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David Khin Han PhD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 3501
MC 3501
263 Farmington Avenue
Phone860-679-2444
Fax860-679-1201
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee JG, McKinney KQ, Lee YY, Chung HN, Pavlopoulos AJ, Jung KY, Kim WK, Kuroda MJ, Han DK, Hwang S. A draft map of rhesus monkey tissue proteome for biomedical research. PLoS One. 2015; 10(5):e0126243. PMID: 25974132; PMCID: PMC4431823.
    2. Qendro V, Lundgren DH, Rezaul K, Mahony F, Ferrell N, Bi A, Latifi A, Chowdhury D, Gygi S, Haas W, Wilson L, Murphy M, Han DK. Large-scale proteomic characterization of melanoma expressed proteins reveals nestin and vimentin as biomarkers that can potentially distinguish melanoma subtypes. J Proteome Res. 2014 Nov 7; 13(11):5031-40. PMID: 25322343.
      View in: PubMed
    3. Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov; 14(11):1166-72. PMID: 24076635; PMCID: PMC4014310.
    4. Subramani J, Ghosh M, Rahman MM, Caromile LA, Gerber C, Rezaul K, Han DK, Shapiro LH. Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking. J Immunol. 2013 Oct 1; 191(7):3905-12. PMID: 23997214; PMCID: PMC3810388.
    5. Hwang SI, Han DK. Subcellular fractionation for identification of biomarkers: serial detergent extraction by subcellular accessibility and solubility. Methods Mol Biol. 2013; 1002:25-35. PMID: 23625392.
      View in: PubMed
    6. Secor ER, Szczepanek SM, Singh A, Guernsey L, Natarajan P, Rezaul K, Han DK, Thrall RS, Silbart LK. LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr. Evid Based Complement Alternat Med. 2012; 2012:548486. PMID: 23082082; PMCID: PMC3467939.
    7. McKinney KQ, Lee JG, Sindram D, Russo MW, Han DK, Bonkovsky HL, Hwang SI. Identification of differentially expressed proteins from primary versus metastatic pancreatic cancer cells using subcellular proteomics. Cancer Genomics Proteomics. 2012 Sep-Oct; 9(5):257-63. PMID: 22990105.
      View in: PubMed
    8. Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 2; 209(7):1325-34. PMID: 22734047; PMCID: PMC3405500.
    9. Murphy MJ, Rezaul K, Phelps A, Han DK. Proteomic analysis of formalin-fixed, paraffin-embedded melanoma. J Cutan Pathol. 2012 Apr; 39(4):464-6. PMID: 22236207.
      View in: PubMed
    10. Lee YY, McKinney KQ, Ghosh S, Iannitti DA, Martinie JB, Caballes FR, Russo MW, Ahrens WA, Lundgren DH, Han DK, Bonkovsky HL, Hwang SI. Subcellular tissue proteomics of hepatocellular carcinoma for molecular signature discovery. J Proteome Res. 2011 Nov 4; 10(11):5070-83. PMID: 21913717.
      View in: PubMed
    11. Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T. Engagement of S1P1-degradative mechanisms leads to vascular leak in mice. J Clin Invest. 2011 Jun; 121(6):2290-300. PMID: 21555855; PMCID: PMC3104755.
    12. Rezaul K, Murphy M, Lundgren DH, Wilson L, Han DK. Combined mass spectrometry- and immunohistochemistry-based approach to determine protein expression in archival melanoma--proof of principle. Pigment Cell Melanoma Res. 2010 Dec; 23(6):849-52. PMID: 20849468.
      View in: PubMed
    13. Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, Han D, Li Z. Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun. 2010; 1:79. PMID: 20865800.
      View in: PubMed
    14. McKinney KQ, Lee YY, Choi HS, Groseclose G, Iannitti DA, Martinie JB, Russo MW, Lundgren DH, Han DK, Bonkovsky HL, Hwang SI. Discovery of putative pancreatic cancer biomarkers using subcellular proteomics. J Proteomics. 2011 Jan 1; 74(1):79-88. PMID: 20807598.
      View in: PubMed
    15. Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R, Hla T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. J Biol Chem. 2010 Aug 27; 285(35):26825-31. PMID: 20558741; PMCID: PMC2930681.
    16. Rezaul K, Thumar JK, Lundgren DH, Eng JK, Claffey KP, Wilson L, Han DK. Differential protein expression profiles in estrogen receptor-positive and -negative breast cancer tissues using label-free quantitative proteomics. Genes Cancer. 2010 Mar; 1(3):251-71. PMID: 21779449; PMCID: PMC3092194.
    17. Lundgren DH, Hwang SI, Wu L, Han DK. Role of spectral counting in quantitative proteomics. Expert Rev Proteomics. 2010 Feb; 7(1):39-53. PMID: 20121475.
      View in: PubMed
    18. Mayya V, Han DK. Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations. Expert Rev Proteomics. 2009 Dec; 6(6):605-18. PMID: 19929607; PMCID: PMC2931417.
    19. Lundgren DH, Martinez H, Wright ME, Han DK. Protein identification using Sorcerer 2 and SEQUEST. Curr Protoc Bioinformatics. 2009 Dec; Chapter 13:Unit 13.3. PMID: 19957274.
      View in: PubMed
    20. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009; 2(84):ra46. PMID: 19690332.
      View in: PubMed
    21. Ishii A, Dutta R, Wark GM, Hwang SI, Han DK, Trapp BD, Pfeiffer SE, Bansal R. Human myelin proteome and comparative analysis with mouse myelin. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14605-10. PMID: 19706548; PMCID: PMC2732873.
    22. Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci. 2009 Jul; 12(7):864-71. PMID: 19525941; PMCID: PMC2739046.
    23. Rodriguez-Pinto D, Sparkowski J, Keough MP, Phoenix KN, Vumbaca F, Han DK, Gundelfinger ED, Beesley P, Claffey KP. Identification of novel tumor antigens with patient-derived immune-selected antibodies. Cancer Immunol Immunother. 2009 Feb; 58(2):221-34. PMID: 18568347; PMCID: PMC2833102.
    24. Rezaul K, Wilson LL, Han DK. Direct tissue proteomics in human diseases: potential applications to melanoma research. Expert Rev Proteomics. 2008 Jun; 5(3):405-12. PMID: 18532908.
      View in: PubMed
    25. Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 2008 Feb 28; 451(7182):1076-81. PMID: 18278032.
      View in: PubMed
    26. Vumbaca F, Phoenix KN, Rodriguez-Pinto D, Han DK, Claffey KP. Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis. Mol Cell Biol. 2008 Jan; 28(2):772-83. PMID: 18039850; PMCID: PMC2223436.
    27. Lee YM, Venkataraman K, Hwang SI, Han DK, Hla T. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat. 2007 Nov; 84(3-4):154-62. PMID: 17991617; PMCID: PMC2646377.
    28. Wu L, Hwang SI, Rezaul K, Lu LJ, Mayya V, Gerstein M, Eng JK, Lundgren DH, Han DK. Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling. Mol Cell Proteomics. 2007 Aug; 6(8):1343-53. PMID: 17519225.
      View in: PubMed
    29. Bagnato C, Thumar J, Mayya V, Hwang SI, Zebroski H, Claffey KP, Haudenschild C, Eng JK, Lundgren DH, Han DK. Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics. 2007 Jun; 6(6):1088-102. PMID: 17339633.
      View in: PubMed
    30. Choudhary D, Jansson I, Rezaul K, Han DK, Sarfarazi M, Schenkman JB. Cyp1b1 protein in the mouse eye during development: an immunohistochemical study. Drug Metab Dispos. 2007 Jun; 35(6):987-94. PMID: 17325023.
      View in: PubMed
    31. Wu L, Han DK. Overcoming the dynamic range problem in mass spectrometry-based shotgun proteomics. Expert Rev Proteomics. 2006 Dec; 3(6):611-9. PMID: 17181475.
      View in: PubMed
    32. Jasavala R, Martinez H, Thumar J, Andaya A, Gingras AC, Eng JK, Aebersold R, Han DK, Wright ME. Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. Mol Cell Proteomics. 2007 Feb; 6(2):252-71. PMID: 17052974.
      View in: PubMed
    33. Mayya V, Rezual K, Wu L, Fong MB, Han DK. Absolute quantification of multisite phosphorylation by selective reaction monitoring mass spectrometry: determination of inhibitory phosphorylation status of cyclin-dependent kinases. Mol Cell Proteomics. 2006 Jun; 5(6):1146-57. PMID: 16546994.
      View in: PubMed
    34. Hwang SI, Lundgren DH, Mayya V, Rezaul K, Cowan AE, Eng JK, Han DK. Systematic characterization of nuclear proteome during apoptosis: a quantitative proteomic study by differential extraction and stable isotope labeling. Mol Cell Proteomics. 2006 Jun; 5(6):1131-45. PMID: 16540461.
      View in: PubMed
    35. Lundgren DH, Han DK, Eng JK. Protein identification using TurboSEQUEST. Curr Protoc Bioinformatics. 2005 Jul; Chapter 13:Unit 13.3. PMID: 18428747.
      View in: PubMed
    36. Wright ME, Han DK, Aebersold R. Mass spectrometry-based expression profiling of clinical prostate cancer. Mol Cell Proteomics. 2005 Apr; 4(4):545-54. PMID: 15695425.
      View in: PubMed
    37. Mayya V, Rezaul K, Cong YS, Han D. Systematic comparison of a two-dimensional ion trap and a three-dimensional ion trap mass spectrometer in proteomics. Mol Cell Proteomics. 2005 Feb; 4(2):214-23. PMID: 15608339; PMCID: PMC1487187.
    38. Rezaul K, Wu L, Mayya V, Hwang SI, Han D. A systematic characterization of mitochondrial proteome from human T leukemia cells. Mol Cell Proteomics. 2005 Feb; 4(2):169-81. PMID: 15598749; PMCID: PMC1487188.
    39. Paik JH, Skoura A, Chae SS, Cowan AE, Han DK, Proia RL, Hla T. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004 Oct 1; 18(19):2392-403. PMID: 15371328; PMCID: PMC522989.
    40. Taylor CM, Marta CB, Claycomb RJ, Han DK, Rasband MN, Coetzee T, Pfeiffer SE. Proteomic mapping provides powerful insights into functional myelin biology. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4643-8. PMID: 15070771; PMCID: PMC384800.
    41. Chang SH, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF, Hla T. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):591-6. PMID: 14688410; PMCID: PMC327192.
    42. Lundgren DH, Eng J, Wright ME, Han DK. PROTEOME-3D: an interactive bioinformatics tool for large-scale data exploration and knowledge discovery. Mol Cell Proteomics. 2003 Nov; 2(11):1164-76. PMID: 12960178; PMCID: PMC1487189.
    43. Arur S, Uche UE, Rezaul K, Fong M, Scranton V, Cowan AE, Mohler W, Han DK. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003 Apr; 4(4):587-98. PMID: 12689596.
      View in: PubMed
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