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Siu-Pok Yee PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentGenetics and Developmental Biology
AddressMC 3001
MC 3001
263 Farmington Avenue
Phone860-679-3726
Fax860-679-8345
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    Other Positions
    TitleDirector
    InstitutionUConn Health Center
    DepartmentGene Targeting and Transgenic Facility


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Enkhmandakh B, Stoddard C, Mack K, He W, Kaback D, Yee SP, Bayarsaihan D. Generation of a mouse model for a conditional inactivation of Gtf2i allele. Genesis. 2016 Jul; 54(7):407-12. PMID: 27194223.
      View in: PubMed
    2. Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S. Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption. J Biol Chem. 2016 Jan 22; 291(4):1538-51. PMID: 26627824.
      View in: PubMed
    3. Shuhaibar LC, Egbert JR, Edmund AB, Uliasz TF, Dickey DM, Yee SP, Potter LR, Jaffe LA. Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Dev Biol. 2016 Jan 1; 409(1):194-201. PMID: 26522847.
      View in: PubMed
    4. Feng ZC, Popell A, Li J, Silverstein J, Oakie A, Yee SP, Wang R. c-Kit Receptor Signaling Regulates Islet Vasculature, ß-Cell Survival, and Function In Vivo. Diabetes. 2015 Nov; 64(11):3852-66. PMID: 26253609.
      View in: PubMed
    5. Du EX, Wang XF, Yang WC, Kaback D, Yee SP, Qin CL, George A, Hao JJ. Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. Int J Oral Sci. 2015 Jun; 7(2):89-94. PMID: 25537657.
      View in: PubMed
    6. Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ. Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome. Acta Neuropathol. 2015 Aug; 130(2):171-83. PMID: 25975378; PMCID: PMC4503865.
    7. Dole NS, Kapinas K, Kessler CB, Yee SP, Adams DJ, Pereira RC, Delany AM. A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433. J Bone Miner Res. 2015 Apr; 30(4):723-32. PMID: 25262637; PMCID: PMC4376624 [Available on 04/01/16].
    8. Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, Bardeesy N, Gingras AC, Yee SP, Screaton RA. Role of the SIK2-p35-PJA2 complex in pancreatic ß-cell functional compensation. Nat Cell Biol. 2014 Mar; 16(3):234-44. PMID: 24561619; PMCID: PMC4107453.
    9. Feng ZC, Li J, Turco BA, Riopel M, Yee SP, Wang R. Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model. Diabetologia. 2012 Aug; 55(8):2214-25. PMID: 22581040.
      View in: PubMed
    10. McGirr R, Hu S, Yee SP, Kovacs MS, Lee TY, Dhanvantari S. Towards PET imaging of intact pancreatic beta cell mass: a transgenic strategy. Mol Imaging Biol. 2011 Oct; 13(5):962-72. PMID: 20924688.
      View in: PubMed
    11. Valiyeva F, Jiang F, Elmaadawi A, Moussa M, Yee SP, Raptis L, Izawa JI, Yang BB, Greenberg NM, Wang F, Xuan JW. Characterization of the oncogenic activity of the novel TRIM59 gene in mouse cancer models. Mol Cancer Ther. 2011 Jul; 10(7):1229-40. PMID: 21593385.
      View in: PubMed
    12. Regnault TR, Zhao L, Chiu JS, Gottheil SK, Foran A, Yee SP. Peroxisome Proliferator-Activated Receptor -ß/d, -? Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism. PPAR Res. 2010; 2010:129173. PMID: 21113404; PMCID: PMC2991640.
    13. Wu Y, Li J, Saleem S, Yee SP, Hardikar AA, Wang R. c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Lab Invest. 2010 Sep; 90(9):1373-84. PMID: 20531294.
      View in: PubMed
    14. Saleem S, Li J, Yee SP, Fellows GF, Goodyer CG, Wang R. beta1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival. J Pathol. 2009 Oct; 219(2):182-92. PMID: 19544355.
      View in: PubMed
    15. Shan SW, Lee DY, Deng Z, Shatseva T, Jeyapalan Z, Du WW, Zhang Y, Xuan JW, Yee SP, Siragam V, Yang BB. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol. 2009 Aug; 11(8):1031-8. PMID: 19633662.
      View in: PubMed
    16. Li TY, Colley D, Barr KJ, Yee SP, Kidder GM. Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43. J Cell Sci. 2007 Dec 1; 120(Pt 23):4117-25. PMID: 18032785.
      View in: PubMed
    17. Krishnamurthy M, Ayazi F, Li J, Lyttle AW, Woods M, Wu Y, Yee SP, Wang R. c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Endocrinology. 2007 Nov; 148(11):5520-30. PMID: 17673521.
      View in: PubMed
    18. Shen E, Fan J, Chen R, Yee SP, Peng T. Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes. J Mol Cell Cardiol. 2007 Sep; 43(3):308-18. PMID: 17655858.
      View in: PubMed
    19. Watson CS, Bialek P, Anzo M, Khosravi J, Yee SP, Han VK. Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction. Endocrinology. 2006 Mar; 147(3):1175-86. PMID: 16293667.
      View in: PubMed
    20. Zou MX, Butcher DT, Sadikovic B, Groves TC, Yee SP, Rodenhiser DI. Characterization of functional elements in the neurofibromatosis (NF1) proximal promoter region. Oncogene. 2004 Jan 15; 23(2):330-9. PMID: 14647436.
      View in: PubMed
    21. Qutob MS, Bhattacharjee RN, Pollari E, Yee SP, Torchia J. Microtubule-dependent subcellular redistribution of the transcriptional coactivator p/CIP. Mol Cell Biol. 2002 Sep; 22(18):6611-26. PMID: 12192059; PMCID: PMC135647.
    22. Feng Q, Song W, Lu X, Hamilton JA, Lei M, Peng T, Yee SP. Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation. 2002 Aug 13; 106(7):873-9. PMID: 12176963.
      View in: PubMed
    23. Xu Q, Yu L, Liu L, Cheung CF, Li X, Yee SP, Yang XJ, Wu Z. p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression. Mol Biol Cell. 2002 Jun; 13(6):1940-52. PMID: 12058061; PMCID: PMC117616.
    24. Varghese R, Gagliardi AD, Bialek PE, Yee SP, Wagner GF, Dimattia GE. Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. Endocrinology. 2002 Mar; 143(3):868-76. PMID: 11861508.
      View in: PubMed
    25. Underhill C, Qutob MS, Yee SP, Torchia J. A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J Biol Chem. 2000 Dec 22; 275(51):40463-70. PMID: 11013263.
      View in: PubMed
    26. Bialek P, Chan CT, Yee SP. Characterization of a novel insertional mouse mutation, kkt: A closely linked modifier of Pax1. Dev Biol. 2000 Feb 15; 218(2):354-66. PMID: 10656775.
      View in: PubMed
    27. Lee KK, Tang MK, Yew DT, Chow PH, Yee SP, Schneider C, Brancolini C. gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb. Dev Biol. 1999 Mar 1; 207(1):14-25. PMID: 10049561.
      View in: PubMed
    28. Jänne M, Deol HK, Power SG, Yee SP, Hammond GL. Human sex hormone-binding globulin gene expression in transgenic mice. Mol Endocrinol. 1998 Jan; 12(1):123-36. PMID: 9440816.
      View in: PubMed
    29. Yee SP, Rigby PW. The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev. 1993 Jul; 7(7A):1277-89. PMID: 8391506.
      View in: PubMed
    30. Meckling-Gill KA, Yee SP, Schrader JW, Pawson T. A retrovirus encoding the v-fps protein-tyrosine kinase induces factor-independent growth and tumorigenicity in FDC-P1 cells. Biochim Biophys Acta. 1992 Oct 6; 1137(1):65-72. PMID: 1390902.
      View in: PubMed
    31. Chow LH, Yee SP, Pawson T, McManus BM. Progressive cardiac fibrosis and myocyte injury in v-fps transgenic mice. A model for primary disorders of connective tissue in the heart? Lab Invest. 1991 Apr; 64(4):457-62. PMID: 2016851.
      View in: PubMed
    32. Yee SP, Mock D, Greer P, Maltby V, Rossant J, Bernstein A, Pawson T. Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase. Mol Cell Biol. 1989 Dec; 9(12):5491-9. PMID: 2555699; PMCID: PMC363719.
    33. Yee SP, Mock D, Maltby V, Silver M, Rossant J, Bernstein A, Pawson T. Cardiac and neurological abnormalities in v-fps transgenic mice. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5873-7. PMID: 2788278; PMCID: PMC297733.
    34. Letwin K, Yee SP, Pawson T. Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene. 1988 Dec; 3(6):621-7. PMID: 2485255.
      View in: PubMed
    35. Yee SP, Branton PE. External cell surface protein phosphorylation in normal and Rous sarcoma virus transformed chick embryo fibroblasts. J Cell Physiol. 1981 Jan; 106(1):149-63. PMID: 6259183.
      View in: PubMed
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