Keywords
Last Name
Institution

Ernesto Canalis MD

TitleDirector of Research
InstitutionSaint Francis Hospital and Medical Center
DepartmentResearch
Address114 Woodland Street
Phone860-714-4068
Fax860-714-8053
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    Other Positions
    TitleProfessor
    InstitutionUConn Health Center
    DepartmentMedicine

    TitleProfessor
    InstitutionUConn Health Center
    DepartmentOrthopaedic Surgery


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Canalis E, Zanotti S. Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations. Curr Osteoporos Rep. 2016 Aug; 14(4):126-31. PMID: 27241678.
      View in: PubMed
    2. Zanotti S, Canalis E. Notch Signaling and the Skeleton. Endocr Rev. 2016 Jun; 37(3):223-53. PMID: 27074349.
      View in: PubMed
    3. Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S. Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption. J Biol Chem. 2016 Jan 22; 291(4):1538-51. PMID: 26627824.
      View in: PubMed
    4. Canalis E, Bridgewater D, Schilling L, Zanotti S. Canonical Notch activation in osteocytes causes osteopetrosis. Am J Physiol Endocrinol Metab. 2016 Jan 15; 310(2):E171-82. PMID: 26578715.
      View in: PubMed
    5. Zanotti S, Canalis E. The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele. J Cell Biochem. 2016 May; 117(5):1222-32. PMID: 26456319.
      View in: PubMed
    6. DeMambro VE, Le PT, Guntur AR, Maridas DE, Canalis E, Nagano K, Baron R, Clemmons DR, Rosen CJ. Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. Endocrinology. 2015 Nov; 156(11):4129-40. PMID: 26230658; PMCID: PMC4606757 [Available on 11/01/16].
    7. Zanotti S, Canalis E. Activation of Nfatc2 in osteoblasts causes osteopenia. J Cell Physiol. 2015 Jul; 230(7):1689-95. PMID: 25573264; PMCID: PMC4380686 [Available on 07/01/16].
    8. Mirza F, Canalis E. Management of endocrine disease: Secondary osteoporosis: pathophysiology and management. Eur J Endocrinol. 2015 Sep; 173(3):R131-51. PMID: 25971649; PMCID: PMC4534332 [Available on 06/01/16].
    9. Choudhary S, Canalis E, Estus T, Adams D, Pilbeam C. Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice. PLoS One. 2015; 10(3):e0120164. PMID: 25781979; PMCID: PMC4363701.
    10. Canalis E, Zanotti S. Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis. 2014; 9:200. PMID: 25491639; PMCID: PMC4269900.
    11. Canalis E, Kranz L, Zanotti S. Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol. 2014 Nov; 229(11):1736-43. PMID: 24664870; PMCID: PMC4117815.
    12. Canalis E, Zanotti S, Smerdel-Ramoya A. Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Bone. 2014 Jul; 64:273-80. PMID: 24792956; PMCID: PMC4069863.
    13. Yang J, Velikoff M, Canalis E, Horowitz JC, Kim KK. Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15; 306(8):L786-96. PMID: 24508728; PMCID: PMC3989723.
    14. Zanotti S, Canalis E. Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. Bone. 2014 May; 62:22-8. PMID: 24508387; PMCID: PMC3970724.
    15. Zanotti S, Kalajzic I, Aguila HL, Canalis E. Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells. PLoS One. 2014; 9(1):e86757. PMID: 24489784; PMCID: PMC3904935.
    16. He Q, Yang X, Gong Y, Kovalenko D, Canalis E, Rosen CJ, Friesel RE. Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. J Bone Miner Res. 2014; 29(5):1217-31. PMID: 24127237; PMCID: PMC3984377.
    17. Canalis E. Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. Nat Rev Endocrinol. 2013 Oct; 9(10):575-83. PMID: 23938284.
      View in: PubMed
    18. Canalis E, Adams DJ, Boskey A, Parker K, Kranz L, Zanotti S. Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem. 2013 Aug 30; 288(35):25614-25. PMID: 23884415; PMCID: PMC3757222.
    19. Zanotti S, Canalis E. Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice. J Biol Chem. 2013 Jul 26; 288(30):21547-57. PMID: 23782701; PMCID: PMC3724615.
    20. Zanotti S, Canalis E. Notch signaling in skeletal health and disease. Eur J Endocrinol. 2013 Jun; 168(6):R95-103. PMID: 23554451; PMCID: PMC4501254.
    21. Canalis E, Parker K, Feng JQ, Zanotti S. Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology. 2013 Feb; 154(2):623-34. PMID: 23275471; PMCID: PMC3548181.
    22. Zanotti S, Canalis E. Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes. Endocrinology. 2013 Feb; 154(2):762-72. PMID: 23264614; PMCID: PMC3548184.
    23. Zanotti S, Smerdel-Ramoya A, Canalis E. Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. J Biol Chem. 2013 Jan 4; 288(1):624-32. PMID: 23166323; PMCID: PMC3537061.
    24. Baud'huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12207-12. PMID: 22761317; PMCID: PMC3409793.
    25. Canalis E, Brunet LJ, Parker K, Zanotti S. Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology. 2012 Apr; 153(4):1616-26. PMID: 22334719; PMCID: PMC3320258.
    26. Zanotti S, Canalis E. Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling. J Cell Biochem. 2012 Feb; 113(2):449-56. PMID: 21928348; PMCID: PMC3253257.
    27. Canalis E, Parker K, Zanotti S. Gremlin1 is required for skeletal development and postnatal skeletal homeostasis. J Cell Physiol. 2012 Jan; 227(1):269-77. PMID: 21412775; PMCID: PMC3132213.
    28. Zanotti S, Canalis E. Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int. 2012 Feb; 90(2):69-75. PMID: 22002679; PMCID: PMC3272107.
    29. Myers M, Tripurani SK, Middlebrook B, Economides AN, Canalis E, Pangas SA. Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod. 2011 Dec; 85(6):1175-82. PMID: 21832168; PMCID: PMC3223251.
    30. Kawai M, Breggia AC, DeMambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. J Biol Chem. 2011 Apr 22; 286(16):14670-80. PMID: 21372140; PMCID: PMC3077664.
    31. Smerdel-Ramoya A, Zanotti S, Canalis E. Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms. J Cell Biochem. 2011 Feb; 112(2):715-22. PMID: 21268093; PMCID: PMC3059361.
    32. Beamer WG, Shultz KL, Coombs HF, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR. BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res. 2011 Jan; 26(1):88-99. PMID: 20687154; PMCID: PMC3179313.
    33. Zanotti S, Smerdel-Ramoya A, Canalis E. Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem. 2011 Feb 11; 286(6):4576-88. PMID: 21131365; PMCID: PMC3039329.
    34. Zanotti S, Smerdel-Ramoya A, Canalis E. HES1 (hairy and enhancer of split 1) is a determinant of bone mass. J Biol Chem. 2011 Jan 28; 286(4):2648-57. PMID: 21084301; PMCID: PMC3024760.
    35. Mazziotti G, Canalis E, Giustina A. Drug-induced osteoporosis: mechanisms and clinical implications. Am J Med. 2010 Oct; 123(10):877-84. PMID: 20920685.
      View in: PubMed
    36. Canalis E. New treatment modalities in osteoporosis. Endocr Pract. 2010 Sep-Oct; 16(5):855-63. PMID: 20350910; PMCID: PMC3278773.
    37. Yang M, Trettel LB, Adams DJ, Harrison JR, Canalis E, Kream BE. Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation. Bone. 2010 Sep; 47(3):573-82. PMID: 20541046; PMCID: PMC2926146.
    38. Canalis E, Zanotti S, Beamer WG, Economides AN, Smerdel-Ramoya A. Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology. 2010 Aug; 151(8):3490-501. PMID: 20534727; PMCID: PMC2940511.
    39. Smerdel-Ramoya A, Zanotti S, Canalis E. Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage. J Cell Biochem. 2010 May 15; 110(2):477-83. PMID: 20235153; PMCID: PMC3008370.
    40. Canalis E. Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab. 2010 Apr; 95(4):1496-504. PMID: 20375217; PMCID: PMC2853988.
    41. Pereira RM, Carvalho JF, Canalis E. Glucocorticoid-induced osteoporosis in rheumatic diseases. Clinics (Sao Paulo). 2010; 65(11):1197-205. PMID: 21243296; PMCID: PMC2999719.
    42. DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marín de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol. 2010 Mar; 204(3):241-53. PMID: 20032200; PMCID: PMC3033737.
    43. Zanotti S, Canalis E. Notch and the skeleton. Mol Cell Biol. 2010 Feb; 30(4):886-96. PMID: 19995916; PMCID: PMC2815558.
    44. Zaidi M, Turner CH, Canalis E, Pacifici R, Sun L, Iqbal J, Guo XE, Silverman S, Epstein S, Rosen CJ. Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep. 2009 Dec; 7(4):118-26. PMID: 19968915.
      View in: PubMed
    45. Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S. Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Endocrinology. 2010 Jan; 151(1):221-33. PMID: 19934377; PMCID: PMC2803142.
    46. Canalis E. Growth factor control of bone mass. J Cell Biochem. 2009 Nov 1; 108(4):769-77. PMID: 19718659; PMCID: PMC3004749.
    47. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res. 2009 Aug; 24(8):1481-92. PMID: 19257833; PMCID: PMC2718800.
    48. Zanotti S, Stadmeyer L, Smerdel-Ramoya A, Durant D, Canalis E. Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. J Endocrinol. 2009 May; 201(2):263-74. PMID: 19218285; PMCID: PMC2674520.
    49. Mazziotti G, Giustina A, Canalis E, Bilezikian JP. Treatment of glucocorticoid-induced osteoporsis. Ther Adv Musculoskelet Dis. 2009 Feb; 1(1):27-34. PMID: 22870425; PMCID: PMC3382670.
    50. Ackert-Bicknell CL, Demissie S, Marín de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Miner Res. 2008 Sep; 23(9):1398-408. PMID: 18707223; PMCID: PMC2683155.
    51. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Canalis E. Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2. J Cell Biochem. 2008 Jul 1; 104(4):1421-6. PMID: 18286547.
      View in: PubMed
    52. Smerdel-Ramoya A, Zanotti S, Deregowski V, Canalis E. Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem. 2008 Aug 15; 283(33):22690-9. PMID: 18583340; PMCID: PMC2504891.
    53. Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Canalis E. Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology. 2008 Sep; 149(9):4374-81. PMID: 18535099; PMCID: PMC2553373.
    54. Pearsall RS, Canalis E, Cornwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Grinberg A, Werner ED, Glatt V, Stadmeyer L, Smith D, Seehra J, Bouxsein ML. A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):7082-7. PMID: 18460605; PMCID: PMC2383948.
    55. Canalis E. Notch signaling in osteoblasts. Sci Signal. 2008; 1(17):pe17. PMID: 18445833.
      View in: PubMed
    56. Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 2008 Aug; 29(5):535-59. PMID: 18436706; PMCID: PMC2726838.
    57. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Durant D, Radtke F, Canalis E. Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology. 2008 Aug; 149(8):3890-9. PMID: 18420737; PMCID: PMC2488209.
    58. Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN. The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development. 2008 May; 135(9):1713-23. PMID: 18353862.
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    59. Deregowski V, Canalis E. Gene delivery by retroviruses. Methods Mol Biol. 2008; 455:157-62. PMID: 18463818.
      View in: PubMed
    60. Nagatomo KJ, Tompkins KA, Fong H, Zhang H, Foster BL, Chu EY, Murakami A, Stadmeyer L, Canalis E, Somerman MJ. Transgenic overexpression of gremlin results in developmental defects in enamel and dentin in mice. Connect Tissue Res. 2008; 49(6):391-400. PMID: 19085239; PMCID: PMC2852574.
    61. Canalis E. Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist. Ann N Y Acad Sci. 2007 Nov; 1116:50-8. PMID: 18083920.
      View in: PubMed
    62. Mazziotti G, Giustina A, Canalis E, Bilezikian JP. Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects. Arq Bras Endocrinol Metabol. 2007 Nov; 51(8):1404-12. PMID: 18209880.
      View in: PubMed
    63. Gazzerro E, Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Economides AN, Canalis E. Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem. 2007 Oct 26; 282(43):31549-57. PMID: 17785465.
      View in: PubMed
    64. Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. N Engl J Med. 2007 Aug 30; 357(9):905-16. PMID: 17761594.
      View in: PubMed
    65. Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res. 2007 Aug; 22(8):1197-207. PMID: 17488199.
      View in: PubMed
    66. Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF, Donahue LR, Canalis E, Rosen CJ. Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes. J Bone Miner Res. 2007 Aug; 22(8):1187-96. PMID: 17451375.
      View in: PubMed
    67. Canalis E, Mazziotti G, Giustina A, Bilezikian JP. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int. 2007 Oct; 18(10):1319-28. PMID: 17566815.
      View in: PubMed
    68. Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem. 2007 Jul 6; 282(27):19762-72. PMID: 17500060.
      View in: PubMed
    69. Pereira RC, Stadmeyer LE, Smith DL, Rydziel S, Canalis E. CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Bone. 2007 Mar; 40(3):619-26. PMID: 17095306; PMCID: PMC1850334.
    70. Gazzerro E, Deregowski V, Stadmeyer L, Gale NW, Economides AN, Canalis E. Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Bone. 2006 Dec; 39(6):1252-60. PMID: 16934545.
      View in: PubMed
    71. Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E. Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage. J Bone Miner Res. 2006 Aug; 21(8):1317-26. PMID: 16869730.
      View in: PubMed
    72. Gazzerro E, Canalis E. Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):51-65. PMID: 17029022.
      View in: PubMed
    73. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006 May; 189(2):289-99. PMID: 16648296.
      View in: PubMed
    74. Mazziotti G, Angeli A, Bilezikian JP, Canalis E, Giustina A. Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab. 2006 May-Jun; 17(4):144-9. PMID: 16678739.
      View in: PubMed
    75. Pereira RC, Stadmeyer L, Marciniak SJ, Ron D, Canalis E. C/EBP homologous protein is necessary for normal osteoblastic function. J Cell Biochem. 2006 Feb 15; 97(3):633-40. PMID: 16220546.
      View in: PubMed
    76. Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem. 2006 Mar 10; 281(10):6203-10. PMID: 16407293.
      View in: PubMed
    77. Parisi MS, Gazzerro E, Rydziel S, Canalis E. Expression and regulation of CCN genes in murine osteoblasts. Bone. 2006 May; 38(5):671-7. PMID: 16311085.
      View in: PubMed
    78. Canalis E. Mechanisms of glucocorticoid action in bone. Curr Osteoporos Rep. 2005 Sep; 3(3):98-102. PMID: 16131429.
      View in: PubMed
    79. Gazzerro E, Deregowski V, Vaira S, Canalis E. Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro. Endocrinology. 2005 Sep; 146(9):3875-82. PMID: 15919755.
      View in: PubMed
    80. Canalis E. The fate of circulating osteoblasts. N Engl J Med. 2005 May 12; 352(19):2014-6. PMID: 15888703.
      View in: PubMed
    81. Varghese S, Rydziel S, Canalis E. Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. J Cell Physiol. 2005 Feb; 202(2):391-9. PMID: 15389594.
      View in: PubMed
    82. Canalis E, Deregowski V, Pereira RC, Gazzerro E. Signals that determine the fate of osteoblastic cells. J Endocrinol Invest. 2005; 28(8 Suppl):3-7. PMID: 16329200.
      View in: PubMed
    83. Durant D, Pereira RM, Canalis E. Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro. Bone. 2004 Dec; 35(6):1256-62. PMID: 15589207.
      View in: PubMed
    84. Gazzerro E, Pereira RC, Jorgetti V, Olson S, Economides AN, Canalis E. Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology. 2005 Feb; 146(2):655-65. PMID: 15539560.
      View in: PubMed
    85. Wyzga N, Varghese S, Wikel S, Canalis E, Sylvester FA. Effects of activated T cells on osteoclastogenesis depend on how they are activated. Bone. 2004 Sep; 35(3):614-20. PMID: 15336596.
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    86. Durant D, Pereira R, Stadmeyer L, Canalis E. Transgenic mice expressing selected insulin-like growth factor-binding protein-5 fragments do not exhibit enhanced bone formation. Growth Horm IGF Res. 2004 Aug; 14(4):319-27. PMID: 15231301.
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    87. Canalis E, Bilezikian JP, Angeli A, Giustina A. Perspectives on glucocorticoid-induced osteoporosis. Bone. 2004 Apr; 34(4):593-8. PMID: 15050888.
      View in: PubMed
    88. Pereira RC, Delany AM, Canalis E. CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. Endocrinology. 2004 Apr; 145(4):1952-60. PMID: 14684614.
      View in: PubMed
    89. Varghese S, Canalis E. Transcriptional regulation of collagenase-3 by interleukin-1 alpha in osteoblasts. J Cell Biochem. 2003 Dec 1; 90(5):1007-14. PMID: 14624460.
      View in: PubMed
    90. Rydziel S, Delany AM, Canalis E. AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts. J Biol Chem. 2004 Feb 13; 279(7):5397-404. PMID: 14645243.
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    91. Sciaudone M, Gazzerro E, Priest L, Delany AM, Canalis E. Notch 1 impairs osteoblastic cell differentiation. Endocrinology. 2003 Dec; 144(12):5631-9. PMID: 12960086.
      View in: PubMed
    92. Canalis E. Mechanisms of glucocorticoid-induced osteoporosis. Curr Opin Rheumatol. 2003 Jul; 15(4):454-7. PMID: 12819474.
      View in: PubMed
    93. Boskey AL, Moore DJ, Amling M, Canalis E, Delany AM. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003 Jun; 18(6):1005-11. PMID: 12817752.
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    94. Franchimont N, Canalis E. Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease. Autoimmun Rev. 2003 Jun; 2(4):224-8. PMID: 12848950.
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    95. Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 2003 Jun; 144(6):2588-96. PMID: 12746322.
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    96. Devlin RD, Du Z, Pereira RC, Kimble RB, Economides AN, Jorgetti V, Canalis E. Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology. 2003 May; 144(5):1972-8. PMID: 12697704.
      View in: PubMed
    97. Canalis E, Economides AN, Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev. 2003 Apr; 24(2):218-35. PMID: 12700180.
      View in: PubMed
    98. Gazzerro E, Du Z, Devlin RD, Rydziel S, Priest L, Economides AN, Canalis E. Noggin arrests stromal cell differentiation in vitro. Bone. 2003 Feb; 32(2):111-9. PMID: 12633782.
      View in: PubMed
    99. Canalis E, Pereira RC, Delany AM. Effects of glucocorticoids on the skeleton. J Pediatr Endocrinol Metab. 2002 Dec; 15 Suppl 5:1341-5. PMID: 12510988.
      View in: PubMed
    100. Devlin RD, Du Z, Buccilli V, Jorgetti V, Canalis E. Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. Endocrinology. 2002 Oct; 143(10):3955-62. PMID: 12239107.
      View in: PubMed
    101. Canalis E, Delany AM. Mechanisms of glucocorticoid action in bone. Ann N Y Acad Sci. 2002 Jun; 966:73-81. PMID: 12114261.
      View in: PubMed
    102. Canalis E, Delany AM. 11beta-hydroxysteroid dehydrogenase, an amplifier of glucocorticoid action in osteoblasts. J Bone Miner Res. 2002 Jun; 17(6):987-90. PMID: 12054174.
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    103. Pereira RC, Delany AM, Canalis E. Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone. 2002 May; 30(5):685-91. PMID: 11996905.
      View in: PubMed
    104. Pereira RM, Delany AM, Durant D, Canalis E. Cortisol regulates the expression of Notch in osteoblasts. J Cell Biochem. 2002; 85(2):252-8. PMID: 11948681.
      View in: PubMed
    105. Delany AM, Pereira RM, Pereira RC, Canalis E. The cellular and molecular basis of glucocorticoid actions in bone. Front Horm Res. 2002; 30:2-12. PMID: 11892267.
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    106. Canalis E, Giustina A. Glucocorticoid-induced osteoporosis: summary of a workshop. J Clin Endocrinol Metab. 2001 Dec; 86(12):5681-5. PMID: 11739419.
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    107. Delany AM, Durant D, Canalis E. Glucocorticoid suppression of IGF I transcription in osteoblasts. Mol Endocrinol. 2001 Oct; 15(10):1781-9. PMID: 11579210.
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    108. Pereira RM, Delany AM, Canalis E. Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone. 2001 May; 28(5):484-90. PMID: 11344047.
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    109. Delany AM, Canalis E. The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts. Endocrinology. 2001 Apr; 142(4):1561-6. PMID: 11250937.
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    110. Pereira RC, Economides AN, Canalis E. Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Endocrinology. 2000 Dec; 141(12):4558-63. PMID: 11108268.
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    111. Varghese S, Canalis E. Alendronate stimulates collagenase 3 expression in osteoblasts by posttranscriptional mechanisms. J Bone Miner Res. 2000 Dec; 15(12):2345-51. PMID: 11127199.
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    112. Rydziel S, Durant D, Canalis E. Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex. J Cell Physiol. 2000 Sep; 184(3):326-33. PMID: 10911363.
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    113. Pereira RC, Durant D, Canalis E. Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E570-6. PMID: 10950824.
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    114. Canalis E. Novel treatments for osteoporosis. J Clin Invest. 2000 Jul; 106(2):177-9. PMID: 10903331; PMCID: PMC314318.
    115. Varghese S, Rydziel S, Canalis E. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Endocrinology. 2000 Jun; 141(6):2185-91. PMID: 10830307.
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    116. Delany AM, Amling M, Priemel M, Howe C, Baron R, Canalis E. Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest. 2000 Apr; 105(7):915-23. PMID: 10749571; PMCID: PMC377474.
    117. Blanquaert F, Pereira RC, Canalis E. Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E509-15. PMID: 10710506.
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    118. Franchimont N, Rydziel S, Canalis E. Transforming growth factor-beta increases interleukin-6 transcripts in osteoblasts. Bone. 2000 Mar; 26(3):249-53. PMID: 10709997.
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    119. Pereira RC, Rydziel S, Canalis E. Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts. J Cell Physiol. 2000 Feb; 182(2):239-46. PMID: 10623888.
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    120. Pereira RC, Jorgetti V, Canalis E. Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts. Am J Physiol. 1999 Sep; 277(3 Pt 1):E496-504. PMID: 10484362.
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    121. Pereira RC, Canalis E. Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts. Endocrinology. 1999 May; 140(5):1998-2003. PMID: 10218947.
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    122. Franchimont N, Durant D, Rydziel S, Canalis E. Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. J Biol Chem. 1999 Mar 5; 274(10):6783-9. PMID: 10037779.
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    123. Varghese S, Yu K, Canalis E. Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. Am J Physiol. 1999 Mar; 276(3 Pt 1):E465-71. PMID: 10070011.
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    124. Blanquaert F, Delany AM, Canalis E. Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts. Endocrinology. 1999 Mar; 140(3):1069-74. PMID: 10067827.
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    125. Gazzerro E, Rydziel S, Canalis E. Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts. Endocrinology. 1999 Feb; 140(2):562-7. PMID: 9927278.
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    126. Pereira RC, Blanquaert F, Canalis E. Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts. Endocrinology. 1999 Jan; 140(1):228-32. PMID: 9886829.
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    127. Gazzerro E, Gangji V, Canalis E. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest. 1998 Dec 15; 102(12):2106-14. PMID: 9854046; PMCID: PMC509165.
    128. Gabbitas B, Canalis E. Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. Am J Physiol. 1998 Aug; 275(2 Pt 1):E222-8. PMID: 9688622.
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    129. Delany AM, Canalis E. Dual regulation of stromelysin-3 by fibroblast growth factor-2 in murine osteoblasts. J Biol Chem. 1998 Jun 26; 273(26):16595-600. PMID: 9632732.
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    130. Gangji V, Rydziel S, Gabbitas B, Canalis E. Insulin-like growth factor II promoter expression in cultured rodent osteoblasts and adult rat bone. Endocrinology. 1998 May; 139(5):2287-92. PMID: 9564836.
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    131. Delany AM, Canalis E. Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. Am J Physiol. 1998 Mar; 274(3 Pt 1):C734-40. PMID: 9530105.
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    132. Franchimont N, Gangji V, Durant D, Canalis E. Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. Endocrinology. 1997 Dec; 138(12):5248-55. PMID: 9389508.
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    133. Rydziel S, Delany AM, Canalis E. Insulin-like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures. J Cell Biochem. 1997 Nov 1; 67(2):176-83. PMID: 9328823.
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    134. Franchimont N, Rydziel S, Canalis E. Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells. J Clin Invest. 1997 Oct 1; 100(7):1797-803. PMID: 9312180; PMCID: PMC508365.
    135. Canalis E. Insulin-like growth factors and osteoporosis. Bone. 1997 Sep; 21(3):215-6. PMID: 9276085.
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    136. Gabbitas B, Canalis E. Retinoic acid regulates the expression of insulin-like growth factors I and II in osteoblasts. J Cell Physiol. 1997 Aug; 172(2):253-64. PMID: 9258346.
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    137. Franchimont N, Durant D, Canalis E. Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Endocrinology. 1997 Aug; 138(8):3380-6. PMID: 9231791.
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    138. Gabbitas B, Canalis E. Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts. J Cell Biochem. 1997 Jul 1; 66(1):77-86. PMID: 9215530.
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    139. Franchimont N, Rydziel S, Delany AM, Canalis E. Interleukin-6 and its soluble receptor cause a marked induction of collagenase 3 expression in rat osteoblast cultures. J Biol Chem. 1997 May 2; 272(18):12144-50. PMID: 9115285.
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    140. Varghese S, Canalis E. Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. Endocrinology. 1997 Mar; 138(3):1035-40. PMID: 9048606.
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    141. Rydziel S, Varghese S, Canalis E. Transforming growth factor beta1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures. J Cell Physiol. 1997 Feb; 170(2):145-52. PMID: 9009143.
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    142. Delany AM, Rydziel S, Canalis E. Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. Endocrinology. 1996 Nov; 137(11):4665-70. PMID: 8895331.
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    143. Rydziel S, Canalis E. Expression and growth factor regulation of platelet-derived growth factor B transcripts in primary osteoblast cell cultures. Endocrinology. 1996 Oct; 137(10):4115-9. PMID: 8828465.
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    144. Canalis E. Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab. 1996 Oct; 81(10):3441-7. PMID: 8855781.
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    145. Gabbitas B, Canalis E. Retinoic acid stimulates the transcription of insulin-like growth factor binding protein-6 in skeletal cells. J Cell Physiol. 1996 Oct; 169(1):15-22. PMID: 8841418.
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    146. Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone. 1996 Jun; 18(6):517-23. PMID: 8805991.
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    147. Pash JM, Canalis E. Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells. Endocrinology. 1996 Jun; 137(6):2375-82. PMID: 8641189.
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    148. Gabbitas B, Canalis E. Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts. Endocrinology. 1996 May; 137(5):1687-92. PMID: 8612502.
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    149. Gabbitas B, Pash JM, Delany AM, Canalis E. Cortisol inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures by transcriptional mechanisms. J Biol Chem. 1996 Apr 12; 271(15):9033-8. PMID: 8621551.
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    150. Varghese S, Delany AM, Liang L, Gabbitas B, Jeffrey JJ, Canalis E. Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures. Endocrinology. 1996 Feb; 137(2):431-7. PMID: 8593786.
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    151. Franchimont N, Canalis E. Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. Endocrinology. 1995 Dec; 136(12):5469-75. PMID: 7588297.
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    152. Delany AM, Jeffrey JJ, Rydziel S, Canalis E. Cortisol increases interstitial collagenase expression in osteoblasts by post-transcriptional mechanisms. J Biol Chem. 1995 Nov 3; 270(44):26607-12. PMID: 7592884.
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    153. Delany AM, Canalis E. Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. Endocrinology. 1995 Nov; 136(11):4776-81. PMID: 7588206.
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    154. Burstein FD, Canalis RF, Canalis EM, Ariyan S. Scanning electron microscopy and gel electrophoresis of vascularized periosteal autografts. Plast Reconstr Surg. 1989 Mar; 83(3):500-10. PMID: 2919203.
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    155. Dietrich JW, Canalis EM, Maina DM, Raisz LG. Effects of glucocorticoids on fetal rat bone collagen synthesis in vitro. Endocrinology. 1979 Mar; 104(3):715-21. PMID: 436731.
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    156. Raisz LG, Maina DM, Gworek SC, Dietrich JW, Canalis EM. Hormonal control of bone collagen synthesis in vitro: inhibitory effect of 1-hydroxylated vitamin D metabolites. Endocrinology. 1978 Mar; 102(3):731-5. PMID: 743989.
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    157. Raisz LG, Canalis EM, Dietrich JW, Kream BE, Gworek SC. Hormonal regulation of bone formation. Recent Prog Horm Res. 1978; 34:335-56. PMID: 366683.
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    158. Canalis EM, Hintz RL, Dietrich JW, Maina DM, Raisz LG. Effect of somatomedin and growth hormone on bone collagen synthesis in vitro. Metabolism. 1977 Oct; 26(10):1079-87. PMID: 895522.
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    159. Mundy GR, Canalis EM, Raisz LG. Calcium and the kidney: renal osteodystrophy and renal calculi. Conn Med. 1977 Apr; 41(4):205-9. PMID: 852281.
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    160. Canalis EM, Dietrich JW, Maina DM, Raisz LG. Hormonal control of bone collagen synthesis in vitro. Effects of insulin and glucagon. Endocrinology. 1977 Mar; 100(3):668-74. PMID: 401359.
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    161. Canalis EM, Mundy GR, Raisz LG. Paget's disease of bone: recent advances in therapy. Conn Med. 1977 Feb; 41(2):79-83. PMID: 138526.
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    162. Canalis EM, Mundy GR, Raisz LG. Hypercalcemia: diagnosis and therapy. Conn Med. 1977 Jan; 41(1):16-21. PMID: 137799.
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    163. Raisz LG, Mundy GR, Dietrich JW, Canalis EM. Hormonal regulation of mineral metabolism. Int Rev Physiol. 1977; 16:199-240. PMID: 198389.
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    164. Mundy GR, Canalis EM, Raisz LG. Osteopenia: osteoporosis, osteomalacia and other forms of decreased mineralized bone mass. Conn Med. 1976 Nov; 40(11):753-7. PMID: 975804.
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    165. Mundy GR, Canalis EM, Raisz LG. Modern concepts of calcium homeostasis. Conn Med. 1976 Oct; 40(10):680-4. PMID: 975794.
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    166. Mundy GR, Shapiro JL, Bandelin JG, Canalis EM, Raisz LG. Direct stimulation of bone resorption by thyroid hormones. J Clin Invest. 1976 Sep; 58(3):529-34. PMID: 182721; PMCID: PMC333209.
    167. Dietrich JW, Canalis EM, Maina DM, Raisz LG. Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin. Endocrinology. 1976 Apr; 98(4):943-9. PMID: 945152.
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    168. Raisz LG, Dietrich JW, Canalis EM. Factors influencing bone formation in organ culture. Isr J Med Sci. 1976 Feb; 12(2):108-14. PMID: 1262198.
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