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Last Name
Institution

Leo Lefrançois PhD

TitleProfessor and Chair
InstitutionUConn Health Center
DepartmentImmunology
AddressMC 1319
MC 1319
263 Farmington Avenue
Phone860-679-3242
Fax860-679-1868
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    Other Positions
    TitleDirector
    InstitutionUConn Health Center
    DepartmentCenter for Integrated Immunology and Vaccine Research

    TitleDirector
    InstitutionUConn Health Center
    DepartmentFlow Cytometry Facility


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sharma N, Benechet AP, Lefrançois L, Khanna KM. CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues. J Immunol. 2015 Dec 1; 195(11):5227-36. PMID: 26500349; PMCID: PMC4655190 [Available on 12/01/16].
    2. Colpitts SL, Puddington L, Lefrançois L. IL-15 receptor a signaling constrains the development of IL-17-producing ?d T cells. Proc Natl Acad Sci U S A. 2015 Aug 4; 112(31):9692-7. PMID: 26195801; PMCID: PMC4534247 [Available on 02/04/16].
    3. Bose TO, Colpitts SL, Pham QM, Puddington L, Lefrançois L. CD11a is essential for normal development of hematopoietic intermediates. J Immunol. 2014 Sep 15; 193(6):2863-72. PMID: 25108025; PMCID: PMC4157082.
    4. Sheridan BS, Pham QM, Lee YT, Cauley LS, Puddington L, Lefrançois L. Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function. Immunity. 2014 May 15; 40(5):747-57. PMID: 24792910; PMCID: PMC4045016.
    5. Masopust D, Vezys V, Marzo AL, Lefrançois L. Pillars article: preferential localization of effector memory cells in nonlymphoid tissue. Science. 2001. 291: 2413-2417. J Immunol. 2014 Feb 1; 192(3):845-9. PMID: 24443507.
      View in: PubMed
    6. Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol. 2013 Sep 15; 191(6):3017-24. PMID: 23966624; PMCID: PMC3896262.
    7. Plumlee CR, Sheridan BS, Cicek BB, Lefrançois L. Environmental cues dictate the fate of individual CD8+ T cells responding to infection. Immunity. 2013 Aug 22; 39(2):347-56. PMID: 23932571; PMCID: PMC3817618.
    8. Sheridan BS, Romagnoli PA, Pham QM, Fu HH, Alonzo F, Schubert WD, Freitag NE, Lefrançois L. ?d T cells exhibit multifunctional and protective memory in intestinal tissues. Immunity. 2013 Jul 25; 39(1):184-95. PMID: 23890071; PMCID: PMC3749916.
    9. Xu D, Fu HH, Obar JJ, Park JJ, Tamada K, Yagita H, Lefrançois L. A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection. PLoS One. 2013; 8(2):e56539. PMID: 23409193; PMCID: PMC3569435.
    10. Turner DL, Bickham KL, Farber DL, Lefrançois L. Splenic priming of virus-specific CD8 T cells following influenza virus infection. J Virol. 2013 Apr; 87(8):4496-506. PMID: 23388712; PMCID: PMC3624369.
    11. Bose TO, Pham QM, Jellison ER, Mouries J, Ballantyne CM, Lefrançois L. CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes. Infect Immun. 2013 Apr; 81(4):1140-51. PMID: 23357382; PMCID: PMC3639604.
    12. Jellison ER, Turner MJ, Blair DA, Lingenheld EG, Zu L, Puddington L, Lefrançois L. Distinct mechanisms mediate naive and memory CD8 T-cell tolerance. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21438-43. PMID: 23236165; PMCID: PMC3535649.
    13. Cauley LS, Lefrançois L. Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells. Mucosal Immunol. 2013 Jan; 6(1):14-23. PMID: 23131785; PMCID: PMC4034055.
    14. Sheridan BS, Lefrançois L. Isolation of mouse lymphocytes from small intestine tissues. Curr Protoc Immunol. 2012 Nov; Chapter 3:Unit3.19. PMID: 23129154.
      View in: PubMed
    15. McNamara JT, Schramm CM, Singh A, Secor ER, Guernsey LA, Lefrançois L, Thrall RS. Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol. 2012 May; 180(5):1991-2000. PMID: 22452921; PMCID: PMC3349839.
    16. Khanna KM, Lefrançois L. B cells, not just for antibody anymore. Immunity. 2012 Mar 23; 36(3):315-7. PMID: 22444627; PMCID: PMC3687144.
    17. Colpitts SL, Stoklasek TA, Plumlee CR, Obar JJ, Guo C, Lefrançois L. Cutting edge: the role of IFN-a receptor and MyD88 signaling in induction of IL-15 expression in vivo. J Immunol. 2012 Mar 15; 188(6):2483-7. PMID: 22327071; PMCID: PMC3294000.
    18. Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol. 2011 Dec 1; 187(11):5510-4. PMID: 22058417; PMCID: PMC3221837.
    19. Obar JJ, Jellison ER, Sheridan BS, Blair DA, Pham QM, Zickovich JM, Lefrançois L. Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol. 2011 Nov 15; 187(10):4967-78. PMID: 21987662; PMCID: PMC3208080.
    20. Blair DA, Turner DL, Bose TO, Pham QM, Bouchard KR, Williams KJ, McAleer JP, Cauley LS, Vella AT, Lefrançois L. Duration of antigen availability influences the expansion and memory differentiation of T cells. J Immunol. 2011 Sep 1; 187(5):2310-21. PMID: 21775679; PMCID: PMC3159832.
    21. Sheridan BS, Lefrançois L. Regional and mucosal memory T cells. Nat Immunol. 2011 Jun; 12(6):485-91. PMID: 21739671; PMCID: PMC3224372.
    22. Wu CA, Paveglio SA, Lingenheld EG, Zhu L, Lefrançois L, Puddington L. Transmission of murine cytomegalovirus in breast milk: a model of natural infection in neonates. J Virol. 2011 May; 85(10):5115-24. PMID: 21367905; PMCID: PMC3126164.
    23. Sheridan BS, Lefrançois L. Intraepithelial lymphocytes: to serve and protect. Curr Gastroenterol Rep. 2010 Dec; 12(6):513-21. PMID: 20890736; PMCID: PMC3224371.
    24. Stoklasek TA, Colpitts SL, Smilowitz HM, Lefrançois L. MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Ra complex. J Immunol. 2010 Dec 1; 185(11):6857-65. PMID: 21041729; PMCID: PMC3150213.
    25. Khanna KM, Blair DA, Vella AT, McSorley SJ, Datta SK, Lefrançois L. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol. 2010 Jul 1; 185(1):239-52. PMID: 20530268; PMCID: PMC2997353.
    26. Obar JJ, Lefrançois L. Early signals during CD8 T cell priming regulate the generation of central memory cells. J Immunol. 2010 Jul 1; 185(1):263-72. PMID: 20519649; PMCID: PMC2997352.
    27. Obar JJ, Lefrançois L. Early events governing memory CD8+ T-cell differentiation. Int Immunol. 2010 Aug; 22(8):619-25. PMID: 20504887; PMCID: PMC2908475.
    28. Zehn D, Turner MJ, Lefrançois L, Bevan MJ. Lack of original antigenic sin in recall CD8(+) T cell responses. J Immunol. 2010 Jun 1; 184(11):6320-6. PMID: 20439913; PMCID: PMC2982183.
    29. Lefrançois L, Obar JJ. Once a killer, always a killer: from cytotoxic T cell to memory cell. Immunol Rev. 2010 May; 235(1):206-18. PMID: 20536565; PMCID: PMC2989239.
    30. Obar JJ, Lefrançois L. Memory CD8+ T cell differentiation. Ann N Y Acad Sci. 2010 Jan; 1183:251-66. PMID: 20146720; PMCID: PMC2836783.
    31. Obar JJ, Molloy MJ, Jellison ER, Stoklasek TA, Zhang W, Usherwood EJ, Lefrançois L. CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):193-8. PMID: 19966302; PMCID: PMC2806751.
    32. Lefrançois L, Masopust D. The road not taken: memory T cell fate 'decisions'. Nat Immunol. 2009 Apr; 10(4):369-70. PMID: 19295636; PMCID: PMC3224369.
    33. Khanna KM, Aguila CC, Redman JM, Suarez-Ramirez JE, Lefrançois L, Cauley LS. In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol. 2008 Dec; 38(12):3304-15. PMID: 19009527; PMCID: PMC2662394.
    34. Mousavi SF, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefrançois L, Borst J, Sugamura K, Ishii N. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol. 2008 Nov 1; 181(9):5990-6001. PMID: 18941188; PMCID: PMC2784683.
    35. Turner MJ, Jellison ER, Lingenheld EG, Puddington L, Lefrançois L. Avidity maturation of memory CD8 T cells is limited by self-antigen expression. J Exp Med. 2008 Aug 4; 205(8):1859-68. PMID: 18625745; PMCID: PMC2525599.
    36. Obar JJ, Khanna KM, Lefrançois L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity. 2008 Jun; 28(6):859-69. PMID: 18499487; PMCID: PMC2836785.
    37. Khanna KM, Lefrançois L. Geography and plumbing control the T cell response to infection. Immunol Cell Biol. 2008 Jul; 86(5):416-22. PMID: 18392042; PMCID: PMC3224370.
    38. McAleer JP, Zammit DJ, Lefrançois L, Rossi RJ, Vella AT. The lipopolysaccharide adjuvant effect on T cells relies on nonoverlapping contributions from the MyD88 pathway and CD11c+ cells. J Immunol. 2007 Nov 15; 179(10):6524-35. PMID: 17982041.
      View in: PubMed
    39. Khanna KM, McNamara JT, Lefrançois L. In situ imaging of the endogenous CD8 T cell response to infection. Science. 2007 Oct 5; 318(5847):116-20. PMID: 17916739; PMCID: PMC2846662.
    40. Blair DA, Lefrançois L. Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15045-50. PMID: 17827281; PMCID: PMC1986610.
    41. Marzo AL, Yagita H, Lefrançois L. Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells. J Immunol. 2007 Jul 1; 179(1):36-40. PMID: 17579018; PMCID: PMC2861291.
    42. Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrançois L, Li Z. Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity. 2007 Feb; 26(2):215-26. PMID: 17275357; PMCID: PMC2847270.
    43. Turner DL, Cauley LS, Khanna KM, Lefrançois L. Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol. 2007 Feb; 81(4):2039-46. PMID: 17151119; PMCID: PMC1797569.
    44. Klonowski KD, Marzo AL, Williams KJ, Lee SJ, Pham QM, Lefrançois L. CD8 T cell recall responses are regulated by the tissue tropism of the memory cell and pathogen. J Immunol. 2006 Nov 15; 177(10):6738-46. PMID: 17082587; PMCID: PMC2847276.
    45. Stoklasek TA, Schluns KS, Lefrançois L. Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol. 2006 Nov 1; 177(9):6072-80. PMID: 17056533; PMCID: PMC2847275.
    46. Klonowski KD, Williams KJ, Marzo AL, Lefrançois L. Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development. J Immunol. 2006 Oct 1; 177(7):4247-51. PMID: 16982855; PMCID: PMC2847272.
    47. Moyron-Quiroz JE, Rangel-Moreno J, Hartson L, Kusser K, Tighe MP, Klonowski KD, Lefrançois L, Cauley LS, Harmsen AG, Lund FE, Randall TD. Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs. Immunity. 2006 Oct; 25(4):643-54. PMID: 17045819.
      View in: PubMed
    48. Lefrançois L, Marzo AL. The descent of memory T-cell subsets. Nat Rev Immunol. 2006 Aug; 6(8):618-23. PMID: 16868553.
      View in: PubMed
    49. Tan X, Lefrançois L. Novel IL-15 isoforms generated by alternative splicing are expressed in the intestinal epithelium. Genes Immun. 2006 Jul; 7(5):407-16. PMID: 16791279.
      View in: PubMed
    50. Cose S, Brammer C, Zammit DJ, Blair DA, Lefrançois L. CD4 T cells inhibit the CD8 T cell response during low-dose virus infection. Int Immunol. 2006 Aug; 18(8):1285-93. PMID: 16769750.
      View in: PubMed
    51. Cose S, Brammer C, Khanna KM, Masopust D, Lefrançois L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur J Immunol. 2006 Jun; 36(6):1423-33. PMID: 16708400.
      View in: PubMed
    52. Lefrançois L. Development, trafficking, and function of memory T-cell subsets. Immunol Rev. 2006 Jun; 211:93-103. PMID: 16824120.
      View in: PubMed
    53. Zammit DJ, Turner DL, Klonowski KD, Lefrançois L, Cauley LS. Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity. 2006 Apr; 24(4):439-49. PMID: 16618602; PMCID: PMC2861289.
    54. Zammit DJ, Lefrançois L. Dendritic cell-T cell interactions in the generation and maintenance of CD8 T cell memory. Microbes Infect. 2006 Apr; 8(4):1108-15. PMID: 16549379.
      View in: PubMed
    55. Lefrançois L, Puddington L. Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo. Annu Rev Immunol. 2006; 24:681-704. PMID: 16551263.
      View in: PubMed
    56. Marzo AL, Klonowski KD, Le Bon A, Borrow P, Tough DF, Lefrançois L. Initial T cell frequency dictates memory CD8+ T cell lineage commitment. Nat Immunol. 2005 Aug; 6(8):793-9. PMID: 16025119; PMCID: PMC2849311.
    57. Klonowski KD, Lefrançois L. The CD8 memory T cell subsystem: integration of homeostatic signaling during migration. Semin Immunol. 2005 Jun; 17(3):219-29. PMID: 15826827.
      View in: PubMed
    58. Zammit DJ, Cauley LS, Pham QM, Lefrançois L. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity. 2005 May; 22(5):561-70. PMID: 15894274; PMCID: PMC2857562.
    59. Schluns KS, Stoklasek T, Lefrançois L. The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both? Int J Biochem Cell Biol. 2005 Aug; 37(8):1567-71. PMID: 15896666.
      View in: PubMed
    60. D'Souza WN, Lefrançois L. Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo. Eur J Immunol. 2004 Nov; 34(11):2977-85. PMID: 15384078.
      View in: PubMed
    61. Liu Z, Lefrançois L. Intestinal epithelial antigen induces mucosal CD8 T cell tolerance, activation, and inflammatory response. J Immunol. 2004 Oct 1; 173(7):4324-30. PMID: 15383561.
      View in: PubMed
    62. Marzo AL, Vezys V, Klonowski KD, Lee SJ, Muralimohan G, Moore M, Tough DF, Lefrançois L. Fully functional memory CD8 T cells in the absence of CD4 T cells. J Immunol. 2004 Jul 15; 173(2):969-75. PMID: 15240684.
      View in: PubMed
    63. Klonowski KD, Williams KJ, Marzo AL, Blair DA, Lingenheld EG, Lefrançois L. Dynamics of blood-borne CD8 memory T cell migration in vivo. Immunity. 2004 May; 20(5):551-62. PMID: 15142524.
      View in: PubMed
    64. Masopust D, Vezys V, Usherwood EJ, Cauley LS, Olson S, Marzo AL, Ward RL, Woodland DL, Lefrançois L. Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J Immunol. 2004 Apr 15; 172(8):4875-82. PMID: 15067066.
      View in: PubMed
    65. Schluns KS, Nowak EC, Cabrera-Hernandez A, Puddington L, Lefrançois L, Aguila HL. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5616-21. PMID: 15060278; PMCID: PMC397446.
    66. D'Souza WN, Lefrançois L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol. 2003 Dec 1; 171(11):5727-35. PMID: 14634080.
      View in: PubMed
    67. Schluns KS, Klonowski KD, Lefrançois L. Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells. Blood. 2004 Feb 1; 103(3):988-94. PMID: 14512307.
      View in: PubMed
    68. Lefrançois L, Marzo A, Williams K. Sustained response initiation is required for T cell clonal expansion but not for effector or memory development in vivo. J Immunol. 2003 Sep 15; 171(6):2832-9. PMID: 12960304.
      View in: PubMed
    69. Schluns KS, Lefrançois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol. 2003 Apr; 3(4):269-79. PMID: 12669018.
      View in: PubMed
    70. Masopust D, Lefrançois L. CD8 T-cell memory: the other half of the story. Microbes Infect. 2003 Mar; 5(3):221-6. PMID: 12681411.
      View in: PubMed
    71. Vezys V, Lefrançois L. Cutting edge: inflammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen. J Immunol. 2002 Dec 15; 169(12):6677-80. PMID: 12471097.
      View in: PubMed
    72. Lefrançois L, Masopust D. T cell immunity in lymphoid and non-lymphoid tissues. Curr Opin Immunol. 2002 Aug; 14(4):503-8. PMID: 12088686.
      View in: PubMed
    73. D'Souza WN, Schluns KS, Masopust D, Lefrançois L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol. 2002 Jun 1; 168(11):5566-72. PMID: 12023352.
      View in: PubMed
    74. Schluns KS, Williams K, Ma A, Zheng XX, Lefrançois L. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol. 2002 May 15; 168(10):4827-31. PMID: 11994430.
      View in: PubMed
    75. Marzo AL, Vezys V, Williams K, Tough DF, Lefrançois L. Tissue-level regulation of Th1 and Th2 primary and memory CD4 T cells in response to Listeria infection. J Immunol. 2002 May 1; 168(9):4504-10. PMID: 11970995.
      View in: PubMed
    76. Lefrançois L. Dual personality of memory T cells. Trends Immunol. 2002 May; 23(5):226-8. PMID: 12102732.
      View in: PubMed
    77. Makki A, Weidt G, Blachere NE, Lefrançois L, Srivastava PK. Immunization against a dominant tumor antigen abrogates immunogenicity of the tumor. Cancer Immun. 2002 Apr 16; 2:4. PMID: 12747749.
      View in: PubMed
    78. Lefrançois L, Marzo AL, Masopust D, Schluns KS, Vezy V. Migration of primary and memory CD8 T cells. Adv Exp Med Biol. 2002; 512:141-6. PMID: 12405198.
      View in: PubMed
    79. Lefrançois L, Lycke N. Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr Protoc Immunol. 2001 May; Chapter 3:Unit 3.19. PMID: 18432783.
      View in: PubMed
    80. Pope C, Kim SK, Marzo A, Masopust D, Williams K, Jiang J, Shen H, Lefrançois L. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J Immunol. 2001 Mar 1; 166(5):3402-9. PMID: 11207297.
      View in: PubMed
    81. Masopust D, Vezys V, Marzo AL, Lefrançois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 2001 Mar 23; 291(5512):2413-7. PMID: 11264538.
      View in: PubMed
    82. Masopust D, Jiang J, Shen H, Lefrançois L. Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection. J Immunol. 2001 Feb 15; 166(4):2348-56. PMID: 11160292.
      View in: PubMed
    83. Lefrançois L, Vezys V. Transgenic mouse model of intestine-specific mucosal injury and repair. J Natl Cancer Inst Monogr. 2001; (29):21-5. PMID: 11694561.
      View in: PubMed
    84. Schluns KS, Kieper WC, Jameson SC, Lefrançois L. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol. 2000 Nov; 1(5):426-32. PMID: 11062503.
      View in: PubMed
    85. Vezys V, Olson S, Lefrançois L. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity. 2000 May; 12(5):505-14. PMID: 10843383.
      View in: PubMed
    86. Laky K, Lefrançois L, Lingenheld EG, Ishikawa H, Lewis JM, Olson S, Suzuki K, Tigelaar RE, Puddington L. Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med. 2000 May 1; 191(9):1569-80. PMID: 10790431; PMCID: PMC2213426.
    87. Lefrançois L, Altman JD, Williams K, Olson S. Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells. J Immunol. 2000 Jan 15; 164(2):725-32. PMID: 10623816.
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    88. Boivin-Angèle S, Lefrançois L, Froment O, Spiethoff A, Bogdanffy MS, Wegener K, Wesch H, Barbin A, Bancel B, Trépo C, Bartsch H, Swenberg J, Marion MJ. Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. Int J Cancer. 2000 Jan 15; 85(2):223-7. PMID: 10629081.
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    89. Lefrançois L, Olson S, Masopust D. A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response. J Exp Med. 1999 Nov 1; 190(9):1275-84. PMID: 10544199; PMCID: PMC2195681.
    90. Kim SK, Schluns KS, Lefrançois L. Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J Immunol. 1999 Oct 15; 163(8):4125-32. PMID: 10510347.
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    91. Lefrançois L, Parker CM, Olson S, Muller W, Wagner N, Schön MP, Puddington L. The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med. 1999 May 17; 189(10):1631-8. PMID: 10330442; PMCID: PMC2193647.
    92. Lefrançois L, Puddington L. Anatomy of T-cell development in the intestine. Gastroenterology. 1998 Dec; 115(6):1588-91. PMID: 9834291.
      View in: PubMed
    93. Kim SK, Reed DS, Olson S, Schnell MJ, Rose JK, Morton PA, Lefrançois L. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proc Natl Acad Sci U S A. 1998 Sep 1; 95(18):10814-9. PMID: 9724787; PMCID: PMC27978.
    94. Laky K, Lefrançois L, von Freeden-Jeffry U, Murray R, Puddington L. The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells. J Immunol. 1998 Jul 15; 161(2):707-13. PMID: 9670946.
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    95. Reed DS, Olson S, Lefrançois L. Glycosyltransferase regulation mediated by pre-TCR signaling in early thymocyte development. Int Immunol. 1998 Apr; 10(4):445-51. PMID: 9620600.
      View in: PubMed
    96. Kim SK, Reed DS, Heath WR, Carbone F, Lefrançois L. Activation and migration of CD8 T cells in the intestinal mucosa. J Immunol. 1997 Nov 1; 159(9):4295-306. PMID: 9379025.
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    97. Laky K, Lefrançois L, Puddington L. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J Immunol. 1997 Feb 1; 158(3):1417-27. PMID: 9013987.
      View in: PubMed
    98. Lefrançois L, Fuller B, Huleatt JW, Olson S, Puddington L. On the front lines: intraepithelial lymphocytes as primary effectors of intestinal immunity. Springer Semin Immunopathol. 1997; 18(4):463-75. PMID: 9144865.
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    99. Huleatt JW, Lefrançois L. Beta2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity. 1996 Sep; 5(3):263-73. PMID: 8808681.
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    100. Lefrançois L, Puddington L. The role of the thymus in intestinal intraepithelial T-cell development. Ann N Y Acad Sci. 1996 Feb 13; 778:36-46. PMID: 8610990.
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    101. Fuller B, Lefrançois L. Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes. J Immunol. 1995 Sep 15; 155(6):2808-11. PMID: 7673696.
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    102. Huleatt JW, Lefrançois L. Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo. J Immunol. 1995 Jun 1; 154(11):5684-93. PMID: 7751620.
      View in: PubMed
    103. Lefrançois L, Puddington L. Extrathymic intestinal T-cell development: virtual reality? Immunol Today. 1995 Jan; 16(1):16-21. PMID: 7880383.
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    104. Puddington L, Olson S, Lefrançois L. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity. 1994 Dec; 1(9):733-9. PMID: 7534619.
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    105. Lefrançois L, Olson S. A novel pathway of thymus-directed T lymphocyte maturation. J Immunol. 1994 Aug 1; 153(3):987-95. PMID: 8027568.
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    106. Lefrançois L, Barrett TA, Havran WL, Puddington L. Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells. Eur J Immunol. 1994 Mar; 24(3):635-40. PMID: 7907296.
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    107. Gramzinski RA, Adams E, Gross JA, Goodman TG, Allison JP, Lefrançois L. T cell receptor-triggered activation of intraepithelial lymphocytes in vitro. Int Immunol. 1993 Feb; 5(2):145-53. PMID: 8383994.
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    108. Badiner G, Goodman TG, Lefrançois L. Selection of intestinal intraepithelial lymphocyte T cell receptors: evidence for a dynamic tissue-specific process. Int Immunol. 1993 Feb; 5(2):223-6. PMID: 8452818.
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    109. Lefrançois L. Maturation, selection and specificity of Tcr gamma delta T cells. Immunol Res. 1992; 11(1):54-65. PMID: 1534829.
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    110. Lefrançois L. Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire? Immunol Today. 1991 Dec; 12(12):436-8. PMID: 1786079.
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    111. Lefrançois L. Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser. Semin Immunol. 1991 Mar; 3(2):99-108. PMID: 1832321.
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    112. Thomas ML, Lefrançois L. Differential expression of the leucocyte-common antigen family. Immunol Today. 1988 Oct; 9(10):320-6. PMID: 2978372.
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    113. Goodman T, Lefrançois L. Expression of the gamma-delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature. 1988 Jun 30; 333(6176):855-8. PMID: 2968521.
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    114. Puddington L, Bevan MJ, Rose JK, Lefrançois L. N protein is the predominant antigen recognized by vesicular stomatitis virus-specific cytotoxic T cells. J Virol. 1986 Nov; 60(2):708-17. PMID: 3022003; PMCID: PMC288945.
    115. Lefrançois L, Bevan MJ. Novel antigenic determinants of the T200 glycoprotein expressed preferentially by activated cytotoxic T lymphocytes. J Immunol. 1985 Jul; 135(1):374-83. PMID: 2582040.
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    116. Lefrançois L, Bevan MJ. Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies. Nature. 1985 Apr 4-10; 314(6010):449-52. PMID: 2580241.
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    117. Hale AH, Ruebush MJ, Lefrançois L. Cross-reactive anti-vesicular stomatitis virus (VSV) cytotoxic T lymphocytes recognize the major surface glycoprotein. Eur J Immunol. 1981 May; 11(5):434-6. PMID: 6266837.
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