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Last Name
Institution

Marja M Hurley MD

TitleProfessor
InstitutionUConn Health Center
DepartmentMedicine
AddressMC 1850
MC 1850
263 Farmington Avenue
Phone860-679-3867
Fax860-679-1875
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    Other Positions
    TitleDirector
    InstitutionUConn Health Center
    DepartmentHealth Career Opportunity Programs

    TitleAssociate Dean, School of Medicine
    InstitutionUConn Health Center
    DepartmentMedical Deans Office


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hurley MM, Adams DJ, Wang L, Jiang X, Burt PM, Du E, Xiao L. Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2. J Cell Biochem. 2016 Mar; 117(3):599-611. PMID: 26252425.
      View in: PubMed
    2. Du E, Xiao L, Hurley MM. FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice. J Cell Biochem. 2016 Sep; 117(9):1991-2000. PMID: 26762209.
      View in: PubMed
    3. Hurley MM, Gronowicz G, Zhu L, Kuhn LT, Rodner C, Xiao L. Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and ß-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells. J Cell Biochem. 2016 Mar; 117(3):721-9. PMID: 26332075.
      View in: PubMed
    4. Charles LF, Woodman JL, Ueno D, Gronowicz G, Hurley MM, Kuhn LT. Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice. Exp Gerontol. 2015 Apr; 64:62-9. PMID: 25681640; PMCID: PMC4388203 [Available on 04/01/16].
    5. Homer-Bouthiette C, Doetschman T, Xiao L, Hurley MM. Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis. J Biol Chem. 2014 Dec 26; 289(52):36303-14. PMID: 25389287; PMCID: PMC4276890 [Available on 12/26/15].
    6. Gronowicz G, Hurley MM, Kuhn LT. Optimizing BMP-2-induced bone repair with FGF-2. J Am Acad Orthop Surg. 2014 Oct; 22(10):677-9. PMID: 25281263.
      View in: PubMed
    7. Xiao L, Ueno D, Catros S, Homer-Bouthiette C, Charles L, Kuhn L, Hurley MM. Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice. Endocrinology. 2014 Mar; 155(3):965-74. PMID: 24424065; PMCID: PMC3929728.
    8. Agas D, Sabbieti MG, Marchetti L, Xiao L, Hurley MM. FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts. J Cell Physiol. 2013 Nov; 228(11):2149-58. PMID: 23559326.
      View in: PubMed
    9. Sabbieti MG, Agas D, Marchetti L, Coffin JD, Xiao L, Hurley MM. BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice. Endocrinology. 2013 Aug; 154(8):2723-33. PMID: 23715864; PMCID: PMC3713219.
    10. Kuhn LT, Ou G, Charles L, Hurley MM, Rodner CM, Gronowicz G. Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1170-80. PMID: 23531867; PMCID: PMC3826858.
    11. Xiao L, Esliger A, Hurley MM. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013 Jan; 28(1):35-45. PMID: 22836867; PMCID: PMC3519956.
    12. Agas D, Marchetti L, Hurley MM, Sabbieti MG. Prostaglandin F2a: a bone remodeling mediator. J Cell Physiol. 2013 Jan; 228(1):25-9. PMID: 22585670.
      View in: PubMed
    13. Fei Y, Gronowicz G, Hurley MM. Fibroblast growth factor-2, bone homeostasis and fracture repair. Curr Pharm Des. 2013; 19(19):3354-63. PMID: 23432676.
      View in: PubMed
    14. Fei Y, Hurley MM. Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation. J Cell Physiol. 2012 Nov; 227(11):3539-45. PMID: 22378151; PMCID: PMC3371283.
    15. Fei Y, Xu RH, Hurley MM. Stem cell-based bone repair. Am J Stem Cells. 2012; 1(2):106-13. PMID: 23671803; PMCID: PMC3636738.
    16. Fei Y, Xiao L, Doetschman T, Coffin DJ, Hurley MM. Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway. J Biol Chem. 2011 Nov 25; 286(47):40575-83. PMID: 21987573; PMCID: PMC3220493.
    17. Fei Y, Xiao L, Hurley MM. The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression. Biochem Biophys Res Commun. 2011 Aug 19; 412(1):160-4. PMID: 21806973; PMCID: PMC3568701.
    18. Bilezikian JP, Drezner M, Kream B, Stern P, Clemens T, Elderkin A, Siris E, Krane S, Eisman J, Arnold A, Feyen J, Hurley M, Kawaguchi H, Lorenzo J, Peck W, Pilbeam C, Rowe D, Martin TJ, Hock J, DeLuca H, Rodan S, Lukert B, Chen T, Klein-Nulend J. Lawrence G. Raisz November 13, 1925-August 25, 2010. J Bone Miner Res. 2011 May; 26(5):903-11. PMID: 21541991.
      View in: PubMed
    19. Sabbieti MG, Agas D, Marchetti L, Santoni G, Amantini C, Xiao L, Menghi G, Hurley MM. Signaling pathways implicated in PGF2alpha effects on Fgf2+/+ and Fgf2-/- osteoblasts. J Cell Physiol. 2010 Aug; 224(2):465-74. PMID: 20432442.
      View in: PubMed
    20. Ou G, Charles L, Matton S, Rodner C, Hurley M, Kuhn L, Gronowicz G. Fibroblast growth factor-2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone. J Gerontol A Biol Sci Med Sci. 2010 Oct; 65(10):1051-9. PMID: 20643704; PMCID: PMC2949335.
    21. Kang H, Chang W, Hurley M, Vignery A, Wu D. Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):12901-6. PMID: 20616072; PMCID: PMC2919938.
    22. Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM. Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone. 2010 Aug; 47(2):360-70. PMID: 20510392; PMCID: PMC2947437.
    23. Xiao L, Naganawa T, Lorenzo J, Carpenter TO, Coffin JD, Hurley MM. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem. 2010 Jan 22; 285(4):2834-46. PMID: 19933269; PMCID: PMC2807337.
    24. Fei Y, Xiao L, Hurley MM. Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts. Biochem Biophys Res Commun. 2010 Jan 1; 391(1):335-9. PMID: 19913500; PMCID: PMC2930756.
    25. Sabbieti MG, Agas D, Xiao L, Marchetti L, Coffin JD, Doetschman T, Hurley MM. Endogenous FGF-2 is critically important in PTH anabolic effects on bone. J Cell Physiol. 2009 Apr; 219(1):143-51. PMID: 19107841; PMCID: PMC2763338.
    26. Xiao L, Liu P, Li X, Doetschman T, Coffin JD, Drissi H, Hurley MM. Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice. J Biol Chem. 2009 Jan 30; 284(5):3170-82. PMID: 19056741; PMCID: PMC2631953.
    27. Sabbieti MG, Agas D, Materazzi S, Capacchietti M, Materazzi G, Hurley MM, Menghi G, Marchetti L. Prostaglandin F2alpha involves heparan sulphate sugar chains and FGFRs to modulate osteoblast growth and differentiation. J Cell Physiol. 2008 Oct; 217(1):48-59. PMID: 18459126.
      View in: PubMed
    28. Naganawa T, Xiao L, Coffin JD, Doetschman T, Sabbieti MG, Agas D, Hurley MM. Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice. J Cell Biochem. 2008 Apr 15; 103(6):1975-88. PMID: 17955502.
      View in: PubMed
    29. Agas D, Marchetti L, Menghi G, Materazzi S, Materazzi G, Capacchietti M, Hurley MM, Sabbieti MG. Anti-apoptotic Bcl-2 enhancing requires FGF-2/FGF receptor 1 binding in mouse osteoblasts. J Cell Physiol. 2008 Jan; 214(1):145-52. PMID: 17559077.
      View in: PubMed
    30. Agas D, Sabbieti MG, Capacchietti M, Materazzi S, Menghi G, Materazzi G, Hurley MM, Marchetti L. Benzyl butyl phthalate influences actin distribution and cell proliferation in rat Py1a osteoblasts. J Cell Biochem. 2007 Jun 1; 101(3):543-51. PMID: 17171637.
      View in: PubMed
    31. Hurley MM, Plessy BL, Clark-Dufner P. University of Connecticut HPPI pipeline. Acad Med. 2006 Jun; 81(6 Suppl):S25-7. PMID: 16723831.
      View in: PubMed
    32. Marchetti L, Sabbieti MG, Agas D, Menghi M, Materazzi G, Menghi G, Hurley MM. PGF2alpha increases FGF-2 and FGFR2 trafficking in Py1a rat osteoblasts via clathrin independent and importin beta dependent pathway. J Cell Biochem. 2006 Apr 15; 97(6):1379-92. PMID: 16365892.
      View in: PubMed
    33. Hurley MM, Okada Y, Xiao L, Tanaka Y, Ito M, Okimoto N, Nakamura T, Rosen CJ, Doetschman T, Coffin JD. Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):989-94. PMID: 16455048.
      View in: PubMed
    34. Marie PJ, Coffin JD, Hurley MM. FGF and FGFR signaling in chondrodysplasias and craniosynostosis. J Cell Biochem. 2005 Dec 1; 96(5):888-96. PMID: 16149058.
      View in: PubMed
    35. Naganawa T, Xiao L, Abogunde E, Sobue T, Kalajzic I, Sabbieti M, Agas D, Hurley MM. In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice. Biochem Biophys Res Commun. 2006 Jan 13; 339(2):490-8. PMID: 16298332.
      View in: PubMed
    36. Hurley M, Yao W, Lane NE. Changes in serum fibroblast growth factor 2 in patients with glucocorticoid-induced osteoporosis treated with human parathyroid hormone (1-34). Osteoporos Int. 2005 Dec; 16(12):2080-4. PMID: 16133640.
      View in: PubMed
    37. Li X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, Hurley M, Guo C, Boskey A, Sun L, Harris SE, Rowe DW, Ke HZ, Wu D. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005 Sep; 37(9):945-52. PMID: 16056226.
      View in: PubMed
    38. Sobue T, Naganawa T, Xiao L, Okada Y, Tanaka Y, Ito M, Okimoto N, Nakamura T, Coffin JD, Hurley MM. Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice. J Cell Biochem. 2005 May 1; 95(1):83-94. PMID: 15723277.
      View in: PubMed
    39. Sabbieti MG, Marchetti L, Gabrielli MG, Menghi M, Materazzi S, Menghi G, Raisz LG, Hurley MM. Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase. Cell Tissue Res. 2005 Feb; 319(2):267-78. PMID: 15654655.
      View in: PubMed
    40. Xiao L, Naganawa T, Obugunde E, Gronowicz G, Ornitz DM, Coffin JD, Hurley MM. Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. J Biol Chem. 2004 Jun 25; 279(26):27743-52. PMID: 15073186.
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    41. Xiao L, Liu P, Sobue T, Lichtler A, Coffin JD, Hurley MM. Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells. J Cell Biochem. 2003 Aug 15; 89(6):1291-301. PMID: 12898525.
      View in: PubMed
    42. Kalajzic I, Kalajzic Z, Hurley MM, Lichtler AC, Rowe DW. Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin. J Cell Biochem. 2003 Apr 15; 88(6):1168-76. PMID: 12647299.
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    43. Okada Y, Montero A, Zhang X, Sobue T, Lorenzo J, Doetschman T, Coffin JD, Hurley MM. Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone. J Biol Chem. 2003 Jun 6; 278(23):21258-66. PMID: 12665515.
      View in: PubMed
    44. Marchetti L, Sabbieti MG, Menghi M, Materazzi S, Hurley MM, Menghi G. Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts. Histol Histopathol. 2002 Oct; 17(4):1061-6. PMID: 12371133.
      View in: PubMed
    45. Sobue T, Gravely T, Hand A, Min YK, Pilbeam C, Raisz LG, Zhang X, Larocca D, Florkiewicz R, Hurley MM. Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. J Bone Miner Res. 2002 Mar; 17(3):502-12. PMID: 11874241.
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    46. Zhang X, Sobue T, Hurley MM. FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):526-31. PMID: 11779203.
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    47. Sobue T, Zhang X, Florkiewicz RZ, Hurley MM. Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts. Biochem Biophys Res Commun. 2001 Aug 10; 286(1):33-40. PMID: 11485304.
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    48. Menghi G, Sabbieti MG, Marchetti L, Menghi M, Materazzi S, Hurley MM. Phthalate esters influence FGF-2 translocation in Py1a rat osteoblasts. Eur J Morphol. 2001 Jul; 39(3):155-62. PMID: 11910534.
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    49. Montero A, Okada Y, Tomita M, Ito M, Tsurukami H, Nakamura T, Doetschman T, Coffin JD, Hurley MM. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest. 2000 Apr; 105(8):1085-93. PMID: 10772653; PMCID: PMC300831.
    50. Hurley MM, Tetradis S, Huang YF, Hock J, Kream BE, Raisz LG, Sabbieti MG. Parathyroid hormone regulates the expression of fibroblast growth factor-2 mRNA and fibroblast growth factor receptor mRNA in osteoblastic cells. J Bone Miner Res. 1999 May; 14(5):776-83. PMID: 10320526.
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    51. Sabbieti MG, Marchetti L, Abreu C, Montero A, Hand AR, Raisz LG, Hurley MM. Prostaglandins regulate the expression of fibroblast growth factor-2 in bone. Endocrinology. 1999 Jan; 140(1):434-44. PMID: 9886855.
      View in: PubMed
    52. Sabbieti MG, Marchetti L, Hurley MM, Menghi G. PNA lectin as marker of Py1a cell cycle. Eur J Histochem. 1999; 43(1):85-7. PMID: 10340148.
      View in: PubMed
    53. Hurley MM, Lee SK, Raisz LG, Bernecker P, Lorenzo J. Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures. Bone. 1998 Apr; 22(4):309-16. PMID: 9556129.
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    54. Hurley MM, Marcello K, Abreu C, Kessler M. Signal transduction by basic fibroblast growth factor in rat osteoblastic Py1a cells. J Bone Miner Res. 1996 Sep; 11(9):1256-63. PMID: 8864900.
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    55. Hurley MM, Abreu C, Marcello K, Kawaguchi H, Lorenzo J, Kalinowski J, Ray A, Gronowicz G. Regulation of NFIL-6 and IL-6 expression by basic fibroblast growth factor in osteoblasts. J Bone Miner Res. 1996 Jun; 11(6):760-7. PMID: 8725173.
      View in: PubMed
    56. Hakeda Y, Kawaguchi H, Hurley M, Pilbeam CC, Abreu C, Linkhart TA, Mohan S, Kumegawa M, Raisz LG. Intact insulin-like growth factor binding protein-5 (IGFBP-5) associates with bone matrix and the soluble fragments of IGFBP-5 accumulated in culture medium of neonatal mouse calvariae by parathyroid hormone and prostaglandin E2-treatment. J Cell Physiol. 1996 Feb; 166(2):370-9. PMID: 8591997.
      View in: PubMed
    57. Hurley MM, Marcello K, Abreu C, Brinckerhoff CE, Bowik CC, Hibbs MS. Transcriptional regulation of the collagenase gene by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun. 1995 Sep 14; 214(2):331-9. PMID: 7677739.
      View in: PubMed
    58. Kawaguchi H, Pilbeam CC, Gronowicz G, Abreu C, Fletcher BS, Herschman HR, Raisz LG, Hurley MM. Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. J Clin Invest. 1995 Aug; 96(2):923-30. PMID: 7635987; PMCID: PMC185280.
    59. Hurley MM, Abreu C, Hakeda Y. Basic fibroblast growth factor regulates IGF-I binding proteins in the clonal osteoblastic cell line MC3T3-E1. J Bone Miner Res. 1995 Feb; 10(2):222-30. PMID: 7538725.
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    60. Hurley MM, Abreu C, Gronowicz G, Kawaguchi H, Lorenzo J. Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells. J Biol Chem. 1994 Mar 25; 269(12):9392-6. PMID: 8132679.
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    61. Hakeda Y, Yoshizawa K, Hurley M, Kawaguchi H, Tezuka K, Tanaka K, Satoh T, Kumegawa M. Stimulatory effect of a phorbol ester on expression of insulin-like growth factor (IGF) binding protein-2 and level of IGF-I receptors in mouse osteoblastic MC3T3-E1 cells. J Cell Physiol. 1994 Mar; 158(3):444-50. PMID: 7510294.
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    62. Hurley MM, Abreu C, Harrison JR, Lichtler AC, Raisz LG, Kream BE. Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells. J Biol Chem. 1993 Mar 15; 268(8):5588-93. PMID: 8449921.
      View in: PubMed
    63. Kessler MN, Raisz LG, Hurley MM. Interactive effects of basic fibroblast growth factor and heparin on bone in 21-day fetal rat calvariae. Conn Med. 1993 Jan; 57(1):9-11. PMID: 8449008.
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    64. Hurley MM, Kessler M, Gronowicz G, Raisz LG. The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae. Endocrinology. 1992 May; 130(5):2675-82. PMID: 1374012.
      View in: PubMed
    65. Hurley MM, Kream BE, Raisz LG. Structural determinants of the capacity of heparin to inhibit collagen synthesis in 21-day fetal rat calvariae. J Bone Miner Res. 1990 Nov; 5(11):1127-33. PMID: 2176772.
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    66. Hurley MM, Gronowicz G, Kream BE, Raisz LG. Effect of heparin on bone formation in cultured fetal rat calvaria. Calcif Tissue Int. 1990 Mar; 46(3):183-8. PMID: 2106377.
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    67. Hurley MM, Martin DL, Kream BE, Raisz LG. Effects of ethanol and acetaldehyde on collagen synthesis, prostaglandin release and resorption of fetal rat bone in organ culture. Bone. 1990; 11(1):47-51. PMID: 2331431.
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    68. Hurley MM, Fall P, Harrison JR, Petersen DN, Kream BE, Raisz LG. Effects of transforming growth factor alpha and interleukin-1 on DNA synthesis, collagen synthesis, procollagen mRNA levels, and prostaglandin E2 production in cultured fetal rat calvaria. J Bone Miner Res. 1989 Oct; 4(5):731-6. PMID: 2816517.
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    69. Vargas SJ, Diez-Morales LF, Jones TG, Froesch TA, Hurley MM, Raisz LG. Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia: a reanalysis. Am J Med Sci. 1987 Dec; 294(6):415-8. PMID: 3425589.
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    70. Hurley MM, Martin D, Raisz LG. Changes in ethanol concentration during incubation in multiwell tissue culture trays. Proc Soc Exp Biol Med. 1987 Nov; 186(2):139-41. PMID: 3671353.
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    71. Vargas SJ, Jones TG, Hurley MM, Raisz LG. Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones. J Bone Miner Res. 1987 Jun; 2(3):183-9. PMID: 3137774.
      View in: PubMed
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