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Last Name
Institution

Charles Giardina PhD

TitleAssociate Professor
InstitutionUniversity of Connecticut
DepartmentMolecular and Cell Biology
AddressUNIT 3125
Bio/Physics Building, UNIT 3125
91 North Eagleville Road
Phone860-486-0484
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One. 2016; 11(4):e0153818. PMID: 27097159.
      View in: PubMed
    2. Giardina C, Nakanishi M, Khan A, Kuratnik A, Xu W, Brenner B, Rosenberg DW. Regulation of VDR Expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. Cancer Prev Res (Phila). 2015 May; 8(5):387-99. PMID: 25873367; PMCID: PMC4417398 [Available on 05/01/16].
    3. Verma R, Chopra A, Giardina C, Sabbisetti V, Smyth JA, Hightower LE, Perdrizet GA. Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice. Cell Stress Chaperones. 2015 May; 20(3):495-505. PMID: 25648080; PMCID: PMC4406928.
    4. Wright KT, Giardina C, Vella AT. Therapeutic targeting of the inflammome. Biochem Pharmacol. 2014 Nov 15; 92(2):184-91. PMID: 25204592.
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    5. Ononye SN, Vanheyst MD, Giardina C, Wright DL, Anderson AC. Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells. Bioorg Med Chem. 2014 Apr 1; 22(7):2188-93. PMID: 24613456; PMCID: PMC4011186.
    6. Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31; 289(5):2978-91. PMID: 24338023; PMCID: PMC3908429.
    7. Cao L, Kuratnik A, Xu W, Gibson JD, Kolling F, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C. Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation. Mol Carcinog. 2015 Mar; 54(3):189-202. PMID: 24115167.
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    8. Kuratnik A, Giardina C. Intestinal organoids as tissue surrogates for toxicological and pharmacological studies. Biochem Pharmacol. 2013 Jun 15; 85(12):1721-6. PMID: 23623789.
      View in: PubMed
    9. Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina C. Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands. Cancer Biol Ther. 2013 May; 14(5):436-49. PMID: 23377828; PMCID: PMC3672188.
    10. Dai B, Giardina C, Rasmussen TP. Quantitation of nucleosome acetylation and other histone posttranslational modifications using microscale NU-ELISA. Methods Mol Biol. 2013; 981:167-76. PMID: 23381861.
      View in: PubMed
    11. Fuller AM, Giardina C, Hightower LE, Perdrizet GA, Tierney CA. Hyperbaric oxygen preconditioning protects skin from UV-A damage. Cell Stress Chaperones. 2013 Jan; 18(1):97-107. PMID: 22855227; PMCID: PMC3508122.
    12. Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina C. Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol. 2012 May 1; 83(9):1217-28. PMID: 22306067; PMCID: PMC3299870.
    13. Giardina C, Madigan JP, Tierney CA, Brenner BM, Rosenberg DW. Vitamin D resistance and colon cancer prevention. Carcinogenesis. 2012 Mar; 33(3):475-82. PMID: 22180570; PMCID: PMC3384070.
    14. Park HJ, Lee JY, Chung MY, Park YK, Bower AM, Koo SI, Giardina C, Bruno RS. Green tea extract suppresses NF?B activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. J Nutr. 2012 Jan; 142(1):57-63. PMID: 22157544.
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    15. Rigatti MJ, Verma R, Belinsky GS, Rosenberg DW, Giardina C. Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Mol Carcinog. 2012 May; 51(5):363-78. PMID: 21557332; PMCID: PMC3162984.
    16. Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW. Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis. 2011 Mar; 32(3):343-50. PMID: 21098643; PMCID: PMC3047236.
    17. Ju J, Naura AS, Errami Y, Zerfaoui M, Kim H, Kim JG, Abd Elmageed ZY, Abdel-Mageed AB, Giardina C, Beg AA, Smulson ME, Boulares AH. Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment. J Biol Chem. 2010 Dec 24; 285(52):41152-60. PMID: 20966071; PMCID: PMC3003413.
    18. Cao L, Gibson JD, Miyamoto S, Sail V, Verma R, Rosenberg DW, Nelson CE, Giardina C. Intestinal lineage commitment of embryonic stem cells. Differentiation. 2011 Jan; 81(1):1-10. PMID: 20934799.
      View in: PubMed
    19. Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE. Hyperbaric oxygen treatment induces antioxidant gene expression. Ann N Y Acad Sci. 2010 Jun; 1197:178-83. PMID: 20536847.
      View in: PubMed
    20. Verma R, Rigatti MJ, Belinsky GS, Godman CA, Giardina C. DNA damage response to the Mdm2 inhibitor nutlin-3. Biochem Pharmacol. 2010 Feb 15; 79(4):565-74. PMID: 19788889; PMCID: PMC2794967.
    21. Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, Giardina C. Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells. Cell Stress Chaperones. 2010 Jul; 15(4):431-42. PMID: 19949909; PMCID: PMC3082642.
    22. Hosseini-khalili A, Haines DD, Modirian E, Soroush M, Khateri S, Joshi R, Zendehdel K, Ghanei M, Giardina C. Mustard gas exposure and carcinogenesis of lung. Mutat Res. 2009 Aug; 678(1):1-6. PMID: 19559099; PMCID: PMC2811761.
    23. Rosenberg DW, Giardina C, Tanaka T. Mouse models for the study of colon carcinogenesis. Carcinogenesis. 2009 Feb; 30(2):183-96. PMID: 19037092; PMCID: PMC2639048.
    24. Godman CA, Joshi R, Tierney BR, Greenspan E, Rasmussen TP, Wang HW, Shin DG, Rosenberg DW, Giardina C. HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther. 2008 Oct; 7(10):1570-80. PMID: 18769117; PMCID: PMC2614677.
    25. Stevens RG, Pretlow TP, Hurlstone DP, Giardina C, Rosenberg DW. Comment re: "Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention" and "Aberrant crypt foci in the adenoma prevention with celecoxib trial". Cancer Prev Res (Phila). 2008 Aug; 1(3):215-6; author reply 216. PMID: 19138959.
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    26. Noonan E, Giardina C, Hightower L. Hsp70B' and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection. Exp Cell Res. 2008 Aug 1; 314(13):2468-76. PMID: 18579131.
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    27. Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C. HDAC3 overexpression and colon cancer cell proliferation and differentiation. Mol Carcinog. 2008 Feb; 47(2):137-47. PMID: 17849419.
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    28. Spurling CC, Suhl JA, Boucher N, Nelson CE, Rosenberg DW, Giardina C. The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells. Nutr Cancer. 2008; 60(5):692-702. PMID: 18791934.
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    29. Nakanishi M, Ménoret A, Belinsky GS, Giardina C, Godman CA, Vella AT, Rosenberg DW. Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention. Proteomics Clin Appl. 2007 Dec; 1(12):1660-6. PMID: 21136663.
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    30. Belinsky GS, Rajan TV, Saria EA, Giardina C, Rosenberg DW. Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth. Mol Carcinog. 2007 Feb; 46(2):106-16. PMID: 17091473.
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    31. Noonan EJ, Place RF, Giardina C, Hightower LE. Hsp70B' regulation and function. Cell Stress Chaperones. 2007; 12(4):393-402. PMID: 18229458; PMCID: PMC2134801.
    32. Noonan EJ, Place RF, Giardina C, Hightower LE. Hsp70B' regulation and function. Cell Stress Chaperones. 2007; 12(3):219-29. PMID: 17915554; PMCID: PMC1971232.
    33. Ghanei M, Amiri S, Akbari H, Kosari F, Khalili AR, Alaeddini F, Aslani J, Giardina C, Haines DD. Correlation of sulfur mustard exposure and tobacco use with expression (immunoreactivity) of p53 protein in bronchial epithelium of Iranian "mustard lung" patients. Mil Med. 2007 Jan; 172(1):70-4. PMID: 17274270.
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    34. Noonan EJ, Place RF, Rasoulpour RJ, Giardina C, Hightower LE. Cell number-dependent regulation of Hsp70B' expression: evidence of an extracellular regulator. J Cell Physiol. 2007 Jan; 210(1):201-11. PMID: 17044073.
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    35. Stevens RG, Swede H, Heinen CD, Jablonski M, Grupka M, Ross B, Parente M, Tirnauer JS, Giardina C, Rajan TV, Rosenberg DW, Levine J. Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Lett. 2007 Apr 18; 248(2):262-8. PMID: 16950561.
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    36. Aizu W, Belinsky GS, Flynn C, Noonan EJ, Boes CC, Godman CA, Doshi B, Nambiar PR, Rosenberg DW, Giardina C. Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. Biochem Pharmacol. 2006 Oct 16; 72(8):981-91. PMID: 16949053.
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    37. Place RF, Noonan EJ, Giardina C. HDACs and the senescent phenotype of WI-38 cells. BMC Cell Biol. 2005; 6:37. PMID: 16250917; PMCID: PMC1285358.
    38. Place RF, Noonan EJ, Giardina C. HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. Biochem Pharmacol. 2005 Aug 1; 70(3):394-406. PMID: 15950952.
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    39. Dong M, Johnson M, Rezaie A, Ilsley JN, Nakanishi M, Sanders MM, Forouhar F, Levine J, Montrose DC, Giardina C, Rosenberg DW. Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. Clin Cancer Res. 2005 Mar 15; 11(6):2265-71. PMID: 15788676.
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    40. Tong X, Yin L, Joshi S, Rosenberg DW, Giardina C. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. J Biol Chem. 2005 Apr 22; 280(16):15503-9. PMID: 15713675.
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    41. Tong X, Yin L, Washington R, Rosenberg DW, Giardina C. The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation. Mol Cell Biochem. 2004 Oct; 265(1-2):171-83. PMID: 15543947.
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    42. Dong M, Guda K, Nambiar PR, Nakanishi M, Lichtler AC, Nishikawa M, Giardina C, Rosenberg DW. Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells. Carcinogenesis. 2004 Nov; 25(11):2239-46. PMID: 15297369.
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    43. Tong X, Yin L, Giardina C. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. Biochem Biophys Res Commun. 2004 Apr 30; 317(2):463-71. PMID: 15063780.
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    44. Thibodeau MS, Giardina C, Knecht DA, Helble J, Hubbard AK. Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. Toxicol Sci. 2004 Jul; 80(1):34-48. PMID: 15056807.
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    45. Aizu W, Guda K, Nambiar P, Xin T, Thibodeau M, Rosenberg DW, Giardina C. p53 and its co-activator p300 are inversely regulated in the mouse colon in response to carcinogen. Toxicol Lett. 2003 Sep 30; 144(2):213-24. PMID: 12927365.
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    46. Thibodeau M, Giardina C, Hubbard AK. Silica-induced caspase activation in mouse alveolar macrophages is dependent upon mitochondrial integrity and aspartic proteolysis. Toxicol Sci. 2003 Nov; 76(1):91-101. PMID: 12857937.
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    47. Place RF, Haspeslagh D, Giardina C. Induced stabilization of IkappaBalpha can facilitate its re-synthesis and prevent sequential degradation. J Cell Physiol. 2003 Jun; 195(3):470-8. PMID: 12704657.
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    48. Dong M, Guda K, Nambiar PR, Rezaie A, Belinsky GS, Lambeau G, Giardina C, Rosenberg DW. Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis. Carcinogenesis. 2003 Feb; 24(2):307-15. PMID: 12584182.
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    49. Nambiar PR, Giardina C, Guda K, Aizu W, Raja R, Rosenberg DW. Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model. Cancer Res. 2002 Jul 1; 62(13):3667-74. PMID: 12097273.
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    50. Giardina C, Hubbard AK. Growing old with nuclear factor-kappaB. Cell Stress Chaperones. 2002 Apr; 7(2):207-12. PMID: 12380689; PMCID: PMC514819.
    51. Brown JD, Strbuncelj M, Giardina C, O'Neill RJ. Interspecific hybridization induced amplification of Mdm2 on double minutes in a Mus hybrid. Cytogenet Genome Res. 2002; 98(2-3):184-8. PMID: 12698001.
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    52. Yin L, Laevsky G, Giardina C. Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity. J Biol Chem. 2001 Nov 30; 276(48):44641-6. PMID: 11572859.
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    53. Guda K, Giardina C, Nambiar P, Cui H, Rosenberg DW. Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. Mol Carcinog. 2001 Aug; 31(4):204-13. PMID: 11536370.
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    54. Place RF, Haspeslagh D, Hubbard AK, Giardina C. Cytokine-induced stabilization of newly synthesized I(kappa)B-alpha. Biochem Biophys Res Commun. 2001 May 18; 283(4):813-20. PMID: 11350057.
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    55. Hubbard AK, Thibodeau M, Giardina C. Cellular and molecular mechanisms regulating silica-induced adhesion molecule expression in mice. J Environ Pathol Toxicol Oncol. 2001; 20 Suppl 1:45-51. PMID: 11570673.
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    56. Inan MS, Tolmacheva V, Wang QS, Rosenberg DW, Giardina C. Transcription factor NF-kappaB participates in regulation of epithelial cell turnover in the colon. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1282-91. PMID: 11093952.
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    57. Yin L, Hubbard AK, Giardina C. NF-kappa B regulates transcription of the mouse telomerase catalytic subunit. J Biol Chem. 2000 Nov 24; 275(47):36671-5. PMID: 10970902.
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    58. Inan MS, Place R, Tolmacheva V, Wang QS, Hubbard AK, Rosenberg DW, Giardina C. IkappaBbeta-related proteins in normal and transformed colonic epithelial cells. Mol Carcinog. 2000 Sep; 29(1):25-36. PMID: 11020244.
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    59. Crowthers KC, Kline V, Giardina C, Lynes MA. Augmented humoral immune function in metallothionein-null mice. Toxicol Appl Pharmacol. 2000 Aug 1; 166(3):161-72. PMID: 10906280.
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    60. Boulares AH, Giardina C, Inan MS, Khairallah EA, Cohen SD. Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells. Toxicol Sci. 2000 Jun; 55(2):370-5. PMID: 10828269.
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    61. Inan MS, Rasoulpour RJ, Yin L, Hubbard AK, Rosenberg DW, Giardina C. The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology. 2000 Apr; 118(4):724-34. PMID: 10734024.
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    62. Hubbard AK, Giardina C. Regulation of ICAM-1 expression in mouse macrophages. Inflammation. 2000 Apr; 24(2):115-25. PMID: 10718114.
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    63. Boulares HA, Giardina C, Navarro CL, Khairallah EA, Cohen SD. Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity. Toxicol Sci. 1999 Apr; 48(2):264-74. PMID: 10353317.
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    64. Giardina C, Boulares H, Inan MS. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. Biochim Biophys Acta. 1999 Jan 11; 1448(3):425-38. PMID: 9990295.
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    65. Giardina C, Inan MS. Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells. Biochim Biophys Acta. 1998 Mar 5; 1401(3):277-88. PMID: 9540818.
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