; 357(2):356-69. PMID: 21798253; PMCID: PMC3389993.
    9. Shinn-Thomas JH, Mohler WA. New insights into the mechanisms and roles of cell-cell fusion. Int Rev Cell Mol Biol. 2011; 289:149-209. PMID: 21749901.
      View in: PubMed
    10. Chen B, Liu P, Wang SJ, Ge Q, Zhan H, Mohler WA, Wang ZW. a-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells. EMBO J. 2010 Sep 15; 29(18):3184-95. PMID: 20700105; PMCID: PMC2944068.
    11. Sobota JA, Mohler WA, Cowan AE, Eipper BA, Mains RE. Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. BMC Neurosci. 2010; 11:32. PMID: 20202202; PMCID: PMC2838897.
    12. Mohler WA, Isaacson AB. Imaging embryonic development in Caenorhabditis elegans. Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.top71. PMID: 20194475.
      View in: PubMed
    13. Mohler WA, Isaacson AB. Suspended embryo mount for imaging Caenorhabditis elegans. Cold Spring Harb Protoc. 2010 Mar; 2010(3):pdb.prot5388. PMID: 20194457.
      View in: PubMed
    14. Mohler WA. Google 'EarthWorm'. Nat Methods. 2009 Sep; 6(9):635-6. PMID: 19718015.
      View in: PubMed
    15. Patel FB, Bernadskaya YY, Chen E, Jobanputra A, Pooladi Z, Freeman KL, Gally C, Mohler WA, Soto MC. The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Dev Biol. 2008 Dec 15; 324(2):297-309. PMID: 18938151; PMCID: PMC2629559.
    16. Plotnikov SV, Kenny AM, Walsh SJ, Zubrowski B, Joseph C, Scranton VL, Kuchel GA, Dauser D, Xu M, Pilbeam CC, Adams DJ, Dougherty RP, Campagnola PJ, Mohler WA. Measurement of muscle disease by quantitative second-harmonic generation imaging. J Biomed Opt. 2008 Jul-Aug; 13(4):044018. PMID: 19021346.
      View in: PubMed
    17. Zajac M, Dacanay B, Mohler WA, Wolgemuth CW. Depolymerization-driven flow in nematode spermatozoa relates crawling speed to size and shape. Biophys J. 2008 May 15; 94(10):3810-23. PMID: 18227129; PMCID: PMC2367178.
    18. Shinn-Thomas JH, Scranton VL, Mohler WA. Quantitative assays for cell fusion. Methods Mol Biol. 2008; 475:347-61. PMID: 18979254.
      View in: PubMed
    19. Ems S, Mohler WA. Ultrastructural imaging of cell fusion in Caenorhabditis elegans. Methods Mol Biol. 2008; 475:245-62. PMID: 18979248.
      View in: PubMed
    20. Ems S, Mohler WA. Optical imaging of cell fusion and fusion proteins in Caenorhabditis elegans. Methods Mol Biol. 2008; 475:223-44. PMID: 18979247.
      View in: PubMed
    21. Nadiarnykh O, Plotnikov S, Mohler WA, Kalajzic I, Redford-Badwal D, Campagnola PJ. Second harmonic generation imaging microscopy studies of osteogenesis imperfecta. J Biomed Opt. 2007 Sep-Oct; 12(5):051805. PMID: 17994883.
      View in: PubMed
    22. Dupuy D, Bertin N, Hidalgo CA, Venkatesan K, Tu D, Lee D, Rosenberg J, Svrzikapa N, Blanc A, Carnec A, Carvunis AR, Pulak R, Shingles J, Reece-Hoyes J, Hunt-Newbury R, Viveiros R, Mohler WA, Tasan M, Roth FP, Le Peuch C, Hope IA, Johnsen R, Moerman DG, Barabási AL, Baillie D, Vidal M. Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nat Biotechnol. 2007 Jun; 25(6):663-8. PMID: 17486083.
      View in: PubMed
    23. Chen EH, Grote E, Mohler W, Vignery A. Cell-cell fusion. FEBS Lett. 2007 May 22; 581(11):2181-93. PMID: 17395182.
      View in: PubMed
    24. Nadiarnykh O, Lacomb RB, Campagnola PJ, Mohler WA. Coherent and incoherent SHG in fibrillar cellulose matrices. Opt Express. 2007 Mar 19; 15(6):3348-60. PMID: 19532576.
      View in: PubMed
    25. Balla S, Thapar V, Verma S, Luong T, Faghri T, Huang CH, Rajasekaran S, del Campo JJ, Shinn JH, Mohler WA, Maciejewski MW, Gryk MR, Piccirillo B, Schiller SR, Schiller MR. Minimotif Miner: a tool for investigating protein function. Nat Methods. 2006 Mar; 3(3):175-7. PMID: 16489333.
      View in: PubMed
    26. Plotnikov SV, Millard AC, Campagnola PJ, Mohler WA. Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres. Biophys J. 2006 Jan 15; 90(2):693-703. PMID: 16258040; PMCID: PMC1367074.
    27. Plotnikov S, Juneja V, Isaacson AB, Mohler WA, Campagnola PJ. Optical clearing for improved contrast in second harmonic generation imaging of skeletal muscle. Biophys J. 2006 Jan 1; 90(1):328-39. PMID: 16214853; PMCID: PMC1367031.
    28. Wang J, Mohler WA, Savage-Dunn C. C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling. Development. 2005 Aug; 132(15):3505-13. PMID: 16000380.
      View in: PubMed
    29. del Campo JJ, Opoku-Serebuoh E, Isaacson AB, Scranton VL, Tucker M, Han M, Mohler WA. Fusogenic activity of EFF-1 is regulated via dynamic localization in fusing somatic cells of C. elegans. Curr Biol. 2005 Mar 8; 15(5):413-23. PMID: 15753035.
      View in: PubMed
    30. Arur S, Uche UE, Rezaul K, Fong M, Scranton V, Cowan AE, Mohler W, Han DK. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003 Apr; 4(4):587-98. PMID: 12689596.
      View in: PubMed
    31. Mohler W, Millard AC, Campagnola PJ. Second harmonic generation imaging of endogenous structural proteins. Methods. 2003 Jan; 29(1):97-109. PMID: 12543075.
      View in: PubMed
    32. Millard AC, Campagnola PJ, Mohler W, Lewis A, Loew LM. Second harmonic imaging microscopy. Methods Enzymol. 2003; 361:47-69. PMID: 12624906.
      View in: PubMed
    33. Eliceiri KW, Rueden C, Mohler WA, Hibbard WL, White JG. Analysis of multidimensional biological image data. Biotechniques. 2002 Dec; 33(6):1268-73. PMID: 12503311.
      View in: PubMed
    34. Mohler WA, Shemer G, del Campo JJ, Valansi C, Opoku-Serebuoh E, Scranton V, Assaf N, White JG, Podbilewicz B. The type I membrane protein EFF-1 is essential for developmental cell fusion. Dev Cell. 2002 Mar; 2(3):355-62. PMID: 11879640.
      View in: PubMed
    35. Campagnola PJ, Millard AC, Terasaki M, Hoppe PE, Malone CJ, Mohler WA. Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues. Biophys J. 2002 Jan; 82(1 Pt 1):493-508. PMID: 11751336; PMCID: PMC1302489.
    36. Heid PJ, Raich WB, Smith R, Mohler WA, Simokat K, Gendreau SB, Rothman JH, Hardin J. The zinc finger protein DIE-1 is required for late events during epithelial cell rearrangement in C. elegans. Dev Biol. 2001 Aug 1; 236(1):165-80. PMID: 11456452.
      View in: PubMed
    37. Campagnola PJ, Clark HA, Mohler WA, Lewis A, Loew LM. Second-harmonic imaging microscopy of living cells. J Biomed Opt. 2001 Jul; 6(3):277-86. PMID: 11516317.
      View in: PubMed
    38. Skop AR, Bergmann D, Mohler WA, White JG. Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex. Curr Biol. 2001 May 15; 11(10):735-46. PMID: 11378383; PMCID: PMC3733387.
    39. Charlton CA, Mohler WA, Blau HM. Neural cell adhesion molecule (NCAM) and myoblast fusion. Dev Biol. 2000 May 1; 221(1):112-9. PMID: 10772795.
      View in: PubMed
    40. Hoier EF, Mohler WA, Kim SK, Hajnal A. The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Genes Dev. 2000 Apr 1; 14(7):874-86. PMID: 10766743; PMCID: PMC316495.
    41. Mohler WA. Visual reality: using computer reconstruction and animation to magnify the microscopist's perception. Mol Biol Cell. 1999 Oct; 10(10):3061-5. PMID: 10512850; PMCID: PMC25558.
    42. Mohler W, White J. Multiphoton laser scanning microscopy for four-dimensional analysis of Caenorhabditis elegans embryonic development. Opt Express. 1998 Oct 26; 3(9):325-31. PMID: 19384377.
      View in: PubMed
    43. Mohler WA, Simske JS, Williams-Masson EM, Hardin JD, White JG. Dynamics and ultrastructure of developmental cell fusions in the Caenorhabditis elegans hypodermis. Curr Biol. 1998 Sep 24; 8(19):1087-90. PMID: 9768364.
      View in: PubMed
    44. Mohler WA, White JG. Stereo-4-D reconstruction and animation from living fluorescent specimens. Biotechniques. 1998 Jun; 24(6):1006-10, 1012. PMID: 9631195.
      View in: PubMed
    45. Charlton CA, Mohler WA, Radice GL, Hynes RO, Blau HM. Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J Cell Biol. 1997 Jul 28; 138(2):331-6. PMID: 9230075; PMCID: PMC2138190.
    46. Yang JT, Rando TA, Mohler WA, Rayburn H, Blau HM, Hynes RO. Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle. J Cell Biol. 1996 Nov; 135(3):829-35. PMID: 8909554; PMCID: PMC2121061.
    47. Mohler WA, Blau HM. Gene expression and cell fusion analyzed by lacZ complementation in mammalian cells. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12423-7. PMID: 8901597; PMCID: PMC38007.
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