Keywords
Last Name
Institution

Guo-Hua Fong PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentCell Biology
AddressMC 3501
MC 3501
263 Farmington Avenue
Phone860-679-2373
Fax860-679-1201
vCardDownload vCard
    Other Positions
    TitleAssociate Professor
    InstitutionUConn Health Center
    DepartmentCell Biology
    DivisionCenter for Vascular Biology


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest. 2016 May 2; 126(5):1926-38. PMID: 27088801.
      View in: PubMed
    2. Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016 Mar 2; 8(328):328ra29. PMID: 26936506.
      View in: PubMed
    3. Chen Y, Zhang HS, Fong GH, Xi QL, Wu GH, Bai CG, Ling ZQ, Fan L, Xu YM, Qin YQ, Yuan TL, Sun H, Fang J. PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function. J Biol Chem. 2015 Aug 14; 290(33):20580-9. PMID: 26124271; PMCID: PMC4536461 [Available on 08/14/16].
    4. Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N. Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. J Am Soc Nephrol. 2016 Feb; 27(2):428-38. PMID: 26054543.
      View in: PubMed
    5. Fong GH. Potential contributions of intimal and plaque hypoxia to atherosclerosis. Curr Atheroscler Rep. 2015 Jun; 17(6):510. PMID: 25876920.
      View in: PubMed
    6. Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N. Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. Mol Cell Biol. 2015 Aug; 35(15):2658-72. PMID: 26012551; PMCID: PMC4524113 [Available on 02/01/16].
    7. Ho VC, Fong GH. Vasculogenesis and Angiogenesis in VEGF Receptor-1 Deficient Mice. Methods Mol Biol. 2015; 1332:161-76. PMID: 26285753; PMCID: PMC4544766.
    8. Rishi MT, Selvaraju V, Thirunavukkarasu M, Shaikh IA, Takeda K, Fong GH, Palesty JA, Sanchez JA, Maulik N. Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia. Microvasc Res. 2015 Jan; 97:181-8. PMID: 25446011.
      View in: PubMed
    9. Rahman MM, Ghosh M, Subramani J, Fong GH, Carlson ME, Shapiro LH. CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury. Stem Cells. 2014 Jun; 32(6):1564-77. PMID: 24307555; PMCID: PMC4037355.
    10. Duan LJ, Takeda K, Fong GH. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014 Apr; 184(4):1240-50. PMID: 24508125; PMCID: PMC3970000.
    11. Duan LJ, Takeda K, Fong GH. Hypoxia inducible factor-2a regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS One. 2014; 9(1):e84736. PMID: 24475033; PMCID: PMC3903483.
    12. Takeda K, Duan LJ, Takeda H, Fong GH. Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism. Am J Pathol. 2014 Mar; 184(3):686-96. PMID: 24440788; PMCID: PMC3936330.
    13. Rahman MM, Subramani J, Ghosh M, Denninger JK, Takeda K, Fong GH, Carlson ME, Shapiro LH. CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle. Front Physiol. 2014; 4:402. PMID: 24409152; PMCID: PMC3885827.
    14. Oriowo B, Thirunavukkarasu M, Selvaraju V, Adluri RS, Zhan L, Takeda K, Fong GH, Sanchez JA, Maulik N. Targeted gene deletion of prolyl hydroxylase domain protein 3 triggers angiogenesis and preserves cardiac function by stabilizing hypoxia inducible factor 1 alpha following myocardial infarction. Curr Pharm Des. 2014; 20(9):1305-10. PMID: 23978105.
      View in: PubMed
    15. Ikeda J, Ichiki T, Matsuura H, Inoue E, Kishimoto J, Watanabe A, Sankoda C, Kitamoto S, Tokunou T, Takeda K, Fong GH, Sunagawa K. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc. 2013 Jun; 2(3):e000178. PMID: 23778187; PMCID: PMC3698781.
    16. Criscimanna A, Duan LJ, Rhodes JA, Fendrich V, Wickline E, Hartman DJ, Monga SP, Lotze MT, Gittes GK, Fong GH, Esni F. PanIN-specific regulation of Wnt signaling by HIF2a during early pancreatic tumorigenesis. Cancer Res. 2013 Aug 1; 73(15):4781-90. PMID: 23749643; PMCID: PMC3736839.
    17. Matsuura H, Ichiki T, Inoue E, Nomura M, Miyazaki R, Hashimoto T, Ikeda J, Takayanagi R, Fong GH, Sunagawa K. Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance. Circulation. 2013 May 28; 127(21):2078-87. PMID: 23630130.
      View in: PubMed
    18. Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1a and upregulation of peroxisome proliferator-activated receptor-a. Circ Res. 2013 Apr 12; 112(8):1135-49. PMID: 23476056; PMCID: PMC3871171.
    19. Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B. HIF-1a is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2a-induced excessive erythropoiesis. Blood. 2013 Feb 21; 121(8):1436-45. PMID: 23264599; PMCID: PMC3628111.
    20. Grant CL, Caromile LA, Ho V, Durrani K, Rahman MM, Claffey KP, Fong GH, Shapiro LH. Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization. PLoS One. 2012; 7(7):e41285. PMID: 22815987; PMCID: PMC3399825.
    21. Xie L, Pi X, Mishra A, Fong G, Peng J, Patterson C. PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest. 2012 Aug; 122(8):2827-36. PMID: 22797300; PMCID: PMC3408739.
    22. Ho VC, Duan LJ, Cronin C, Liang BT, Fong GH. Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice. Circulation. 2012 Aug 7; 126(6):741-52. PMID: 22753193; PMCID: PMC3442373.
    23. Adluri RS, Thirunavukkarasu M, Dunna NR, Zhan L, Oriowo B, Takeda K, Sanchez JA, Otani H, Maulik G, Fong GH, Maulik N. Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1a transcription factor and its target genes in mice. Antioxid Redox Signal. 2011 Oct 1; 15(7):1789-97. PMID: 21083501; PMCID: PMC3159109.
    24. Duan LJ, Takeda K, Fong GH. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am J Pathol. 2011 Apr; 178(4):1881-90. PMID: 21435465; PMCID: PMC3078463.
    25. Verma M, Asakura Y, Hirai H, Watanabe S, Tastad C, Fong GH, Ema M, Call JA, Lowe DA, Asakura A. Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice. Hum Mol Genet. 2010 Nov 1; 19(21):4145-59. PMID: 20705734; PMCID: PMC2951865.
    26. Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F. Impaired pancreatic development in Hif2-alpha deficient mice. Biochem Biophys Res Commun. 2010 Aug 27; 399(3):440-5. PMID: 20678473.
      View in: PubMed
    27. Li X, Sutherland S, Takeda K, Fong GH, Lee FS. Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice. Blood Cells Mol Dis. 2010 Jun 15; 45(1):9-19. PMID: 20400342; PMCID: PMC2878925.
    28. Roszell B, Mondrinos MJ, Seaton A, Simons DM, Koutzaki SH, Fong GH, Lelkes PI, Finck CM. Efficient derivation of alveolar type II cells from embryonic stem cells for in vivo application. Tissue Eng Part A. 2009 Nov; 15(11):3351-65. PMID: 19388834; PMCID: PMC2811058.
    29. Roszell B, Seaton A, Fong GH, Finck CM. Cell-based therapy improves cell viability and increases airway size in an explant model. Exp Lung Res. 2009 Aug; 35(6):501-13. PMID: 19842834.
      View in: PubMed
    30. Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal. 2009; 2(78):ra33. PMID: 19584355; PMCID: PMC2788937.
    31. Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6152-7. PMID: 19369214; PMCID: PMC2669337.
    32. Fong GH. Regulation of angiogenesis by oxygen sensing mechanisms. J Mol Med (Berl). 2009 Jun; 87(6):549-60. PMID: 19288062.
      View in: PubMed
    33. Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I. Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res. 2008 Aug 1; 103(3):261-8. PMID: 18583712.
      View in: PubMed
    34. Fong GH. Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis. 2008; 11(2):121-40. PMID: 18327686.
      View in: PubMed
    35. Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X. VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest. 2008 Mar; 118(3):913-23. PMID: 18259607; PMCID: PMC2230661.
    36. Fong GH, Takeda K. Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ. 2008 Apr; 15(4):635-41. PMID: 18259202.
      View in: PubMed
    37. Murakami M, Zheng Y, Hirashima M, Suda T, Morita Y, Ooehara J, Ema H, Fong GH, Shibuya M. VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):658-64. PMID: 18174461.
      View in: PubMed
    38. Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood. 2008 Mar 15; 111(6):3229-35. PMID: 18056838; PMCID: PMC2265459.
    39. Takeda K, Cowan A, Fong GH. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007 Aug 14; 116(7):774-81. PMID: 17646578.
      View in: PubMed
    40. Takeda K, Fong GH. Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation. Hypertension. 2007 Jan; 49(1):178-84. PMID: 17101841.
      View in: PubMed
    41. Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol. 2006 Nov; 26(22):8336-46. PMID: 16966370; PMCID: PMC1636770.
    42. Duan LJ, Zhang-Benoit Y, Fong GH. Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation. 2005 May 3; 111(17):2227-32. PMID: 15851592.
      View in: PubMed
    43. Jones DH, Li TY, Arystarkhova E, Barr KJ, Wetzel RK, Peng J, Markham K, Sweadner KJ, Fong GH, Kidder GM. Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13; 280(19):19003-11. PMID: 15755730.
      View in: PubMed
    44. Duan W, Gabril MY, Moussa M, Chan FL, Sakai H, Fong G, Xuan JW. Knockin of SV40 Tag oncogene in a mouse adenocarcinoma of the prostate model demonstrates advantageous features over the transgenic model. Oncogene. 2005 Feb 24; 24(9):1510-24. PMID: 15674347.
      View in: PubMed
    45. Lelievre E, Bourbon PM, Duan LJ, Nussbaum RL, Fong GH. Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice. Blood. 2005 May 15; 105(10):3935-8. PMID: 15687236; PMCID: PMC1895075.
    46. Addya S, Shiroto K, Turoczi T, Zhan L, Kaga S, Fukuda S, Surrey S, Duan LJ, Fong GH, Yamamoto F, Maulik N. Ischemic preconditioning-mediated cardioprotection is disrupted in heterozygous Flt-1 (VEGFR-1) knockout mice. J Mol Cell Cardiol. 2005 Feb; 38(2):345-51. PMID: 15698841.
      View in: PubMed
    47. Duan LJ, Imamoto A, Fong GH. Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization. Blood. 2004 Feb 15; 103(4):1370-2. PMID: 14576066.
      View in: PubMed
    48. Duan LJ, Nagy A, Fong GH. Gastrulation and angiogenesis, not endothelial specification, is sensitive to partial deficiency in vascular endothelial growth factor-a in mice. Biol Reprod. 2003 Dec; 69(6):1852-8. PMID: 12890722.
      View in: PubMed
    49. Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):117-23. PMID: 12506063.
      View in: PubMed
    50. Onita T, Ji PG, Xuan JW, Sakai H, Kanetake H, Maxwell PH, Fong GH, Gabril MY, Moussa M, Chin JL. Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer. Clin Cancer Res. 2002 Feb; 8(2):471-80. PMID: 11839666.
      View in: PubMed
    51. Peng J, Zhang L, Drysdale L, Fong GH. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8386-91. PMID: 10880563; PMCID: PMC26957.
    52. Fong GH, Zhang L, Bryce DM, Peng J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development. 1999 Jul; 126(13):3015-25. PMID: 10357944.
      View in: PubMed
    53. Fong GH, Klingensmith J, Wood CR, Rossant J, Breitman ML. Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. Dev Dyn. 1996 Sep; 207(1):1-10. PMID: 8875071.
      View in: PubMed
    54. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995 Jul 6; 376(6535):66-70. PMID: 7596436.
      View in: PubMed
    Fong's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _