Last Name

Bruce J Mayer PhD

InstitutionUConn Health Center
DepartmentGenetics and Developmental Biology
AddressMC 6403
Cell and Genome Sciences Building, MC 6403
400 Farmington Avenue
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jadwin JA, Oh D, Curran TG, Ogiue-Ikeda M, Jia L, White FM, Machida K, Yu J, Mayer BJ. Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases. Elife. 2016; 5. PMID: 27071344.
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    2. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Correction: Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2015 Dec 7; 211(5):1095-8. PMID: 26644519.
      View in: PubMed
    3. Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, Mayer BJ. Integration of linear and dendritic actin nucleation in Nck-induced actin comets. Mol Biol Cell. 2016 Jan 15; 27(2):247-59. PMID: 26609071.
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    4. Mayer BJ. The discovery of modular binding domains: building blocks of cell signalling. Nat Rev Mol Cell Biol. 2015 Nov; 16(11):691-8. PMID: 26420231.
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    5. Jadwin JA, Mayer BJ, Machida K. Detection and quantification of protein-protein interactions by far-western blotting. Methods Mol Biol. 2015; 1312:379-98. PMID: 26044019.
      View in: PubMed
    6. Taslimi A, Vrana JD, Chen D, Borinskaya S, Mayer BJ, Kennedy MJ, Tucker CL. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun. 2014; 5:4925. PMID: 25233328; PMCID: PMC4170572.
    7. Ng KY, Yin T, Machida K, Wu YI, Mayer BJ. Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity. Oncogene. 2015 May 14; 34(20):2650-9. PMID: 25043303; PMCID: PMC4302068.
    8. Mayer BJ. Tony Pawson and the germination and flowering of cell signaling: an appreciation. BMC Biol. 2013; 11:95. PMID: 24502764; PMCID: PMC3765445.
    9. Jones MC, Machida K, Mayer BJ, Turner CE. Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell. 2013 Jun; 24(12):1882-94. PMID: 23615439; PMCID: PMC3681694.
    10. Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G. The SH2 domain interaction landscape. Cell Rep. 2013 Apr 25; 3(4):1293-305. PMID: 23545499; PMCID: PMC4110347.
    11. Ditlev JA, Mayer BJ, Loew LM. There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton. Biophys J. 2013 Feb 5; 104(3):520-32. PMID: 23442903; PMCID: PMC3566448.
    12. Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG. Coordinated activation of the Rac-GAP ß2-chimaerin by an atypical proline-rich domain and diacylglycerol. Nat Commun. 2013; 4:1849. PMID: 23673634; PMCID: PMC3700536.
    13. Oh D, Ogiue-Ikeda M, Jadwin JA, Machida K, Mayer BJ, Yu J. Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14024-9. PMID: 22886086; PMCID: PMC3435163.
    14. Ditlev JA, Michalski PJ, Huber G, Rivera GM, Mohler WA, Loew LM, Mayer BJ. Stoichiometry of Nck-dependent actin polymerization in living cells. J Cell Biol. 2012 May 28; 197(5):643-58. PMID: 22613834; PMCID: PMC3365498.
    15. Mayer BJ. Perspective: Dynamics of receptor tyrosine kinase signaling complexes. FEBS Lett. 2012 Aug 14; 586(17):2575-9. PMID: 22584051; PMCID: PMC3413745.
    16. Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA. Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. J Cell Sci. 2010 Nov 15; 123(Pt 22):3923-32. PMID: 20980387; PMCID: PMC2972274.
    17. Machida K, Eschrich S, Li J, Bai Y, Koomen J, Mayer BJ, Haura EB. Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling. PLoS One. 2010; 5(10):e13470. PMID: 20976048; PMCID: PMC2957407.
    18. Zheng J, Machida K, Antoku S, Ng KY, Claffey KP, Mayer BJ. Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation. Oncogene. 2010 Dec 2; 29(48):6378-89. PMID: 20729917; PMCID: PMC2996469.
    19. Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010 Aug 4; 584(15):3279-86. PMID: 20598684; PMCID: PMC2917628.
    20. Lazer G, Pe'er L, Farago M, Machida K, Mayer BJ, Katzav S. Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. J Biol Chem. 2010 Jul 23; 285(30):23075-85. PMID: 20457609; PMCID: PMC2906301.
    21. Rivera GM, Vasilescu D, Papayannopoulos V, Lim WA, Mayer BJ. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol Cell. 2009 Nov 13; 36(3):525-35. PMID: 19917259; PMCID: PMC2793683.
    22. Antoku S, Mayer BJ. Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals. J Cell Sci. 2009 Nov 15; 122(Pt 22):4228-38. PMID: 19861495; PMCID: PMC2776506.
    23. Mayer BJ, Blinov ML, Loew LM. Molecular machines or pleiomorphic ensembles: signaling complexes revisited. J Biol. 2009; 8(9):81. PMID: 19835637; PMCID: PMC2776906.
    24. Hu T, Shi G, Larose L, Rivera GM, Mayer BJ, Zhou R. Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1. Biochemistry. 2009 Jul 14; 48(27):6369-78. PMID: 19505147; PMCID: PMC2750895.
    25. Lapetina S, Mader CC, Machida K, Mayer BJ, Koleske AJ. Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J Cell Biol. 2009 May 4; 185(3):503-19. PMID: 19414610; PMCID: PMC2700396.
    26. Machida K, Mayer BJ. Detection of protein-protein interactions by far-western blotting. Methods Mol Biol. 2009; 536:313-29. PMID: 19378071.
      View in: PubMed
    27. Dierck K, Machida K, Mayer BJ, Nollau P. Profiling the tyrosine phosphorylation state using SH2 domains. Methods Mol Biol. 2009; 527:131-55, ix. PMID: 19241011.
      View in: PubMed
    28. Antoku S, Saksela K, Rivera GM, Mayer BJ. A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors. J Cell Sci. 2008 Sep 15; 121(Pt 18):3071-82. PMID: 18768933; PMCID: PMC2768557.
    29. Sharma A, Mayer BJ. Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. BMC Cell Biol. 2008; 9:50. PMID: 18793427; PMCID: PMC2553404.
    30. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 2008 Aug 21; 454(7207):1005-8. PMID: 18650806; PMCID: PMC2749708.
    31. Mayer BJ. Clues to the evolution of complex signaling machinery. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9453-4. PMID: 18621723; PMCID: PMC2474536.
    32. Machida K, Thompson CM, Dierck K, Jablonowski K, Kärkkäinen S, Liu B, Zhang H, Nash PD, Newman DK, Nollau P, Pawson T, Renkema GH, Saksela K, Schiller MR, Shin DG, Mayer BJ. High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell. 2007 Jun 22; 26(6):899-915. PMID: 17588523.
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    33. Dierck K, Machida K, Voigt A, Thimm J, Horstmann M, Fiedler W, Mayer BJ, Nollau P. Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains. Nat Methods. 2006 Sep; 3(9):737-44. PMID: 16929320.
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    34. Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ. Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9536-41. PMID: 16769879; PMCID: PMC1476694.
    35. Mayer BJ. Protein-protein interactions in signaling cascades. Methods Mol Biol. 2006; 332:79-99. PMID: 16878686.
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    36. Itoh RE, Kurokawa K, Fujioka A, Sharma A, Mayer BJ, Matsuda M. A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes. Exp Cell Res. 2005 Jul 1; 307(1):142-52. PMID: 15922734.
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    37. Machida K, Mayer BJ. The SH2 domain: versatile signaling module and pharmaceutical target. Biochim Biophys Acta. 2005 Feb 14; 1747(1):1-25. PMID: 15680235.
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    38. Rivera GM, Briceño CA, Takeshima F, Snapper SB, Mayer BJ. Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization. Curr Biol. 2004 Jan 6; 14(1):11-22. PMID: 14711409.
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    39. Sharma A, Antoku S, Fujiwara K, Mayer BJ. Functional interaction trap: a strategy for validating the functional consequences of tyrosine phosphorylation of specific substrates in vivo. Mol Cell Proteomics. 2003 Nov; 2(11):1217-24. PMID: 14519720.
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    40. Machida K, Mayer BJ, Nollau P. Profiling the global tyrosine phosphorylation state. Mol Cell Proteomics. 2003 Apr; 2(4):215-33. PMID: 12754303.
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    41. Fujiwara K, Poikonen K, Aleman L, Valtavaara M, Saksela K, Mayer BJ. A single-chain antibody/epitope system for functional analysis of protein-protein interactions. Biochemistry. 2002 Oct 22; 41(42):12729-38. PMID: 12379115.
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    42. Aasland R, Abrams C, Ampe C, Ball LJ, Bedford MT, Cesareni G, Gimona M, Hurley JH, Jarchau T, Lehto VP, Lemmon MA, Linding R, Mayer BJ, Nagai M, Sudol M, Walter U, Winder SJ. Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett. 2002 Feb 20; 513(1):141-4. PMID: 11911894.
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    43. Parrini MC, Lei M, Harrison SC, Mayer BJ. Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell. 2002 Jan; 9(1):73-83. PMID: 11804587.
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    44. Smith JM, Mayer BJ. Abl: mechanisms of regulation and activation. Front Biosci. 2002 Jan 1; 7:d31-42. PMID: 11779715.
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    45. Mayer BJ. SH3 domains: complexity in moderation. J Cell Sci. 2001 Apr; 114(Pt 7):1253-63. PMID: 11256992.
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