Keywords
Last Name
Institution

Bruce T Liang MD, FACC

TitleProfessor and Chief
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 3946
Academic Research Building, MC 3946
263 Farmington Avenue
Phone860-679-4944
Fax860-679-1426
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    Other Positions
    TitleDirector
    InstitutionUConn Health Center
    DepartmentCalhoun Cardiology Center

    TitleRay Neag Distinguished Professor of Vascular Biology and Cardiology
    InstitutionUConn Health Center
    DepartmentMedicine
    DivisionCardiology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gonzalez-Fajardo L, Mahajan LH, Ndaya D, Hargrove D, Manautou JE, Liang BT, Chen MH, Kasi RM, Lu X. Reduced in vivo toxicity of doxorubicin by encapsulation in cholesterol-containing self-assembled nanoparticles. Pharmacol Res. 2016 May; 107:93-101. PMID: 26976795.
      View in: PubMed
    2. Herbert Pratt C, Potter CS, Fairfield H, Reinholdt LG, Bergstrom DE, Harris BS, Greenstein I, Dadras SS, Liang BT, Schofield PN, Sundberg JP. Dsp rul: a spontaneous mouse mutation in desmoplakin as a model of Carvajal-Huerta syndrome. Exp Mol Pathol. 2015 Apr; 98(2):164-72. PMID: 25659760; PMCID: PMC4388778 [Available on 04/01/16].
    3. Yang R, Beqiri D, Shen JB, Redden JM, Dodge-Kafka K, Jacobson KA, Liang BT. P2X4 receptor-eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure. Comput Struct Biotechnol J. 2015; 13:1-7. PMID: 25750695; PMCID: PMC4348440.
    4. Shen JB, Yang R, Pappano A, Liang BT. Cardiac P2X purinergic receptors as a new pathway for increasing Na? entry in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1469-77. PMID: 25239801; PMCID: PMC4233301.
    5. Yang T, Shen JB, Yang R, Redden J, Dodge-Kafka K, Grady J, Jacobson KA, Liang BT. Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Circ Heart Fail. 2014 May; 7(3):510-8. PMID: 24622244; PMCID: PMC4289151.
    6. Pereira FE, Cronin C, Ghosh M, Zhou SY, Agosto M, Subramani J, Wang R, Shen JB, Schacke W, Liang B, Yang TH, McAulliffe B, Liang BT, Shapiro LH. CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. Cardiovasc Res. 2013 Oct 1; 100(1):74-83. PMID: 23761403; PMCID: PMC3778957.
    7. Zhou S, Yang T, Jacobson KA, Liang BT. The therapeutic effect of 2-cyclohexylthio-AMP in heart failure. J Cardiovasc Pharmacol. 2013 Jun; 61(6):553-9. PMID: 23474842; PMCID: PMC3676730.
    8. Kumar TS, Yang T, Mishra S, Cronin C, Chakraborty S, Shen JB, Liang BT, Jacobson KA. 5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity. J Med Chem. 2013 Feb 14; 56(3):902-14. PMID: 23286881; PMCID: PMC3574217.
    9. Yang R, Liang BT. Cardiac P2X(4) receptors: targets in ischemia and heart failure? Circ Res. 2012 Aug 3; 111(4):397-401. PMID: 22859669.
      View in: PubMed
    10. Ho VC, Duan LJ, Cronin C, Liang BT, Fong GH. Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice. Circulation. 2012 Aug 7; 126(6):741-52. PMID: 22753193; PMCID: PMC3442373.
    11. Urso ML, Wang R, Zambraski EJ, Liang BT. Adenosine A3 receptor stimulation reduces muscle injury following physical trauma and is associated with alterations in the MMP/TIMP response. J Appl Physiol (1985). 2012 Feb; 112(4):658-70. PMID: 22114177.
      View in: PubMed
    12. Fishman P, Bar-Yehuda S, Liang BT, Jacobson KA. Pharmacological and therapeutic effects of A3 adenosine receptor agonists. Drug Discov Today. 2012 Apr; 17(7-8):359-66. PMID: 22033198; PMCID: PMC3289754.
    13. Singh KP, Jaffe AS, Liang BT. The clinical impact of circulating caspase-3 p17 level: a potential new biomarker for myocardial injury and cardiovascular disease. Future Cardiol. 2011 Jul; 7(4):443-5. PMID: 21797739.
      View in: PubMed
    14. Agosto M, Azrin M, Singh K, Jaffe AS, Liang BT. Serum caspase-3 p17 fragment is elevated in patients with ST-segment elevation myocardial infarction: a novel observation. J Am Coll Cardiol. 2011 Jan 11; 57(2):220-1. PMID: 21211695.
      View in: PubMed
    15. Montrose DC, Kadaveru K, Ilsley JN, Root SH, Rajan TV, Ramesh M, Nichols FC, Liang BT, Sonin D, Hand AR, Zarini S, Murphy RC, Belinsky GS, Nakanishi M, Rosenberg DW. cPLA2 is protective against COX inhibitor-induced intestinal damage. Toxicol Sci. 2010 Sep; 117(1):122-32. PMID: 20562220; PMCID: PMC2923287.
    16. Wang R, Urso ML, Zambraski EJ, Rader EP, Campbell KP, Liang BT. Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury. Am J Physiol Regul Integr Comp Physiol. 2010 Jul; 299(1):R259-67. PMID: 20427727; PMCID: PMC2904144.
    17. Kumar TS, Zhou SY, Joshi BV, Balasubramanian R, Yang T, Liang BT, Jacobson KA. Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor. J Med Chem. 2010 Mar 25; 53(6):2562-76. PMID: 20192270; PMCID: PMC2880888.
    18. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar TS, Jacobson KA, Hintze T, Recchia FA, Liang BT. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. J Pharmacol Exp Ther. 2010 Jun; 333(3):920-8. PMID: 20200116; PMCID: PMC2879931.
    19. Du J, Xie J, Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res. 2010 Mar 19; 106(5):992-1003. PMID: 20075334; PMCID: PMC2907241.
    20. Shen JB, Shutt R, Agosto M, Pappano A, Liang BT. Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1089-95. PMID: 19201994; PMCID: PMC2670706.
    21. Mamedova LK, Wang R, Besada P, Liang BT, Jacobson KA. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008 Sep-Oct; 58(3-4):232-9. PMID: 18805489; PMCID: PMC2586120.
    22. Sonin D, Zhou SY, Cronin C, Sonina T, Wu J, Jacobson KA, Pappano A, Liang BT. Role of P2X purinergic receptors in the rescue of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H1191-H1197. PMID: 18641271; PMCID: PMC2544491.
    23. Zheng J, Wang R, Zambraski E, Wu D, Jacobson KA, Liang BT. Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3685-91. PMID: 17921328.
      View in: PubMed
    24. Shen JB, Shutt R, Pappano A, Liang BT. Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3056-62. PMID: 17873021.
      View in: PubMed
    25. Jacobson KA, Gao ZG, Liang BT. Neoceptors: reengineering GPCRs to recognize tailored ligands. Trends Pharmacol Sci. 2007 Mar; 28(3):111-6. PMID: 17280720; PMCID: PMC2495023.
    26. Shen JB, Cronin C, Sonin D, Joshi BV, Gongora Nieto M, Harrison D, Jacobson KA, Liang BT. P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1077-84. PMID: 17040972.
      View in: PubMed
    27. Gao ZG, Duong HT, Sonina T, Kim SK, Van Rompaey P, Van Calenbergh S, Mamedova L, Kim HO, Kim MJ, Kim AY, Liang BT, Jeong LS, Jacobson KA. Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists. J Med Chem. 2006 May 4; 49(9):2689-702. PMID: 16640329; PMCID: PMC3471142.
    28. Shen JB, Pappano AJ, Liang BT. Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors. FASEB J. 2006 Feb; 20(2):277-84. PMID: 16449800.
      View in: PubMed
    29. Jacobson KA, Gao ZG, Tchilibon S, Duong HT, Joshi BV, Sonin D, Liang BT. Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. J Med Chem. 2005 Dec 29; 48(26):8103-7. PMID: 16366590; PMCID: PMC2597460.
    30. Yang A, Sonin D, Jones L, Barry WH, Liang BT. A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy. Am J Physiol Heart Circ Physiol. 2004 Sep; 287(3):H1096-103. PMID: 15130891.
      View in: PubMed
    31. Du G, Huang P, Liang BT, Frohman MA. Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell. 2004 Mar; 15(3):1024-30. PMID: 14718562; PMCID: PMC363061.
    32. Mozzicato S, Joshi BV, Jacobson KA, Liang BT. Role of direct RhoA-phospholipase D1 interaction in mediating adenosine-induced protection from cardiac ischemia. FASEB J. 2004 Feb; 18(2):406-8. PMID: 14688204.
      View in: PubMed
    33. Jian B, Xu J, Connolly J, Savani RC, Narula N, Liang B, Levy RJ. Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells. Am J Pathol. 2002 Dec; 161(6):2111-21. PMID: 12466127; PMCID: PMC1850922.
    34. Xu J, Jian B, Chu R, Lu Z, Li Q, Dunlop J, Rosenzweig-Lipson S, McGonigle P, Levy RJ, Liang B. Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. Am J Pathol. 2002 Dec; 161(6):2209-18. PMID: 12466135; PMCID: PMC1850896.
    35. Hu B, Senkler C, Yang A, Soto F, Liang BT. P2X4 receptor is a glycosylated cardiac receptor mediating a positive inotropic response to ATP. J Biol Chem. 2002 May 3; 277(18):15752-7. PMID: 11864978.
      View in: PubMed
    36. Hu B, Mei QB, Yao XJ, Smith E, Barry WH, Liang BT. A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor. FASEB J. 2001 Dec; 15(14):2739-41. PMID: 11606481.
      View in: PubMed
    37. Lee JE, Bokoch G, Liang BT. A novel cardioprotective role of RhoA: new signaling mechanism for adenosine. FASEB J. 2001 Sep; 15(11):1886-94. PMID: 11532968.
      View in: PubMed
    38. Mei Q, Liang BT. P2 purinergic receptor activation enhances cardiac contractility in isolated rat and mouse hearts. Am J Physiol Heart Circ Physiol. 2001 Jul; 281(1):H334-41. PMID: 11406501.
      View in: PubMed
    39. Huh J, Gross GJ, Nagase H, Liang BT. Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H377-83. PMID: 11123254.
      View in: PubMed
    40. Jacobson KA, Xie R, Young L, Chang L, Liang BT. A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists. J Biol Chem. 2000 Sep 29; 275(39):30272-9. PMID: 10887176; PMCID: PMC3561767.
    41. Parsons M, Young L, Lee JE, Jacobson KA, Liang BT. Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D. FASEB J. 2000 Jul; 14(10):1423-31. PMID: 10877835.
      View in: PubMed
    42. Liang BT, Jacobson KA. Adenosine and ischemic preconditioning. Curr Pharm Des. 1999 Dec; 5(12):1029-41. PMID: 10607860; PMCID: PMC3561763.
    43. Stambaugh K, Elliott GT, Jacobson KA, Liang BT. Additive effects of late preconditioning produced by monophosphoryl lipid A and the early preconditioning mediated by adenosine receptors and KATP channel. Circulation. 1999 Jun 29; 99(25):3300-7. PMID: 10385506.
      View in: PubMed
    44. Liang BT, Gross GJ. Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels. Circ Res. 1999 Jun 25; 84(12):1396-400. PMID: 10381891.
      View in: PubMed
    45. Dougherty C, Barucha J, Schofield PR, Jacobson KA, Liang BT. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor. FASEB J. 1998 Dec; 12(15):1785-92. PMID: 9837869.
      View in: PubMed
    46. Liang BT. Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection. Biochem J. 1998 Dec 1; 336 ( Pt 2):337-43. PMID: 9820809; PMCID: PMC1219876.
    47. Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6995-9. PMID: 9618527; PMCID: PMC22715.
    48. Podrasky E, Xu D, Liang BT. A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor. Am J Physiol. 1997 Nov; 273(5 Pt 2):H2380-7. PMID: 9374775.
      View in: PubMed
    49. Liang BT. Protein kinase C-mediated preconditioning of cardiac myocytes: role of adenosine receptor and KATP channel. Am J Physiol. 1997 Aug; 273(2 Pt 2):H847-53. PMID: 9277502.
      View in: PubMed
    50. Stambaugh K, Jacobson KA, Jiang JL, Liang BT. A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. Am J Physiol. 1997 Jul; 273(1 Pt 2):H501-5. PMID: 9249524.
      View in: PubMed
    51. Liang BT. Direct preconditioning of cardiac ventricular myocytes via adenosine A1 receptor and KATP channel. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1769-77. PMID: 8945890.
      View in: PubMed
    52. Strickler J, Jacobson KA, Liang BT. Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors. J Clin Invest. 1996 Oct 15; 98(8):1773-9. PMID: 8878427; PMCID: PMC507615.
    53. Liang BT, Morley JF. A new cyclic AMP-independent, Gs-mediated stimulatory mechanism via the adenosine A2a receptor in the intact cardiac cell. J Biol Chem. 1996 Aug 2; 271(31):18678-85. PMID: 8702522.
      View in: PubMed
    54. Liang BT. A novel method of identifying living transfected cardiac myocyte. Nucleic Acids Res. 1996 Apr 1; 24(7):1382-4. PMID: 8614647; PMCID: PMC145767.
    55. Liang BT, Haltiwanger B. Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Circ Res. 1995 Feb; 76(2):242-51. PMID: 7834835.
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    56. Hanna AK, Miller J, Liang BT, DiSesa VJ. Reversible contractile dysfunction in reversible experimental cardiac allograft rejection: alterations in the beta-receptor-stimulated adenylylcyclase pathway. J Surg Res. 1993 Jun; 54(6):610-5. PMID: 8412072.
      View in: PubMed
    57. Langer DJ, Kuo A, Kariko K, Ahuja M, Klugherz BD, Ivanics KM, Hoxie JA, Williams WV, Liang BT, Cines DB, et al. Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways. Circ Res. 1993 Feb; 72(2):330-40. PMID: 7678205.
      View in: PubMed
    58. Liang BT, Hirsch AJ. Homologous sensitisation of embryonic chick atrial myocytes to adenosine: mediation by adenosine A1 receptor and guanine nucleotide binding protein. Cardiovasc Res. 1993 Jan; 27(1):102-10. PMID: 8458019.
      View in: PubMed
    59. Xu H, Miller J, Liang BT. High-efficiency gene transfer into cardiac myocytes. Nucleic Acids Res. 1992 Dec 11; 20(23):6425-6. PMID: 1475211; PMCID: PMC334546.
    60. Hanna AK, Louie M, Miller J, Hirsch A, Liang BT, DiSesa VJ. Molecular mechanism of contractile dysfunction in cardiac allograft rejection. J Surg Res. 1992 May; 52(5):472-5. PMID: 1619916.
      View in: PubMed
    61. Liang BT. Adenosine receptors and cardiovascular function. Trends Cardiovasc Med. 1992 May-Jun; 2(3):100-8. PMID: 21239268.
      View in: PubMed
    62. Xu D, Kong HY, Liang BT. Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes. Circ Res. 1992 Jan; 70(1):56-65. PMID: 1727688.
      View in: PubMed
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