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M Hicham Drissi PhD

TitleAssociate Professor
InstitutionUConn Health Center
DepartmentOrthopaedic Surgery
AddressMC 5456
Medical Arts & Research Building, MC 5456
263 Farmington Avenue
Phone860-679-6698
Fax860-679-2109
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    Other Positions
    TitleDirector of Research
    InstitutionUConn Health Center
    DepartmentOrthopaedic Surgery

    TitleAssociate Professor
    InstitutionUConn Health Center
    DepartmentGenetics and Developmental Biology

    TitleAssociate Professor
    InstitutionUConn Health Center
    DepartmentInstitute for Regenerative Engineering


    Collapse Overview 
    Collapse overview
    Dr. Drissi’s areas of research focus on defining the cellular and molecular pathways that govern skeletal development and repair with a particular emphasis on cell growth and differentiation during endochondral ossification. A significant part of Dr. Drissi’s programs is committed to investigating mesenchymal progenitor cell commitment to the bone and cartilage phenotypes. These areas of interest provide direct translational application to orthopaedic problems ranging from osteoarthritis and fracture repair to skeletal dysplasia.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Drissi H, Paglia DN. Surgical procedures and experimental outcomes of closed fractures in rodent models. Methods Mol Biol. 2015; 1226:193-211. PMID: 25331052.
      View in: PubMed
    2. Drissi H, Gibson JD, Guzzo RM, Xu RH. Derivation and Chondrogenic Commitment of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors. Methods Mol Biol. 2015; 1340:65-78. PMID: 26445831.
      View in: PubMed
    3. Bradley EW, Drissi MH. Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway. J Cell Physiol. 2011 Jun; 226(6):1683-93. PMID: 21413026.
      View in: PubMed
    4. Virk MS, Sugiyama O, Park SH, Gambhir SS, Adams DJ, Drissi H, Lieberman JR. "Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther. 2011 May; 19(5):960-8. PMID: 21343916; PMCID: PMC3098640.
    5. Guzzo RM, Andreeva V, Spicer DB, Drissi MH. Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice. Int J Dev Biol. 2011; 55(6):641-7. PMID: 21769775.
      View in: PubMed
    6. Bradley EW, Drissi MH. WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways. Mol Endocrinol. 2010 Aug; 24(8):1581-93. PMID: 20573686.
      View in: PubMed
    7. Mazzocca AD, McCarthy MB, Chowaniec DM, Cote MP, Arciero RA, Drissi H. Rapid isolation of human stem cells (connective tissue progenitor cells) from the proximal humerus during arthroscopic rotator cuff surgery. Am J Sports Med. 2010 Jul; 38(7):1438-47. PMID: 20375368.
      View in: PubMed
    8. Huang H, Chikazu D, Voznesensky OS, Herschman HR, Kream BE, Drissi H, Pilbeam CC. Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. J Bone Miner Res. 2010 Apr; 25(4):819-29. PMID: 19821778; PMCID: PMC3153333.
    9. Chen J, Gupta T, Barasz JA, Kalajzic Z, Yeh WC, Drissi H, Hand AR, Wadhwa S. Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model. Arch Oral Biol. 2009 Dec; 54(12):1091-8. PMID: 19896116; PMCID: PMC2787630.
    10. Xiao L, Liu P, Li X, Doetschman T, Coffin JD, Drissi H, Hurley MM. Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem. 2009 Jan 30; 284(5):3170-82. PMID: 19056741; PMCID: PMC2631953.
    11. Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther. 2008 Mar; 16(3):466-73. PMID: 18180771; PMCID: PMC2705193.
    12. Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects. J Bone Joint Surg Am. 2006 Apr; 88(4):753-61. PMID: 16595465.
      View in: PubMed
    13. Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43. PMID: 15389629.
      View in: PubMed
    14. Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. J Bone Miner Res. 2005 Jul; 20(7):1136-48. PMID: 15940366.
      View in: PubMed
    15. Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem. 2003 Dec 15; 90(6):1287-98. PMID: 14635200.
      View in: PubMed
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