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Paul M Epstein PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 6125
MC 6125
263 Farmington Avenue
Phone860-679-2810
Fax860-679-3693
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dong H, Carlton ME, Lerner A, Epstein PM. Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells. Front Pharmacol. 2015; 6:230. PMID: 26528184; PMCID: PMC4602131.
    2. Dong H, Claffey KP, Brocke S, Epstein PM. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul; 152(1):17-28. PMID: 26022351.
      View in: PubMed
    3. Dong H, Claffey KP, Brocke S, Epstein PM. Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells. Springerplus. 2013; 2:680. PMID: 24683528; PMCID: PMC3967736.
    4. Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013 Dec 15; 456(3):463-73. PMID: 24007532.
      View in: PubMed
    5. Vang AG, Ben-Sasson SZ, Dong H, Kream B, DeNinno MP, Claffey MM, Housley W, Clark RB, Epstein PM, Brocke S. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010; 5(8):e12011. PMID: 20711499; PMCID: PMC2918507.
    6. Epstein P. The ecology of climate change and infectious diseases: comment. Ecology. 2010 Mar; 91(3):925-8; discussion 928-9. PMID: 20426350.
      View in: PubMed
    7. Dong H, Zitt C, Auriga C, Hatzelmann A, Epstein PM. Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells. Biochem Pharmacol. 2010 Feb 1; 79(3):321-9. PMID: 19737543.
      View in: PubMed
    8. Dong H, Osmanova V, Epstein PM, Brocke S. Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Biochem Biophys Res Commun. 2006 Jun 30; 345(2):713-9. PMID: 16696947.
      View in: PubMed
    9. Lerner A, Epstein PM. Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J. 2006 Jan 1; 393(Pt 1):21-41. PMID: 16336197; PMCID: PMC1383661.
    10. Tiwari S, Dong H, Kim EJ, Weintraub L, Epstein PM, Lerner A. Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation. Biochem Pharmacol. 2005 Feb 1; 69(3):473-83. PMID: 15652238.
      View in: PubMed
    11. Le M, Lu Y, Li Y, Greene RW, Epstein PM, Rosenberg PA. Zaprinast stimulates extracellular adenosine accumulation in rat pontine slices. Neurosci Lett. 2004 Nov 16; 371(1):12-7. PMID: 15500958.
      View in: PubMed
    12. Lu Y, Li Y, Herin GA, Aizenman E, Epstein PM, Rosenberg PA. Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons. Eur J Neurosci. 2004 May; 19(10):2669-81. PMID: 15147301.
      View in: PubMed
    13. Andreeva SG, Dikkes P, Epstein PM, Rosenberg PA. Expression of cGMP-specific phosphodiesterase 9A mRNA in the rat brain. J Neurosci. 2001 Nov 15; 21(22):9068-76. PMID: 11698617.
      View in: PubMed
    14. Paskind M, Johnston C, Epstein PM, Timm J, Wickramasinghe D, Belanger E, Rodman L, Magada D, Voss J. Structure and promoter activity of the mouse CDC25A gene. Mamm Genome. 2000 Dec; 11(12):1063-9. PMID: 11130973.
      View in: PubMed
    15. Epstein PM. Antisense inhibition of phosphodiesterase expression. Methods. 1998 Jan; 14(1):21-33. PMID: 9500855.
      View in: PubMed
    16. Jiang X, Paskind M, Weltzien R, Epstein PM. Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes. Cell Biochem Biophys. 1998; 28(2-3):135-60. PMID: 9515164.
      View in: PubMed
    17. Jiang X, Li J, Paskind M, Epstein PM. Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20):11236-41. PMID: 8855339; PMCID: PMC1074519.
    18. Yang Q, Paskind M, Bolger G, Thompson WJ, Repaske DR, Cutler LS, Epstein PM. A novel cyclic GMP stimulated phosphodiesterase from rat brain. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1850-8. PMID: 7811274.
      View in: PubMed
    19. Mednieks MI, Epstein PM, Hachisu R, Hand AR, Esquire RG. Cyclic AMP-reactive proteins in human saliva. Arch Oral Biol. 1994 Oct; 39(10):869-75. PMID: 7741656.
      View in: PubMed
    20. Smilowitz HM, Aramli L, Xu D, Epstein PM. Phosphotyrosine phosphatase activity in human platelets. Life Sci. 1991; 49(1):29-37. PMID: 1646922.
      View in: PubMed
    21. Jansson I, Curti M, Epstein PM, Peterson JA, Schenkman JB. Relationship between phosphorylation and cytochrome P450 destruction. Arch Biochem Biophys. 1990 Dec; 283(2):285-92. PMID: 2275544.
      View in: PubMed
    22. Grasso JA, Bruno M, Yates AA, Wei LT, Epstein PM. Calmodulin dependence of transferrin receptor recycling in rat reticulocytes. Biochem J. 1990 Feb 15; 266(1):261-72. PMID: 2310376; PMCID: PMC1131123.
    23. Henderson EG, Post-Munson DJ, Reynolds LS, Epstein PM. Echothiophate and cogeners decrease the voltage dependence of end-plate current decay in frog skeletal muscle. J Pharmacol Exp Ther. 1989 Dec; 251(3):810-6. PMID: 2481033.
      View in: PubMed
    24. Epstein PM, Curti M, Jansson I, Huang CK, Schenkman JB. Phosphorylation of cytochrome P450: regulation by cytochrome b5. Arch Biochem Biophys. 1989 Jun; 271(2):424-32. PMID: 2543294.
      View in: PubMed
    25. Jansson I, Epstein PM, Bains S, Schenkman JB. Inverse relationship between cytochrome P-450 phosphorylation and complexation with cytochrome b5. Arch Biochem Biophys. 1987 Dec; 259(2):441-8. PMID: 3426238.
      View in: PubMed
    26. Epstein PM, Moraski S, Hachisu R. Identification and characterization of a Ca2+-calmodulin-sensitive cyclic nucleotide phosphodiesterase in a human lymphoblastoid cell line. Biochem J. 1987 Apr 15; 243(2):533-9. PMID: 2820385; PMCID: PMC1147887.
    27. Epstein PM, Andrenyak DM, Smith CJ, Pappano AJ. Ontogenetic changes in adenylate cyclase, cyclic AMP phosphodiesterase and calmodulin in chick ventricular myocardium. Biochem J. 1987 Apr 15; 243(2):525-31. PMID: 2820384; PMCID: PMC1147886.
    28. Sarmiento JG, Epstein PM, Rowe WA, Chester DW, Smilowitz H, Wehinger E, Janis RA. Photoaffinity labelling of a 33-35,000 dalton protein in cardiac, skeletal and smooth muscle membranes using a new 125I-labelled 1,4-dihydropyridine calcium channel antagonist. Life Sci. 1986 Dec 22; 39(25):2401-9. PMID: 2432371.
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    29. Onali P, Strada SJ, Chang L, Epstein PM, Hersh EM, Thompson WJ. Purification and characterization of high-affinity cyclic adenosine 5'-monophosphate phosphodiesterases from human acute myelogenous leukemic cells. Cancer Res. 1985 Mar; 45(3):1384-91. PMID: 2982489.
      View in: PubMed
    30. Epstein PM, Lambert JJ. Displacement of [3H]phencyclidine binding to Torpedo electric organ membrane by calcium channel antagonists. Biochem Pharmacol. 1984 Dec 15; 33(24):4087-9. PMID: 6508854.
      View in: PubMed
    31. Rodan SB, Fischer MK, Egan JJ, Epstein PM, Rodan GA. The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells. Endocrinology. 1984 Sep; 115(3):951-8. PMID: 6086291.
      View in: PubMed
    32. Epstein PM, Hachisu R. Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 16:303-24. PMID: 6202124.
      View in: PubMed
    33. Epstein PM, Strada SJ, Sarada K, Thompson WJ. Catalytic and kinetic properties of purified high-affinity cyclic AMP phosphodiesterase from dog kidney. Arch Biochem Biophys. 1982 Oct 1; 218(1):119-33. PMID: 6293381.
      View in: PubMed
    34. Volle RL, Alkadhi KA, Branisteanu DD, Reynolds LS, Epstein PM, Smilowitz H, Lambert JJ, Henderson EG. Ketamine and ditran block end-plate ion conductance and [3H]phencyclidine binding to electric organ membrane. J Pharmacol Exp Ther. 1982 Jun; 221(3):570-6. PMID: 6123584.
      View in: PubMed
    35. Sarada K, Epstein PM, Strada SJ, Thompson WJ. Analysis of cyclic nucleotide phosphodiesterase(s) by radioimmunoassay. Arch Biochem Biophys. 1982 Apr 15; 215(1):183-98. PMID: 6284039.
      View in: PubMed
    36. Epstein PM, Fiss K, Hachisu R, Andrenyak DM. Interaction of calcium antagonists with cyclic AMP phosphodiesterases and calmodulin. Biochem Biophys Res Commun. 1982 Apr 14; 105(3):1142-9. PMID: 6284165.
      View in: PubMed
    37. Strada SJ, Epstein PM, Gardner EA, Thompson WJ, Stancel GM. Evidence for convertible forms of soluble uterine cyclic nucleotide phosphodiesterase. Biochim Biophys Acta. 1981 Sep 15; 661(1):12-20. PMID: 6271215.
      View in: PubMed
    38. Cheng KC, Lambert JJ, Henderson EG, Smilowitz H, Epstein PM. Postsynaptic inhibition of neuromuscular transmission by trifluoperazine. J Pharmacol Exp Ther. 1981 Apr; 217(1):44-50. PMID: 6259329.
      View in: PubMed
    39. Volpi M, Sha'afi RI, Epstein PM, Andrenyak DM, Feinstein MB. Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):795-9. PMID: 6262771; PMCID: PMC319889.
    40. Lewinski UH, Mavligit GM, Epstein PM, Hersh EM, Ortez RA, Thompson WJ. Cyclic nucleotide alterations in mixed leukocyte reaction: a preliminary report. Biomedicine. 1980 Nov; 33(7):217-9. PMID: 6261846.
      View in: PubMed
    41. Biegon RL, Epstein PM, Pappano AJ. Muscarinic antagonism of the effects of phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle. J Pharmacol Exp Ther. 1980 Nov; 215(2):348-56. PMID: 6160237.
      View in: PubMed
    42. Epstein PM, Mills JS, Hersh EM, Strada SJ, Thompson WJ. Activation of cyclic nucleotide phosphodiesterase from isolated human peripheral blood lymphocytes by mitogenic agents. Cancer Res. 1980 Feb; 40(2):379-86. PMID: 6243252.
      View in: PubMed
    43. Thompson WJ, Ross CP, Hersh EM, Epstein PM, Strada SJ. Activation of human lymphocyte high affinity cyclic AMP phosphodiesterase by culture with 1-methyl-3-isobutylxanthine. J Cyclic Nucleotide Res. 1980; 6(1):25-36. PMID: 6155390.
      View in: PubMed
    44. Volpi M, Sha'afi RI, Epstein PM, Andrenyak D, Feinstein MB. Antagonism of calmodulin by local anesthetics, mepacrine, and propranolol. Ann N Y Acad Sci. 1980; 356:441-2. PMID: 6263163.
      View in: PubMed
    45. Thompson WJ, Epstein PM, Strada SJ. Purification and characterization of high-affinity cyclic adenosine monophosphate phosphodiesterase from dog kidney. Biochemistry. 1979 Nov 13; 18(23):5228-37. PMID: 227451.
      View in: PubMed
    46. Pledger WJ, Thompson WJ, Epstein PM, Strada SJ. Regulation of cyclic nucleotide phosphodiesterase forms by serum and insulin in cultured fibroblasts. J Cell Physiol. 1979 Sep; 100(3):497-507. PMID: 226555.
      View in: PubMed
    47. Pledger WJ, Gardner RM, Epstein PM, Thompson WJ, Strada SJ, Wlodyka L. Cell cycle traverse and macromolecular synthesis in BHK fibroblasts as affected by insulin. Exp Cell Res. 1979 Feb; 118(2):389-95. PMID: 216563.
      View in: PubMed
    48. Thompson WJ, Terasaki WL, Epstein PM, Strada SJ. Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme. Adv Cyclic Nucleotide Res. 1979; 10:69-92. PMID: 222125.
      View in: PubMed
    49. Epstein PM, Pledger WJ, Gardner EA, Stancel GM, Thompson WJ, Strada SJ. Activation of mammalian cyclic AMP phosphodiesterases by trypsin. Biochim Biophys Acta. 1978 Dec 8; 527(2):442-55. PMID: 215213.
      View in: PubMed
    50. Epstein PM, Silverman PM. Induction of cyclic AMP phosphodiesterase in Blastocladiella emersonii and its relation to cyclic AMP metabolism. J Bacteriol. 1978 Sep; 135(3):968-75. PMID: 211117; PMCID: PMC222471.
    51. Epstein PM, Mills JS, Ross CP, Strada SJ, Hersh EM, Thompson WJ. Increased cyclic nucleotide phosphodiesterase activity associated with proliferation and cancer in human and murine lymphoid cells. Cancer Res. 1977 Nov; 37(11):4016-23. PMID: 198126.
      View in: PubMed
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