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Last Name
Institution

David F Grant PhD

TitleAssociate Professor
InstitutionUniversity of Connecticut
DepartmentPharmaceutical Sciences
AddressUNIT 3092
Pharmacy/Bio, UNIT 3092
69 N Eagleville Road
Phone860-486-4265
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Menikarachchi LC, Dubey R, Hill DW, Brush DN, Grant DF. Development of Database Assisted Structure Identification (DASI) Methods for Nontargeted Metabolomics. Metabolites. 2016; 6(2). PMID: 27258318.
      View in: PubMed
    2. Hamdalla MA, Rajasekaran S, Grant DF, Mandoiu II. Metabolic pathway predictions for metabolomics: a molecular structure matching approach. J Chem Inf Model. 2015 Mar 23; 55(3):709-18. PMID: 25668446.
      View in: PubMed
    3. Hall LM, Hill DW, Menikarachchi LC, Chen MH, Hall LH, Grant DF. Optimizing artificial neural network models for metabolomics and systems biology: an example using HPLC retention index data. Bioanalysis. 2015; 7(8):939-55. PMID: 25966007; PMCID: PMC4462168 [Available on 03/01/16].
    4. Paglia G, Angel P, Williams JP, Richardson K, Olivos HJ, Thompson JW, Menikarachchi L, Lai S, Walsh C, Moseley A, Plumb RS, Grant DF, Palsson BO, Langridge J, Geromanos S, Astarita G. Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification. Anal Chem. 2015 Jan 20; 87(2):1137-44. PMID: 25495617; PMCID: PMC4302848.
    5. Hall LH, Hall LM, Hill DW, Hawkins DM, Chen MH, Grant DF. Development of a two-step indirect method for modeling Ecom50. Curr Comput Aided Drug Des. 2014; 10(4):374-82. PMID: 25549758.
      View in: PubMed
    6. Hall LM, Hill DW, Hall LH, Kormos TM, Grant DF. Development of HPLC Retention Index QSAR Models for Nontargeted Metabolomics. Adv Chromatogr. 2014; 51:241-79. PMID: 26462375.
      View in: PubMed
    7. Menikarachchi LC, Hill DW, Hamdalla MA, Mandoiu II, Grant DF. In silico enzymatic synthesis of a 400,000 compound biochemical database for nontargeted metabolomics. J Chem Inf Model. 2013 Sep 23; 53(9):2483-92. PMID: 23991755; PMCID: PMC3819714.
    8. Menikarachchi LC, Hamdalla MA, Hill DW, Grant DF. Chemical structure identification in metabolomics: computational modeling of experimental features. Comput Struct Biotechnol J. 2013; 5:e201302005. PMID: 24688698; PMCID: PMC3962140.
    9. Hamdalla MA, Mandoiu II, Hill DW, Rajasekaran S, Grant DF. BioSM: metabolomics tool for identifying endogenous mammalian biochemical structures in chemical structure space. J Chem Inf Model. 2013 Mar 25; 53(3):601-12. PMID: 23330685; PMCID: PMC3866231.
    10. Menikarachchi LC, Cawley S, Hill DW, Hall LM, Hall L, Lai S, Wilder J, Grant DF. MolFind: a software package enabling HPLC/MS-based identification of unknown chemical structures. Anal Chem. 2012 Nov 6; 84(21):9388-94. PMID: 23039714; PMCID: PMC3523192.
    11. Hill DW, Baveghems CL, Albaugh DR, Kormos TM, Lai S, Ng HK, Grant DF. Correlation of Ecom50 values between mass spectrometers: effect of collision cell radiofrequency voltage on calculated survival yield. Rapid Commun Mass Spectrom. 2012 Oct 15; 26(19):2303-10. PMID: 22956322; PMCID: PMC3439163.
    12. Hall LM, Hall LH, Kertesz TM, Hill DW, Sharp TR, Oblak EZ, Dong YW, Wishart DS, Chen MH, Grant DF. Development of Ecom50 and retention index models for nontargeted metabolomics: identification of 1,3-dicyclohexylurea in human serum by HPLC/mass spectrometry. J Chem Inf Model. 2012 May 25; 52(5):1222-37. PMID: 22489687; PMCID: PMC3376006.
    13. Kertesz TM, Hill DW, Albaugh DR, Hall LH, Hall LM, Grant DF. Database searching for structural identification of metabolites in complex biofluids for mass spectrometry-based metabonomics. Bioanalysis. 2009 Dec; 1(9):1627-43. PMID: 21083108.
      View in: PubMed
    14. Kertesz TM, Hall LH, Hill DW, Grant DF. CE50: quantifying collision induced dissociation energy for small molecule characterization and identification. J Am Soc Mass Spectrom. 2009 Sep; 20(9):1759-67. PMID: 19616966.
      View in: PubMed
    15. Albaugh DR, Hall LM, Hill DW, Kertesz TM, Parham M, Hall LH, Grant DF. Prediction of HPLC retention index using artificial neural networks and IGroup E-state indices. J Chem Inf Model. 2009 Apr; 49(4):788-99. PMID: 19309176.
      View in: PubMed
    16. Cao L, Zhang P, Grant DF. An insect farnesyl phosphatase homologous to the N-terminal domain of soluble epoxide hydrolase. Biochem Biophys Res Commun. 2009 Feb 27; 380(1):188-92. PMID: 19168029; PMCID: PMC2657470.
    17. EnayetAllah AE, Luria A, Luo B, Tsai HJ, Sura P, Hammock BD, Grant DF. Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase. J Biol Chem. 2008 Dec 26; 283(52):36592-8. PMID: 18974052; PMCID: PMC2605982.
    18. Hill DW, Kertesz TM, Fontaine D, Friedman R, Grant DF. Mass spectral metabonomics beyond elemental formula: chemical database querying by matching experimental with computational fragmentation spectra. Anal Chem. 2008 Jul 15; 80(14):5574-82. PMID: 18547062.
      View in: PubMed
    19. Luo B, Norris C, Bolstad ES, Knecht DA, Grant DF. Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase. J Mol Biol. 2008 Jun 27; 380(1):31-41. PMID: 18513744; PMCID: PMC2515390.
    20. Sura P, Sura R, Enayetallah AE, Grant DF. Distribution and expression of soluble epoxide hydrolase in human brain. J Histochem Cytochem. 2008 Jun; 56(6):551-9. PMID: 18319271; PMCID: PMC2386770.
    21. Ghosh S, Grant DF, Dey DK, Hill DW. A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles. BMC Bioinformatics. 2008; 9:38. PMID: 18215299; PMCID: PMC2253516.
    22. Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. J Neurosci. 2007 Apr 25; 27(17):4642-9. PMID: 17460077.
      View in: PubMed
    23. Enayetallah AE, French RA, Grant DF. Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms. J Mol Histol. 2006 May; 37(3-4):133-41. PMID: 16957870.
      View in: PubMed
    24. Yang J, Morton MD, Hill DW, Grant DF. NMR and HPLC-MS/MS analysis of synthetically prepared linoleic acid diol glucuronides. Chem Phys Lipids. 2006 Apr; 140(1-2):75-87. PMID: 16500631.
      View in: PubMed
    25. Enayetallah AE, Grant DF. Effects of human soluble epoxide hydrolase polymorphisms on isoprenoid phosphate hydrolysis. Biochem Biophys Res Commun. 2006 Mar 3; 341(1):254-60. PMID: 16414022.
      View in: PubMed
    26. Enayetallah AE, French RA, Barber M, Grant DF. Cell-specific subcellular localization of soluble epoxide hydrolase in human tissues. J Histochem Cytochem. 2006 Mar; 54(3):329-35. PMID: 16314446.
      View in: PubMed
    27. Srivastava PK, Sharma VK, Kalonia DS, Grant DF. Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Arch Biochem Biophys. 2004 Jul 15; 427(2):164-9. PMID: 15196990.
      View in: PubMed
    28. Enayetallah AE, French RA, Thibodeau MS, Grant DF. Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. J Histochem Cytochem. 2004 Apr; 52(4):447-54. PMID: 15033996.
      View in: PubMed
    29. Nowak G, Grant DF, Moran JH. Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia. Toxicol Lett. 2004 Mar 1; 147(2):161-75. PMID: 14757320.
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    30. Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol. 2003 Aug; 64(2):482-90. PMID: 12869654.
      View in: PubMed
    31. Ha J, Dobretsov M, Kurten RC, Grant DF, Stimers JR. Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. Toxicol Appl Pharmacol. 2002 Jul 1; 182(1):76-83. PMID: 12127265.
      View in: PubMed
    32. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002 Jun; 143(6):2376-84. PMID: 12021203.
      View in: PubMed
    33. Mitchell LA, Moran JH, Grant DF. Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. Toxicol Lett. 2002 Feb 7; 126(3):187-96. PMID: 11814707.
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    34. Mitchell LA, Grant DF, Melchert RB, Petty NM, Kennedy RH. Linoleic acid metabolites act to increase contractility in isolated rat heart. Cardiovasc Toxicol. 2002; 2(3):219-30. PMID: 12665667.
      View in: PubMed
    35. Moran JH, Mitchell LA, Grant DF. Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. Toxicol Appl Pharmacol. 2001 Nov 1; 176(3):153-61. PMID: 11714247.
      View in: PubMed
    36. Sarang SS, Plotkin MD, Gullans SR, Cummings BS, Grant DF, Schnellmann RG. Identification of the gamma-aminobutyric acid receptor beta(2) and beta(3) subunits in rat, rabbit, and human kidneys. J Am Soc Nephrol. 2001 Jun; 12(6):1107-13. PMID: 11373333.
      View in: PubMed
    37. Jude AR, Little JM, Czernik PJ, Tephly TR, Grant DF, Radominska-Pandya A. Glucuronidation of linoleic acid diols by human microsomal and recombinant UDP-glucuronosyltransferases: identification of UGT2B7 as the major isoform involved. Arch Biochem Biophys. 2001 May 15; 389(2):176-86. PMID: 11339806.
      View in: PubMed
    38. Moran JH, Nowak G, Grant DF. Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. Toxicol Appl Pharmacol. 2001 Apr 15; 172(2):150-61. PMID: 11298501.
      View in: PubMed
    39. Moran JH, Mon T, Hendrickson TL, Mitchell LA, Grant DF. Defining mechanisms of toxicity for linoleic acid monoepoxides and diols in Sf-21 cells. Chem Res Toxicol. 2001 Apr; 14(4):431-7. PMID: 11304132.
      View in: PubMed
    40. Moran JH, Mitchell LA, Bradbury JA, Qu W, Zeldin DC, Schnellmann RG, Grant DF. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. Toxicol Appl Pharmacol. 2000 Nov 1; 168(3):268-79. PMID: 11042099.
      View in: PubMed
    41. Jude AR, Little JM, Freeman JP, Evans JE, Radominska-Pandya A, Grant DF. Linoleic acid diols are novel substrates for human UDP-glucuronosyltransferases. Arch Biochem Biophys. 2000 Aug 15; 380(2):294-302. PMID: 10933884.
      View in: PubMed
    42. Greene JF, Zheng J, Grant DF, Hammock BD. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol Sci. 2000 Feb; 53(2):352-60. PMID: 10696783.
      View in: PubMed
    43. Stimers JR, Dobretsov M, Hastings SL, Jude AR, Grant DF. Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. Biochim Biophys Acta. 1999 Jun 10; 1438(3):359-68. PMID: 10366778.
      View in: PubMed
    44. Mullen RT, Trelease RN, Duerk H, Arand M, Hammock BD, Oesch F, Grant DF. Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants. FEBS Lett. 1999 Feb 26; 445(2-3):301-5. PMID: 10094477.
      View in: PubMed
    45. Sarang SS, Miller GW, Grant DF, Schnellmann RG. Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys. Nephron. 1999; 82(3):254-60. PMID: 10395998.
      View in: PubMed
    46. Grant DF, Bessho T, Reardon JT. Nucleotide excision repair of melphalan monoadducts. Cancer Res. 1998 Nov 15; 58(22):5196-200. PMID: 9823332.
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    47. York JL, Maddox LC, Zimniak P, McHugh TE, Grant DF. Reduction of MTT by glutathione S-transferase. Biotechniques. 1998 Oct; 25(4):622-4, 626-8. PMID: 9793644.
      View in: PubMed
    48. Moran JH, Weise R, Schnellmann RG, Freeman JP, Grant DF. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. Toxicol Appl Pharmacol. 1997 Sep; 146(1):53-9. PMID: 9299596.
      View in: PubMed
    49. Moghaddam MF, Grant DF, Cheek JM, Greene JF, Williamson KC, Hammock BD. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nat Med. 1997 May; 3(5):562-6. PMID: 9142128.
      View in: PubMed
    50. Parker AG, Pinot F, Grant DF, Spearow J, Hammock BD. Regulation of mouse liver microsomal esterases by clofibrate and sexual hormones. Biochem Pharmacol. 1996 Mar 8; 51(5):677-85. PMID: 8615905.
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    51. Grant DF, Greene JF, Pinot F, Borhan B, Moghaddam MF, Hammock BD, McCutchen B, Ohkawa H, Luo G, Guenthner TM. Development of an in situ toxicity assay system using recombinant baculoviruses. Biochem Pharmacol. 1996 Feb 23; 51(4):503-15. PMID: 8619897.
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    52. Borhan B, Jones AD, Pinot F, Grant DF, Kurth MJ, Hammock BD. Mechanism of soluble epoxide hydrolase. Formation of an alpha-hydroxy ester-enzyme intermediate through Asp-333. J Biol Chem. 1995 Nov 10; 270(45):26923-30. PMID: 7592938.
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    53. Pinot F, Grant DF, Spearow JL, Parker AG, Hammock BD. Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice. Biochem Pharmacol. 1995 Aug 8; 50(4):501-8. PMID: 7646556.
      View in: PubMed
    54. Pinot F, Grant DF, Beetham JK, Parker AG, Borhan B, Landt S, Jones AD, Hammock BD. Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase. J Biol Chem. 1995 Apr 7; 270(14):7968-74. PMID: 7713895.
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    55. Harshman LG, Ward VK, Beetham JK, Grant DF, Grahan LJ, Zraket CA, Heckel DG, Hammock BD. Cloning, characterization, and genetics of the juvenile hormone esterase gene from Heliothis virescens. Insect Biochem Mol Biol. 1994 Jul; 24(7):671-6. PMID: 7915171.
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    56. Grant DF, Spearow JL, Storms DH, Edelhoff S, Adler DA, Disteche CM, Taylor BA, Hammock BD. Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene. Pharmacogenetics. 1994 Apr; 4(2):64-72. PMID: 7915936.
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    57. Hammock BD, Pinot F, Beetham JK, Grant DF, Arand ME, Oesch F. Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase. Biochem Biophys Res Commun. 1994 Feb 15; 198(3):850-6. PMID: 8117289.
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    58. Arand M, Grant DF, Beetham JK, Friedberg T, Oesch F, Hammock BD. Sequence similarity of mammalian epoxide hydrolases to the bacterial haloalkane dehalogenase and other related proteins. Implication for the potential catalytic mechanism of enzymatic epoxide hydrolysis. FEBS Lett. 1994 Feb 7; 338(3):251-6. PMID: 8307189.
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    59. Grant DF, Storms DH, Hammock BD. Molecular cloning and expression of murine liver soluble epoxide hydrolase. J Biol Chem. 1993 Aug 15; 268(23):17628-33. PMID: 8349642.
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    60. Moody DE, Gibson GG, Grant DF, Magdalou J, Rao MS. Peroxisome proliferators, a unique set of drug-metabolizing enzyme inducers: commentary on a symposium. Drug Metab Dispos. 1992 Nov-Dec; 20(6):779-91. PMID: 1362927.
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    61. Grant DF, Hammock BD. Genetic and molecular evidence for a trans-acting regulatory locus controlling glutathione S-transferase-2 expression in Aedes aegypti. Mol Gen Genet. 1992 Aug; 234(2):169-76. PMID: 1508145.
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