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Institution

Douglas J Adams PhD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentOrthopaedic Surgery
AddressMC 4037
Medical Arts & Research Building, MC 4037
263 Farmington Avenue
Phone860-679-4976
Fax860-679-6649
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Adams DJ, Rowe DW, Ackert-Bicknell CL. Genetics of aging bone. Mamm Genome. 2016 Aug; 27(7-8):367-80. PMID: 27272104.
      View in: PubMed
    2. Hurley MM, Adams DJ, Wang L, Jiang X, Burt PM, Du E, Xiao L. Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2. J Cell Biochem. 2016 Mar; 117(3):599-611. PMID: 26252425.
      View in: PubMed
    3. Gohil SV, Kuo CL, Adams DJ, Maye P, Rowe DW, Nair LS. Evaluation of the donor cell contribution in rhBMP-2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice. J Biomed Mater Res A. 2016 Apr; 104(4):928-41. PMID: 26703977.
      View in: PubMed
    4. Bougioukli S, Jain A, Sugiyama O, Tinsley BA, Tang AH, Tan MH, Adams DJ, Kostenuik PJ, Lieberman JR. Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect. Bone. 2016 Mar; 84:93-103. PMID: 26723577.
      View in: PubMed
    5. Tinsley BA, Dukas A, Pensak MJ, Adams DJ, Tang AH, Ominsky MS, Ke HZ, Lieberman JR. Systemic Administration of Sclerostin Antibody Enhances Bone Morphogenetic Protein-Induced Femoral Defect Repair in a Rat Model. J Bone Joint Surg Am. 2015 Nov 18; 97(22):1852-9. PMID: 26582615.
      View in: PubMed
    6. Adams DJ, Ackert-Bicknell CL. Genetic regulation of bone strength: a review of animal model studies. Bonekey Rep. 2015; 4:714. PMID: 26157577; PMCID: PMC4495779 [Available on 07/08/16].
    7. Hagiwara Y, Dyment NA, Jiang X, Jiang Ping H, Ackert-Bicknell C, Adams DJ, Rowe DW. Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair. J Orthop Res. 2015 Jul; 33(7):948-56. PMID: 25639792.
      View in: PubMed
    8. Dole NS, Kapinas K, Kessler CB, Yee SP, Adams DJ, Pereira RC, Delany AM. A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433. J Bone Miner Res. 2015 Apr; 30(4):723-32. PMID: 25262637; PMCID: PMC4376624 [Available on 04/01/16].
    9. Choudhary S, Canalis E, Estus T, Adams D, Pilbeam C. Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice. PLoS One. 2015; 10(3):e0120164. PMID: 25781979; PMCID: PMC4363701.
    10. Sharmin F, Adams D, Pensak M, Dukas A, Lieberman J, Khan Y. Biofunctionalizing devitalized bone allografts through polymer-mediated short and long term growth factor delivery. J Biomed Mater Res A. 2015 Sep; 103(9):2847-54. PMID: 25689463.
      View in: PubMed
    11. Gohil SV, Adams DJ, Maye P, Rowe DW, Nair LS. Evaluation of rhBMP-2 and bone marrow derived stromal cell mediated bone regeneration using transgenic fluorescent protein reporter mice. J Biomed Mater Res A. 2014 Dec; 102(12):4568-80. PMID: 24677665.
      View in: PubMed
    12. Matthews BG, Grcevic D, Wang L, Hagiwara Y, Roguljic H, Joshi P, Shin DG, Adams DJ, Kalajzic I. Analysis of aSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing. J Bone Miner Res. 2014; 29(5):1283-94. PMID: 24190076.
      View in: PubMed
    13. Alaee F, Virk MS, Tang H, Sugiyama O, Adams DJ, Stolina M, Dwyer D, Ominsky MS, Ke HZ, Lieberman JR. Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model. J Orthop Res. 2014 Feb; 32(2):197-203. PMID: 24600701.
      View in: PubMed
    14. Canalis E, Adams DJ, Boskey A, Parker K, Kranz L, Zanotti S. Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem. 2013 Aug 30; 288(35):25614-25. PMID: 23884415; PMCID: PMC3757222.
    15. Aguila HL, Mun SH, Kalinowski J, Adams DJ, Lorenzo JA, Lee SK. Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7-deficient female mice. J Bone Miner Res. 2012 May; 27(5):1030-42. PMID: 22258693; PMCID: PMC3361560.
    16. Amini AR, Adams DJ, Laurencin CT, Nukavarapu SP. Optimally porous and biomechanically compatible scaffolds for large-area bone regeneration. Tissue Eng Part A. 2012 Jul; 18(13-14):1376-88. PMID: 22401817.
      View in: PubMed
    17. Grcevic D, Pejda S, Matthews BG, Repic D, Wang L, Li H, Kronenberg MS, Jiang X, Maye P, Adams DJ, Rowe DW, Aguila HL, Kalajzic I. In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells. 2012 Feb; 30(2):187-96. PMID: 22083974; PMCID: PMC3560295.
    18. Boxberger JI, Adams DJ, Diaz-Doran V, Akkarapaka NB, Kolb ED. Radius fracture repair using volumetrically expanding polyurethane bone cement. J Hand Surg Am. 2011 Aug; 36(8):1294-302. PMID: 21715102.
      View in: PubMed
    19. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011 Jun; 26(6):1197-206. PMID: 21611962; PMCID: PMC3312754.
    20. Virk MS, Sugiyama O, Park SH, Gambhir SS, Adams DJ, Drissi H, Lieberman JR. "Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther. 2011 May; 19(5):960-8. PMID: 21343916; PMCID: PMC3098640.
    21. Sobue T, Yeh WC, Chhibber A, Utreja A, Diaz-Doran V, Adams D, Kalajzic Z, Chen J, Wadhwa S. Murine TMJ loading causes increased proliferation and chondrocyte maturation. J Dent Res. 2011 Apr; 90(4):512-6. PMID: 21248355; PMCID: PMC3065547.
    22. Hainfeld JF, O'Connor MJ, Dilmanian FA, Slatkin DN, Adams DJ, Smilowitz HM. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions. Br J Radiol. 2011 Jun; 84(1002):526-33. PMID: 21081567; PMCID: PMC3473629.
    23. Ushiku C, Adams DJ, Jiang X, Wang L, Rowe DW. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. J Orthop Res. 2010 Oct; 28(10):1338-47. PMID: 20839319.
      View in: PubMed
    24. Rungruanganunt P, Kelly JR, Adams DJ. Two imaging techniques for 3D quantification of pre-cementation space for CAD/CAM crowns. J Dent. 2010 Dec; 38(12):995-1000. PMID: 20801185.
      View in: PubMed
    25. Yang M, Trettel LB, Adams DJ, Harrison JR, Canalis E, Kream BE. Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation. Bone. 2010 Sep; 47(3):573-82. PMID: 20541046; PMCID: PMC2926146.
    26. Clinthorne JF, Adams DJ, Fenton JI, Ritz BW, Gardner EM. Short-term re-feeding of previously energy-restricted C57BL/6 male mice restores body weight and body fat and attenuates the decline in natural killer cell function after primary influenza infection. J Nutr. 2010 Aug; 140(8):1495-501. PMID: 20534876; PMCID: PMC2903303.
    27. Xu M, Choudhary S, Voznesensky O, Gao Q, Adams D, Diaz-Doran V, Wu Q, Goltzman D, Raisz LG, Pilbeam CC. Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice. Bone. 2010 Aug; 47(2):341-52. PMID: 20471507; PMCID: PMC3056501.
    28. Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE. Hyponatremia-induced osteoporosis. J Bone Miner Res. 2010 Mar; 25(3):554-63. PMID: 19751154; PMCID: PMC3153395.
    29. Fretz JA, Nelson T, Xi Y, Adams DJ, Rosen CJ, Horowitz MC. Altered metabolism and lipodystrophy in the early B-cell factor 1-deficient mouse. Endocrinology. 2010 Apr; 151(4):1611-21. PMID: 20172967; PMCID: PMC2850234.
    30. Brownstein CA, Zhang J, Stillman A, Ellis B, Troiano N, Adams DJ, Gundberg CM, Lifton RP, Carpenter TO. Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse. Endocrinology. 2010 Feb; 151(2):492-501. PMID: 19952276; PMCID: PMC2817612.
    31. Igwe JC, Jiang X, Paic F, Ma L, Adams DJ, Baldock PA, Pilbeam CC, Kalajzic I. Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity. J Cell Biochem. 2009 Oct 15; 108(3):621-30. PMID: 19670271; PMCID: PMC2754602.
    32. Balic A, Adams D, Mina M. Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Oct; 238(10):2599-613. PMID: 19777594; PMCID: PMC2806060.
    33. Freilich M, Shafer D, Wei M, Kompalli R, Adams D, Kuhn L. Implant system for guiding a new layer of bone. Computed microtomography and histomorphometric analysis in the rabbit mandible. Clin Oral Implants Res. 2009 Feb; 20(2):201-7. PMID: 19191797.
      View in: PubMed
    34. Plotnikov SV, Kenny AM, Walsh SJ, Zubrowski B, Joseph C, Scranton VL, Kuchel GA, Dauser D, Xu M, Pilbeam CC, Adams DJ, Dougherty RP, Campagnola PJ, Mohler WA. Measurement of muscle disease by quantitative second-harmonic generation imaging. J Biomed Opt. 2008 Jul-Aug; 13(4):044018. PMID: 19021346.
      View in: PubMed
    35. Kalajzic Z, Li H, Wang LP, Jiang X, Lamothe K, Adams DJ, Aguila HL, Rowe DW, Kalajzic I. Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population. Bone. 2008 Sep; 43(3):501-10. PMID: 18571490; PMCID: PMC2614133.
    36. Kawano T, Troiano N, Adams DJ, Wu JJ, Sun BH, Insogna K. The anabolic response to parathyroid hormone is augmented in Rac2 knockout mice. Endocrinology. 2008 Aug; 149(8):4009-15. PMID: 18467443; PMCID: PMC2488220.
    37. Haapala SA, Faghri PD, Adams DJ. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue. J Neuroeng Rehabil. 2008; 5:14. PMID: 18439300; PMCID: PMC2396645.
    38. Machado do Reis L, Kessler CB, Adams DJ, Lorenzo J, Jorgetti V, Delany AM. Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice. Bone. 2008 Aug; 43(2):264-73. PMID: 18499553; PMCID: PMC2604811.
    39. Chandhoke TK, Huang YF, Liu F, Gronowicz GA, Adams DJ, Harrison JR, Kream BE. Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor. Bone. 2008 Jul; 43(1):101-9. PMID: 18460422; PMCID: PMC2474743.
    40. Barisic-Dujmovic T, Boban I, Adams DJ, Clark SH. Marfan-like skeletal phenotype in the tight skin (Tsk) mouse. Calcif Tissue Int. 2007 Oct; 81(4):305-15. PMID: 17705049.
      View in: PubMed
    41. Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology. 2007 Aug; 148(8):3875-86. PMID: 17495007.
      View in: PubMed
    42. Liu F, Lee SK, Adams DJ, Gronowicz GA, Kream BE. CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment. Bone. 2007 Apr; 40(4):1135-43. PMID: 17275432; PMCID: PMC1995436.
    43. Mazzocca AD, Burton KJ, Romeo AA, Santangelo S, Adams DA, Arciero RA. Biomechanical evaluation of 4 techniques of distal biceps brachii tendon repair. Am J Sports Med. 2007 Feb; 35(2):252-8. PMID: 17192318.
      View in: PubMed
    44. Eswarakumar VP, Ozcan F, Lew ED, Bae JH, Tomé F, Booth CJ, Adams DJ, Lax I, Schlessinger J. Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proc Natl Acad Sci U S A. 2006 Dec 5; 103(49):18603-8. PMID: 17132737; PMCID: PMC1693709.
    45. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006 Nov; 21(11):1704-12. PMID: 17002560.
      View in: PubMed
    46. Sher LB, Harrison JR, Adams DJ, Kream BE. Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int. 2006 Aug; 79(2):118-25. PMID: 16927049.
      View in: PubMed
    47. Benthien RA, Aronow MS, Doran-Diaz V, Sullivan RJ, Naujoks R, Adams DJ. Cyclic loading of Achilles tendon repairs: a comparison of polyester and polyblend suture. Foot Ankle Int. 2006 Jul; 27(7):512-8. PMID: 16842718.
      View in: PubMed
    48. Savage T, Bennett T, Huang YF, Kelly PL, Durant NE, Adams DJ, Mina M, Harrison JR. Mandibular phenotype of p20C/EBPbeta transgenic mice: Reduced alveolar bone mass and site-specific dentin dysplasia. Bone. 2006 Sep; 39(3):552-64. PMID: 16682266.
      View in: PubMed
    49. Lee SK, Kalinowski JF, Jacquin C, Adams DJ, Gronowicz G, Lorenzo JA. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res. 2006 May; 21(5):695-702. PMID: 16734384.
      View in: PubMed
    50. Jiang J, Lichtler AC, Gronowicz GA, Adams DJ, Clark SH, Rosen CJ, Kream BE. Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling. Bone. 2006 Sep; 39(3):494-504. PMID: 16644298.
      View in: PubMed
    51. Rodner CM, Adams DJ, Diaz-Doran V, Tate JP, Santangelo SA, Mazzocca AD, Arciero RA. Medial opening wedge tibial osteotomy and the sagittal plane: the effect of increasing tibial slope on tibiofemoral contact pressure. Am J Sports Med. 2006 Sep; 34(9):1431-41. PMID: 16636350.
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    52. He J, Rosen CJ, Adams DJ, Kream BE. Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. Bone. 2006 Jun; 38(6):826-35. PMID: 16427371.
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    53. Aronow MS, Diaz-Doran V, Sullivan RJ, Adams DJ. The effect of triceps surae contracture force on plantar foot pressure distribution. Foot Ankle Int. 2006 Jan; 27(1):43-52. PMID: 16442028.
      View in: PubMed
    54. Adams DJ, Mazzocca AD, Fulkerson JP. Residual strength of the quadriceps versus patellar tendon after harvesting a central free tendon graft. Arthroscopy. 2006 Jan; 22(1):76-9. PMID: 16399465.
      View in: PubMed
    55. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshi K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002. J Bone Miner Res. 2005 Oct; 20(10):1888-98. PMID: 16355502.
      View in: PubMed
    56. Alberta FG, Aronow MS, Barrero M, Diaz-Doran V, Sullivan RJ, Adams DJ. Ligamentous Lisfranc joint injuries: a biomechanical comparison of dorsal plate and transarticular screw fixation. Foot Ankle Int. 2005 Jun; 26(6):462-73. PMID: 15960913.
      View in: PubMed
    57. Butterfield KJ, Bennett J, Gronowicz G, Adams D. Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model. J Oral Maxillofac Surg. 2005 Mar; 63(3):370-6. PMID: 15742289.
      View in: PubMed
    58. Xu M, Choudhary S, Goltzman D, Ledgard F, Adams D, Gronowicz G, Koczon-Jaremko B, Raisz L, Pilbeam C. Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? Endocrinology. 2005 Apr; 146(4):1843-53. PMID: 15625247.
      View in: PubMed
    59. Harrison JR, Huang YF, Wilson KA, Kelly PL, Adams DJ, Gronowicz GA, Clark SH. Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice. J Biol Chem. 2005 Mar 4; 280(9):8117-24. PMID: 15598659.
      View in: PubMed
    60. Curran AR, Adams DJ, Gill JL, Steiner ME, Scheller AD. The biomechanical effects of low-dose irradiation on bone-patellar tendon-bone allografts. Am J Sports Med. 2004 Jul-Aug; 32(5):1131-5. PMID: 15262633.
      View in: PubMed
    61. Adams DJ, Brosche KM, Lewis JL. Effect of specimen thickness on fracture toughness of bovine patellar cartilage. J Biomech Eng. 2003 Dec; 125(6):927-9. PMID: 14986422.
      View in: PubMed
    62. Sher LB, Woitge HW, Adams DJ, Gronowicz GA, Krozowski Z, Harrison JR, Kream BE. Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Endocrinology. 2004 Feb; 145(2):922-9. PMID: 14617568.
      View in: PubMed
    63. Mazzocca AD, Nissen CW, Geary M, Adams DJ. Valgus medial collateral ligament rupture causes concomitant loading and damage of the anterior cruciate ligament. J Knee Surg. 2003 Jul; 16(3):148-51. PMID: 12943283.
      View in: PubMed
    64. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshio K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J Bone Miner Res. 2002 Aug; 17(8):1430-40. PMID: 12162497.
      View in: PubMed
    65. Ravalin RV, Mazzocca AD, Grady-Benson JC, Nissen CW, Adams DJ. Biomechanical comparison of patellar tendon repairs in a cadaver model: an evaluation of gap formation at the repair site with cyclic loading. Am J Sports Med. 2002 Jul-Aug; 30(4):469-73. PMID: 12130398.
      View in: PubMed
    66. Mach DB, Rogers SD, Sabino MC, Luger NM, Schwei MJ, Pomonis JD, Keyser CP, Clohisy DR, Adams DJ, O'Leary P, Mantyh PW. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience. 2002; 113(1):155-66. PMID: 12123694.
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    67. Wang LZ, Gorlin J, Michaud SE, Janmey PA, Goddeau RP, Kuuse R, Uibo R, Adams D, Sawyer ES. Purification of salmon clotting factors and their use as tissue sealants. Thromb Res. 2000 Dec 15; 100(6):537-48. PMID: 11152934.
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    68. Adams DJ, Spirt AA, Brown TD, Fritton SP, Rubin CT, Brand RA. Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories. J Biomech. 1997 Jul; 30(7):671-8. PMID: 9239546.
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    69. Adams DJ, Pedersen DR, Brand RA, Rubin CT, Brown TD. Three-dimensional geometric and structural symmetry of the turkey ulna. J Orthop Res. 1995 Sep; 13(5):690-9. PMID: 7472747.
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    70. Takai S, Woo SL, Livesay GA, Adams DJ, Fu FH. Determination of the in situ loads on the human anterior cruciate ligament. J Orthop Res. 1993 Sep; 11(5):686-95. PMID: 8410469.
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    71. Shoemaker SC, Adams D, Daniel DM, Woo SL. Quadriceps/anterior cruciate graft interaction. An in vitro study of joint kinematics and anterior cruciate ligament graft tension. Clin Orthop Relat Res. 1993 Sep; (294):379-90. PMID: 8358944.
      View in: PubMed
    72. Woo SL, Hollis JM, Adams DJ, Lyon RM, Takai S. Tensile properties of the human femur-anterior cruciate ligament-tibia complex. The effects of specimen age and orientation. Am J Sports Med. 1991 May-Jun; 19(3):217-25. PMID: 1867330.
      View in: PubMed
    73. Hollis JM, Takai S, Adams DJ, Horibe S, Woo SL. The effects of knee motion and external loading on the length of the anterior cruciate ligament (ACL): a kinematic study. J Biomech Eng. 1991 May; 113(2):208-14. PMID: 1875695.
      View in: PubMed
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