Last Name

Kazuya Machida PhD, MD

TitleAssistant Professor
InstitutionUConn Health Center
DepartmentGenetics and Developmental Biology
AddressMC 6403
Cell and Genome Sciences Building, MC 6403
400 Farmington Avenue
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jadwin JA, Oh D, Curran TG, Ogiue-Ikeda M, Jia L, White FM, Machida K, Yu J, Mayer BJ. Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases. Elife. 2016; 5. PMID: 27071344.
      View in: PubMed
    2. Thompson CM, Bloom LR, Ogiue-Ikeda M, Machida K. SH2-PLA: a sensitive in-solution approach for quantification of modular domain binding by proximity ligation and real-time PCR. BMC Biotechnol. 2015; 15:60. PMID: 26112401; PMCID: PMC4482279.
    3. Jadwin JA, Mayer BJ, Machida K. Detection and quantification of protein-protein interactions by far-western blotting. Methods Mol Biol. 2015; 1312:379-98. PMID: 26044019.
      View in: PubMed
    4. Ng KY, Yin T, Machida K, Wu YI, Mayer BJ. Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity. Oncogene. 2015 May 14; 34(20):2650-9. PMID: 25043303; PMCID: PMC4302068.
    5. Gifford SM, Liu W, Mader CC, Halo TL, Machida K, Boggon TJ, Koleske AJ. Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. J Biol Chem. 2014 Jul 11; 289(28):19704-13. PMID: 24891505; PMCID: PMC4094080.
    6. Jones MC, Machida K, Mayer BJ, Turner CE. Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell. 2013 Jun; 24(12):1882-94. PMID: 23615439; PMCID: PMC3681694.
    7. Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G. The SH2 domain interaction landscape. Cell Rep. 2013 Apr 25; 3(4):1293-305. PMID: 23545499; PMCID: PMC4110347.
    8. Oh D, Ogiue-Ikeda M, Jadwin JA, Machida K, Mayer BJ, Yu J. Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14024-9. PMID: 22886086; PMCID: PMC3435163.
    9. Machida K, Khenkhar M, Nollau P. Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling. Genes Cancer. 2012 May; 3(5-6):353-61. PMID: 23226573; PMCID: PMC3513784.
    10. Jadwin JA, Ogiue-Ikeda M, Machida K. The application of modular protein domains in proteomics. FEBS Lett. 2012 Aug 14; 586(17):2586-96. PMID: 22710164; PMCID: PMC3413744.
    11. Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA. Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation. J Cell Sci. 2010 Nov 15; 123(Pt 22):3923-32. PMID: 20980387; PMCID: PMC2972274.
    12. Machida K, Eschrich S, Li J, Bai Y, Koomen J, Mayer BJ, Haura EB. Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling. PLoS One. 2010; 5(10):e13470. PMID: 20976048; PMCID: PMC2957407.
    13. Zheng J, Machida K, Antoku S, Ng KY, Claffey KP, Mayer BJ. Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation. Oncogene. 2010 Dec 2; 29(48):6378-89. PMID: 20729917; PMCID: PMC2996469.
    14. Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010 Aug 4; 584(15):3279-86. PMID: 20598684; PMCID: PMC2917628.
    15. Lazer G, Pe'er L, Farago M, Machida K, Mayer BJ, Katzav S. Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity. J Biol Chem. 2010 Jul 23; 285(30):23075-85. PMID: 20457609; PMCID: PMC2906301.
    16. Lapetina S, Mader CC, Machida K, Mayer BJ, Koleske AJ. Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. J Cell Biol. 2009 May 4; 185(3):503-19. PMID: 19414610; PMCID: PMC2700396.
    17. Machida K, Mayer BJ. Detection of protein-protein interactions by far-western blotting. Methods Mol Biol. 2009; 536:313-29. PMID: 19378071.
      View in: PubMed
    18. Dierck K, Machida K, Mayer BJ, Nollau P. Profiling the tyrosine phosphorylation state using SH2 domains. Methods Mol Biol. 2009; 527:131-55, ix. PMID: 19241011.
      View in: PubMed
    19. Machida K, Thompson CM, Dierck K, Jablonowski K, Kärkkäinen S, Liu B, Zhang H, Nash PD, Newman DK, Nollau P, Pawson T, Renkema GH, Saksela K, Schiller MR, Shin DG, Mayer BJ. High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell. 2007 Jun 22; 26(6):899-915. PMID: 17588523.
      View in: PubMed
    20. Dierck K, Machida K, Voigt A, Thimm J, Horstmann M, Fiedler W, Mayer BJ, Nollau P. Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains. Nat Methods. 2006 Sep; 3(9):737-44. PMID: 16929320.
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    21. Machida K, Mayer BJ. The SH2 domain: versatile signaling module and pharmaceutical target. Biochim Biophys Acta. 2005 Feb 14; 1747(1):1-25. PMID: 15680235.
      View in: PubMed
    22. Takenouchi Y, Oo ML, Senga T, Watanabe Y, Machida K, Miyazaki K, Nimura Y, Hamaguchi M. Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells. Oncol Rep. 2004 May; 11(5):1059-62. PMID: 15069547.
      View in: PubMed
    23. Machida K, Mayer BJ, Nollau P. Profiling the global tyrosine phosphorylation state. Mol Cell Proteomics. 2003 Apr; 2(4):215-33. PMID: 12754303.
      View in: PubMed
    24. Ruhul Amin AR, Machida K, Oshima K, Oo ML, Thant AA, Senga T, Matsuda S, Akhand AA, Maeda A, Kurosaki T, Hamaguchi M. A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. Oncogene. 2002 Dec 12; 21(57):8871-8. PMID: 12483539.
      View in: PubMed
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