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Stefano Zanotti PhD

TitleResearch Scientist
InstitutionSaint Francis Hospital and Medical Center
DepartmentResearch
Address114 Woodland Street
Phone860-714-5250
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    Other Positions
    TitleAssistant Professor
    InstitutionUConn Health Center
    DepartmentMedicine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Canalis E, Zanotti S. Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations. Curr Osteoporos Rep. 2016 Aug; 14(4):126-31. PMID: 27241678.
      View in: PubMed
    2. Zanotti S, Canalis E. Notch Signaling and the Skeleton. Endocr Rev. 2016 Jun; 37(3):223-53. PMID: 27074349.
      View in: PubMed
    3. Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S. Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption. J Biol Chem. 2016 Jan 22; 291(4):1538-51. PMID: 26627824.
      View in: PubMed
    4. Canalis E, Bridgewater D, Schilling L, Zanotti S. Canonical Notch activation in osteocytes causes osteopetrosis. Am J Physiol Endocrinol Metab. 2016 Jan 15; 310(2):E171-82. PMID: 26578715.
      View in: PubMed
    5. Zanotti S, Canalis E. The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele. J Cell Biochem. 2016 May; 117(5):1222-32. PMID: 26456319.
      View in: PubMed
    6. Zanotti S, Canalis E. Activation of Nfatc2 in osteoblasts causes osteopenia. J Cell Physiol. 2015 Jul; 230(7):1689-95. PMID: 25573264; PMCID: PMC4380686 [Available on 07/01/16].
    7. Canalis E, Zanotti S. Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis. 2014; 9:200. PMID: 25491639; PMCID: PMC4269900.
    8. Canalis E, Kranz L, Zanotti S. Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol. 2014 Nov; 229(11):1736-43. PMID: 24664870; PMCID: PMC4117815.
    9. Canalis E, Zanotti S, Smerdel-Ramoya A. Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Bone. 2014 Jul; 64:273-80. PMID: 24792956; PMCID: PMC4069863.
    10. Zanotti S, Canalis E. Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. Bone. 2014 May; 62:22-8. PMID: 24508387; PMCID: PMC3970724.
    11. Zanotti S, Kalajzic I, Aguila HL, Canalis E. Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells. PLoS One. 2014; 9(1):e86757. PMID: 24489784; PMCID: PMC3904935.
    12. Sylvester FA, Gordon CM, Thayu M, Burnham JM, Denson LA, Essers J, Ferrari S, Gupta N, Hewison M, Koletzko S, McCabe L, Pappa H, Sanderson I, Ward L, Zanotti S. Report of the CCFA pediatric bone, growth and muscle health workshop, New York City, November 11-12, 2011, with updates. Inflamm Bowel Dis. 2013 Dec; 19(13):2919-26. PMID: 23974992.
      View in: PubMed
    13. Zanotti S, Canalis E. Interleukin 6 mediates selected effects of Notch in chondrocytes. Osteoarthritis Cartilage. 2013 Nov; 21(11):1766-73. PMID: 23954701; PMCID: PMC3795792.
    14. Canalis E, Adams DJ, Boskey A, Parker K, Kranz L, Zanotti S. Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem. 2013 Aug 30; 288(35):25614-25. PMID: 23884415; PMCID: PMC3757222.
    15. Zanotti S, Canalis E. Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice. J Biol Chem. 2013 Jul 26; 288(30):21547-57. PMID: 23782701; PMCID: PMC3724615.
    16. Zanotti S, Canalis E. Notch signaling in skeletal health and disease. Eur J Endocrinol. 2013 Jun; 168(6):R95-103. PMID: 23554451; PMCID: PMC4501254.
    17. Canalis E, Parker K, Feng JQ, Zanotti S. Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology. 2013 Feb; 154(2):623-34. PMID: 23275471; PMCID: PMC3548181.
    18. Zanotti S, Canalis E. Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes. Endocrinology. 2013 Feb; 154(2):762-72. PMID: 23264614; PMCID: PMC3548184.
    19. Zanotti S, Smerdel-Ramoya A, Canalis E. Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. J Biol Chem. 2013 Jan 4; 288(1):624-32. PMID: 23166323; PMCID: PMC3537061.
    20. Canalis E, Brunet LJ, Parker K, Zanotti S. Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology. 2012 Apr; 153(4):1616-26. PMID: 22334719; PMCID: PMC3320258.
    21. Zanotti S, Canalis E. Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling. J Cell Biochem. 2012 Feb; 113(2):449-56. PMID: 21928348; PMCID: PMC3253257.
    22. Canalis E, Parker K, Zanotti S. Gremlin1 is required for skeletal development and postnatal skeletal homeostasis. J Cell Physiol. 2012 Jan; 227(1):269-77. PMID: 21412775; PMCID: PMC3132213.
    23. Zanotti S, Canalis E. Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int. 2012 Feb; 90(2):69-75. PMID: 22002679; PMCID: PMC3272107.
    24. Smerdel-Ramoya A, Zanotti S, Canalis E. Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms. J Cell Biochem. 2011 Feb; 112(2):715-22. PMID: 21268093; PMCID: PMC3059361.
    25. Zanotti S, Smerdel-Ramoya A, Canalis E. Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem. 2011 Feb 11; 286(6):4576-88. PMID: 21131365; PMCID: PMC3039329.
    26. Zanotti S, Smerdel-Ramoya A, Canalis E. HES1 (hairy and enhancer of split 1) is a determinant of bone mass. J Biol Chem. 2011 Jan 28; 286(4):2648-57. PMID: 21084301; PMCID: PMC3024760.
    27. Canalis E, Zanotti S, Beamer WG, Economides AN, Smerdel-Ramoya A. Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology. 2010 Aug; 151(8):3490-501. PMID: 20534727; PMCID: PMC2940511.
    28. Smerdel-Ramoya A, Zanotti S, Canalis E. Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage. J Cell Biochem. 2010 May 15; 110(2):477-83. PMID: 20235153; PMCID: PMC3008370.
    29. Zanotti S, Canalis E. Notch and the skeleton. Mol Cell Biol. 2010 Feb; 30(4):886-96. PMID: 19995916; PMCID: PMC2815558.
    30. Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S. Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Endocrinology. 2010 Jan; 151(1):221-33. PMID: 19934377; PMCID: PMC2803142.
    31. Zanotti S, Stadmeyer L, Smerdel-Ramoya A, Durant D, Canalis E. Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. J Endocrinol. 2009 May; 201(2):263-74. PMID: 19218285; PMCID: PMC2674520.
    32. Manduca P, Castagnino A, Lombardini D, Marchisio S, Soldano S, Ulivi V, Zanotti S, Garbi C, Ferrari N, Palmieri D. Role of MT1-MMP in the osteogenic differentiation. Bone. 2009 Feb; 44(2):251-65. PMID: 19027888.
      View in: PubMed
    33. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Canalis E. Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2. J Cell Biochem. 2008 Jul 1; 104(4):1421-6. PMID: 18286547.
      View in: PubMed
    34. Smerdel-Ramoya A, Zanotti S, Deregowski V, Canalis E. Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem. 2008 Aug 15; 283(33):22690-9. PMID: 18583340; PMCID: PMC2504891.
    35. Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Canalis E. Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology. 2008 Sep; 149(9):4374-81. PMID: 18535099; PMCID: PMC2553373.
    36. Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Durant D, Radtke F, Canalis E. Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology. 2008 Aug; 149(8):3890-9. PMID: 18420737; PMCID: PMC2488209.
    37. Gazzerro E, Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Economides AN, Canalis E. Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem. 2007 Oct 26; 282(43):31549-57. PMID: 17785465.
      View in: PubMed
    38. Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem. 2007 Jul 6; 282(27):19762-72. PMID: 17500060.
      View in: PubMed
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