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Hector L Aguila PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentImmunology
AddressMC 3710
MC 3710
263 Farmington Avenue
Phone860-679-7658
Fax860-679-1265
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Choudhary S, Goetjen A, Estus T, Jacome-Galarza CE, Aguila HL, Lorenzo J, Pilbeam C. Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts. J Biol Chem. 2016 Feb 19; 291(8):3882-94. PMID: 26703472.
      View in: PubMed
    2. Mathias CB, Guernsey LA, Zammit D, Brammer C, Wu CA, Thrall RS, Aguila HL. Pro-inflammatory role of natural killer cells in the development of allergic airway disease. Clin Exp Allergy. 2014 Apr; 44(4):589-601. PMID: 24397722; PMCID: PMC3985123.
    3. Hammond MD, Taylor RA, Mullen MT, Ai Y, Aguila HL, Mack M, Kasner SE, McCullough LD, Sansing LH. CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci. 2014 Mar 12; 34(11):3901-9. PMID: 24623768; PMCID: PMC3951693.
    4. Shoji KF, Sáez PJ, Harcha PA, Aguila HL, Sáez JC. Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin). 2014; 8(2):142-56. PMID: 24590064; PMCID: PMC4048303.
    5. Zanotti S, Kalajzic I, Aguila HL, Canalis E. Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells. PLoS One. 2014; 9(1):e86757. PMID: 24489784; PMCID: PMC3904935.
    6. Kuhn LT, Liu Y, Boyd NL, Dennis JE, Jiang X, Xin X, Charles LF, Wang L, Aguila HL, Rowe DW, Lichtler AC, Goldberg AJ. Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells. Tissue Eng Part A. 2014 Jan; 20(1-2):365-77. PMID: 23952622; PMCID: PMC4350005.
    7. Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol. 2013 Sep 15; 191(6):3017-24. PMID: 23966624; PMCID: PMC3896262.
    8. Jacome-Galarza CE, Lee SK, Lorenzo JA, Aguila HL. Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res. 2013 May; 28(5):1203-13. PMID: 23165930; PMCID: PMC3625454.
    9. Mun SH, Won HY, Hernandez P, Aguila HL, Lee SK. Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass. J Bone Miner Res. 2013 Apr; 28(4):948-59. PMID: 23044992; PMCID: PMC3563845.
    10. Cvija H, Kovacic N, Katavic V, Ivcevic S, Aguila HL, Marusic A, Grcevic D. Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes. Inflammation. 2012 Oct; 35(5):1618-31. PMID: 22699680.
      View in: PubMed
    11. Aguila HL, Mun SH, Kalinowski J, Adams DJ, Lorenzo JA, Lee SK. Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7-deficient female mice. J Bone Miner Res. 2012 May; 27(5):1030-42. PMID: 22258693; PMCID: PMC3361560.
    12. Grcevic D, Pejda S, Matthews BG, Repic D, Wang L, Li H, Kronenberg MS, Jiang X, Maye P, Adams DJ, Rowe DW, Aguila HL, Kalajzic I. In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells. 2012 Feb; 30(2):187-96. PMID: 22083974; PMCID: PMC3560295.
    13. Ohishi M, Ono W, Ono N, Khatri R, Marzia M, Baker EK, Root SH, Wilson TL, Iwamoto Y, Kronenberg HM, Aguila HL, Purton LE, Schipani E. A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis. Am J Pathol. 2012 Feb; 180(2):811-8. PMID: 22155108; PMCID: PMC3349873.
    14. Jacome-Galarza CE, Lee SK, Lorenzo JA, Aguila HL. Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow. J Bone Miner Res. 2011 Jun; 26(6):1207-16. PMID: 21611963; PMCID: PMC3312755.
    15. Chen IP, Wang L, Jiang X, Aguila HL, Reichenberger EJ. A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD). Hum Mol Genet. 2011 Mar 1; 20(5):948-61. PMID: 21149338; PMCID: PMC3033186.
    16. Balic A, Aguila HL, Mina M. Identification of cells at early and late stages of polarization during odontoblast differentiation using pOBCol3.6GFP and pOBCol2.3GFP transgenic mice. Bone. 2010 Nov; 47(5):948-58. PMID: 20728593; PMCID: PMC2957651.
    17. Aguila HL. Hematopoietic niches: targets of GVHD. Blood. 2010 Jul 1; 115(26):5284-5. PMID: 20595520.
      View in: PubMed
    18. Winnicka B, O'Conor C, Schacke W, Vernier K, Grant CL, Fenteany FH, Pereira FE, Liang B, Kaur A, Zhao R, Montrose DC, Rosenberg DW, Aguila HL, Shapiro LH. CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse. J Leukoc Biol. 2010 Aug; 88(2):347-59. PMID: 20430777; PMCID: PMC2908940.
    19. Balic A, Aguila HL, Caimano MJ, Francone VP, Mina M. Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars. Bone. 2010 Jun; 46(6):1639-51. PMID: 20193787; PMCID: PMC2881695.
    20. Staron M, Yang Y, Liu B, Li J, Shen Y, Zúñiga-Pflücker JC, Aguila HL, Goldschneider I, Li Z. gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood. 2010 Mar 25; 115(12):2380-90. PMID: 19965672; PMCID: PMC2845896.
    21. Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. 2009 Dec; 119(12):3530-43. PMID: 19884656; PMCID: PMC2786787.
    22. Jacquin C, Koczon-Jaremko B, Aguila HL, Leng L, Bucala R, Kuchel GA, Lee SK. Macrophage migration inhibitory factor inhibits osteoclastogenesis. Bone. 2009 Oct; 45(4):640-9. PMID: 19591967.
      View in: PubMed
    23. San Miguel SM, Fatahi MR, Li H, Igwe JC, Aguila HL, Kalajzic I. Defining a visual marker of osteoprogenitor cells within the periodontium. J Periodontal Res. 2010 Feb; 45(1):60-70. PMID: 19453851; PMCID: PMC2871067.
    24. Bandyopadhyay S, Long M, Qui HZ, Hagymasi AT, Slaiby AM, Mihalyo MA, Aguila HL, Mittler RS, Vella AT, Adler AJ. Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. J Immunol. 2008 Dec 1; 181(11):7728-37. PMID: 19017962; PMCID: PMC2846364.
    25. Kalajzic Z, Li H, Wang LP, Jiang X, Lamothe K, Adams DJ, Aguila HL, Rowe DW, Kalajzic I. Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population. Bone. 2008 Sep; 43(3):501-10. PMID: 18571490; PMCID: PMC2614133.
    26. Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood. 2008 Mar 15; 111(6):3229-35. PMID: 18056838; PMCID: PMC2265459.
    27. Kalajzic I, Kalajzic Z, Wang L, Jiang X, Lamothe K, San Miguel SM, Aguila HL, Rowe DW. Pericyte/myofibroblast phenotype of osteoprogenitor cell. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):320-2. PMID: 18094492.
      View in: PubMed
    28. Taxel P, Kaneko H, Lee SK, Aguila HL, Raisz LG, Lorenzo JA. Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study. Osteoporos Int. 2008 Feb; 19(2):193-9. PMID: 17768586.
      View in: PubMed
    29. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006 Nov; 21(11):1704-12. PMID: 17002560.
      View in: PubMed
    30. Boban I, Jacquin C, Prior K, Barisic-Dujmovic T, Maye P, Clark SH, Aguila HL. The 3.6 kb DNA fragment from the rat Col1a1 gene promoter drives the expression of genes in both osteoblast and osteoclast lineage cells. Bone. 2006 Dec; 39(6):1302-12. PMID: 16938497.
      View in: PubMed
    31. Maxwell JR, Yadav R, Rossi RJ, Ruby CE, Weinberg AD, Aguila HL, Vella AT. IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. J Immunol. 2006 Jul 1; 177(1):234-45. PMID: 16785519.
      View in: PubMed
    32. Aguila HL. Regulation of hematopoietic niches by sympathetic innervation. Bioessays. 2006 Jul; 28(7):687-91. PMID: 16850400.
      View in: PubMed
    33. Aguila HL, Rowe DW. Skeletal development, bone remodeling, and hematopoiesis. Immunol Rev. 2005 Dec; 208:7-18. PMID: 16313337.
      View in: PubMed
    34. Jacquin C, Gran DE, Lee SK, Lorenzo JA, Aguila HL. Identification of multiple osteoclast precursor populations in murine bone marrow. J Bone Miner Res. 2006 Jan; 21(1):67-77. PMID: 16355275.
      View in: PubMed
    35. Schluns KS, Nowak EC, Cabrera-Hernandez A, Puddington L, Lefrançois L, Aguila HL. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5616-21. PMID: 15060278; PMCID: PMC397446.
    36. Visnjic D, Kalajzic Z, Rowe DW, Katavic V, Lorenzo J, Aguila HL. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood. 2004 May 1; 103(9):3258-64. PMID: 14726388.
      View in: PubMed
    37. Katavic V, Grcevic D, Lee SK, Kalinowski J, Jastrzebski S, Dougall W, Anderson D, Puddington L, Aguila HL, Lorenzo JA. The surface antigen CD45R identifies a population of estrogen-regulated murine marrow cells that contain osteoclast precursors. Bone. 2003 Jun; 32(6):581-90. PMID: 12810165.
      View in: PubMed
    38. Cooper MA, Bush JE, Fehniger TA, VanDeusen JB, Waite RE, Liu Y, Aguila HL, Caligiuri MA. In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. Blood. 2002 Nov 15; 100(10):3633-8. PMID: 12393617.
      View in: PubMed
    39. Visnjic D, Kalajzic I, Gronowicz G, Aguila HL, Clark SH, Lichtler AC, Rowe DW. Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice. J Bone Miner Res. 2001 Dec; 16(12):2222-31. PMID: 11760835.
      View in: PubMed
    40. Kim S, Iizuka K, Aguila HL, Weissman IL, Yokoyama WM. In vivo natural killer cell activities revealed by natural killer cell-deficient mice. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2731-6. PMID: 10694580; PMCID: PMC15998.
    41. Gandy KL, Domen J, Aguila H, Weissman IL. CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity. 1999 Nov; 11(5):579-90. PMID: 10591183.
      View in: PubMed
    42. Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL. From stem cells to lymphocytes: biology and transplantation. Immunol Rev. 1997 Jun; 157:13-40. PMID: 9255619.
      View in: PubMed
    43. Aguila HL, Weissman IL. Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells. Blood. 1996 Feb 15; 87(4):1225-31. PMID: 8608208.
      View in: PubMed
    44. Aguila HL, Hershberger RJ, Weissman IL. Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10192-6. PMID: 7479752; PMCID: PMC40762.
    45. Uchida N, Aguila HL, Fleming WH, Jerabek L, Weissman IL. Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells. Blood. 1994 Jun 15; 83(12):3758-79. PMID: 7911343.
      View in: PubMed
    46. French DL, Pollock RR, Aguila HL, Scharff MD. The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding. J Immunol. 1991 Mar 15; 146(6):2010-6. PMID: 1672339.
      View in: PubMed
    47. De Ioannes AE, Aguila HL. Amino terminal sequence of heavy and light chains from ratfish immunoglobulin. Immunogenetics. 1989; 30(3):175-80. PMID: 2506127.
      View in: PubMed
    48. Spira G, Aguila HL, Scharff MD. T15 PC-binding monoclonal antibodies retain specificity when they switch from IgM to IgG. J Immunol. 1988 Apr 15; 140(8):2675-80. PMID: 3128603.
      View in: PubMed
    49. Scharff MD, Aguila HL, Behar SM, Chien NC, DePinho R, French DL, Pollock RR, Shin SU. Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells. Immunol Rev. 1987 Apr; 96:75-90. PMID: 3298011.
      View in: PubMed
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